S1597 Modeling Gastric Luminal Rifabutin Concentrations: RHB-105 (Rifabutin 50 mg Q8H) Provides More Favorable Exposure for Helicobacter pylori Eradication Than Generic Rifabutin 150 mg BID or 300 mg QD
Howden, Colin W., Pendse, Salil, Jamindar, Mansi, Sheldon, Kely L.
Published in The American journal of gastroenterology (01.10.2022)
Published in The American journal of gastroenterology (01.10.2022)
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Physiologically‐based pharmacokinetic modelling to predict intragastric rifabutin concentrations in the treatment of Helicobacter pylori infection
Howden, Colin W., Shah, Shailja, Pendse, Salil N., Offman, Elliot, Almenoff, June S., Sheldon, Kely L.
Published in Alimentary pharmacology & therapeutics (01.07.2023)
Published in Alimentary pharmacology & therapeutics (01.07.2023)
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Journal Article
Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respiration
Rostovtseva, Tatiana K, Sheldon, Kely L, Hassanzadeh, Elnaz, Monge, Claire, Saks, Valdur, Bezrukov, Sergey M, Sackett, Dan L
Published in Proceedings of the National Academy of Sciences - PNAS (02.12.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (02.12.2008)
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Voltage-dependent anion channels modulate mitochondrial metabolism in cancer cells: regulation by free tubulin and erastin
Maldonado, Eduardo N, Sheldon, Kely L, DeHart, David N, Patnaik, Jyoti, Manevich, Yefim, Townsend, Danyelle M, Bezrukov, Sergey M, Rostovtseva, Tatiana K, Lemasters, John J
Published in The Journal of biological chemistry (26.04.2013)
Published in The Journal of biological chemistry (26.04.2013)
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S1451 Pitfalls of Physician-Directed Treatment of H. pylori Infection: Results From Two Phase 3 Clinical Trials and Real-World Prescribing Data
Howden, Colin, Sheldon, Kely L., Almenoff, June S., Chey, William D.
Published in The American journal of gastroenterology (01.10.2021)
Published in The American journal of gastroenterology (01.10.2021)
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Sa1381 PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODELING CONFIRMS RIFABUTIN, AMOXICILLIN, AND OMEPRAZOLE BIOEQUIVALENCE BETWEEN Q8H AND TID DOSING FOR LOW-DOSE RIFABUTIN TRIPLE THERAPY (RHB-105) FOR THE ERADICATION OF HELICOBACTER PYLORI IN ADULT PATIENTS
Vakil, Nimish, Offman, Elliot M., Almenoff, June S., Sheldon, Kely L.
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2023)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2023)
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S1342 Efficacy of H. pylori Eradication by Low-Dose Rifabutin Triple Therapy (RHB-105) Is Unaffected by BMI: Post-hoc Analysis From Two Phase 3 Trials
Sheldon, Kely L., Moss, Steven, Al Samman, Mohd Amer, Offman, Elliot, Panas, Raymond M., Almenoff, June
Published in The American journal of gastroenterology (01.10.2020)
Published in The American journal of gastroenterology (01.10.2020)
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Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer
Paredes, Felipe, Sheldon, Kely, Lassègue, Bernard, Williams, Holly C., Faidley, Elizabeth A., Benavides, Gloria A., Torres, Gloria, Sanhueza-Olivares, Fernanda, Yeligar, Samantha M., Griendling, Kathy K., Darley-Usmar, Victor, San Martin, Alejandra
Published in Proceedings of the National Academy of Sciences - PNAS (20.02.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (20.02.2018)
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Tu1077: PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODEL TO ESTIMATE INTRAGASTRIC RIFABUTIN CONCENTRATIONS FOLLOWING RIFABUTIN 50 MG Q8H (RHB-105) OR 150 MG QD: MORE FAVORABLE EXPOSURE FOR HELICOBACTER PYLORI ERADICATON WITH Q8H DOSING
Howden, Colin W., Pendse, Salil N., Bush, Mark A., Almenoff, June S., Sheldon, Kely L.
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2022)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2022)
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Tu1078: LOW-DOSE RIFABUTIN TRIPLE THERAPY (RHB-105) MAINTAINS HIGH HELICOBACTER PYLORI ERADICATION RATES AND SHOWS FAVORABLE SAFETY AND EFFICACY IN SUBJECTS WITH DIABETES MELLITUS
Howden, Colin W., Johns, Barry R., Almenoff, June S., Sheldon, Kely L.
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2022)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2022)
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Journal Article
Poldip2 is an oxygen-sensitive protein that controls PDH and aKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer
Paredes, Felipe, Sheldon, Kely, Lassègue, Bernard, Williams, Holly C, Faidley, Elizabeth A, Benavides, Gloria A, Torres, Gloria, Sanhueza-Olivares, Fernanda, Yeligar, Samantha M, Griendling, Kathy K, Darley-Usmar, Victor, San Martin, Alejandra
Published in Proceedings of the National Academy of Sciences - PNAS (20.02.2018)
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Published in Proceedings of the National Academy of Sciences - PNAS (20.02.2018)
Journal Article
Antagonists of the Inhibitory Effect of Free Tubulin on VDAC Induce Oxidative Stress and Mitochondrial Dysfunction
DeHart, David N., Gooz, Monika, Rostovtseva, Tatiana K., Sheldon, Kely L., Lemasters, John J., Maldonado, Eduardo N.
Published in Biophysical journal (28.01.2014)
Published in Biophysical journal (28.01.2014)
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