Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile
Kehne, J H, Baron, B M, Carr, A A, Chaney, S F, Elands, J, Feldman, D J, Frank, R A, van Giersbergen, P L, McCloskey, T C, Johnson, M P, McCarty, D R, Poirot, M, Senyah, Y, Siegel, B W, Widmaier, C
Published in The Journal of pharmacology and experimental therapeutics (01.05.1996)
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Published in The Journal of pharmacology and experimental therapeutics (01.05.1996)
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The role of 5-HT2A receptors in antipsychotic activity
Schmidt, C J, Sorensen, S M, Kehne, J H, Carr, A A, Palfreyman, M G
Published in Life sciences (1973) (12.05.1995)
Published in Life sciences (1973) (12.05.1995)
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Preclinical Antipsychotic Activity of The Selective 5-HT2 Antagonist, MDL100,907
Schmidt, CJ, Kehne, JH, Moser, PC, Sorensen, SM
Published in Neuropsychopharmacology (New York, N.Y.) (25.07.2003)
Published in Neuropsychopharmacology (New York, N.Y.) (25.07.2003)
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The peripheral NK-1/NK-2 receptor antagonist MDL 105,172A inhibits tachykinin-mediated respiratory effects in guinea-pigs
Kudlacz, E M, Knippenberg, R W, Shatzer, S A, Kehne, J H, McCloskey, T C, Burkholder, T P
Published in Journal of autonomic pharmacology (01.04.1997)
Published in Journal of autonomic pharmacology (01.04.1997)
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Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist
Baron, Bruce M, Harrison, Boyd L, Kehne, John H, Schmidt, Christopher J, Van Giersbergen, Paul L.M, White, H.Steven, Siegel, Barry W, Senyah, Yaw, McCloskey, Timothy C, Fadayel, Gina M, Taylor, Vicki L, Murawsky, Michael K, Nyce, Phillip, Salituro, Francesco G
Published in European journal of pharmacology (04.04.1997)
Published in European journal of pharmacology (04.04.1997)
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NMDA receptor complex antagonists have potential anxiolytic effects as measured with separation-induced ultrasonic vocalizations
Kehne, J H, McCloskey, T C, Baron, B M, Chi, E M, Harrison, B L, Whitten, J P, Palfreyman, M G
Published in European journal of pharmacology (14.02.1991)
Published in European journal of pharmacology (14.02.1991)
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5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents
Kane, John M, Staeger, Michael A, Dalton, Christopher R, Miller, Francis P, Dudley, Mark W, Ogden, Ann Marie L, Kehne, John H, Ketteler, Herbert J, McCloskey, Timothy C
Published in Journal of medicinal chemistry (01.01.1994)
Published in Journal of medicinal chemistry (01.01.1994)
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3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the N-methyl-D-aspartic acid receptor associated glycine binding site
SALITURO, F. G, HARRISON, B. L, BARON, B. M, NYCE, P. L, STEWART, K. T, KEHNE, J. H, WHITE, H. S, MCDONALD, I. A
Published in Journal of medicinal chemistry (15.05.1992)
Published in Journal of medicinal chemistry (15.05.1992)
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Effects of the serotonin releasers 3,4-methylenedioxymethamphetamine (MDMA), 4-chloroamphetamine (PCA) and fenfluramine on acoustic and tactile startle reflexes in rats
Kehne, J H, McCloskey, T C, Taylor, V L, Black, C K, Fadayel, G M, Schmidt, C J
Published in The Journal of pharmacology and experimental therapeutics (01.01.1992)
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Published in The Journal of pharmacology and experimental therapeutics (01.01.1992)
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Cyclic Nitrone Free Radical Traps: Isolation, Identification, and Synthesis of 3,3-Dimethyl-3,4-dihydroisoquinolin-4-ol N-Oxide, a Metabolite with Reduced Side Effects
Thomas, Craig E, Bernardelli, Patrick, Bowen, S. Marc, Chaney, Stephen F, Friedrich, Dirk, Janowick, David A, Jones, Bryan K, Keeley, Frederick J, Kehne, John H, Ketteler, Bert, Ohlweiler, David F, Paquette, Leo A, Robke, David J, Fevig, Thomas L
Published in Journal of medicinal chemistry (06.12.1996)
Published in Journal of medicinal chemistry (06.12.1996)
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Journal Article
Preclinical characterization of MDL 27,192 as a potential broad spectrum anticonvulsant agent with neuroprotective properties
Kehne, John H, Kane, J.Michael, Chaney, Stephen F, Hurst, Gail, McCloskey, Timothy C, Petty, Margaret A, Senyah, Yaw, Wolf, Harold H, Zobrist, Ray, White, H.Steve
Published in Epilepsy research (01.04.1997)
Published in Epilepsy research (01.04.1997)
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Contribution of serotonin neurotoxins to understanding psychiatric disorders: the role of 5-HT2 receptors in schizophrenia and antipsychotic activity
Schmidt, C J, Kehne, J H, Carr, A A, Fadayel, G M, Humphreys, T M, Kettler, H J, McCloskey, T C, Padich, R A, Taylor, V L, Sorensen, S M
Published in International clinical psychopharmacology (01.11.1993)
Published in International clinical psychopharmacology (01.11.1993)
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