Phase I clinical study of NMB58, a novel positron emission tomography (PET)-myocardial perfusion imaging tracer, conducted to evaluate its safety and pharmacokinetics in Japanese healthy adult males
Kawano, Mirai, Tsuchiya, Junichi, Bae, Hyeyeol, Kimura, Koichiro, Yokoyama, Kota, Takahashi, Marie, Honda, Makiko, Tominaga, Masato, Tateishi, Ukihide
Published in Annals of nuclear medicine (01.05.2021)
Published in Annals of nuclear medicine (01.05.2021)
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Novel Marmoset Cytochrome P450 2C19 in Livers Efficiently Metabolizes Human P450 2C9 and 2C19 Substrates, S-Warfarin, Tolbutamide, Flurbiprofen, and Omeprazole
Uehara, Shotaro, Uno, Yasuhiro, Inoue, Takashi, Kawano, Mirai, Shimizu, Makiko, Toda, Akiko, Utoh, Masahiro, Sasaki, Erika, Yamazaki, Hiroshi
Published in Drug metabolism and disposition (01.10.2015)
Published in Drug metabolism and disposition (01.10.2015)
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Oxidation of R- and S-omeprazole stereoselectively mediated by liver microsomal cytochrome P450 2C19 enzymes from cynomolgus monkeys and common marmosets
Uehara, Shotaro, Kawano, Mirai, Murayama, Norie, Uno, Yasuhiro, Utoh, Masahiro, Inoue, Takashi, Sasaki, Erika, Yamazaki, Hiroshi
Published in Biochemical pharmacology (15.11.2016)
Published in Biochemical pharmacology (15.11.2016)
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Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling
Utoh, Masahiro, Suemizu, Hiroshi, Mitsui, Marina, Kawano, Mirai, Toda, Akiko, Uehara, Shotaro, Uno, Yasuhiro, Shimizu, Makiko, Sasaki, Erika, Yamazaki, Hiroshi
Published in Xenobiotica (01.12.2016)
Published in Xenobiotica (01.12.2016)
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Journal Article
R-warfarin clearances from plasma associated with polymorphic cytochrome P450 2C19 and simulated by individual physiologically based pharmacokinetic models for 11 cynomolgus monkeys
Utoh, Masahiro, Kusama, Takashi, Miura, Tomonori, Mitsui, Marina, Kawano, Mirai, Hirano, Takahiro, Shimizu, Makiko, Uno, Yasuhiro, Yamazaki, Hiroshi
Published in Xenobiotica (01.02.2018)
Published in Xenobiotica (01.02.2018)
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Journal Article
Individual Differences in Metabolic Clearance of S-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers
Uehara, Shotaro, Uno, Yasuhiro, Inoue, Takashi, Kawano, Mirai, Shimizu, Makiko, Toda, Akiko, Utoh, Masahiro, Sasaki, Erika, Yamazaki, Hiroshi
Published in Drug metabolism and disposition (01.07.2016)
Published in Drug metabolism and disposition (01.07.2016)
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