Evidence-informed clinical practice recommendations for treatment of type 1 diabetes complicated by problematic hypoglycemia
Choudhary, Pratik, Rickels, Michael R, Senior, Peter A, Vantyghem, Marie-Christine, Maffi, Paola, Kay, Thomas W, Keymeulen, Bart, Inagaki, Nobuya, Saudek, Frantisek, Lehmann, Roger, Hering, Bernhard J
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Published in Diabetologia (01.11.2017)
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Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients
Coppieters, Ken T, Dotta, Francesco, Amirian, Natalie, Campbell, Peter D, Kay, Thomas W H, Atkinson, Mark A, Roep, Bart O, von Herrath, Matthias G
Published in The Journal of experimental medicine (16.01.2012)
Published in The Journal of experimental medicine (16.01.2012)
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Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation
Bhattacharyya, Sandip, Zhao, Yuxing, Kay, Thomas W.H, Muglia, Louis J
Published in Proceedings of the National Academy of Sciences - PNAS (07.06.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (07.06.2011)
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Increased Thyroidal Activity on Routine FDG-PET/CT after Combination Immune Checkpoint Inhibition: Temporal Associations with Clinical and Biochemical Thyroiditis
Galligan, Anna, Wallace, Roslyn, Krishnamurthy, Balasubramanian, Kay, Thomas W H, Sachithanandan, Nirupa, Chiang, Cherie, Sandhu, Shahneen, Hicks, Rodney J, Iravani, Amir
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Published in Cancers (01.12.2023)
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Development of a standardized MRI protocol for pancreas assessment in humans
Virostko, John, Craddock, Richard C, Williams, Jonathan M, Triolo, Taylor M, Hilmes, Melissa A, Kang, Hakmook, Du, Liping, Wright, Jordan J, Kinney, Mara, Maki, Jeffrey H, Medved, Milica, Waibel, Michaela, Kay, Thomas W H, Thomas, Helen E, Greeley, Siri Atma W, Steck, Andrea K, Moore, Daniel J, Powers, Alvin C
Published in PloS one (24.08.2021)
Published in PloS one (24.08.2021)
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Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans
Simeonovic, Charmaine J, Popp, Sarah K, Starrs, Lora M, Brown, Debra J, Ziolkowski, Andrew F, Ludwig, Barbara, Bornstein, Stefan R, Wilson, J Dennis, Pugliese, Alberto, Kay, Thomas W H, Thomas, Helen E, Loudovaris, Thomas, Choong, Fui Jiun, Freeman, Craig, Parish, Christopher R
Published in PloS one (07.02.2018)
Published in PloS one (07.02.2018)
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IL-17F induces inflammation, dysfunction and cell death in mouse islets
Catterall, Tara, Fynch, Stacey, Kay, Thomas W H, Thomas, Helen E, Sutherland, Andrew P R
Published in Scientific reports (04.08.2020)
Published in Scientific reports (04.08.2020)
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The JAK1 Selective Inhibitor ABT 317 Blocks Signaling Through Interferon-γ and Common γ Chain Cytokine Receptors to Reverse Autoimmune Diabetes in NOD Mice
Ge, Tingting, Jhala, Gaurang, Fynch, Stacey, Akazawa, Satoru, Litwak, Sara, Pappas, Evan G, Catterall, Tara, Vakil, Ishan, Long, Andrew J, Olson, Lisa M, Krishnamurthy, Balasubramanian, Kay, Thomas W, Thomas, Helen E
Published in Frontiers in immunology (04.12.2020)
Published in Frontiers in immunology (04.12.2020)
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Deficiency of the innate immune adaptor STING promotes autoreactive T cell expansion in NOD mice
Akazawa, Satoru, Mackin, Leanne, Jhala, Gaurang, Fynch, Stacey, Catterall, Tara, Selck, Claudia, Graham, Kate L., Krishnamurthy, Balasubramanian, Pappas, Evan G., Kwong, Chun-Ting J., Sutherland, Andrew P. R., Kay, Thomas W. H., Brodnicki, Thomas C., Thomas, Helen E.
Published in Diabetologia (01.04.2021)
Published in Diabetologia (01.04.2021)
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Proinsulin-specific, HLA-DQ8, and HLA-DQ8-transdimer-restricted CD4+ T cells infiltrate islets in type 1 diabetes
Pathiraja, Vimukthi, Kuehlich, Janine P, Campbell, Peter D, Krishnamurthy, Balasubramanian, Loudovaris, Thomas, Coates, P Toby H, Brodnicki, Thomas C, O'Connell, Philip J, Kedzierska, Katherine, Rodda, Christine, Bergman, Philip, Hill, Erin, Purcell, Anthony W, Dudek, Nadine L, Thomas, Helen E, Kay, Thomas W H, Mannering, Stuart I
Published in Diabetes (New York, N.Y.) (01.01.2015)
Published in Diabetes (New York, N.Y.) (01.01.2015)
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TIGIT acts as an immune checkpoint upon inhibition of PD1 signaling in autoimmune diabetes
Trivedi, Prerak, Jhala, Gaurang, De George, David J, Chiu, Chris, Selck, Claudia, Ge, Tingting, Catterall, Tara, Elkerbout, Lorraine, Boon, Louis, Joller, Nicole, Kay, Thomas W, Thomas, Helen E, Krishnamurthy, Balasubramanian
Published in Frontiers in immunology (12.03.2024)
Published in Frontiers in immunology (12.03.2024)
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Autoreactive T cells induce necrosis and not BCL-2-regulated or death receptor-mediated apoptosis or RIPK3-dependent necroptosis of transplanted islets in a mouse model of type 1 diabetes
Zhao, Yuxing, Scott, Nicholas A., Fynch, Stacey, Elkerbout, Lorraine, Wong, W. Wei-Lynn, Mason, Kylie D., Strasser, Andreas, Huang, David C., Kay, Thomas W. H., Thomas, Helen E.
Published in Diabetologia (01.01.2015)
Published in Diabetologia (01.01.2015)
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T-Cell-Specific PTPN2 Deficiency in NOD Mice Accelerates the Development of Type 1 Diabetes and Autoimmune Comorbidities
Wiede, Florian, Brodnicki, Thomas C, Goh, Pei Kee, Leong, Yew A, Jones, Gareth W, Yu, Di, Baxter, Alan G, Jones, Simon A, Kay, Thomas W H, Tiganis, Tony
Published in Diabetes (New York, N.Y.) (01.06.2019)
Published in Diabetes (New York, N.Y.) (01.06.2019)
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Deficiency in Type I Interferon Signaling Prevents the Early Interferon-Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice
HONG SHENG QUAH, MIRANDA-HERNANDEZ, Socorro, GRAHAM, Kate L, KHOO, Aimee, HARDING, Ashley, FYNCH, Stacey, ELKERBOUT, Lorraine, BRODNICKI, Thomas C, BAXTER, Alan G, KAY, Thomas W. H, THOMAS, Helen E
Published in Diabetes (New York, N.Y.) (01.03.2014)
Published in Diabetes (New York, N.Y.) (01.03.2014)
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Baricitinib and β-Cell Function in Patients with New-Onset Type 1 Diabetes
Waibel, Michaela, Wentworth, John M, So, Michelle, Couper, Jennifer J, Cameron, Fergus J, MacIsaac, Richard J, Atlas, Gabby, Gorelik, Alexandra, Litwak, Sara, Sanz-Villanueva, Laura, Trivedi, Prerak, Ahmed, Simi, Martin, Francis J, Doyle, Madeleine E, Harbison, Jessica E, Hall, Candice, Krishnamurthy, Balasubramanian, Colman, Peter G, Harrison, Leonard C, Thomas, Helen E, Kay, Thomas W H
Published in The New England journal of medicine (07.12.2023)
Published in The New England journal of medicine (07.12.2023)
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Liver-Specific Suppressor of Cytokine Signaling-3 Deletion in Mice Enhances Hepatic Insulin Sensitivity and Lipogenesis Resulting in Fatty Liver and Obesity
SACHITHANANDAN, Nirupa, FAM, Barbara C, HEVENER, Andrea L, KAY, Thomas W. H, STEINBERG, Gregory R, FYNCH, Stacey, DZAMKO, Nicolas, WATT, Matthew J, WORMALD, Sam, HONEYMAN, Jane, GALIC, Sandra, PROIETTO, Joseph, ANDRIKOPOULOS, Sofianos
Published in Hepatology (Baltimore, Md.) (01.11.2010)
Published in Hepatology (Baltimore, Md.) (01.11.2010)
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Rotavirus Infection Accelerates Type 1 Diabetes in Mice with Established Insulitis
GRAHAM, Kate L, SANDERS, Natalie, YAN TAN, ALLISON, Janette, KAY, Thomas W. H, COULSON, Barbara S
Published in Journal of Virology (01.07.2008)
Published in Journal of Virology (01.07.2008)
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Inhibition of Y1 receptor signaling improves islet transplant outcome
Loh, Kim, Shi, Yan-Chuan, Walters, Stacey, Bensellam, Mohammed, Lee, Kailun, Dezaki, Katsuya, Nakata, Masanori, Ip, Chi Kin, Chan, Jeng Yie, Gurzov, Esteban N, Thomas, Helen E, Waibel, Michaela, Cantley, James, Kay, Thomas W, Yada, Toshihiko, Laybutt, D Ross, Grey, Shane T, Herzog, Herbert
Published in Nature communications (08.09.2017)
Published in Nature communications (08.09.2017)
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