Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer
Davidson, Shawn M., Papagiannakopoulos, Thales, Olenchock, Benjamin A., Heyman, Julia E., Keibler, Mark A., Luengo, Alba, Bauer, Matthew R., Jha, Abhishek K., O’Brien, James P., Pierce, Kerry A., Gui, Dan Y., Sullivan, Lucas B., Wasylenko, Thomas M., Subbaraj, Lakshmipriya, Chin, Christopher R., Stephanopolous, Gregory, Mott, Bryan T., Jacks, Tyler, Clish, Clary B., Vander Heiden, Matthew G.
Published in Cell metabolism (08.03.2016)
Published in Cell metabolism (08.03.2016)
Get full text
Journal Article
The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival
Wang, Haizhen, Nicolay, Brandon N., Chick, Joel M., Gao, Xueliang, Geng, Yan, Ren, Hong, Gao, Hui, Yang, Guizhi, Williams, Juliet A., Suski, Jan M., Keibler, Mark A., Sicinska, Ewa, Gerdemann, Ulrike, Haining, W. Nicholas, Roberts, Thomas M., Polyak, Kornelia, Gygi, Steven P., Dyson, Nicholas J., Sicinski, Piotr
Published in Nature (London) (15.06.2017)
Published in Nature (London) (15.06.2017)
Get full text
Journal Article
Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors
Davidson, Shawn M, Jonas, Oliver, Keibler, Mark A, Hou, Han Wei, Luengo, Alba, Mayers, Jared R, Wyckoff, Jeffrey, Del Rosario, Amanda M, Whitman, Matthew, Chin, Christopher R, Condon, Kendall J, Lammers, Alex, Kellersberger, Katherine A, Stall, Brian K, Stephanopoulos, Gregory, Bar-Sagi, Dafna, Han, Jongyoon, Rabinowitz, Joshua D, Cima, Michael J, Langer, Robert, Vander Heiden, Matthew G
Published in Nature medicine (01.02.2017)
Published in Nature medicine (01.02.2017)
Get full text
Journal Article
A self-assembling hydrophobically modified chitosan capable of reversible hemostatic action
Dowling, Matthew B, Kumar, Rakesh, Keibler, Mark A, Hess, John R, Bochicchio, Grant V, Raghavan, Srinivasa R
Published in Biomaterials (01.05.2011)
Published in Biomaterials (01.05.2011)
Get full text
Journal Article
Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation
Berrios, Christian, Padi, Megha, Keibler, Mark A, Park, Donglim Esther, Molla, Vadim, Cheng, Jingwei, Lee, Soo Mi, Stephanopoulos, Gregory, Quackenbush, John, DeCaprio, James A
Published in PLoS pathogens (01.11.2016)
Published in PLoS pathogens (01.11.2016)
Get full text
Journal Article
Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism
FENDT, Sarah-Maria, BELL, Eric L, PATNAIK, Akash, BLOUIN, Marie Jose, CANTLEY, Lewis C, GUARENTE, Leonard, BLENIS, John, POLLAK, Michael N, OLUMI, Aria F, VANDER HEIDEN, Matthew G, STEPHANOPOULOS, Gregory, KEIBLER, Mark A, DAVIDSON, Shawn M, WIRTH, Gregory J, FISKE, Brian, MAYERS, Jared R, SCHWAB, Matthias, BELLINGER, Gary, CSIBI, Alfredo
Published in Cancer research (Chicago, Ill.) (15.07.2013)
Published in Cancer research (Chicago, Ill.) (15.07.2013)
Get full text
Journal Article
Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells
Hung, Yin P, Teragawa, Carolyn, Kosaisawe, Nont, Gillies, Taryn E, Pargett, Michael, Minguet, Marta, Distor, Kevin, Rocha-Gregg, Briana L, Coloff, Jonathan L, Keibler, Mark A, Stephanopoulos, Gregory, Yellen, Gary, Brugge, Joan S, Albeck, John G
Published in eLife (14.12.2017)
Published in eLife (14.12.2017)
Get full text
Journal Article
Stable Isotope-Assisted Untargeted Metabolomics Identifies ALDH1A1-Driven Erythronate Accumulation in Lung Cancer Cells
Zhang, Jie, Keibler, Mark A, Dong, Wentao, Ghelfi, Jenny, Cordes, Thekla, Kanashova, Tamara, Pailot, Arnaud, Linster, Carole L, Dittmar, Gunnar, Metallo, Christian M, Lautenschlaeger, Tim, Hiller, Karsten, Stephanopoulos, Gregory
Published in Biomedicines (01.10.2023)
Published in Biomedicines (01.10.2023)
Get full text
Journal Article
Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells
Fendt, Sarah-Maria, Bell, Eric L., Keibler, Mark A., Olenchock, Benjamin A., Mayers, Jared R., Wasylenko, Thomas M., Vokes, Natalie I., Guarente, Leonard, Heiden, Matthew G. Vander, Stephanopoulos, Gregory
Published in Nature communications (2013)
Published in Nature communications (2013)
Get full text
Journal Article
Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers
Yusuf, Rushdia Zareen, Saez, Borja, Sharda, Azeem, van Gastel, Nick, Yu, Vionnie W.C., Baryawno, Ninib, Scadden, Elizabeth W., Acharya, Sanket, Chattophadhyay, Shrikanta, Huang, Cherrie, Viswanathan, Vasanthi, S'aulis, Dana, Cobert, Julien, Sykes, David B., Keibler, Mark A., Das, Sudeshna, Hutchinson, John N., Churchill, Michael, Mukherjee, Siddhartha, Lee, Dongjun, Mercier, Francois, Doench, John, Bullinger, Lars, Logan, David J., Schreiber, Stuart, Stephanopoulos, Gregory, Rizzo, William B., Scadden, David T.
Published in Blood (10.09.2020)
Published in Blood (10.09.2020)
Get full text
Journal Article
Metabolic requirements for cancer cell proliferation
Keibler, Mark A, Wasylenko, Thomas M, Kelleher, Joanne K, Iliopoulos, Othon, Vander Heiden, Matthew G, Stephanopoulos, Gregory
Published in Cancer & metabolism (18.08.2016)
Published in Cancer & metabolism (18.08.2016)
Get full text
Journal Article
Differential substrate use in EGF‐ and oncogenic KRAS‐stimulated human mammary epithelial cells
Keibler, Mark A., Dong, Wentao, Korthauer, Keegan D., Hosios, Aaron M., Moon, Sun Jin, Sullivan, Lucas B., Liu, Nian, Abbott, Keene L., Arevalo, Orlando D., Ho, Kailing, Lee, Jennifer, Phanse, Aasavari S., Kelleher, Joanne K., Iliopoulos, Othon, Coloff, Jonathan L., Vander Heiden, Matthew G., Stephanopoulos, Gregory
Published in The FEBS journal (01.10.2021)
Published in The FEBS journal (01.10.2021)
Get full text
Journal Article
Expanding the concepts and tools of metabolic engineering to elucidate cancer metabolism
Keibler, Mark A., Fendt, Sarah-Maria, Stephanopoulos, Gregory
Published in Biotechnology progress (01.11.2012)
Published in Biotechnology progress (01.11.2012)
Get full text
Journal Article
The metabolic function of cyclin D3CDK6 kinase in cancer cell survival
Wang, Haizhen, Nicolay, Brandon N, Chick, Joel M, Gao, Xueliang, Geng, Yan, Ren, Hong, Gao, Hui, Yang, Guizhi, Williams, Juliet A, Suski, Jan M, Keibler, Mark A, Sicinska, Ewa, Gerdemann, Ulrike, Haining, W. Nicholas, Roberts, Thomas M, Polyak, Kornelia, Gygi, Steven P, Dyson, Nicholas J, Sicinski, Piotr
Published in Nature (London) (15.06.2017)
Published in Nature (London) (15.06.2017)
Get full text
Journal Article
Reductive glutamine metabolism is a function of the [alpha]-ketoglutarate to citrate ratio in cells
Fendt, Sarah-maria, Bell, Eric L, Keibler, Mark A, Olenchock, Benjamin A, Mayers, Jared R, Wasylenko, Thomas M, Vokes, Natalie I, Guarente, Leonard, Heiden, Matthew G Vander, Stephanopoulos, Gregory
Published in Nature communications (01.07.2013)
Published in Nature communications (01.07.2013)
Get full text
Journal Article
Non-targeted metabolomics identifies erythronate accumulation in cancer cells
Zhang, Jie, Keibler, Mark A, Dong, Wentao, Ghelfi, Jenny, Cordes, Thekla, Kanashova, Tamara, Pailot, Arnaud, Linster, Carole, Dittmar, Gunnar, Metallo, Christian M, Lautenschlaeger, Tim, Hiller, Karsten, Stephanopoulos, Gregory
Published in bioRxiv (04.12.2022)
Published in bioRxiv (04.12.2022)
Get full text
Paper