Interpretable classification of Alzheimer's disease pathologies with a convolutional neural network pipeline
Tang, Ziqi, Chuang, Kangway V, DeCarli, Charles, Jin, Lee-Way, Beckett, Laurel, Keiser, Michael J, Dugger, Brittany N
Published in Nature communications (15.05.2019)
Published in Nature communications (15.05.2019)
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Large―scale prediction and testing of drug activity on side―effect targets
LOUNKINE, Eugen, KEISER, Michael J, SHOICHET, Brian K, URBAN, Laszlo, WHITEBREAD, Steven, MIKHAILOV, Dmitri, HAMON, Jacques, JENKINS, Jeremy L, LAVAN, Paul, WEBER, Eckhard, DOAK, Allison K, COTE, Serge
Published in Nature (London) (21.06.2012)
Published in Nature (London) (21.06.2012)
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Journal Article
Relating protein pharmacology by ligand chemistry
Irwin, John J, Shoichet, Brian K, Keiser, Michael J, Roth, Bryan L, Armbruster, Blaine N, Ernsberger, Paul
Published in Nature biotechnology (01.02.2007)
Published in Nature biotechnology (01.02.2007)
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Journal Article
Predicting new molecular targets for known drugs
Shoichet, Brian K, Roth, Bryan L, Keiser, Michael J, Setola, Vincent, Irwin, John J, Laggner, Christian, Abbas, Atheir I, Hufeisen, Sandra J, Jensen, Niels H, Kuijer, Michael B, Matos, Roberto C, Tran, Thuy B, Whaley, Ryan, Glennon, Richard A, Hert, Jérôme, Thomas, Kelan L. H, Edwards, Douglas D
Published in Nature (London) (12.11.2009)
Published in Nature (London) (12.11.2009)
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Journal Article
Quantifying biogenic bias in screening libraries
Shoichet, Brian K, Hert, Jérôme, Irwin, John J, Laggner, Christian, Keiser, Michael J
Published in Nature chemical biology (01.07.2009)
Published in Nature chemical biology (01.07.2009)
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Journal Article
Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation
McCarroll, Matthew N, Gendelev, Leo, Kinser, Reid, Taylor, Jack, Bruni, Giancarlo, Myers-Turnbull, Douglas, Helsell, Cole, Carbajal, Amanda, Rinaldi, Capria, Kang, Hye Jin, Gong, Jung Ho, Sello, Jason K, Tomita, Susumu, Peterson, Randall T, Keiser, Michael J, Kokel, David
Published in Nature communications (09.09.2019)
Published in Nature communications (09.09.2019)
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Journal Article
Evolutionarily Conserved Roles for Blood-Brain Barrier Xenobiotic Transporters in Endogenous Steroid Partitioning and Behavior
Hindle, Samantha J., Munji, Roeben N., Dolghih, Elena, Gaskins, Garrett, Orng, Souvinh, Ishimoto, Hiroshi, Soung, Allison, DeSalvo, Michael, Kitamoto, Toshihiro, Keiser, Michael J., Jacobson, Matthew P., Daneman, Richard, Bainton, Roland J.
Published in Cell reports (Cambridge) (31.10.2017)
Published in Cell reports (Cambridge) (31.10.2017)
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Journal Article
Leveraging Large-scale Behavioral Profiling in Zebrafish to Explore Neuroactive Polypharmacology
McCarroll, Matthew N, Gendelev, Leo, Keiser, Michael J, Kokel, David
Published in ACS chemical biology (15.04.2016)
Published in ACS chemical biology (15.04.2016)
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Journal Article
Learning chemical sensitivity reveals mechanisms of cellular response
Connell, William, Garcia, Kristle, Goodarzi, Hani, Keiser, Michael J
Published in Communications biology (15.09.2024)
Published in Communications biology (15.09.2024)
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Journal Article
In silico discovery of repetitive elements as key sequence determinants of 3D genome folding
Gunsalus, Laura M., Keiser, Michael J., Pollard, Katherine S.
Published in Cell genomics (11.10.2023)
Published in Cell genomics (11.10.2023)
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Journal Article
Chemical informatics and target identification in a zebrafish phenotypic screen
Laggner, Christian, Kokel, David, Setola, Vincent, Tolia, Alexandra, Lin, Henry, Irwin, John J, Keiser, Michael J, Cheung, Chung Yan J, Minor, Jr, Daniel L, Roth, Bryan L, Peterson, Randall T, Shoichet, Brian K
Published in Nature chemical biology (18.12.2011)
Published in Nature chemical biology (18.12.2011)
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Journal Article
Deep learning from multiple experts improves identification of amyloid neuropathologies
Wong, Daniel R, Tang, Ziqi, Mew, Nicholas C, Das, Sakshi, Athey, Justin, McAleese, Kirsty E, Kofler, Julia K, Flanagan, Margaret E, Borys, Ewa, White, 3rd, Charles L, Butte, Atul J, Dugger, Brittany N, Keiser, Michael J
Published in Acta neuropathologica communications (28.04.2022)
Published in Acta neuropathologica communications (28.04.2022)
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Journal Article
Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach
Ruderfer, Douglas M, Charney, Alexander W, Readhead, Ben, Kidd, Brian A, Kähler, Anna K, Kenny, Paul J, Keiser, Michael J, Moran, Jennifer L, Hultman, Christina M, Scott, Stuart A, Sullivan, Patrick F, Purcell, Shaun M, Dudley, Joel T, Sklar, Pamela
Published in The Lancet. Psychiatry (01.04.2016)
Published in The Lancet. Psychiatry (01.04.2016)
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Journal Article
Toward a generalizable machine learning workflow for neurodegenerative disease staging with focus on neurofibrillary tangles
Vizcarra, Juan C, Pearce, Thomas M, Dugger, Brittany N, Keiser, Michael J, Gearing, Marla, Crary, John F, Kiely, Evan J, Morris, Meaghan, White, Bartholomew, Glass, Jonathan D, Farrell, Kurt, Gutman, David A
Published in Acta neuropathologica communications (18.12.2023)
Published in Acta neuropathologica communications (18.12.2023)
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Journal Article
Learning Molecular Representations for Medicinal Chemistry
Chuang, Kangway V, Gunsalus, Laura M, Keiser, Michael J
Published in Journal of medicinal chemistry (27.08.2020)
Published in Journal of medicinal chemistry (27.08.2020)
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Journal Article
Learning Molecular Representations for Medicinal Chemistry: Miniperspective
Chuang, Kangway V, Gunsalus, Laura M, Keiser, Michael J
Published in Journal of medicinal chemistry (27.08.2020)
Published in Journal of medicinal chemistry (27.08.2020)
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Journal Article
Stress testing reveals gaps in clinic readiness of image-based diagnostic artificial intelligence models
Young, Albert T, Fernandez, Kristen, Pfau, Jacob, Reddy, Rasika, Cao, Nhat Anh, von Franque, Max Y, Johal, Arjun, Wu, Benjamin V, Wu, Rachel R, Chen, Jennifer Y, Fadadu, Raj P, Vasquez, Juan A, Tam, Andrew, Keiser, Michael J, Wei, Maria L
Published in NPJ digital medicine (21.01.2021)
Published in NPJ digital medicine (21.01.2021)
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Journal Article
The Presynaptic Component of the Serotonergic System is Required for Clozapine's Efficacy
YADAV, Prem N, ABBAS, Atheir I, IRWIN, John J, SHOICHET, Brian K, DENERIS, Evan S, GINGRICH, Jay, BECK, Sheryl G, ROTH, Bryan L, FARRELL, Martilias S, SETOLA, Vincent, SCIAKY, Noah, HUANG, Xi-Ping, KROEZE, Wesley K, CRAWFORD, Latasha K, PIEL, David A, KEISER, Michael J
Published in Neuropsychopharmacology (New York, N.Y.) (01.02.2011)
Published in Neuropsychopharmacology (New York, N.Y.) (01.02.2011)
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