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Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms

by Rusu, Victor, Hoch, Eitan, Mercader, Josep M., Tenen, Danielle E., Gymrek, Melissa, Hartigan, Christina R., DeRan, Michael, Guzman, Gaelen, Deik, Amy A., Pierce, Kerry A., Dennis, Courtney, Clish, Clary B., Carr, Steven A., Wagner, Bridget K., Chen, Brian H., Ng, Maggie C.Y., Chen, Brian H., Guo, Xiuqing, Liu, Jiankang, Bielinski, Suzette J., Nalls, Michael A., Rasmussen-Torvik, Laura J., Evans, Daniel S., Sun, Yan V., Patel, Sanjay R., Lu, Yingchang, Long, Jirong, Armstrong, Loren L., Yang, Lingyao, Snively, Beverly M., Palmer, Nicholette D., Mudgal, Poorva, Keene, Keith L., Freedman, Barry I., Goodarzi, Mark O., Correa, Adolfo, Sims, Mario, Couper, David, Pankow, James S., Boerwinkle, Eric, Adeyemo, Adebowale, Doumatey, Ayo, Vaidya, Dhananjay, Sedor, John R., Kabagambe, Edmond K., McKnight, Barbara, Rice, Kenneth, Bielak, Lawrence F., Gottesman, Omri, Cai, Qiuyin, Zheng, Wei, Blot, William J., Lowe, William L., Pacheco, Jennifer A., Crawford, Dana C., Rich, Stephen S., Shu, Xiao-Ou, Loos, Ruth J.F., Borecki, Ingrid B., Peyser, Patricia A., Fornage, Myriam, Evans, Michele K., Becker, Diane M., Kao, W.H. Linda, Wilson, James G., Sale, Michèle M., Liu, Simin, Rotimi, Charles N., Bowden, Donald W., Huerta-Chagoya, Alicia, Moreno-Macías, Hortensia, Manning, Alisa, Caulkins, Lizz, Burtt, Noël P., Flannick, Jason, Patterson, Nick, Tusié-Luna, Teresa, Altshuler, David, Florez, Jose C., Martínez-Hernández, Angélica, Centeno-Cruz, Federico, Zerrweck, Carlos, Contreras-Cubas, Cecilia, Córdova, Emilio, Soberón, Xavier, Orozco, Lorena, González-Villalpando, María Elena, Haiman, Christopher A., Le Marchand, Loic, Kolonel, Laurence, Rodríguez-Torres, Maribel, Segura-Kato, Yayoi, Rodríguez-Guillén, Rosario, Gómez, Donají, Alvirde, Ulices, Cortes, Maria L., Centeno-Cruz, Federico, Zerrweck, Carlos, Orozco, Lorena, Jacobs, Suzanne B.R.
Published in Cell (29.06.2017)

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Journal Article

A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes

by Mercader, Josep M, Liao, Rachel G, Bell, Avery D, Dymek, Zachary, Estrada, Karol, Tukiainen, Taru, Huerta-Chagoya, Alicia, Moreno-Macías, Hortensia, Jablonski, Kathleen A, Hanson, Robert L, Walford, Geoffrey A, Moran, Ignasi, Chen, Ling, Agarwala, Vineeta, Ordoñez-Sánchez, María Luisa, Rodríguez-Guillen, Rosario, Rodríguez-Torres, Maribel, Segura-Kato, Yayoi, García-Ortiz, Humberto, Centeno-Cruz, Federico, Barajas-Olmos, Francisco, Caulkins, Lizz, Puppala, Sobha, Fontanillas, Pierre, Williams, Amy L, Bonàs-Guarch, Sílvia, Hartl, Chris, Ripke, Stephan, Tooley, Katherine, Lane, Jacqueline, Zerrweck, Carlos, Martínez-Hernández, Angélica, Córdova, Emilio J, Mendoza-Caamal, Elvia, Contreras-Cubas, Cecilia, González-Villalpando, María E, Cruz-Bautista, Ivette, Muñoz-Hernández, Liliana, Gómez-Velasco, Donaji, Alvirde, Ulises, Henderson, Brian E, Wilkens, Lynne R, Le Marchand, Loic, Arellano-Campos, Olimpia, Riba, Laura, Harden, Maegan, Gabriel, Stacey, Abboud, Hanna E, Cortes, Maria L, Revilla-Monsalve, Cristina, Islas-Andrade, Sergio, Soberon, Xavier, Curran, Joanne E, Jenkinson, Christopher P, DeFronzo, Ralph A, Lehman, Donna M, Hanis, Craig L, Bell, Graeme I, Boehnke, Michael, Blangero, John, Duggirala, Ravindranath, Saxena, Richa, MacArthur, Daniel, Ferrer, Jorge, McCarroll, Steven A, Torrents, David, Knowler, William C, Baier, Leslie J, Burtt, Noel, González-Villalpando, Clicerio, Haiman, Christopher A, Aguilar-Salinas, Carlos A, Tusié-Luna, Teresa, Flannick, Jason, Jacobs, Suzanne B R, Orozco, Lorena, Altshuler, David, Florez, Jose C
Published in Diabetes (New York, N.Y.) (01.11.2017)

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Journal Article