New Pyridyl and Dihydroisoquinoline Alkaloids Isolated from the Chevron Nemertean Amphiporus angulatus
Kem, William R, Soti, Ferenc, Rocca, James R, Johnson, Jodie V
Published in Marine drugs (22.03.2024)
Published in Marine drugs (22.03.2024)
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Journal Article
Initial Phase 2 Trial of a Nicotinic Agonist in Schizophrenia
Freedman, Robert, Olincy, Ann, Buchanan, Robert W., Harris, Josette G., Gold, James M., Johnson, Lynn, Allensworth, Diana, Guzman-Bonilla, Alejandrina, Clement, Bettye, Ball, M. Patricia, Kutnick, Jay, Pender, Vicki, Martin, Laura F., Stevens, Karen E., Wagner, Brandie D., Zerbe, Gary O., Soti, Ferenc, Kem, William R.
Published in The American journal of psychiatry (01.08.2008)
Published in The American journal of psychiatry (01.08.2008)
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Journal Article
Interactions of Nereistoxin and Its Analogs with Vertebrate Nicotinic Acetylcholine Receptors and Molluscan ACh Binding Proteins
Kem, William R, Andrud, Kristin, Bruno, Galen, Xing, Hong, Soti, Ferenc, Talley, Todd T, Taylor, Palmer
Published in Marine drugs (04.01.2022)
Published in Marine drugs (04.01.2022)
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Journal Article
Effects of an Alpha 7-Nicotinic Agonist on Default Network Activity in Schizophrenia
Tregellas, Jason R, Tanabe, Jody, Rojas, Donald C, Shatti, Shireen, Olincy, Ann, Johnson, Lynn, Martin, Laura F, Soti, Ferenc, Kem, William R, Leonard, Sherry, Freedman, Robert
Published in Biological psychiatry (1969) (01.01.2011)
Published in Biological psychiatry (1969) (01.01.2011)
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Journal Article
Prevention of Burn-Induced Inflammatory Responses and Muscle Wasting by GTS-21, a Specific Agonist for α7 Nicotinic Acetylcholine Receptors
Kashiwagi, Shizuka, Khan, Mohammed A S, Yasuhara, Shingo, Goto, Takahisa, Kem, William R, Tompkins, Ronald G, Kaneki, Masao, Martyn, J A Jeevendra
Published in Shock (Augusta, Ga.) (01.01.2017)
Published in Shock (Augusta, Ga.) (01.01.2017)
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Journal Article
Systemic Administration of α7-Nicotinic Acetylcholine Receptor Ligands Does Not Improve Renal Injury or Behavior in Mice With Advanced Systemic Lupus Erythematosus
Morales, Jessica Y, Young-Stubbs, Cassandra M, Shimoura, Caroline G, Kem, William R, Uteshev, Victor V, Mathis, Keisa W
Published in Frontiers in medicine (13.04.2021)
Published in Frontiers in medicine (13.04.2021)
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Journal Article
APS8, a polymeric alkylpyridinium salt blocks α7 nAChR and induces apoptosis in non-small cell lung carcinoma
Zovko, Ana, Viktorsson, Kristina, Lewensohn, Rolf, Kološa, Katja, Filipič, Metka, Xing, Hong, Kem, William R, Paleari, Laura, Turk, Tom
Published in Marine drugs (16.07.2013)
Published in Marine drugs (16.07.2013)
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Journal Article
Hydroxy Metabolites of the Alzheimer's Drug Candidate 3-[(2,4-Dimethoxy)Benzylidene]-Anabaseine Dihydrochloride (GTS-21): Their Molecular Properties, Interactions with Brain Nicotinic Receptors, and Brain Penetration
Kem, William R, Mahnir, Vladimir M, Prokai, Laszlo, Papke, Roger L, Cao, Xuefang, LeFrancois, Susan, Wildeboer, Kristin, Prokai-Tatrai, Katalin, Porter-Papke, Julia, Soti, Ferenc
Published in Molecular pharmacology (01.01.2004)
Published in Molecular pharmacology (01.01.2004)
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Journal Article
Continuous administration of a selective α7 nicotinic partial agonist, DMXBA, improves sensory inhibition without causing tachyphylaxis or receptor upregulation in DBA/2 mice
Stevens, Karen E, Cornejo, Brandon, Adams, Catherine E, Zheng, Lijun, Yonchek, Joan, Hoffman, Keith L, Christians, Uwe, Kem, William R
Published in Brain research (2010)
Published in Brain research (2010)
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Journal Article
Brief Report: Initial Trial of Alpha7-Nicotinic Receptor Stimulation in Two Adult Patients with Autism Spectrum Disorder
Olincy, Ann, Blakeley-Smith, Audrey, Johnson, Lynn, Kem, William R., Freedman, Robert
Published in Journal of autism and developmental disorders (01.12.2016)
Published in Journal of autism and developmental disorders (01.12.2016)
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Journal Article
The nonopioid cholinergic agonist GTS-21 mitigates morphine-induced aggravation of burn injury pain together with inhibition of spinal microglia activation in young rats
Ren, Yang, Zhou, Yinhui, You, Zerong, Deng, Hao, Kem, William R., Mao, Jianren, Zhang, Wei, Martyn, J.A. Jeevendra
Published in British journal of anaesthesia : BJA (01.12.2022)
Published in British journal of anaesthesia : BJA (01.12.2022)
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Journal Article
Pharmacokinetic Limitations on Effects of an Alpha7-Nicotinic Receptor Agonist in Schizophrenia: Randomized Trial with an Extended-Release Formulation
Kem, William R, Olincy, Ann, Johnson, Lynn, Harris, Josette, Wagner, Brandie D, Buchanan, Robert W, Christians, Uwe, Freedman, Robert
Published in Neuropsychopharmacology (New York, N.Y.) (01.02.2018)
Published in Neuropsychopharmacology (New York, N.Y.) (01.02.2018)
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Journal Article
Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mouse model of Alzheimer's disease
Takata, Kazuyuki, Amamiya, Takahide, Mizoguchi, Hiroaki, Kawanishi, Shohei, Kuroda, Eriko, Kitamura, Risa, Ito, Aina, Saito, Yuki, Tawa, Manami, Nagasawa, Tomofumi, Okamoto, Haruka, Sugino, Yuko, Takegami, Shigehiko, Kitade, Tatsuya, Toda, Yuki, Kem, William R., Kitamura, Yoshihisa, Shimohama, Shun, Ashihara, Eishi
Published in Neurobiology of aging (01.02.2018)
Published in Neurobiology of aging (01.02.2018)
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Journal Article
Nonopioid GTS-21 Mitigates Burn Injury Pain in Rats by Decreasing Spinal Cord Inflammatory Responses
Zhou, Yinhui, Leung-Pitt, Yiuka, Deng, Hao, Ren, Yang, You, Zerong, Kem, William R., Shen, Shiqian, Zhang, Wei, Mao, Jianren, Martyn, J. A. Jeevendra
Published in Anesthesia and analgesia (01.01.2021)
Published in Anesthesia and analgesia (01.01.2021)
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Journal Article
A pilot study of transdermal nicotine effects on facial emotion responding in non-smoking healthy controls and individuals with schizophrenia: Feasibility and effect size estimates
Conley, Alexander C., Albert, Kimberly M., Armstrong, Kristan, Johnson, Jodie V., Kem, William R., Newhouse, Paul A., Lewis, Alan S.
Published in Schizophrenia research (01.12.2022)
Published in Schizophrenia research (01.12.2022)
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