SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis
Tahlan, Kapil, Wilson, Regina, Kastrinsky, David B, Arora, Kriti, Nair, Vinod, Fischer, Elizabeth, Barnes, S. Whitney, Walker, John R, Alland, David, Barry, Clifton E., III, Boshoff, Helena I
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Published in Antimicrobial Agents and Chemotherapy (01.04.2012)
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Monotherapy efficacy of blood–brain barrier permeable small molecule reactivators of protein phosphatase 2A in glioblastoma
Merisaari, Joni, Denisova, Oxana V, Doroszko, Milena, Le Joncour, Vadim, Johansson, Patrik, Leenders, William P J, Kastrinsky, David B, Zaware, Nilesh, Narla, Goutham, Laakkonen, Pirjo, Nelander, Sven, Ohlmeyer, Michael, Westermarck, Jukka
Published in Brain communications (01.01.2020)
Published in Brain communications (01.01.2020)
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Asymmetric Total Synthesis of (+)- and ent-(−)-Yatakemycin and Duocarmycin SA: Evaluation of Yatakemycin Key Partial Structures and Its Unnatural Enantiomer
Tichenor, Mark S, Trzupek, John D, Kastrinsky, David B, Shiga, Futoshi, Hwang, Inkyu, Boger, Dale L
Published in Journal of the American Chemical Society (13.12.2006)
Published in Journal of the American Chemical Society (13.12.2006)
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Total Synthesis, Structure Revision, and Absolute Configuration of (+)-Yatakemycin
Tichenor, Mark S, Kastrinsky, David B, Boger, Dale L
Published in Journal of the American Chemical Society (14.07.2004)
Published in Journal of the American Chemical Society (14.07.2004)
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Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth
Sangodkar, Jaya, Perl, Abbey, Tohme, Rita, Kiselar, Janna, Kastrinsky, David B, Zaware, Nilesh, Izadmehr, Sudeh, Mazhar, Sahar, Wiredja, Danica D, O'Connor, Caitlin M, Hoon, Divya, Dhawan, Neil S, Schlatzer, Daniela, Yao, Shen, Leonard, Daniel, Borczuk, Alain C, Gokulrangan, Giridharan, Wang, Lifu, Svenson, Elena, Farrington, Caroline C, Yuan, Eric, Avelar, Rita A, Stachnik, Agnes, Smith, Blake, Gidwani, Vickram, Giannini, Heather M, McQuaid, Daniel, McClinch, Kimberly, Wang, Zhizhi, Levine, Alice C, Sears, Rosalie C, Chen, Edward Y, Duan, Qiaonan, Datt, Manish, Haider, Shozeb, Ma'ayan, Avi, DiFeo, Analisa, Sharma, Neelesh, Galsky, Matthew D, Brautigan, David L, Ioannou, Yiannis A, Xu, Wenqing, Chance, Mark R, Ohlmeyer, Michael, Narla, Goutham
Published in The Journal of clinical investigation (01.06.2017)
Published in The Journal of clinical investigation (01.06.2017)
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Reengineered tricyclic anti-cancer agents
Kastrinsky, David B., Sangodkar, Jaya, Zaware, Nilesh, Izadmehr, Sudeh, Dhawan, Neil S., Narla, Goutham, Ohlmeyer, Michael
Published in Bioorganic & medicinal chemistry (01.10.2015)
Published in Bioorganic & medicinal chemistry (01.10.2015)
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Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer
McClinch, Kimberly, Avelar, Rita A, Callejas, David, Izadmehr, Sudeh, Wiredja, Danica, Perl, Abbey, Sangodkar, Jaya, Kastrinsky, David B, Schlatzer, Daniela, Cooper, Maxwell, Kiselar, Janna, Stachnik, Agnes, Yao, Shen, Hoon, Divya, McQuaid, Daniel, Zaware, Nilesh, Gong, Yixuan, Brautigan, David L, Plymate, Stephen R, Sprenger, Cynthia C T, Oh, William K, Levine, Alice C, Kirschenbaum, Alexander, Sfakianos, John P, Sears, Rosalie, DiFeo, Analisa, Ioannou, Yiannis, Ohlmeyer, Michael, Narla, Goutham, Galsky, Matthew D
Published in Cancer research (Chicago, Ill.) (15.04.2018)
Published in Cancer research (Chicago, Ill.) (15.04.2018)
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Identifying a Small Molecule Blocking Antigen Presentation in Autoimmune Thyroiditis
Li, Cheuk Wun, Menconi, Francesca, Osman, Roman, Mezei, Mihaly, Jacobson, Eric M., Concepcion, Erlinda, David, Chella S., Kastrinsky, David B., Ohlmeyer, Michael, Tomer, Yaron
Published in The Journal of biological chemistry (19.02.2016)
Published in The Journal of biological chemistry (19.02.2016)
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Corrigendum to “Reengineered tricyclic anti-cancer agents” [Bioorg. Med. Chem. 23 (2015) 6528–6534]
Kastrinsky, David B., Sangodkar, Jaya, Zaware, Nilesh, McClinch, Kimberly, Farrington, Caroline C., Giannini, Heather M., Izadmehr, Sudeh, Dhawan, Neil S., Narla, Goutham, Ohlmeyer, Michael
Published in Bioorganic & medicinal chemistry (01.12.2015)
Published in Bioorganic & medicinal chemistry (01.12.2015)
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Synthesis and evaluation of a series of C5′-substituted duocarmycin SA analogs
Robertson, William M., Kastrinsky, David B., Hwang, Inkyu, Boger, Dale L.
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
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DNA Alkylation Properties of Yatakemycin
Parrish, Jay P, Kastrinsky, David B, Wolkenberg, Scott E, Igarashi, Yasuhiro, Boger, Dale L
Published in Journal of the American Chemical Society (10.09.2003)
Published in Journal of the American Chemical Society (10.09.2003)
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Establishment of substituent effects in the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065
Parrish, Jay P., Kastrinsky, David B., Stauffer, Frederic, Hedrick, Michael P., Hwang, Inkyu, Boger, Dale L.
Published in Bioorganic & medicinal chemistry (15.08.2003)
Published in Bioorganic & medicinal chemistry (15.08.2003)
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Synthesis and Evaluation of Duocarmycin and CC-1065 Analogues Incorporating the 1,2,9,9a-Tetrahydrocyclopropa[c]benz[e]-3-azaindol-4-one (CBA) Alkylation Subunit
Parrish, Jay P, Kastrinsky, David B, Hwang, Inkyu, Boger, Dale L
Published in Journal of organic chemistry (14.11.2003)
Published in Journal of organic chemistry (14.11.2003)
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Journal Article
Monotherapy efficacy of BBB-permeable small molecule activators of PP2A in glioblastoma
Merisaari, Joni, Denisova, Oxana V, Doroszko, Milena, Vadim Le Joncour, Johansson, Patrik, Leenders, William Pj, Kastrinsky, David B, Zaware Nilesh, Narla, Goutham, Laakkonen, Pirjo, Nelander, Sven, Ohlmeyer, Michael, Westermarck, Jukka
Published in bioRxiv (27.09.2019)
Published in bioRxiv (27.09.2019)
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