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Chemical ligation methods for the tagging of DNA-encoded chemical libraries
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Published in Current opinion in chemical biology (01.06.2015)
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Aptamers as therapeutics
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DNA-encoded chemistry: enabling the deeper sampling of chemical space
Goodnow, Robert A., Dumelin, Christoph E., Keefe, Anthony D.
Published in Nature reviews. Drug discovery (01.02.2017)
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Wilson, David S., Keefe, Anthony D., Szostak, Jack W.
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Published in Proceedings of the National Academy of Sciences - PNAS (27.03.2001)
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Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry
Cuozzo, John W, Clark, Matthew A, Keefe, Anthony D, Kohlmann, Anna, Mulvihill, Mark, Ni, Haihong, Renzetti, Louis M, Resnicow, Daniel I, Ruebsam, Frank, Sigel, Eric A, Thomson, Heather A, Wang, Ce, Xie, Zhifeng, Zhang, Ying
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Machine Learning on DNA-Encoded Libraries: A New Paradigm for Hit Finding
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Published in Journal of medicinal chemistry (27.08.2020)
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Screening Ultra-Large Encoded Compound Libraries Leads to Novel Protein–Ligand Interactions and High Selectivity
Collie, Gavin W., Clark, Matthew A., Keefe, Anthony D., Madin, Andrew, Read, Jon A., Rivers, Emma L., Zhang, Ying
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Bispecific Estrogen Receptor α Degraders Incorporating Novel Binders Identified Using DNA-Encoded Chemical Library Screening
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Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA‐Encoded Chemical Library
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Published in Chembiochem : a European journal of chemical biology (04.05.2017)
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Published in Journal of medicinal chemistry (13.04.2023)
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Rational Design of Macrocyclic Noncovalent Inhibitors of SARS-CoV‑2 Mpro from a DNA-Encoded Chemical Library Screening Hit That Demonstrate Potent Inhibition against Pan-Coronavirus Homologues and Nirmatrelvir-Resistant Variants
Wang, Xu, Gotchev, Dimitar, Fan, Kristi Yi, Vega, Marvin M., Mani, Nagraj, McGovern-Gooch, Kayleigh, Cuconati, Andrea, Tercero, Breanna, Wang, Xiaohe, Carpino, Philip, Maskos, Klaus, Centrella, Paolo A., Schmitt, Andreas, Preuss, Franziska, Prasad, Archna, Chen, Chia-yi, Clark, Matthew A., Guilinger, John P., Johnstone, Shawn, von König, Konstanze, Keefe, Anthony D., Liu, Jenny, Turcotte, Stéphane, Zhang, Ying, Konz Makino, Debora L., Lam, Angela M., Cole, Andrew G., Sofia, Michael J.
Published in Journal of medicinal chemistry (14.11.2024)
Published in Journal of medicinal chemistry (14.11.2024)
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Rational Design of Macrocyclic Noncovalent Inhibitors of SARS-CoV-2 M pro from a DNA-Encoded Chemical Library Screening Hit That Demonstrate Potent Inhibition against Pan-Coronavirus Homologues and Nirmatrelvir-Resistant Variants
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Published in Journal of medicinal chemistry (14.11.2024)
Published in Journal of medicinal chemistry (14.11.2024)
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Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning
Ahmad, Shabbir, Xu, Jin, Feng, Jianwen A., Hutchinson, Ashley, Zeng, Hong, Ghiabi, Pegah, Dong, Aiping, Centrella, Paolo A., Clark, Matthew A., Guié, Marie-Aude, Guilinger, John P., Keefe, Anthony D., Zhang, Ying, Cerruti, Thomas, Cuozzo, John W., von Rechenberg, Moritz, Bolotokova, Albina, Li, Yanjun, Loppnau, Peter, Seitova, Alma, Li, Yen-Yen, Santhakumar, Vijayaratnam, Brown, Peter J., Ackloo, Suzanne, Halabelian, Levon
Published in Journal of medicinal chemistry (14.12.2023)
Published in Journal of medicinal chemistry (14.12.2023)
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