Prion protein is decreased in Alzheimer's brain and inversely correlates with BACE1 activity, amyloid-β levels and Braak stage
Whitehouse, Isobel J, Miners, J Scott, Glennon, Elizabeth B C, Kehoe, Patrick G, Love, Seth, Kellett, Katherine A B, Hooper, Nigel M
Published in PloS one (05.04.2013)
Published in PloS one (05.04.2013)
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Tau Proteolysis in the Pathogenesis of Tauopathies: Neurotoxic Fragments and Novel Biomarkers
Quinn, James P., Corbett, Nicola J., Kellett, Katherine A. B., Hooper, Nigel M.
Published in Journal of Alzheimer's disease (01.01.2018)
Published in Journal of Alzheimer's disease (01.01.2018)
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Book Review
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Nanoparticle-Enabled Enrichment of Longitudinal Blood Proteomic Fingerprints in Alzheimer’s Disease
Hadjidemetriou, Marilena, Rivers-Auty, Jack, Papafilippou, Lana, Eales, James, Kellett, Katherine A. B, Hooper, Nigel M, Lawrence, Catherine B, Kostarelos, Kostas
Published in ACS nano (27.04.2021)
Published in ACS nano (27.04.2021)
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Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake
Banerjee, Sreemoti, Andrew, Robert J, Duff, Christopher J, Fisher, Kate, Jackson, Carolyn D, Lawrence, Catherine B, Maeda, Nobuyo, Greenspan, Daniel S, Kellett, Katherine A B, Hooper, Nigel M
Published in Scientific reports (06.08.2019)
Published in Scientific reports (06.08.2019)
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Journal Article
BIN1 is decreased in sporadic but not familial Alzheimer's disease or in aging
Glennon, Elizabeth B C, Whitehouse, Isobel J, Miners, J Scott, Kehoe, Patrick G, Love, Seth, Kellett, Katherine A B, Hooper, Nigel M
Published in PloS one (21.10.2013)
Published in PloS one (21.10.2013)
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Journal Article
Author Correction: Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake
Banerjee, Sreemoti, Andrew, Robert J, Duff, Christopher J, Fisher, Kate, Jackson, Carolyn D, Lawrence, Catherine B, Maeda, Nobuyo, Greenspan, Daniel S, Kellett, Katherine A B, Hooper, Nigel M
Published in Scientific reports (11.02.2020)
Published in Scientific reports (11.02.2020)
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Ablation of Prion Protein in Wild Type Human Amyloid Precursor Protein (APP) Transgenic Mice Does Not Alter The Proteolysis of APP, Levels of Amyloid-β or Pathologic Phenotype
Whitehouse, Isobel J, Brown, Deborah, Baybutt, Herbert, Diack, Abigail B, Kellett, Katherine A B, Piccardo, Pedro, Manson, Jean C, Hooper, Nigel M
Published in PloS one (22.07.2016)
Published in PloS one (22.07.2016)
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Discovery of Biphenylacetamide-Derived Inhibitors of BACE1 Using de Novo Structure-Based Molecular Design
Mok, N. Yi, Chadwick, James, Kellett, Katherine A. B, Casas-Arce, Eva, Hooper, Nigel M, Johnson, A. Peter, Fishwick, Colin W. G
Published in Journal of medicinal chemistry (14.03.2013)
Published in Journal of medicinal chemistry (14.03.2013)
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Journal Article
Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening
Yi Mok, N., Chadwick, James, Kellett, Katherine A.B., Hooper, Nigel M., Johnson, A. Peter, Fishwick, Colin W.G.
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
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Journal Article
Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers
Jarosz-Griffiths, Heledd H., Corbett, Nicola J., Rowland, Helen A., Fisher, Kate, Jones, Alys C., Baron, Jennifer, Howell, Gareth J., Cowley, Sally A., Chintawar, Satyan, Cader, M. Zameel, Kellett, Katherine A.B., Hooper, Nigel M.
Published in The Journal of biological chemistry (26.04.2019)
Published in The Journal of biological chemistry (26.04.2019)
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Journal Article
Tau pathology and neurochemical changes associated with memory dysfunction in an optimised murine model of global cerebral ischaemia - A potential model for vascular dementia?
Khan, Sabah, Yuldasheva, Nadira Y., Batten, Trevor F.C., Pickles, Alasdair R., Kellett, Katherine A.B., Saha, Sikha
Published in Neurochemistry international (01.09.2018)
Published in Neurochemistry international (01.09.2018)
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Journal Article
Modelling Sporadic Alzheimer’s Disease Using Induced Pluripotent Stem Cells
Rowland, Helen A., Hooper, Nigel M., Kellett, Katherine A. B.
Published in Neurochemical research (01.12.2018)
Published in Neurochemical research (01.12.2018)
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Journal Article
Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer's disease: metabolic basis for dementia
Xu, Jingshu, Begley, Paul, Church, Stephanie J, Patassini, Stefano, McHarg, Selina, Kureishy, Nina, Hollywood, Katherine A, Waldvogel, Henry J, Liu, Hong, Zhang, Shaoping, Lin, Wanchang, Herholz, Karl, Turner, Clinton, Synek, Beth J, Curtis, Maurice A, Rivers-Auty, Jack, Lawrence, Catherine B, Kellett, Katherine A B, Hooper, Nigel M, Vardy, Emma R L C, Wu, Donghai, Unwin, Richard D, Faull, Richard L M, Dowsey, Andrew W, Cooper, Garth J S
Published in Scientific reports (09.06.2016)
Published in Scientific reports (09.06.2016)
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Journal Article
The Transcriptionally Active Amyloid Precursor Protein (APP) Intracellular Domain Is Preferentially Produced from the 695 Isoform of APP in a β-Secretase-dependent Pathway
Belyaev, Nikolai D., Kellett, Katherine A.B., Beckett, Caroline, Makova, Natalia Z., Revett, Timothy J., Nalivaeva, Natalia N., Hooper, Nigel M., Turner, Anthony J.
Published in The Journal of biological chemistry (31.12.2010)
Published in The Journal of biological chemistry (31.12.2010)
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Journal Article
Plasma metals as potential biomarkers in dementia: a case–control study in patients with sporadic Alzheimer’s disease
Xu, Jingshu, Church, Stephanie J., Patassini, Stefano, Begley, Paul, Kellett, Katherine A. B., Vardy, Emma R. L. C., Unwin, Richard D., Hooper, Nigel M., Cooper, Garth J. S.
Published in Biometals (01.04.2018)
Published in Biometals (01.04.2018)
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