Residues Glutamate 216 and Aspartate 301 Are Key Determinants of Substrate Specificity and Product Regioselectivity in Cytochrome P450 2D6
Paine, Mark J.I., McLaughlin, Lesley A., Flanagan, Jack U., Kemp, Carol A., Sutcliffe, Michael J., Roberts, Gordon C.K., Wolf, C. Roland
Published in The Journal of biological chemistry (07.02.2003)
Published in The Journal of biological chemistry (07.02.2003)
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Validation of Model of Cytochrome P450 2D6: An in Silico Tool for Predicting Metabolism and Inhibition
Kemp, Carol A, Flanagan, Jack U, van Eldik, Annamaria J, Maréchal, Jean-Didier, Wolf, C. Roland, Roberts, Gordon C. K, Paine, Mark J. I, Sutcliffe, Michael J
Published in Journal of medicinal chemistry (21.10.2004)
Published in Journal of medicinal chemistry (21.10.2004)
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IN SILICO PREDICTION OF DRUG BINDING TO CYP2D6: IDENTIFICATION OF A NEW METABOLITE OF METOCLOPRAMIDE
JINGLEI YU, PAINE, Mark J. I, MARECHAL, Jean-Didier, KEMP, Carol A, WARD, Clive J, BROWN, Simon, SUTCLIFFE, Michael J, ROBERTS, Gordon C. K, RANKIN, Elaine M, WOLF, C. Roland
Published in Drug metabolism and disposition (01.08.2006)
Published in Drug metabolism and disposition (01.08.2006)
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Progress in cytochrome P450 active site modeling
Kemp, Carol A., Maréchal, Jean-Didier, Sutcliffe, Michael J.
Published in Archives of biochemistry and biophysics (15.01.2005)
Published in Archives of biochemistry and biophysics (15.01.2005)
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Chronic pain self-management for older adults: a randomized controlled trial [ISRCTN11899548]
Ersek, Mary, Turner, Judith A, Cain, Kevin C, Kemp, Carol A
Published in BMC geriatrics (30.07.2004)
Published in BMC geriatrics (30.07.2004)
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Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite
Flanagan, Jack U, Maréchal, Jean-Didier, Ward, Richard, Kemp, Carol A, McLaughlin, Lesley A, Sutcliffe, Michael J, Roberts, Gordon C K, Paine, Mark J I, Wolf, C Roland
Published in Biochemical journal (01.06.2004)
Published in Biochemical journal (01.06.2004)
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Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding
McLaughlin, Lesley A, Paine, Mark J I, Kemp, Carol A, Maréchal, Jean-Didier, Flanagan, Jack U, Ward, Clive J, Sutcliffe, Michael J, Roberts, Gordon C K, Wolf, C Roland
Published in The Journal of biological chemistry (18.11.2005)
Published in The Journal of biological chemistry (18.11.2005)
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Journal Article
Thermodynamic and Biophysical Characterization of Cytochrome P450 BioI from Bacillus subtilis
Lawson, Rachel J, Leys, David, Sutcliffe, Michael J, Kemp, Carol A, Cheesman, Myles R, Smith, Susan J, Clarkson, John, Smith, W. Ewen, Haq, Ihtshamul, Perkins, John B, Munro, Andrew W
Published in Biochemistry (Easton) (05.10.2004)
Published in Biochemistry (Easton) (05.10.2004)
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Impact of incorporating the 2C5 crystal structure into comparative models of cytochrome P450 2D6
Kirton, Stewart B., Kemp, Carol A., Tomkinson, Nicholas P., St.-Gallay, Steven, Sutcliffe, Michael J.
Published in Proteins, structure, function, and bioinformatics (01.11.2002)
Published in Proteins, structure, function, and bioinformatics (01.11.2002)
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Journal Article
Why Is Quinidine an Inhibitor of Cytochrome P450 2D6?
McLaughlin, Lesley A., Paine, Mark J.I., Kemp, Carol A., Maréchal, Jean-Didier, Flanagan, Jack U., Ward, Clive J., Sutcliffe, Michael J., Roberts, Gordon C.K., Wolf, C. Roland
Published in The Journal of biological chemistry (18.11.2005)
Published in The Journal of biological chemistry (18.11.2005)
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Journal Article