Discovery of N-(6-(5-fluoro-2-(piperidin-1-yl)phenyl)pyridazin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)methanesulfonamide as a brain-permeable and metabolically stable kynurenine monooxygenase inhibitor
Tsuboi, Katsunori, Kimura, Hidenori, Nakatsuji, Yoshie, Kassai, Momoe, Deai, Yoko, Isobe, Yoshiaki
Published in Bioorganic & medicinal chemistry letters (15.07.2021)
Published in Bioorganic & medicinal chemistry letters (15.07.2021)
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N-(6-phenylpyridazin-3-yl)benzenesulfonamides as highly potent, brain-permeable, and orally active kynurenine monooxygenase inhibitors
Kimura, Hidenori, Suda, Hitoshi, Kassai, Momoe, Endo, Mika, Deai, Yoko, Yahata, Masahiro, Miyajima, Mari, Isobe, Yoshiaki
Published in Bioorganic & medicinal chemistry letters (01.02.2021)
Published in Bioorganic & medicinal chemistry letters (01.02.2021)
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DSR-98776, a novel selective mGlu5 receptor negative allosteric modulator with potent antidepressant and antimanic activity
Kato, Taro, Takata, Makoto, Kitaichi, Maiko, Kassai, Momoe, Inoue, Mitsuhiro, Ishikawa, Chihiro, Hirose, Wataru, Yoshida, Kozo, Shimizu, Isao
Published in European journal of pharmacology (15.06.2015)
Published in European journal of pharmacology (15.06.2015)
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Synthesis, structure–activity relationships and biological evaluation of 4,5,6,7-tetrahydropyrazolopyrazines as metabotropic glutamate receptor 5 negative allosteric modulators
Hirose, Wataru, Kato, Yoshihiro, Yamamoto, Takayoshi, Kassai, Momoe, Takata, Makoto, Hayashi, Shun, Arai, Yukiyo, Imai, Satoki, Yoshida, Kohzo
Published in Bioorganic & medicinal chemistry letters (15.08.2016)
Published in Bioorganic & medicinal chemistry letters (15.08.2016)
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