Aliskiren, an Oral Renin Inhibitor, Provides Dose-Dependent Efficacy and Sustained 24-Hour Blood Pressure Control in Patients With Hypertension
Oh, Byung-Hee, MD, PhD, FACC, Mitchell, Jerry, MD, PhD, Herron, James R., MD, Chung, Jenny, PharmD, Khan, Mahmudul, PhD, Keefe, Deborah L., MD, MPH, FACC
Published in Journal of the American College of Cardiology (20.03.2007)
Published in Journal of the American College of Cardiology (20.03.2007)
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Comparative efficacy and safety of aliskiren, an oral direct renin inhibitor, and ramipril in hypertension: a 6-month, randomized, double-blind trial
Andersen, Karl, Weinberger, Myron H, Egan, Brent, Constance, Christian M, Ali, Mohammed A, Jin, James, Keefe, Deborah L
Published in Journal of hypertension (01.03.2008)
Published in Journal of hypertension (01.03.2008)
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Aliskiren, a Novel Oral Renin Inhibitor, Provides Dose-Dependent Efficacy and Placebo-Like Tolerability in Japanese Patients with Hypertension
Kushiro, Toshio, Itakura, Hiroshige, Abo, Yoshihisa, Gotou, Hiromi, Terao, Shinji, Keefe, Deborah L
Published in Hypertension research (01.12.2006)
Published in Hypertension research (01.12.2006)
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Journal Article
Long-term safety, tolerability, and antihypertensive efficacy of aliskiren, an oral direct renin inhibitor, in Japanese patients with hypertension
Kushiro, Toshio, Itakura, Hiroshige, Abo, Yoshihisa, Gotou, Hiromi, Terao, Shinji, Keefe, Deborah L
Published in Hypertension research (01.03.2009)
Published in Hypertension research (01.03.2009)
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Evaluation of the dose—response relationship of aliskiren, a direct renin inhibitor, in an 8-week, multicenter, randomized, double-blind, parallel-group, placebo-controlled study in adult patients with stage 1 or 2 essential hypertension
Puig, Juan G., MD, Schunkert, Heribert, MD, Taylor, Addison A., MD, PhD, Boye, Sam, MPH, Jin, James, PhD, Keefe, Deborah L., MD, MPH
Published in Clinical therapeutics (01.12.2009)
Published in Clinical therapeutics (01.12.2009)
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Journal Article
Direct Renin Inhibition With Aliskiren in Obese Patients With Arterial Hypertension
Jordan, Jens, Engeli, Stefan, Boye, Sam W, Le Breton, Stephanie, Keefe, Deborah L
Published in Hypertension (Dallas, Tex. 1979) (01.05.2007)
Published in Hypertension (Dallas, Tex. 1979) (01.05.2007)
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Journal Article
Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure
McMurray, John J V, Pitt, Bertram, Latini, Roberto, Maggioni, Aldo P, Solomon, Scott D, Keefe, Deborah L, Ford, Jessica, Verma, Anil, Lewsey, Jim
Published in Circulation. Heart failure (01.05.2008)
Published in Circulation. Heart failure (01.05.2008)
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Aliskiren-based therapy lowers blood pressure more effectively than hydrochlorothiazide-based therapy in obese patients with hypertension: sub-analysis of a 52-week, randomized, double-blind trial
Schmieder, Roland E, Philipp, Thomas, Guerediaga, Javier, Gorostidi, Manuel, Bush, Christopher, Keefe, Deborah L
Published in Journal of hypertension (01.07.2009)
Published in Journal of hypertension (01.07.2009)
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Efficacy, safety, and tolerability of aliskiren monotherapy administered with a light meal in elderly hypertensive patients: a randomized, double-blind, placebo-controlled, dose-response evaluation study
Villa, Giuseppe, Le Breton, Stephanie, Ibram, Ghionul, Keefe, Deborah L
Published in Journal of clinical pharmacology (01.12.2012)
Published in Journal of clinical pharmacology (01.12.2012)
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Antihypertensive Efficacy of the Oral Direct Renin Inhibitor Aliskiren as Add‐On Therapy in Patients Not Responding to Amlodipine Monotherapy
Drummond, Waymon, Munger, Mark A., Rafique, Mohammed, Maboudian, Mojdeh, Khan, Mahmudul, Keefe, Deborah L.
Published in The journal of clinical hypertension (Greenwich, Conn.) (01.10.2007)
Published in The journal of clinical hypertension (Greenwich, Conn.) (01.10.2007)
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Safety and Tolerability of the Direct Renin Inhibitor Aliskiren: A Pooled Analysis of Clinical Experience in More Than 12,000 Patients With Hypertension
White, William B., Bresalier, Robert, Kaplan, Allen P., Palmer, Biff F., Riddell, Robert H., Lesogor, Anastasia, Chang, William, Keefe, Deborah L.
Published in The journal of clinical hypertension (Greenwich, Conn.) (01.10.2010)
Published in The journal of clinical hypertension (Greenwich, Conn.) (01.10.2010)
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Journal Article
QTc interval prolongation associated with intravenous methadone
Kornick, Craig A, Kilborn, Michael J, Santiago-Palma, Juan, Schulman, Glenn, Thaler, Howard T, Keefe, Deborah L, Katchman, Alexander N, Pezzullo, John C, Ebert, Steven N, Woosley, Raymond L, Payne, Richard, Manfredi, Paolo L
Published in Pain (Amsterdam) (01.10.2003)
Published in Pain (Amsterdam) (01.10.2003)
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Influence of body weight and gender on the pharmacokinetics, pharmacodynamics, and antihypertensive efficacy of aliskiren
Jarugula, Venkateswar, Yeh, Ching-Ming, Howard, Dan, Bush, Christopher, Keefe, Deborah L, Dole, William P
Published in Journal of clinical pharmacology (01.12.2010)
Published in Journal of clinical pharmacology (01.12.2010)
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Journal Article
Effects of the direct renin inhibitor aliskiren and atenolol alone or in combination in patients with hypertension
Dietz, Rainer, Dechend, Ralf, Yu, Chuek-Man, Bheda, Manesh, Ford, Jessica, Prescott, Margaret F, Keefe, Deborah L
Published in Journal of the renin-angiotensin-aldosterone system (01.09.2008)
Published in Journal of the renin-angiotensin-aldosterone system (01.09.2008)
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Journal Article
Safety and Tolerability of the Direct Renin Inhibitor Aliskiren in Combination With Angiotensin Receptor Blockers and Thiazide Diuretics: A Pooled Analysis of Clinical Experience of 12,942 Patients
White, William B., Bresalier, Robert, Kaplan, Allen P., Palmer, Biff F., Riddell, Robert H., Lesogor, Anastasia, Chang, William, Keefe, Deborah L.
Published in The journal of clinical hypertension (Greenwich, Conn.) (01.07.2011)
Published in The journal of clinical hypertension (Greenwich, Conn.) (01.07.2011)
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Journal Article
Comparative effects of aliskiren-based and ramipril-based therapy on the renin system during long-term (6 months) treatment and withdrawal in patients with hypertension
Andersen, Karl, Weinberger, Myron H, Constance, Christian M, Ali, Mohammed A, Jin, James, Prescott, Margaret F, Keefe, Deborah L
Published in Journal of the renin-angiotensin-aldosterone system (01.09.2009)
Published in Journal of the renin-angiotensin-aldosterone system (01.09.2009)
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Journal Article
Long-Term Safety and Tolerability of the Oral Direct Renin Inhibitor Aliskiren with Optional Add-On Hydrochlorothiazide in Patients with Hypertension: A Randomized, Open-Label, Parallel-Group, Multicentre, Dose-Escalation Study with an Extension Phase
Sica, Domenic, Gradman, Alan H., Lederballe, Ole, Kolloch, Rainer E., Zhang, Jack, Keefe, Deborah L.
Published in Clinical drug investigation (01.12.2011)
Published in Clinical drug investigation (01.12.2011)
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