Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor
Garcia Fortanet, Jorge, Chen, Christine Hiu-Tung, Chen, Ying-Nan P, Chen, Zhouliang, Deng, Zhan, Firestone, Brant, Fekkes, Peter, Fodor, Michelle, Fortin, Pascal D, Fridrich, Cary, Grunenfelder, Denise, Ho, Samuel, Kang, Zhao B, Karki, Rajesh, Kato, Mitsunori, Keen, Nick, LaBonte, Laura R, Larrow, Jay, Lenoir, Francois, Liu, Gang, Liu, Shumei, Lombardo, Franco, Majumdar, Dyuti, Meyer, Matthew J, Palermo, Mark, Perez, Lawrence, Pu, Minying, Ramsey, Timothy, Sellers, William R, Shultz, Michael D, Stams, Travis, Towler, Christopher, Wang, Ping, Williams, Sarah L, Zhang, Ji-Hu, LaMarche, Matthew J
Published in Journal of medicinal chemistry (08.09.2016)
Published in Journal of medicinal chemistry (08.09.2016)
Get full text
Journal Article
Biochemical Characterization of Human SET and MYND Domain-Containing Protein 2 Methyltransferase
Wu, Jiaquan, Cheung, Tony, Grande, Christie, Ferguson, Andrew D, Zhu, Xiahui, Theriault, Kelly, Code, Erin, Birr, Cynthia, Keen, Nick, Chen, Huawei
Published in Biochemistry (Easton) (26.07.2011)
Published in Biochemistry (Easton) (26.07.2011)
Get full text
Journal Article
Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer
LaMarche, Matthew J, Acker, Michael, Argintaru, Andreea, Bauer, Daniel, Boisclair, Julie, Chan, Homan, Chen, Christine Hiu-Tung, Chen, Ying-Nan, Chen, Zhouliang, Deng, Zhan, Dore, Michael, Dunstan, David, Fan, Jianmei, Fekkes, Peter, Firestone, Brant, Fodor, Michelle, Garcia-Fortanet, Jorge, Fortin, Pascal D, Fridrich, Cary, Giraldes, John, Glick, Meir, Grunenfelder, Denise, Hao, Huia-Xiang, Hentemann, Martin, Ho, Samuel, Jouk, Andriana, Kang, Zhao B, Karki, Rajesh, Kato, Mitsunori, Keen, Nick, Koenig, Robert, LaBonte, Laura R, Larrow, Jay, Liu, Gang, Liu, Shumei, Majumdar, Dyuti, Mathieu, Simon, Meyer, Matthew J, Mohseni, Morvarid, Ntaganda, Rukundo, Palermo, Mark, Perez, Lawrence, Pu, Minying, Ramsey, Timothy, Reilly, John, Sarver, Patrick, Sellers, William R, Sendzik, Martin, Shultz, Michael D, Slisz, Joanna, Slocum, Kelly, Smith, Troy, Spence, Stanley, Stams, Travis, Straub, Christopher, Tamez, Victoriano, Toure, Bakary-Barry, Towler, Christopher, Wang, Ping, Wang, Hongyun, Williams, Sarah L, Yang, Fan, Yu, Bing, Zhang, Ji-Hu, Zhu, Suzanne
Published in Journal of medicinal chemistry (25.11.2020)
Published in Journal of medicinal chemistry (25.11.2020)
Get full text
Journal Article
The Activity of the Novel Aurora Kinase B Inhibitor AZD1152 in Acute Myeloid Leukaemia Cells
Joel, Simon P., Oke, Adedayo, Foot, Nichola, Keen, Nick, Bonnet, Dominique, Lister, Thomas A., Fitzgibbon, Jude
Published in Blood (16.11.2005)
Published in Blood (16.11.2005)
Get full text
Journal Article
BICYCLIC PEPTIDE LIGAND PRR-A CONJUGATES AND USES THEREOF
MUDD, Gemma Elizabeth, MCDONNELL, Kevin, KEEN, Nick, IVANOVA-BERNDT, Gabriela, PARK, Peter U
Year of Publication 21.02.2019
Get full text
Year of Publication 21.02.2019
Patent
Structure of the Yeast TAP1 Protein: Dependence of Transcription Activation on the DNA Context of the Target Gene
Aldrich, Teri L., Di Segni, Gianfranco, McConaughy, Betty L., Keen, Nick J., Whelen, Sally, Hall, Benjamin D.
Published in Molecular and cellular biology (01.06.1993)
Published in Molecular and cellular biology (01.06.1993)
Get full text
Journal Article