Search Results - "Kawazu, Masahito"

The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies by Kumagai, Shogo, Togashi, Yosuke, Kamada, Takahiro, Sugiyama, Eri, Nishinakamura, Hitomi, Takeuchi, Yoshiko, Vitaly, Kochin, Itahashi, Kota, Maeda, Yuka, Matsui, Shigeyuki, Shibahara, Takuma, Yamashita, Yasuho, Irie, Takuma, Tsuge, Ayaka, Fukuoka, Shota, Kawazoe, Akihito, Udagawa, Hibiki, Kirita, Keisuke, Aokage, Keiju, Ishii, Genichiro, Kuwata, Takeshi, Nakama, Kenta, Kawazu, Masahito, Ueno, Toshihide, Yamazaki, Naoya, Goto, Koichi, Tsuboi, Masahiro, Mano, Hiroyuki, Doi, Toshihiko, Shitara, Kohei, Nishikawa, Hiroyoshi

“…Immune checkpoint blockade has provided a paradigm shift in cancer therapy, but the success of this approach is very variable; therefore, biomarkers predictive…”

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A Low Tumor Mutational Burden and PTEN Mutations Are Predictors of a Negative Response to PD-1 Blockade in MSI-H/dMMR Gastrointestinal Tumors by Chida, Keigo, Kawazoe, Akihito, Kawazu, Masahito, Suzuki, Toshihiro, Nakamura, Yoshiaki, Nakatsura, Tetsuya, Kuwata, Takeshi, Ueno, Toshihide, Kuboki, Yasutoshi, Kotani, Daisuke, Kojima, Takashi, Taniguchi, Hiroya, Mano, Hiroyuki, Ikeda, Masafumi, Shitara, Kohei, Endo, Itaru, Yoshino, Takayuki

“…This study performed a comprehensive molecular characterization of microsatellite instability-high (MSI-H)/mismatch repair-deficient (dMMR) gastrointestinal…”

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High-Throughput Functional Evaluation of Variants of Unknown Significance in ERBB2 by Nagano, Masaaki, Kohsaka, Shinji, Ueno, Toshihide, Kojima, Shinya, Saka, Kanju, Iwase, Hirotaro, Kawazu, Masahito, Mano, Hiroyuki

“…Purpose: The advent of next-generation sequencing technologies has enabled the identification of several activating mutations of Erb-B2 receptor tyrosine…”

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Highly sensitive fusion detection using plasma cell‐free RNA in non‐small‐cell lung cancers by Hasegawa, Nobuhiko, Kohsaka, Shinji, Kurokawa, Kana, Shinno, Yuki, Takeda Nakamura, Ikuko, Ueno, Toshihide, Kojima, Shinya, Kawazu, Masahito, Suehara, Yoshiyuki, Ishijima, Muneaki, Goto, Yasushi, Kojima, Yuki, Yonemori, Kan, Hayashi, Takuo, Saito, Tsuyoshi, Shukuya, Takehito, Takahashi, Fumiyuki, Takahashi, Kazuhisa, Mano, Hiroyuki

“…ALK, ROS1, and RET kinase fusions are important predictive biomarkers of tyrosine kinase inhibitors (TKIs) in non‐small‐cell lung cancer (NSCLC). Analysis of…”

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Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults by Yasuda, Takahiko, Tsuzuki, Shinobu, Kawazu, Masahito, Hayakawa, Fumihiko, Kojima, Shinya, Ueno, Toshihide, Imoto, Naoto, Kohsaka, Shinji, Kunita, Akiko, Doi, Koichiro, Sakura, Toru, Yujiri, Toshiaki, Kondo, Eisei, Fujimaki, Katsumichi, Ueda, Yasunori, Aoyama, Yasutaka, Ohtake, Shigeki, Takita, Junko, Sai, Eirin, Taniwaki, Masafumi, Kurokawa, Mineo, Morishita, Shinichi, Fukayama, Masashi, Kiyoi, Hitoshi, Miyazaki, Yasushi, Naoe, Tomoki, Mano, Hiroyuki

“…Hiroyuki Mano and colleagues report fusions involving DUX4 in 16.4% of Ph-negative adolescent and young adult acute lymphoblastic leukemia (AYA-ALL) cases…”

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Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations by Inoue, Satoshi, Hirota, Yasushi, Ueno, Toshihide, Fukui, Yamato, Yoshida, Emiko, Hayashi, Takuo, Kojima, Shinya, Takeyama, Reina, Hashimoto, Taiki, Kiyono, Tohru, Ikemura, Masako, Taguchi, Ayumi, Tanaka, Tomoki, Tanaka, Yosuke, Sakata, Seiji, Takeuchi, Kengo, Muraoka, Ayako, Osuka, Satoko, Saito, Tsuyoshi, Oda, Katsutoshi, Osuga, Yutaka, Terao, Yasuhisa, Kawazu, Masahito, Mano, Hiroyuki

“…Uterine adenomyosis is a benign disorder that often co-occurs with endometriosis and/or leiomyoma, and impairs quality of life. The genomic features of…”

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Transcriptomic Profiling of MSI-H/dMMR Gastrointestinal Tumors to Identify Determinants of Responsiveness to Anti–PD-1 Therapy by Chida, Keigo, Kawazoe, Akihito, Suzuki, Toshihiro, Kawazu, Masahito, Ueno, Toshihide, Takenouchi, Kazumasa, Nakamura, Yoshiaki, Kuboki, Yasutoshi, Kotani, Daisuke, Kojima, Takashi, Bando, Hideaki, Mishima, Saori, Kuwata, Takeshi, Sakamoto, Naoya, Watanabe, Jun, Mano, Hiroyuki, Ikeda, Masafumi, Shitara, Kohei, Endo, Itaru, Nakatsura, Tetsuya, Yoshino, Takayuki

“…Transcriptomic profiling was performed for microsatellite instability-high (MSI-H)/mismatch repair-deficient (dMMR) gastrointestinal tumors to determine the…”

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A Hyperactive RelA/p65-Hexokinase 2 Signaling Axis Drives Primary Central Nervous System Lymphoma by Tateishi, Kensuke, Miyake, Yohei, Kawazu, Masahito, Sasaki, Nobuyoshi, Nakamura, Taishi, Sasame, Jo, Yoshii, Yukie, Ueno, Toshihide, Miyake, Akio, Watanabe, Jun, Matsushita, Yuko, Shiba, Norio, Udaka, Naoko, Ohki, Kentaro, Fink, Alexandria L., Tummala, Shilpa S., Natsumeda, Manabu, Ikegaya, Naoki, Nishi, Mayuko, Ohtake, Makoto, Miyazaki, Ryohei, Suenaga, Jun, Murata, Hidetoshi, Aoki, Ichio, Miller, Julie J., Fujii, Yukihiko, Ryo, Akihide, Yamanaka, Shoji, Mano, Hiroyuki, Cahill, Daniel P., Wakimoto, Hiroaki, Chi, Andrew S., Batchelor, Tracy T., Nagane, Motoo, Ichimura, Koichi, Yamamoto, Tetsuya

“…Primary central nervous system lymphoma (PCNSL) is an isolated type of lymphoma of the central nervous system and has a dismal prognosis despite intensive…”

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Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis by Asada, Shuhei, Goyama, Susumu, Inoue, Daichi, Shikata, Shiori, Takeda, Reina, Fukushima, Tsuyoshi, Yonezawa, Taishi, Fujino, Takeshi, Hayashi, Yasutaka, Kawabata, Kimihito Cojin, Fukuyama, Tomofusa, Tanaka, Yosuke, Yokoyama, Akihiko, Yamazaki, Satoshi, Kozuka-Hata, Hiroko, Oyama, Masaaki, Kojima, Shinya, Kawazu, Masahito, Mano, Hiroyuki, Kitamura, Toshio

“…ASXL1 mutations occur frequently in myeloid neoplasms and are associated with poor prognosis. However, the mechanisms by which mutant ASXL1 induces…”

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Genomic characterization of primary central nervous system lymphoma by Fukumura, Kazutaka, Kawazu, Masahito, Kojima, Shinya, Ueno, Toshihide, Sai, Eirin, Soda, Manabu, Ueda, Hiroki, Yasuda, Takahiko, Yamaguchi, Hiroyuki, Lee, Jeunghun, Shishido-Hara, Yukiko, Sasaki, Atsushi, Shirahata, Mitsuaki, Mishima, Kazuhiko, Ichimura, Koichi, Mukasa, Akitake, Narita, Yoshitaka, Saito, Nobuhito, Aburatani, Hiroyuki, Nishikawa, Ryo, Nagane, Motoo, Mano, Hiroyuki

“…Primary central nervous system lymphoma (PCNSL) is a rare malignancy confined to the central nervous system (CNS), and majority of PCNSL is pathologically…”

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Genome-wide CRISPR screening reveals nucleotide synthesis negatively regulates autophagy by Mimura, Kaito, Sakamaki, Jun-Ichi, Morishita, Hideaki, Kawazu, Masahito, Mano, Hiroyuki, Mizushima, Noboru

“…Macroautophagy (hereafter, autophagy) is a process that directs the degradation of cytoplasmic material in lysosomes. In addition to its homeostatic roles,…”

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EXTH-73. PROTEASOME INHIBITION EXPOSES SELECTIVE VULNERABILITY IN CENTRAL NERVOUS SYSTEM LYMPHOMA by Miyake, Yohei, Kawazu, Masahito, Wakimoto, Hiroaki, Tateishi, kensuke, Yamamoto, Tetsuya

“…Central nervous system lymphoma (CNSL), including primary and secondary CNSL, has a poor prognosis despite standard intensive chemotherapy. Since the majority…”

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Genome Doubling Shapes High-Grade Transformation and Novel EWSR1::LARP4 Fusion Shows SOX10 Immunostaining in Hyalinizing Clear Cell Carcinoma of Salivary Gland by Kobayashi, Kenya, Kawazu, Masahito, Yoshimoto, Seiichi, Ueno, Toshihide, Omura, Go, Saito, Yuki, Ando, Mizuo, Ryo, Eigitsu, Sakyo, Airi, Yoshida, Akihiko, Yatabe, Yasushi, Mano, Hiroyuki, Mori, Taisuke

“…Hyalinizing clear cell carcinoma (HCCC) is a rare indolent malignant tumor of minor salivary gland origin with EWSR1::ATF1 rearrangement. Pathologically, the…”

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Deletion of Pak1 in CD11c-Positive Cells Confers Resistance to Mouse Skin Carcinogenesis by Okumura, Kazuhiro, Morinaga, Takao, Saito, Megumi, Tokunaga, Yurika, Otoyama, Keisuke, Tanaka, Sora, Isogai, Eriko, Kawazu, Masahito, Togashi, Yosuke, Araki, Kimi, Wakabayashi, Yuichi

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Multi-omic profiling of peritoneal metastases in gastric cancer identifies molecular subtypes and therapeutic vulnerabilities by Tanaka, Yosuke, Chiwaki, Fumiko, Kojima, Shinya, Kawazu, Masahito, Komatsu, Masayuki, Ueno, Toshihide, Inoue, Satoshi, Sekine, Shigeki, Matsusaki, Keisuke, Matsushita, Hiromichi, Boku, Narikazu, Kanai, Yae, Yatabe, Yasushi, Sasaki, Hiroki, Mano, Hiroyuki

“…Peritoneal metastasis, a hallmark of incurable advanced gastric cancer (GC), presently has no curative therapy and its molecular features have not been…”

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Histone Demethylase JMJD2B Functions as a Co-Factor of Estrogen Receptor in Breast Cancer Proliferation and Mammary Gland Development by Kawazu, Masahito, Saso, Kayoko, Tong, Kit I., McQuire, Tracy, Goto, Kouichiro, Son, Dong-Ok, Wakeham, Andrew, Miyagishi, Makoto, Mak, Tak W., Okada, Hitoshi

“…Estrogen is a key regulator of normal function of female reproductive system and plays a pivotal role in the development and progression of breast cancer…”

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Stem-like progenitor and terminally differentiated TFH-like CD4+ T cell exhaustion in the tumor microenvironment by Zhou, Wenhao, Kawashima, Shusuke, Ishino, Takamasa, Kawase, Katsushige, Ueda, Youki, Yamashita, Kazuo, Watanabe, Tomofumi, Kawazu, Masahito, Dansako, Hiromichi, Suzuki, Yutaka, Nishikawa, Hiroyoshi, Inozume, Takashi, Nagasaki, Joji, Togashi, Yosuke

“…Immune checkpoint inhibitors exert clinical efficacy against various types of cancer through reinvigoration of exhausted CD8+ T cells that attack cancer cells…”

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JMJD2B/KDM4B inactivation in adipose tissues accelerates obesity and systemic metabolic abnormalities by Kang, Changkeun, Saso, Kayoko, Ota, Kazushige, Kawazu, Masahito, Ueda, Takeshi, Okada, Hitoshi

“…Obesity is a serious global health issue; however, the roles of genetics and epigenetics in the onset and progression of obesity are still not completely…”

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Targeting PAK1 is effective against cutaneous squamous cell carcinoma in a syngenic mouse model by Okumura, Kazuhiro, Morinaga, Takao, Saito, Megumi, Tokunaga, Yurika, Otoyama, Keisuke, Tanaka, Sora, Isogai, Eriko, Kawazu, Masahito, Togashi, Yosuke, Hasegawa, Yoshinori, Wakabayashi, Yuichi

“…By taking advantage of forward genetic analysis in mice, we have demonstrated that Pak1 plays a crucial role during DMBA/TPA skin carcinogenesis. Although Pak1…”

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Development of an optimal protocol for molecular profiling of tumor cells in pleural effusions at single‐cell level by Nakamura, Ikuko Takeda, Ikegami, Masachika, Hasegawa, Nobuhiko, Hayashi, Takuo, Ueno, Toshihide, Kawazu, Masahito, Yagishita, Shigehiro, Goto, Yasushi, Shinno, Yuki, Kojima, Yuki, Takamochi, Kazuya, Takahashi, Fumiyuki, Takahashi, Kazuhisa, Mano, Hiroyuki, Kohsaka, Shinji

“…Liquid biopsy analyzes the current status of primary tumors and their metastatic regions. We aimed to develop an optimized protocol for single‐cell sequencing…”

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