Synthesis of 8-oxo-dGTP and its β,γ-CH2-, β,γ-CHF-, and β,γ-CF2- analogues
Zheng, Yiying, Haratipour, Pouya, Kashemirov, Boris A., McKenna, Charles E.
Published in Tetrahedron letters (16.03.2021)
Published in Tetrahedron letters (16.03.2021)
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Toward more potent imidazopyridine inhibitors of Candida albicans Bdf1: Modeling the role of structural waters in selective ligand binding
Zhou, Yingsheng, Overhulse, Justin M., Dupper, Nathan J., Guo, Yanchun, Kashemirov, Boris A., Wei, Kaiyao, Govin, Jérôme, Petosa, Carlo, McKenna, Charles E.
Published in Journal of computational chemistry (15.12.2022)
Published in Journal of computational chemistry (15.12.2022)
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Microwave-Accelerated McKenna Synthesis of Phosphonic Acids: An Investigation
Mustafa, Dana, Overhulse, Justin M, Kashemirov, Boris A, McKenna, Charles E
Published in Molecules (Basel, Switzerland) (01.04.2023)
Published in Molecules (Basel, Switzerland) (01.04.2023)
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Design and Synthesis of Cathepsin-K-Activated Osteoadsorptive Fluorogenic Sentinel (OFS) Probes for Detecting Early Osteoclastic Bone Resorption in a Multiple Myeloma Mouse Model
Richard, Eric T, Morinaga, Kenzo, Zheng, Yiying, Sundberg, Oskar, Hokugo, Akishige, Hui, Kimberly, Zhou, Yipin, Sasaki, Hodaka, Kashemirov, Boris A, Nishimura, Ichiro, McKenna, Charles E
Published in Bioconjugate chemistry (19.05.2021)
Published in Bioconjugate chemistry (19.05.2021)
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Journal Article
Uridine Bisphosphonates Differentiate Phosphoglycosyl Transferase Superfamilies
Seebald, Leah M., Haratipour, Pouya, Jacobs, Michaela R., Bernstein, Hannah M., Kashemirov, Boris A., McKenna, Charles E., Imperiali, Barbara
Published in Journal of the American Chemical Society (07.02.2024)
Published in Journal of the American Chemical Society (07.02.2024)
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The relationship between the chemistry and biological activity of the bisphosphonates
Ebetino, Frank H, Hogan, Anne-Marie L, Sun, Shuting, Tsoumpra, Maria K, Duan, Xuchen, Triffitt, James T, Kwaasi, Aaron A, Dunford, James E, Barnett, Bobby L, Oppermann, Udo, Lundy, Mark W, Boyde, Alan, Kashemirov, Boris A, McKenna, Charles E, Russell, R. Graham G
Published in Bone (New York, N.Y.) (01.07.2011)
Published in Bone (New York, N.Y.) (01.07.2011)
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Modifying the Basicity of the dNTP Leaving Group Modulates Precatalytic Conformational Changes of DNA Polymerase β
Alnajjar, Khadijeh S., Wang, Katarina, Alvarado-Cruz, Isabel, Chavira, Cristian, Negahbani, Amirsoheil, Nakhjiri, Maryam, Minard, Corinne, Garcia-Barboza, Beatriz, Kashemirov, Boris A., McKenna, Charles E., Goodman, Myron F., Sweasy, Joann B.
Published in Biochemistry (Easton) (04.06.2024)
Published in Biochemistry (Easton) (04.06.2024)
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Real-time intravital imaging establishes tumor-associated macrophages as the extraskeletal target of bisphosphonate action in cancer
Junankar, Simon, Shay, Gemma, Jurczyluk, Julie, Ali, Naveid, Down, Jenny, Pocock, Nicholas, Parker, Andrew, Nguyen, Akira, Sun, Shuting, Kashemirov, Boris, McKenna, Charles E, Croucher, Peter I, Swarbrick, Alexander, Weilbaecher, Katherine, Phan, Tri Giang, Rogers, Michael J
Published in Cancer discovery (01.01.2015)
Published in Cancer discovery (01.01.2015)
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Synthesis and anti-cancer potential of potent peripheral MAOA inhibitors designed to limit blood:brain penetration
Jacobs, Michaela R., Olivero, Jennifer E., Ok Choi, Hyun, Liao, Chun-Peng, Kashemirov, Boris A., Katz, Jonathan E., Gross, Mitchell E., McKenna, Charles E.
Published in Bioorganic & medicinal chemistry (07.09.2023)
Published in Bioorganic & medicinal chemistry (07.09.2023)
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Journal Article
Oral USC-093, a novel homoserinamide analogue of the tyrosinamide (S)-HPMPA prodrug USC-087 has decreased nephrotoxicity while maintaining antiviral efficacy against human adenovirus infection of Syrian hamsters
Tollefson, Ann E., Riemann, Samantha B., Ying, Baoling, Spencer, Jacqueline F., Overhulse, Justin M., Kashemirov, Boris A., Wold, William S.M., McKenna, Charles E., Toth, Karoly
Published in Antiviral research (01.02.2024)
Published in Antiviral research (01.02.2024)
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Journal Article
Selective BET bromodomain inhibition as an antifungal therapeutic strategy
Mietton, Flore, Ferri, Elena, Champleboux, Morgane, Zala, Ninon, Maubon, Danièle, Zhou, Yingsheng, Harbut, Mike, Spittler, Didier, Garnaud, Cécile, Courçon, Marie, Chauvel, Murielle, d’Enfert, Christophe, Kashemirov, Boris A., Hull, Mitchell, Cornet, Muriel, McKenna, Charles E., Govin, Jérôme, Petosa, Carlo
Published in Nature communications (18.05.2017)
Published in Nature communications (18.05.2017)
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A Transition-State Perspective on Y‑Family DNA Polymerase η Fidelity in Comparison with X‑Family DNA Polymerases λ and β
Oertell, Keriann, Florián, Jan, Haratipour, Pouya, Crans, Debbie C, Kashemirov, Boris A, Wilson, Samuel H, McKenna, Charles E, Goodman, Myron F
Published in Biochemistry (Easton) (02.04.2019)
Published in Biochemistry (Easton) (02.04.2019)
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Journal Article
Completing the β,γ-CXY-dNTP Stereochemical Probe Toolkit: Synthetic Access to the dCTP Diastereomers and 31 P and 19 F NMR Correlations with Absolute Configurations
Haratipour, Pouya, Minard, Corinne, Nakhjiri, Maryam, Negahbani, Amirsoheil, Chamberlain, Brian T, Osuna, Jorge, Upton, Thomas G, Zhao, Michelle, Kashemirov, Boris A, McKenna, Charles E
Published in Journal of organic chemistry (20.11.2020)
Published in Journal of organic chemistry (20.11.2020)
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A Novel Small Molecule Neurotrophin-3 Analogue Promotes Inner Ear Neurite Outgrowth and Synaptogenesis In vitro
Kempfle, Judith S., Duro, Marlon V., Zhang, Andrea, Amador, Carolina D., Kuang, Richard, Lu, Ryan, Kashemirov, Boris A., Edge, Albert S., McKenna, Charles E., Jung, David H.
Published in Frontiers in cellular neuroscience (15.07.2021)
Published in Frontiers in cellular neuroscience (15.07.2021)
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Journal Article
Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo
Roelofs, Anke J, Stewart, Charlotte A, Sun, Shuting, Błażewska, Katarzyna M, Kashemirov, Boris A, McKenna, Charles E, Russell, R Graham G, Rogers, Michael J, Lundy, Mark W, Ebetino, Frank H, Coxon, Fraser P
Published in Journal of bone and mineral research (01.04.2012)
Published in Journal of bone and mineral research (01.04.2012)
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Mapping Functional Substrate–Enzyme Interactions in the pol β Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs
Batra, Vinod K, Oertell, Keriann, Beard, William A, Kashemirov, Boris A, McKenna, Charles E, Goodman, Myron F, Wilson, Samuel H
Published in Biochemistry (Easton) (03.07.2018)
Published in Biochemistry (Easton) (03.07.2018)
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Journal Article
A pre-catalytic non-covalent step governs DNA polymerase β fidelity
Alnajjar, Khadijeh S, Krylov, Ivan S, Negahbani, Amirsoheil, Haratipour, Pouya, Kashemirov, Boris A, Huang, Ji, Mahmoud, Mariam, McKenna, Charles E, Goodman, Myron F, Sweasy, Joann B
Published in Nucleic acids research (16.12.2019)
Published in Nucleic acids research (16.12.2019)
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Journal Article
Paradoxical androgen receptor regulation by small molecule enantiomers
Patsch, Katherin, Liu, Chao, Zapotoczny, Grzegorz, Sun, Yuanye, Sura, Harish, Ung, Nolan, Sun, Ren X., Haliday, Bethany, Yu, Chen, Aljehani, Mayada, Lee, Jerry S. H., Kashemirov, Boris A., Agus, David B., McKenna, Charles E., Ruderman, Daniel
Published in Proceedings of the National Academy of Sciences - PNAS (23.03.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (23.03.2021)
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Journal Article
Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine
Sun, Shuting, Błażewska, Katarzyna M, Kadina, Anastasia P, Kashemirov, Boris A, Duan, Xuchen, Triffitt, James T, Dunford, James E, Russell, R. Graham G, Ebetino, Frank H, Roelofs, Anke J, Coxon, Fraser P, Lundy, Mark W, McKenna, Charles E
Published in Bioconjugate chemistry (17.02.2016)
Published in Bioconjugate chemistry (17.02.2016)
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