Discovery of N-{2-Methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N′-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine (ASP3026), a Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor
Iikubo, Kazuhiko, Kondoh, Yutaka, Shimada, Itsuro, Matsuya, Takahiro, Mori, Kenichi, Ueno, Yoko, Okada, Minoru
Published in Chemical & pharmaceutical bulletin (2018)
Published in Chemical & pharmaceutical bulletin (2018)
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Discovery of ASP5878: Synthesis and structure–activity relationships of pyrimidine derivatives as pan-FGFRs inhibitors with improved metabolic stability and suppressed hERG channel inhibitory activity
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Published in Bioorganic & medicinal chemistry (01.04.2022)
Published in Bioorganic & medicinal chemistry (01.04.2022)
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Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2
Kuriwaki, Ikumi, Kameda, Minoru, Hisamichi, Hiroyuki, Kikuchi, Shigetoshi, Iikubo, Kazuhiko, Kawamoto, Yuichiro, Moritomo, Hiroyuki, Kondoh, Yutaka, Amano, Yasushi, Tateishi, Yukihiro, Echizen, Yuka, Iwai, Yoshinori, Noda, Atsushi, Tomiyama, Hiroshi, Suzuki, Tomoyuki, Hirano, Masaaki
Published in Bioorganic & medicinal chemistry (15.05.2020)
Published in Bioorganic & medicinal chemistry (15.05.2020)
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Synthesis and structure–activity relationships of pyrazine-2-carboxamide derivatives as novel echinoderm microtubule-associated protein-like 4 (EML4)–anaplastic lymphoma kinase (ALK) inhibitors
Iikubo, Kazuhiko, Kurosawa, Kazuo, Matsuya, Takahiro, Kondoh, Yutaka, Kamikawa, Akio, Moritomo, Ayako, Iwai, Yoshinori, Tomiyama, Hiroshi, Shimada, Itsuro
Published in Bioorganic & medicinal chemistry (15.04.2019)
Published in Bioorganic & medicinal chemistry (15.04.2019)
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Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency
Kuriwaki, Ikumi, Kameda, Minoru, Iikubo, Kazuhiko, Hisamichi, Hiroyuki, Kawamoto, Yuichiro, Kikuchi, Shigetoshi, Moritomo, Hiroyuki, Kondoh, Yutaka, Terasaka, Tadashi, Amano, Yasushi, Tateishi, Yukihiro, Echizen, Yuka, Iwai, Yoshinori, Noda, Atsushi, Tomiyama, Hiroshi, Nakazawa, Taisuke, Hirano, Masaaki
Published in Bioorganic & medicinal chemistry (01.03.2021)
Published in Bioorganic & medicinal chemistry (01.03.2021)
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Synthesis and structure–activity relationship of fused-pyrimidine derivatives as a series of novel GPR119 agonists
Negoro, Kenji, Yonetoku, Yasuhiro, Moritomo, Ayako, Hayakawa, Masahiko, Iikubo, Kazuhiko, Yoshida, Shigeru, Takeuchi, Makoto, Ohta, Mitsuaki
Published in Bioorganic & medicinal chemistry (01.11.2012)
Published in Bioorganic & medicinal chemistry (01.11.2012)
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The first direct synthesis of α-mangostin, a potent inhibitor of the acidic sphingomyelinase
Iikubo, Kazuhiko, Ishikawa, Yuichi, Ando, Noritaka, Umezawa, Kazuo, Nishiyama, Shigeru
Published in Tetrahedron letters (07.01.2002)
Published in Tetrahedron letters (07.01.2002)
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Fused pyridazine derivative
TOMIYAMA, HIROSHI, KOIZUMI, YUKA, NAKAMURA, AKIHIKO, TOYA, HIROKI, IIKUBO, KAZUHIKO, WASHIO, TAKUYA, IWAI, YOSHINORI, YAMASHITA, YUMI, INAGAKI, YUSUKE
Year of Publication 16.08.2024
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Year of Publication 16.08.2024
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DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND
Kurosawa, Kazuo, Tomiyama, Hiroshi, Kamikawa, Akio, Iikubo, Kazuhiko, Kondoh, Yutaka, Shimada, Itsuro, Matsuya, Takahiro, Iwai, Yoshinori
Year of Publication 29.10.2018
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Year of Publication 29.10.2018
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DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND
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Year of Publication 31.07.2018
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Year of Publication 31.07.2018
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DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND
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Year of Publication 10.04.2018
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Kurosawa, Kazuo, Tomiyama, Hiroshi, Kamikawa, Akio, Iikubo, Kazuhiko, Kondoh, Yutaka, Shimada, Itsuro, Matsuya, Takahiro, Iwai, Yoshinori
Year of Publication 06.04.2018
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Year of Publication 02.04.2018
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Year of Publication 02.04.2018
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Kurosawa, Kazuo, Tomiyama, Hiroshi, Kamikawa, Akio, Iikubo, Kazuhiko, Kondoh, Yutaka, Shimada, Itsuro, Matsuya, Takahiro, Iwai, Yoshinori
Year of Publication 26.03.2018
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Year of Publication 26.03.2018
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Kurosawa, Kazuo, Tomiyama, Hiroshi, Kamikawa, Akio, Iikubo, Kazuhiko, Kondoh, Yutaka, Shimada, Itsuro, Matsuya, Takahiro, Iwai, Yoshinori
Year of Publication 21.02.2018
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Year of Publication 21.02.2018
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composto de carboxamida heterocíclica de diamino
Takahiro Matsuya, Akio Kamikawa, Yutaka Kondoh, Kazuo Kurosawa, Kazuhiko Iikubo, Hiroshi Tomiyama, Yoshinori Iwai, Itsuro Shimada
Year of Publication 06.02.2018
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Year of Publication 06.02.2018
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TOMIYAMA, HIROSHI, MATSUYA, TAKAHIRO, KONDOH, YUTAKA, SHIMADA, ITSURO, IIKUBO, KAZUHIKO, KAMIKAWA, AKIO, IWAI, YOSHINORI, KUROSAWA, KAZUO
Year of Publication 28.02.2017
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Year of Publication 28.02.2017
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NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND
OKADA, HARUKI, ASAUMI, MAKOTO, TOMIYAMA, HIROSHI, KURIWAKI, IKUMI, KAMEDA, MINORU, NODA, ATSUSHI, MIYASAKA, KOZO, IWAI, YOSHINORI, TOKUZAKI, KAZUO, HISAMICHI, HIROYUKI, KAWAMOTO, YUICHIRO, SUZUKI, ATSUSHI, TSUNOYAMA, KAZUHISA, IIKUBO, KAZUHIKO, FUTAMI, TAKASHI, SUZUKI, TOMOYUKI, MORITOMO, HIROYUKI
Year of Publication 31.01.2020
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Year of Publication 31.01.2020
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