Design, synthesis and selection of DNA-encoded small-molecule libraries
Morgan, Barry A, Clark, Matthew A, Acharya, Raksha A, Arico-Muendel, Christopher C, Belyanskaya, Svetlana L, Benjamin, Dennis R, Carlson, Neil R, Centrella, Paolo A, Chiu, Cynthia H, Creaser, Steffen P, Cuozzo, John W, Davie, Christopher P, Ding, Yun, Franklin, G Joseph, Franzen, Kurt D, Gefter, Malcolm L, Hale, Steven P, Hansen, Nils J V, Israel, David I, Jiang, Jinwei, Kavarana, Malcolm J, Kelley, Michael S, Kollmann, Christopher S, Li, Fan, Lind, Kenneth, Mataruse, Sibongile, Medeiros, Patricia F, Messer, Jeffrey A, Myers, Paul, O'Keefe, Heather, Oliff, Matthew C, Rise, Cecil E, Satz, Alexander L, Skinner, Steven R, Svendsen, Jennifer L, Tang, Lujia, van Vloten, Kurt, Wagner, Richard W, Yao, Gang, Zhao, Baoguang
Published in Nature Chemical Biology (01.09.2009)
Published in Nature Chemical Biology (01.09.2009)
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Mechanism-Based Competitive Inhibitors of Glyoxalase I: Intracellular Delivery, in Vitro Antitumor Activities, and Stabilities in Human Serum and Mouse Serum
Kavarana, Malcolm J, Kovaleva, Elena G, Creighton, Donald J, Wollman, Megan B, Eiseman, Julie L
Published in Journal of medicinal chemistry (28.01.1999)
Published in Journal of medicinal chemistry (28.01.1999)
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Reaction Mechanism of Glyoxalase I Explored by an X-ray Crystallographic Analysis of the Human Enzyme in Complex with a Transition State Analogue
Cameron, Alexander D, Ridderström, Marianne, Olin, Birgit, Kavarana, Malcolm J, Creighton, Donald J, Mannervik, Bengt
Published in Biochemistry (Easton) (12.10.1999)
Published in Biochemistry (Easton) (12.10.1999)
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Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonists
Evindar, Ghotas, Bernier, Sylvie G., Doyle, Elisabeth, Kavarana, Malcolm J., Satz, Alexander L., Lorusso, Jeanine, Blanchette, Heather S., Saha, Ashis K., Hannig, Gerhard, Morgan, Barry A., Westlin, William F.
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
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Synthesis and evaluation of alkoxy-phenylamides and alkoxy-phenylimidazoles as potent sphingosine-1-phosphate receptor subtype-1 agonists
Evindar, Ghotas, Bernier, Sylvie G., Kavarana, Malcolm J., Doyle, Elisabeth, Lorusso, Jeanine, Kelley, Michael S., Halley, Keith, Hutchings, Amy, Wright, Albion D., Saha, Ashis K., Hannig, Gerhard, Morgan, Barry A., Westlin, William F.
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
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Synthesis and evaluation of arylalkoxy- and biarylalkoxy-phenylamide and phenylimidazoles as potent and selective sphingosine-1-phosphate receptor subtype-1 agonists
Evindar, Ghotas, Satz, Alexander L., Bernier, Sylvie G., Kavarana, Malcolm J., Doyle, Elisabeth, Lorusso, Jeanine, Taghizadeh, Nazbeh, Halley, Keith, Hutchings, Amy, Kelley, Michael S., Wright, Albion D., Saha, Ashis K., Hannig, Gerhard, Morgan, Barry A., Westlin, William F.
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
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Novel Cyclic Templates of α-MSH Give Highly Selective and Potent Antagonists/Agonists for Human Melanocortin-3/4 Receptors
Kavarana, Malcolm J, Trivedi, Dev, Cai, Minying, Ying, Jinfa, Hammer, Matthew, Cabello, Christopher, Grieco, Paolo, Han, Guoxia, Hruby, Victor J
Published in Journal of medicinal chemistry (06.06.2002)
Published in Journal of medicinal chemistry (06.06.2002)
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Solution structures of cyclic melanocortin agonists and antagonists by NMR
Ying, Jinfa, Kövér, Katalin E., Gu, Xuyuan, Han, Guoxia, Trivedi, Dev B., Kavarana, Malcolm J., Hruby, Victor J.
Published in Biopolymers (2003)
Published in Biopolymers (2003)
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Role of Hydrophobic Interactions in Binding S-(N-Aryl/Alkyl-N-hydroxy- carbamoyl)glutathiones to the Active Site of the Antitumor Target Enzyme Glyoxalase I
Kalsi, Avinash, Kavarana, Malcolm J, Lu, Tianfen, Whalen, Dale L, Hamilton, Diana S, Creighton, Donald J
Published in Journal of medicinal chemistry (19.10.2000)
Published in Journal of medicinal chemistry (19.10.2000)
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S-(N-Aryl-N-hydroxycarbamoyl)glutathione Derivatives Are Tight-Binding Inhibitors of Glyoxalase I and Slow Substrates for Glyoxalase II
Murthy, Nunna S. R. K, Bakeris, Tina, Kavarana, Malcolm J, Hamilton, Diana S, Lan, Yin, Creighton, Donald J
Published in Journal of medicinal chemistry (01.07.1994)
Published in Journal of medicinal chemistry (01.07.1994)
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A New Method for Rapidly Generating Inhibitors of Glyoxalase I inside Tumor Cells Using S-(N-Aryl-N-hydroxycarbamoyl)ethylsulfoxides
Hamilton, Diana S, Kavarana, Malcolm J, Sharkey, Ellyn M, Eiseman, Julie L, Creighton, Donald J
Published in Journal of medicinal chemistry (20.05.1999)
Published in Journal of medicinal chemistry (20.05.1999)
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Erratum: Design, synthesis and selection of DNA-encoded small-molecule libraries
Clark, Matthew A, Acharya, Raksha A, Arico-Muendel, Christopher C, Belyanskaya, Svetlana L, Benjamin, Dennis R, Carlson, Neil R, Centrella, Paolo A, Chiu, Cynthia H, Creaser, Steffen P, Cuozzo, John W, Davie, Christopher P, Ding, Yun, Franklin, G Joseph, Franzen, Kurt D, Gefter, Malcolm L, Hale, Steven P, Hansen, Nils J V, Israel, David I, Jiang, Jinwei, Kavarana, Malcolm J, Kelley, Michael S, Kollmann, Christopher S, Li, Fan, Lind, Kenneth, Mataruse, Sibongile, Medeiros, Patricia F, Messer, Jeffrey A, Myers, Paul, O'Keefe, Heather, Oliff, Matthew C, Rise, Cecil E, Satz, Alexander L, Skinner, Steven R, Svendsen, Jennifer L, Tang, Lujia, van Vloten, Kurt, Wagner, Richard W, Yao, Gang, Zhao, Baoguang, Morgan, Barry A
Published in Nature chemical biology (01.10.2009)
Published in Nature chemical biology (01.10.2009)
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