Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death
Orning, Pontus, Weng, Dan, Starheim, Kristian, Ratner, Dmitry, Best, Zachary, Lee, Bettina, Brooks, Alexandria, Xia, Shiyu, Wu, Hao, Kelliher, Michelle A, Berger, Scott B, Gough, Peter J, Bertin, John, Proulx, Megan M, Goguen, Jon D, Kayagaki, Nobuhiko, Fitzgerald, Katherine A, Lien, Egil
Published in Science (American Association for the Advancement of Science) (30.11.2018)
Published in Science (American Association for the Advancement of Science) (30.11.2018)
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RIPK1 mediates a disease-associated microglial response in Alzheimer’s disease
Ofengeim, Dimitry, Mazzitelli, Sonia, Ito, Yasushi, DeWitt, Judy Park, Mifflin, Lauren, Zou, Chengyu, Das, Sudeshna, Adiconis, Xian, Chen, Hongbo, Zhu, Hong, Kelliher, Michelle A., Levin, Joshua Z., Yuan, Junying
Published in Proceedings of the National Academy of Sciences - PNAS (10.10.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (10.10.2017)
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Journal Article
RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3
Dillon, Christopher P., Weinlich, Ricardo, Rodriguez, Diego A., Cripps, James G., Quarato, Giovanni, Gurung, Prajwal, Verbist, Katherine C., Brewer, Taylor L., Llambi, Fabien, Gong, Yi-Nan, Janke, Laura J., Kelliher, Michelle A., Kanneganti, Thirumala-Devi, Green, Douglas R.
Published in Cell (22.05.2014)
Published in Cell (22.05.2014)
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Journal Article
RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS
Ito, Yasushi, Ofengeim, Dimitry, Najafov, Ayaz, Das, Sudeshna, Saberi, Shahram, Li, Ying, Hitomi, Junichi, Zhu, Hong, Chen, Hongbo, Mayo, Lior, Geng, Jiefei, Amin, Palak, DeWitt, Judy Park, Mookhtiar, Adnan Kasim, Florez, Marcus, Ouchida, Amanda Tomie, Fan, Jian-bing, Pasparakis, Manolis, Kelliher, Michelle A., Ravits, John, Yuan, Junying
Published in Science (American Association for the Advancement of Science) (05.08.2016)
Published in Science (American Association for the Advancement of Science) (05.08.2016)
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Journal Article
BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment
Winter, Georg E., Mayer, Andreas, Buckley, Dennis L., Erb, Michael A., Roderick, Justine E., Vittori, Sarah, Reyes, Jaime M., di Iulio, Julia, Souza, Amanda, Ott, Christopher J., Roberts, Justin M., Zeid, Rhamy, Scott, Thomas G., Paulk, Joshiawa, Lachance, Kate, Olson, Calla M., Dastjerdi, Shiva, Bauer, Sophie, Lin, Charles Y., Gray, Nathanael S., Kelliher, Michelle A., Churchman, L. Stirling, Bradner, James E.
Published in Molecular cell (06.07.2017)
Published in Molecular cell (06.07.2017)
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Journal Article
ATACseqQC: a Bioconductor package for post-alignment quality assessment of ATAC-seq data
Ou, Jianhong, Liu, Haibo, Yu, Jun, Kelliher, Michelle A, Castilla, Lucio H, Lawson, Nathan D, Zhu, Lihua Julie
Published in BMC genomics (01.03.2018)
Published in BMC genomics (01.03.2018)
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Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo
Polykratis, Apostolos, Hermance, Nicole, Zelic, Matija, Roderick, Justine, Kim, Chun, Van, Trieu-My, Lee, Thomas H, Chan, Francis K M, Pasparakis, Manolis, Kelliher, Michelle A
Published in The Journal of immunology (1950) (15.08.2014)
Published in The Journal of immunology (1950) (15.08.2014)
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Journal Article
RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis
Dannappel, Marius, Vlantis, Katerina, Kumari, Snehlata, Polykratis, Apostolos, Kim, Chun, Wachsmuth, Laurens, Eftychi, Christina, Lin, Juan, Corona, Teresa, Hermance, Nicole, Zelic, Matija, Kirsch, Petra, Basic, Marijana, Bleich, Andre, Kelliher, Michelle, Pasparakis, Manolis
Published in Nature (London) (04.09.2014)
Published in Nature (London) (04.09.2014)
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Journal Article
NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis
Pandey, Amit K, Yang, Yibin, Jiang, Zhaozhao, Fortune, Sarah M, Coulombe, Francois, Behr, Marcel A, Fitzgerald, Katherine A, Sassetti, Christopher M, Kelliher, Michelle A
Published in PLoS pathogens (01.07.2009)
Published in PLoS pathogens (01.07.2009)
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Therapeutic Targeting of the Cyclin D3:CDK4/6 Complex in T Cell Leukemia
Sawai, Catherine M., Freund, Jacquelyn, Oh, Philmo, Ndiaye-Lobry, Delphine, Bretz, Jamieson C., Strikoudis, Alexandros, Genesca, Lali, Trimarchi, Thomas, Kelliher, Michelle A., Clark, Marcus, Soulier, Jean, Chen-Kiang, Selina, Aifantis, Iannis
Published in Cancer cell (16.10.2012)
Published in Cancer cell (16.10.2012)
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Core Transcriptional Regulatory Circuit Controlled by the TAL1 Complex in Human T Cell Acute Lymphoblastic Leukemia
Sanda, Takaomi, Lawton, Lee N., Barrasa, M. Inmaculada, Fan, Zi Peng, Kohlhammer, Holger, Gutierrez, Alejandro, Ma, Wenxue, Tatarek, Jessica, Ahn, Yebin, Kelliher, Michelle A., Jamieson, Catriona H.M., Staudt, Louis M., Young, Richard A., Look, A. Thomas
Published in Cancer cell (14.08.2012)
Published in Cancer cell (14.08.2012)
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An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia
Knoechel, Birgit, Roderick, Justine E, Williamson, Kaylyn E, Zhu, Jiang, Lohr, Jens G, Cotton, Matthew J, Gillespie, Shawn M, Fernandez, Daniel, Ku, Manching, Wang, Hongfang, Piccioni, Federica, Silver, Serena J, Jain, Mohit, Pearson, Daniel, Kluk, Michael J, Ott, Christopher J, Shultz, Leonard D, Brehm, Michael A, Greiner, Dale L, Gutierrez, Alejandro, Stegmaier, Kimberly, Kung, Andrew L, Root, David E, Bradner, James E, Aster, Jon C, Kelliher, Michelle A, Bernstein, Bradley E
Published in Nature genetics (01.04.2014)
Published in Nature genetics (01.04.2014)
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Journal Article
CYLD Proteolysis Protects Macrophages from TNF-Mediated Auto-necroptosis Induced by LPS and Licensed by Type I IFN
Legarda, Diana, Justus, Scott J., Ang, Rosalind L., Rikhi, Nimisha, Li, Wenjing, Moran, Thomas M., Zhang, Jianke, Mizoguchi, Emiko, Zelic, Matija, Kelliher, Michelle A., Blander, J. Magarian, Ting, Adrian T.
Published in Cell reports (Cambridge) (14.06.2016)
Published in Cell reports (Cambridge) (14.06.2016)
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RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer
Wolfe, Andrew L, Singh, Kamini, Zhong, Yi, Drewe, Philipp, Rajasekhar, Vinagolu K, Sanghvi, Viraj R, Mavrakis, Konstantinos J, Jiang, Man, Roderick, Justine E, Van der Meulen, Joni, Schatz, Jonathan H, Rodrigo, Christina M, Zhao, Chunying, Rondou, Pieter, de Stanchina, Elisa, Teruya-Feldstein, Julie, Kelliher, Michelle A, Speleman, Frank, Porco, Jr, John A, Pelletier, Jerry, Rätsch, Gunnar, Wendel, Hans-Guido
Published in Nature (London) (04.09.2014)
Published in Nature (London) (04.09.2014)
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Journal Article
Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death
Weng, Dan, Marty-Roix, Robyn, Ganesan, Sandhya, Proulx, Megan K., Vladimer, Gregory I., Kaiser, William J., Mocarski, Edward S., Pouliot, Kimberly, Chan, Francis Ka-Ming, Kelliher, Michelle A., Harris, Phillip A., Bertin, John, Gough, Peter J., Shayakhmetov, Dmitry M., Goguen, Jon D., Fitzgerald, Katherine A., Silverman, Neal, Lien, Egil
Published in Proceedings of the National Academy of Sciences - PNAS (20.05.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (20.05.2014)
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Journal Article
RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4
Najjar, Malek, Saleh, Danish, Zelic, Matija, Nogusa, Shoko, Shah, Saumil, Tai, Albert, Finger, Joshua N., Polykratis, Apostolos, Gough, Peter J., Bertin, John, Whalen, Michael J., Pasparakis, Manolis, Balachandran, Siddharth, Kelliher, Michelle, Poltorak, Alexander, Degterev, Alexei
Published in Immunity (Cambridge, Mass.) (19.07.2016)
Published in Immunity (Cambridge, Mass.) (19.07.2016)
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Journal Article
Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis
Roderick, Justine E., Hermance, Nicole, Zelic, Matija, Simmons, Matthew J., Polykratis, Apostolos, Pasparakis, Manolis, Kelliher, Michelle A.
Published in Proceedings of the National Academy of Sciences - PNAS (07.10.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (07.10.2014)
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