Discovery of (5S,6S,9R)‑5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro‑5H‑cyclohepta[b]pyridin-9-yl 4‑(2-oxo-2,3-dihydro‑1H‑imidazo[4,5‑b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): An Oral Calcitonin Gene-Related Peptide (CGRP) Antagonist in Clinical Trials for Treating Migraine
Luo, Guanglin, Chen, Ling, Conway, Charles M., Denton, Rex, Keavy, Deborah, Signor, Laura, Kostich, Walter, Lentz, Kimberley A., Santone, Kenneth S., Schartman, Richard, Browning, Marc, Tong, Gary, Houston, John G., Dubowchik, Gene M., Macor, John E.
Published in Journal of medicinal chemistry (13.12.2012)
Published in Journal of medicinal chemistry (13.12.2012)
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Nicotinic alpha 7 receptor agonists EVP-6124 and BMS-933043, attenuate scopolamine-induced deficits in visuo-spatial paired associates learning
Weed, Michael R, Polino, Joseph, Signor, Laura, Bookbinder, Mark, Keavy, Deborah, Benitex, Yulia, Morgan, Daniel G, King, Dalton, Macor, John E, Zaczek, Robert, Olson, Richard, Bristow, Linda J
Published in PloS one (19.12.2017)
Published in PloS one (19.12.2017)
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The qEEG Signature of Selective NMDA NR2B Negative Allosteric Modulators; A Potential Translational Biomarker for Drug Development
Keavy, Deborah, Bristow, Linda J, Sivarao, Digavalli V, Batchelder, Margaret, King, Dalton, Thangathirupathy, Srinivasan, Macor, John E, Weed, Michael R
Published in PloS one (01.04.2016)
Published in PloS one (01.04.2016)
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Calcitonin gene-related peptide (CGRP) receptor antagonists: Heterocyclic modification of a novel azepinone lead
Luo, Guanglin, Jiang, Xiang-Jun, Chen, Ling, Conway, Charles M., Gulianello, Michael, Kostich, Walter, Keavy, Deborah, Signor, Laura J., Chen, Ping, Davis, Carl, Whiterock, Valerie J., Schartman, Richard, Widmann, Kimberly A., Macor, John E., Dubowchik, Gene M.
Published in Bioorganic & medicinal chemistry letters (01.07.2021)
Published in Bioorganic & medicinal chemistry letters (01.07.2021)
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Negative Allosteric Modulators Selective for The NR2B Subtype of The NMDA Receptor Impair Cognition in Multiple Domains
Weed, Michael R, Bookbinder, Mark, Polino, Joseph, Keavy, Deborah, Cardinal, Rudolf N, Simmermacher-Mayer, Jean, Cometa, Fu-ni L, King, Dalton, Thangathirupathy, Srinivasan, Macor, John E, Bristow, Linda J
Published in Neuropsychopharmacology (New York, N.Y.) (01.01.2016)
Published in Neuropsychopharmacology (New York, N.Y.) (01.01.2016)
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Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): A potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery
Chaturvedula, Prasad V., Mercer, Stephen E., Pin, Sokhom S., Thalody, George, Xu, Cen, Conway, Charlie M., Keavy, Deborah, Signor, Laura, Cantor, Glenn H., Mathias, Neil, Moench, Paul, Denton, Rex, Macci, Robert, Schartman, Richard, Whiterock, Valerie, Davis, Carl, Macor, John E., Dubowchik, Gene M.
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
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Preclinical Characterization of ( R )-3-((3 S ,4 S )-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N -Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder
Bristow, Linda J, Gulia, Jyoti, Weed, Michael R, Srikumar, Bettadapura N, Li, Yu-Wen, Graef, John D, Naidu, Pattipati S, Sanmathi, Charulatha, Aher, Jayant, Bastia, Tanmaya, Paschapur, Mahesh, Kalidindi, Narasimharaju, Kumar, Kuchibhotla Vijaya, Molski, Thaddeus, Pieschl, Rick, Fernandes, Alda, Brown, Jeffrey M, Sivarao, Digavalli V, Newberry, Kimberly, Bookbinder, Mark, Polino, Joseph, Keavy, Deborah, Newton, Amy, Shields, Eric, Simmermacher, Jean, Kempson, James, Li, Jianqing, Zhang, Huiping, Mathur, Arvind, Kallem, Raja Reddy, Sinha, Meenakshee, Ramarao, Manjunath, Vikramadithyan, Reeba K, Thangathirupathy, Srinivasan, Warrier, Jayakumar, Islam, Imadul, Bronson, Joanne J, Olson, Richard E, Macor, John E, Albright, Charlie F, King, Dalton, Thompson, Lorin A, Marcin, Lawrence R, Sinz, Michael
Published in The Journal of pharmacology and experimental therapeutics (01.12.2017)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2017)
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Discovery of (5 S ,6 S ,9 R )-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5 H -cyclohepta[ b ]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1 H -imidazo[4,5- b ]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): An Oral Calcitonin Gene-Related Peptide (CGRP) Antagonist in Clinical Trials for Treating Migraine
Luo, Guanglin, Chen, Ling, Conway, Charles M., Denton, Rex, Keavy, Deborah, Signor, Laura, Kostich, Walter, Lentz, Kimberley A., Santone, Kenneth S., Schartman, Richard, Browning, Marc, Tong, Gary, Houston, John G., Dubowchik, Gene M., Macor, John E.
Published in Journal of medicinal chemistry (13.12.2012)
Published in Journal of medicinal chemistry (13.12.2012)
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Journal Article
Discovery of BMS-846372, a Potent and Orally Active Human CGRP Receptor Antagonist for the Treatment of Migraine
Luo, Guanglin, Chen, Ling, Conway, Charles M, Denton, Rex, Keavy, Deborah, Gulianello, Michael, Huang, Yanling, Kostich, Walter, Lentz, Kimberley A, Mercer, Stephen E, Schartman, Richard, Signor, Laura, Browning, Marc, Macor, John E, Dubowchik, Gene M
Published in ACS medicinal chemistry letters (12.04.2012)
Published in ACS medicinal chemistry letters (12.04.2012)
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