Targeting proteinase-activated receptors: therapeutic potential and challenges
Ramachandran, Rithwik, Noorbakhsh, Farshid, DeFea, Kathryn, Hollenberg, Morley D.
Published in Nature reviews. Drug discovery (01.01.2012)
Published in Nature reviews. Drug discovery (01.01.2012)
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Journal Article
Protease-Activated Receptor 2 (PAR2) Expressed in Sensory Neurons Contributes to Signs of Pain and Neuropathy in Paclitaxel Treated Mice
Kume, Moeno, Ahmad, Ayesha, DeFea, Kathryn A., Vagner, Josef, Dussor, Gregory, Boitano, Scott, Price, Theodore J.
Published in The journal of pain (01.11.2023)
Published in The journal of pain (01.11.2023)
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Journal Article
Cofilin under control of β-arrestin-2 in NMDA-dependent dendritic spine plasticity, long-term depression (LTD), and learning
Pontrello, Crystal G., Sun, Min-Yu, Lin, Alice, Fiacco, Todd A., DeFea, Kathryn A., Ethell, Iryna M.
Published in Proceedings of the National Academy of Sciences - PNAS (14.02.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (14.02.2012)
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Journal Article
Neutrophil Elastase Acts as a Biased Agonist for Proteinase-activated Receptor-2 (PAR2)
Ramachandran, Rithwik, Mihara, Koichiro, Chung, Hyunjae, Renaux, Bernard, Lau, Chang S., Muruve, Daniel A., DeFea, Kathryn A., Bouvier, Michel, Hollenberg, Morley D.
Published in The Journal of biological chemistry (15.07.2011)
Published in The Journal of biological chemistry (15.07.2011)
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Journal Article
β‐Arrestin‐biased proteinase‐activated receptor‐2 antagonist C781 limits allergen‐induced airway hyperresponsiveness and inflammation
Schiff, Hillary V., Rivas, Candy M., Pederson, William P., Sandoval, Estevan, Gillman, Samuel, Prisco, Joy, Kume, Moeno, Dussor, Gregory, Vagner, Josef, Ledford, Julie G., Price, Theodore J., DeFea, Kathryn A., Boitano, Scott
Published in British journal of pharmacology (01.03.2023)
Published in British journal of pharmacology (01.03.2023)
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Journal Article
Alternaria alternata-induced airway epithelial signaling and inflammatory responses via protease-activated receptor-2 expression
Rivas, Candy M., Schiff, Hillary V., Moutal, Aubin, Khanna, Rajesh, Kiela, Pawel R., Dussor, Gregory, Price, Theodore J., Vagner, Josef, DeFea, Kathryn A., Boitano, Scott
Published in Biochemical and biophysical research communications (05.02.2022)
Published in Biochemical and biophysical research communications (05.02.2022)
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Journal Article
C781, a β-Arrestin Biased Antagonist at Protease-Activated Receptor-2 (PAR2), Displays in vivo Efficacy Against Protease-Induced Pain in Mice
Kume, Moeno, Ahmad, Ayesha, Shiers, Stephanie, Burton, Michael D., DeFea, Kathryn A., Vagner, Josef, Dussor, Gregory, Boitano, Scott, Price, Theodore J.
Published in The journal of pain (01.04.2023)
Published in The journal of pain (01.04.2023)
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Journal Article
Proteinase‐activated receptor‐2 antagonist C391 inhibits Alternaria‐induced airway epithelial signalling and asthma indicators in acute exposure mouse models
Rivas, Candy M., Yee, Michael C., Addison, Kenneth J., Lovett, Marissa, Pal, Kasturi, Ledford, Julie G., Dussor, Gregory, Price, Theodore J., Vagner, Josef, DeFea, Kathryn A., Boitano, Scott
Published in British journal of pharmacology (01.05.2022)
Published in British journal of pharmacology (01.05.2022)
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Journal Article
Transactivation of vascular endothelial growth factor receptor-2 by interleukin-8 (IL-8/CXCL8) is required for IL-8/CXCL8-induced endothelial permeability
Petreaca, Melissa L, Yao, Min, Liu, Yan, Defea, Kathryn, Martins-Green, Manuela
Published in Molecular biology of the cell (01.12.2007)
Published in Molecular biology of the cell (01.12.2007)
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Journal Article
Protease-activated receptor-2 signaling through β-arrestin-2 mediates Alternaria alkaline serine protease-induced airway inflammation
Yee, Michael C, Nichols, Heddie L, Polley, Danny, Saifeddine, Mahmoud, Pal, Kasturi, Lee, Kyu, Wilson, Emma H, Daines, Michael O, Hollenberg, Morley D, Boitano, Scott, DeFea, Kathryn A
Published in American journal of physiology. Lung cellular and molecular physiology (01.12.2018)
Published in American journal of physiology. Lung cellular and molecular physiology (01.12.2018)
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Journal Article
AMP-Activated Protein Kinase Functionally Phosphorylates Endothelial Nitric Oxide Synthase Ser633
Chen, Zhen, Peng, I-Chen, Sun, Wei, Su, Mei-I, Hsu, Pang-Hung, Fu, Yi, Zhu, Yi, DeFea, Kathryn, Pan, Songqin, Tsai, Ming-Daw, Shyy, John Y-J
Published in Circulation research (27.02.2009)
Published in Circulation research (27.02.2009)
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Journal Article
β-Arrestin-2 mediates the proinflammatory effects of proteinase-activated receptor-2 in the airway
Nichols, Heddie L, Saffeddine, Mahmoud, Theriot, Barbara S, Hegde, Akhil, Polley, Daniel, El-Mays, Tamer, Vliagoftis, Harissios, Hollenberg, Morley D, Wilson, Emma H, Walker, Julia K. L, DeFea, Kathryn A
Published in Proceedings of the National Academy of Sciences - PNAS (09.10.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (09.10.2012)
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Journal Article
β-Arrestins Scaffold Cofilin with Chronophin to Direct Localized Actin Filament Severing and Membrane Protrusions Downstream of Protease-activated Receptor-2
Zoudilova, Maria, Min, Jungah, Richards, Heddie L., Carter, David, Huang, Timothy, DeFea, Kathryn A.
Published in The Journal of biological chemistry (07.05.2010)
Published in The Journal of biological chemistry (07.05.2010)
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Journal Article
PAR2 activation in the dura causes acute behavioral responses and priming to glyceryl trinitrate in a mouse migraine model
Mason, Bianca N., Hassler, Shayne N., DeFea, Kathryn, Boitano, Scott, Vagner, Josef, Price, Theodore J., Dussor, Greg
Published in Journal of headache and pain (19.04.2023)
Published in Journal of headache and pain (19.04.2023)
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