XPO1 (CRM1) inhibition represses STAT3 activation to drive a survivin-dependent oncogenic switch in triple-negative breast cancer
Cheng, Yan, Holloway, Michael P, Nguyen, Kevin, McCauley, Dilara, Landesman, Yosef, Kauffman, Michael G, Shacham, Sharon, Altura, Rachel A
Published in Molecular cancer therapeutics (01.03.2014)
Published in Molecular cancer therapeutics (01.03.2014)
Get full text
Journal Article
Preclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyopherin inhibitor KPT-330 in Ph+ leukemias
Walker, Christopher J., Oaks, Joshua J., Santhanam, Ramasamy, Neviani, Paolo, Harb, Jason G., Ferenchak, Gregory, Ellis, Justin J., Landesman, Yosef, Eisfeld, Ann-Kathrin, Gabrail, Nash Y., Smith, Carrie L., Caligiuri, Michael A., Hokland, Peter, Roy, Denis Claude, Reid, Alistair, Milojkovic, Dragana, Goldman, John M., Apperley, Jane, Garzon, Ramiro, Marcucci, Guido, Shacham, Sharon, Kauffman, Michael G., Perrotti, Danilo
Published in Blood (24.10.2013)
Published in Blood (24.10.2013)
Get full text
Journal Article
Oral eltanexor treatment of patients with higher-risk myelodysplastic syndrome refractory to hypomethylating agents
Lee, Sangmin, Mohan, Sanjay, Knupp, Jessica, Chamoun, Kamal, de Jonge, Adrienne, Yang, Fan, Baloglu, Erkan, Shah, Jatin, Kauffman, Michael G, Shacham, Sharon, Bhatnagar, Bhavana
Published in Journal of hematology and oncology (03.08.2022)
Published in Journal of hematology and oncology (03.08.2022)
Get full text
Journal Article
Selinexor‐based regimens in patients with multiple myeloma after prior anti‐B‐cell maturation antigen treatment
Baljevic, Muhamed, Gasparetto, Cristina, Schiller, Gary J., Tuchman, Sascha A., Callander, Natalie S., Lentzsch, Suzanne, Monge, Jorge, Kotb, Rami, Bahlis, Nizar J., White, Darrell, Chen, Christine I., Sutherland, Heather J., Madan, Sumit, LeBlanc, Richard, Sebag, Michael, Venner, Christopher P., Bensinger, William I., Biran, Noa, DeCastro, Andrew, Van Domelen, Dane R., Zhang, Chris, Shah, Jatin J., Shacham, Sharon, Kauffman, Michael G., Bentur, Ohad S., Lipe, Brea
Published in EJHaem (01.11.2022)
Published in EJHaem (01.11.2022)
Get full text
Journal Article
Oral Selinexor–Dexamethasone for Triple-Class Refractory Multiple Myeloma
Chari, Ajai, Vogl, Dan T, Gavriatopoulou, Maria, Nooka, Ajay K, Yee, Andrew J, Huff, Carol A, Moreau, Philippe, Dingli, David, Cole, Craig, Lonial, Sagar, Dimopoulos, Meletios, Stewart, A. Keith, Richter, Joshua, Vij, Ravi, Tuchman, Sascha, Raab, Marc S, Weisel, Katja C, Delforge, Michel, Cornell, Robert F, Kaminetzky, David, Hoffman, James E, Costa, Luciano J, Parker, Terri L, Levy, Moshe, Schreder, Martin, Meuleman, Nathalie, Frenzel, Laurent, Mohty, Mohamad, Choquet, Sylvain, Schiller, Gary, Comenzo, Raymond L, Engelhardt, Monika, Illmer, Thomas, Vlummens, Philip, Doyen, Chantal, Facon, Thierry, Karlin, Lionel, Perrot, Aurore, Podar, Klaus, Kauffman, Michael G, Shacham, Sharon, Li, Lingling, Tang, Shijie, Picklesimer, Carla, Saint-Martin, Jean-Richard, Crochiere, Marsha, Chang, Hua, Parekh, Samir, Landesman, Yosef, Shah, Jatin, Richardson, Paul G, Jagannath, Sundar
Published in The New England journal of medicine (22.08.2019)
Published in The New England journal of medicine (22.08.2019)
Get full text
Journal Article
Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo
Kashyap, Trinayan, Murray, Jackelyn, Walker, Christopher J., Chang, Hua, Tamir, Sharon, Hou, Bing, Shacham, Sharon, Kauffman, Michael G., Tripp, Ralph A., Landesman, Yosef
Published in Antiviral research (01.08.2021)
Published in Antiviral research (01.08.2021)
Get full text
Journal Article
A Phase II Study of the Efficacy and Safety of Oral Selinexor in Recurrent Glioblastoma
Lassman, Andrew B, Wen, Patrick Y, van den Bent, Martin J, Plotkin, Scott R, Walenkamp, Annemiek M E, Green, Adam L, Li, Kai, Walker, Christopher J, Chang, Hua, Tamir, Sharon, Henegar, Leah, Shen, Yao, Alvarez, Mariano J, Califano, Andrea, Landesman, Yosef, Kauffman, Michael G, Shacham, Sharon, Mau-Sørensen, Morten
Published in Clinical cancer research (01.02.2022)
Published in Clinical cancer research (01.02.2022)
Get full text
Journal Article
Integrated safety profile of selinexor in multiple myeloma: experience from 437 patients enrolled in clinical trials
Gavriatopoulou, Maria, Chari, Ajai, Chen, Christine, Bahlis, Nizar, Vogl, Dan T., Jakubowiak, Andrzej, Dingli, David, Cornell, Robert F., Hofmeister, Craig C., Siegel, David, Berdeja, Jesus G., Reece, Donna, White, Darrell, Lentzsch, Suzanne, Gasparetto, Cristina, Huff, Carol Ann, Jagannath, Sundar, Baz, Rachid, Nooka, Ajay K., Richter, Joshua, Abonour, Rafat, Parker, Terri L., Yee, Andrew J., Moreau, Philippe, Lonial, Sagar, Tuchman, Sascha, Weisel, Katja C., Mohty, Mohamad, Choquet, Sylvain, Unger, T. J., Li, Kai, Chai, Yi, Li, Lingling, Shah, Jatin, Shacham, Sharon, Kauffman, Michael G., Dimopoulos, Meletios Athanasios
Published in Leukemia (01.09.2020)
Published in Leukemia (01.09.2020)
Get full text
Journal Article
Multiple myeloma triplet therapies: baseline characteristics and control groups – Authors' reply
Grosicki, Sebastian, Moreau, Philippe, Kauffman, Michael G, Dimopoulos, Meletios A, Richardson, Paul G, Delimpasi, Sosana
Published in The Lancet (British edition) (01.05.2021)
Published in The Lancet (British edition) (01.05.2021)
Get full text
Journal Article
Exportin 1 (XPO1) inhibition leads to restoration of tumor suppressor miR-145 and consequent suppression of pancreatic cancer cell proliferation and migration
Azmi, Asfar S, Li, Yiwei, Muqbil, Irfana, Aboukameel, Amro, Senapedis, William, Baloglu, Erkan, Landesman, Yosef, Shacham, Sharon, Kauffman, Michael G, Philip, Philip A, Mohammad, Ramzi M
Published in Oncotarget (10.10.2017)
Published in Oncotarget (10.10.2017)
Get full text
Journal Article
XPO1 Inhibition Preferentially Disrupts the 3D Nuclear Organization of Telomeres in Tumor Cells
Taylor-Kashton, Cheryl, Lichtensztejn, Daniel, Baloglu, Erkan, Senapedis, William, Shacham, Sharon, Kauffman, Michael G., Kotb, Rami, Mai, Sabine
Published in Journal of cellular physiology (01.12.2016)
Published in Journal of cellular physiology (01.12.2016)
Get full text
Journal Article
Selinexor, bortezomib, and dexamethasone versus bortezomib and dexamethasone in previously treated multiple myeloma: Outcomes by cytogenetic risk
Richard, Shambavi, Chari, Ajai, Delimpasi, Sosana, Simonova, Maryana, Spicka, Ivan, Pour, Ludek, Kriachok, Iryna, Dimopoulos, Meletios A., Pylypenko, Halyna, Auner, Holger W., Leleu, Xavier, Usenko, Ganna, Hajek, Roman, Benjamin, Reuben, Dolai, Tuphan Kanti, Sinha, Dinesh Kumar, Venner, Christopher P., Garg, Mamta, Stevens, Don Ambrose, Quach, Hang, Jagannath, Sundar, Moreau, Phillipe, Levy, Moshe, Badros, Ashraf, Anderson, Larry D., Bahlis, Nizar J., Facon, Thierry, Mateos, Maria Victoria, Cavo, Michele, Chang, Hua, Landesman, Yosef, Chai, Yi, Arazy, Melina, Shah, Jatin, Shacham, Sharon, Kauffman, Michael G., Grosicki, Sebastian, Richardson, Paul G.
Published in American journal of hematology (01.09.2021)
Published in American journal of hematology (01.09.2021)
Get full text
Journal Article
Efficacy and tolerability of once‐weekly selinexor, bortezomib, and dexamethasone in comparison with standard twice‐weekly bortezomib and dexamethasone in previously treated multiple myeloma with renal impairment: Subgroup analysis from the BOSTON study
Delimpasi, Sosana, Mateos, Maria Victoria, Auner, Holger W., Gavriatopoulou, Maria, Dimopoulos, Meletios A., Quach, Hang, Pylypenko, Halyna, Hájek, Roman, Leleu, Xavier, Dolai, Tuphan Kanti, Sinha, Dinesh Kumar, Venner, Christopher P., Benjamin, Reuben, Garg, Mamta Krishnan, Doronin, Vadim, Levy, Yair, Moreau, Philippe, Chai, Yi, Arazy, Melina, Shah, Jatin, Shacham, Sharon, Kauffman, Michael G., Richardson, Paul G., Grosicki, Sebastian
Published in American journal of hematology (01.03.2022)
Published in American journal of hematology (01.03.2022)
Get full text
Journal Article
Effect of age and frailty on the efficacy and tolerability of once‐weekly selinexor, bortezomib, and dexamethasone in previously treated multiple myeloma
Auner, Holger W., Gavriatopoulou, Maria, Delimpasi, Sosana, Simonova, Maryana, Spicka, Ivan, Pour, Ludek, Dimopoulos, Meletios A., Kriachok, Iryna, Pylypenko, Halyna, Leleu, Xavier, Doronin, Vadim, Usenko, Ganna, Hajek, Roman, Benjamin, Reuben, Dolai, Tuphan Kanti, Sinha, Dinesh Kumar, Venner, Christopher P., Garg, Mamta, Stevens, Don Ambrose, Quach, Hang, Jagannath, Sundar, Moreau, Phillipe, Levy, Moshe, Badros, Ashraf, Anderson, Larry D., Bahlis, Nizar J., Facon, Thierry, Mateos, Maria Victoria, Cavo, Michele, Chai, Yi, Arazy, Melina, Shah, Jatin, Shacham, Sharon, Kauffman, Michael G., Richardson, Paul G., Grosicki, Sebastian
Published in American journal of hematology (01.06.2021)
Published in American journal of hematology (01.06.2021)
Get full text
Journal Article
A phase 1 clinical trial of oral eltanexor in patients with relapsed or refractory multiple myeloma
Cornell, Robert Frank, Baz, Rachid, Richter, Joshua R., Rossi, Adriana, Vogl, Dan T., Chen, Christine, Shustik, Chaim, Alvarez, Mariano J., Shen, Yao, Unger, T. J., Ben‐Shahar, Osnat, Wang, Hongwei, Baloglu, Erkan, Senapedis, William, Ma, Xiwen, Landesman, Yosef, Bai, Xiang, Bader, Justin, Xu, Hongmei, Marshall, Tracey, Chang, Hua, Walker, Christopher J., Shah, Jatin, Shacham, Sharon, Kauffman, Michael G., Hofmeister, Craig C.
Published in American journal of hematology (01.02.2022)
Published in American journal of hematology (01.02.2022)
Get full text
Journal Article
Anti-tumor activity of selective inhibitors of XPO1/CRM1-mediated nuclear export in diffuse malignant peritoneal mesothelioma: the role of survivin
De Cesare, Michelandrea, Cominetti, Denis, Doldi, Valentina, Lopergolo, Alessia, Deraco, Marcello, Gandellini, Paolo, Friedlander, Sharon, Landesman, Yosef, Kauffman, Michael G, Shacham, Sharon, Pennati, Marzia, Zaffaroni, Nadia
Published in Oncotarget (30.05.2015)
Published in Oncotarget (30.05.2015)
Get full text
Journal Article
Cover Image, Volume 231, Number 12, December 2016
Taylor-Kashton, Cheryl, Lichtensztejn, Daniel, Baloglu, Erkan, Senapedis, William, Shacham, Sharon, Kauffman, Michael G., Kotb, Rami, Mai, Sabine
Published in Journal of cellular physiology (01.12.2016)
Published in Journal of cellular physiology (01.12.2016)
Get full text
Journal Article
Comparison of the Effectiveness and Safety of the Oral Selective Inhibitor of Nuclear Export, Selinexor, in Diffuse Large B Cell Lymphoma Subtypes
Casasnovas, Rene-Olivier, Follows, George, Zijlstra, Josee M., Vermaat, Joost S.P., Kalakonda, Nagesh, Choquet, Sylvain, Neste, Eric Van Den, Hill, Brian, Thieblemont, Catherine, Cavallo, Federica, la Cruz, Fatima De, Kuruvilla, John, Hamad, Nada, Jaeger, Ulrich, Caimi, Paolo F., Gurion, Ronit, Warzocha, Krzysztof, Bakhshi, Sameer, Sancho, Juan-Manuel, Schuster, Michael, Egyed, Miklos, Offner, Fritz, Vassilakopoulos, Theodoros P., Samal, Priyanka, Ku, Matthew, Ma, Xiwen, Chamoun, Kamal, Shah, Jatin, Canales, Miguel, Maerevoet, Marie, Shacham, Sharon, Kauffman, Michael G., Goy, Andre
Published in Clinical lymphoma, myeloma and leukemia (01.01.2022)
Published in Clinical lymphoma, myeloma and leukemia (01.01.2022)
Get full text
Journal Article
Survival among patients with relapsed/refractory diffuse large B cell lymphoma treated with single-agent selinexor in the SADAL study
Maerevoet, Marie, Zijlstra, Josee M, Follows, George, Casasnovas, Rene-Olivier, Vermaat, J. S. P, Kalakonda, Nagesh, Goy, Andre, Choquet, Sylvain, Van Den Neste, Eric, Hill, Brian, Thieblemont, Catherine, Cavallo, Federica, De la Cruz, Fatima, Kuruvilla, John, Hamad, Nada, Jaeger, Ulrich, Caimi, Paolo, Gurion, Ronit, Warzocha, Krzysztof, Bakhshi, Sameer, Sancho, Juan-Manuel, Schuster, Michael, Egyed, Miklos, Offner, Fritz, Vassilakopoulos, Theodoros P, Samal, Priyanka, Ku, Matthew, Ma, Xiwen, Corona, Kelly, Chamoun, Kamal, Shah, Jatin, Shacham, Sharon, Kauffman, Michael G, Canales, Miguel
Published in Journal of hematology and oncology (16.07.2021)
Published in Journal of hematology and oncology (16.07.2021)
Get full text
Journal Article