An Improved Synthesis of the Selective EP4 Receptor Agonist ONO-4819
Ohta, Chisa, Kuwabe, Shin-itsu, Shiraishi, Tai, Shinohara, Ikuo, Araki, Hiroshi, Sakuyama, Shigeru, Makihara, Takayuki, Kawanaka, Yasufumi, Ohuchida, Shuichi, Seko, Takuya
Published in Journal of organic chemistry (06.11.2009)
Published in Journal of organic chemistry (06.11.2009)
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Design and synthesis of a selective EP4-receptor agonist. Part 4: Practical synthesis and biological evaluation of a novel highly selective EP4-receptor agonist
MARUYAMA, Toru, KUWABE, Shin-Itsu, OHUCHIDA, Shuichi, NAKAI, Hisao, HASHIMOTO, Shinsuke, KAWAMURA, Masanori, KONDO, Kigen, TODA, Masaaki, KAWANAKA, Yasufumi, SHIRAISHI, Tai, SHINAGAWA, Yoshiyuki, SAKATA, Kiyoto, SEKI, Akiteru, KISHIDA, Yoko, YOSHIDA, Hideyuki, MARUYAMA, Takayuki
Published in Bioorganic & medicinal chemistry (01.07.2002)
Published in Bioorganic & medicinal chemistry (01.07.2002)
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Design and Synthesis of Orally Bioavailable Inhibitors of Inducible Nitric Oxide Synthase. Identification of 2-Azabicyclo[4.1.0]heptan-3-imines
Kawanaka, Yasufumi, Kobayashi, Kaoru, Kusuda, Shinya, Tatsumi, Tadashi, Murota, Masayuki, Nishiyama, Toshihiko, Hisaichi, Katsuya, Fujii, Atsuko, Hirai, Keisuke, Naka, Masao, Komeno, Masaharu, Odagaki, Yshihiko, Nakai, Hisao, Toda, Masaaki
Published in Bioorganic & medicinal chemistry (17.04.2003)
Published in Bioorganic & medicinal chemistry (17.04.2003)
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Allyl as Protective Group for the Acidic Hydrogen of Malonic Ester
Yamazaki, Takanori, Kasatkin, Aleksandr, Kawanaka, Yasufumi, Sato, Fumie
Published in Journal of organic chemistry (05.04.1996)
Published in Journal of organic chemistry (05.04.1996)
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Journal Article
An Improved Synthesis of the Selective EP4 Receptor Agonist ONO-4819
Ohta, Chisa, Kuwabe, Shin-itsu, Shiraishi, Tai, Shinohara, Ikuo, Araki, Hiroshi, Sakuyama, Shigeru, Makihara, Takayuki, Kawanaka, Yasufumi, Ohuchida, Shuichi, Seko, Takuya
Published in Journal of organic chemistry (19.02.2010)
Published in Journal of organic chemistry (19.02.2010)
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A New Process for Synthesis of the Astrocyte Activation Suppressor, ONO-2506
Hasegawa, Tomoyuki, Kawanaka, Yasufumi, Kasamatsu, Eichi, Ohta, Chisa, Nakabayashi, Kazuhiro, Okamoto, Masaki, Hamano, Masaya, Takahashi, Keiji, Ohuchida, Shuichi, Hamada, Yasumasa
Published in Organic process research & development (01.11.2005)
Published in Organic process research & development (01.11.2005)
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Design and synthesis of inhibitors of inducible nitric oxide synthase. Discovery of a new chemical lead with potential for oral bioavailability
Kawanaka, Yasufumi, Kobayashi, Kaoru, Kusuda, Shinya, Tatsumi, Tadashi, Murota, Masayuki, Nishiyama, Toshihiko, Hisaichi, Katsuya, Fujii, Atsuko, Hirai, Keisuke, Naka, Masao, Komeno, Masaharu, Nakai, Hisao, Toda, Masaaki
Published in European journal of medicinal chemistry (01.03.2003)
Published in European journal of medicinal chemistry (01.03.2003)
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Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. synthesis and biological evaluation of dihydropyridin-2(1H)-imines and 1,5,6,7-tetrahydro-2H-azepin-2-imines
KAWANAKA, Yasufumi, KOBAYASHI, Kaoru, NAKA, Masao, KOMENO, Masaharu, NAKAI, Hisao, TODA, Masaaki, KUSUDA, Shinya, TATSUMI, Tadashi, MUROTA, Masayuki, NISHIYAMA, Toshihiko, HISAICHI, Katsuya, FUJII, Atsuko, HIRAI, Keisuke, NISHIZAKI, Minoru
Published in Bioorganic & medicinal chemistry (06.03.2003)
Published in Bioorganic & medicinal chemistry (06.03.2003)
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Process Development of ONO-2506: A Therapeutic Agent for Stroke and Alzheimer's Disease
Hasegawa, Tomoyuki, Kawanaka, Yasufumi, Kasamatsu, Eiji, Iguchi, Yoichi, Yonekawa, Yoshihira, Okamoto, Masaki, Ohta, Chiaki, Hashimoto, Shinsuke, Ohuchida, Shuichi
Published in Organic process research & development (01.03.2003)
Published in Organic process research & development (01.03.2003)
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BRANCHED CARBOXYLIC ACID COMPOUND AND USE THEREOF
HOSHIKAWA, MASAMITSU, IMAWAKA, HARUO, HASEGAWA, TOMOYUKI, MATSUDA, SAIKO, KAWANAKA, YASUFUMI, AKIYAMA, TSUTOMU, SAKUYAMA, SHIGERU
Year of Publication 20.01.2005
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Year of Publication 20.01.2005
Patent
Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. synthesis and biological evaluation of dihydropyridin-2(1 H)-imines and 1,5,6,7-Tetrahydro-2 H-azepin-2-imines
Kawanaka, Yasufumi, Kobayashi, Kaoru, Kusuda, Shinya, Tatsumi, Tadashi, Murota, Masayuki, Nishiyama, Toshihiko, Hisaichi, Katsuya, Fujii, Atsuko, Hirai, Keisuke, Nishizaki, Minoru, Naka, Masao, Komeno, Masaharu, Nakai, Hisao, Toda, Masaaki
Published in Bioorganic & medicinal chemistry (2003)
Published in Bioorganic & medicinal chemistry (2003)
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Journal Article
Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Part 1: synthesis and biological evaluation of dihydropyridin-2-imines
Kawanaka, Yasufumi, Kobayashi, Kaoru, Kusuda, Shinya, Tatsumi, Tadashi, Murota, Masanori, Nishiyama, Toshihiko, Hisaichi, Katsuya, Fujii, Atsuko, Hirai, Keisuke, Naka, Masao, Komeno, Masaharu, Nakai, Hisao, Toda, Masaaki
Published in Bioorganic & medicinal chemistry letters (02.09.2002)
Published in Bioorganic & medicinal chemistry letters (02.09.2002)
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A Practical Synthesis and Biological Evaluation of 9-Halogenated PGF Analogues
Tani, Kousuke, Naganawa, Atsushi, Ishida, Akiharu, Egashira, Hiromu, Odagaki, Yoshihiko, Miyazaki, Toru, Hasegawa, Tomoyuki, Kawanaka, Yasufumi, Sagawa, Kenji, Harada, Hiroyuki, Ogawa, Mikio, Maruyama, Takayuki, Nakai, Hisao, Ohuchida, Shuichi, Kondo, Kigen, Toda, Masaaki
Published in Bioorganic & medicinal chemistry (01.06.2002)
Published in Bioorganic & medicinal chemistry (01.06.2002)
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Synthesis of a highly selective EP2-receptor agonist
Tani, K, Naganawa, A, Ishida, A, Egashira, H, Odagaki, Y, Miyazaki, T, Hasegawa, T, Kawanaka, Y, Nakai, H, Ohuchida, S, Toda, M
Published in Synlett (01.02.2002)
Published in Synlett (01.02.2002)
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Journal Article
One step synthesis of dihydropyridin-2-imines: Inhibitors of inducible nitric oxide synthase
Kawanaka, Y, Kobayashi, K, Kasuda, S, Tatsumi, T, Murota, M, Nishiyama, T, Hisaichi, K, Fujii, A, Hirai, K, Naka, M, Komeno, M, Nakai, H, Toda, M
Published in Synlett (2002)
Published in Synlett (2002)
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