M1 agonists for the treatment of Alzheimer's disease. Novel properties and clinical update
Fisher, A, Heldman, E, Gurwitz, D, Haring, R, Karton, Y, Meshulam, H, Pittel, Z, Marciano, D, Brandeis, R, Sadot, E, Barg, Y, Pinkas-Kramarski, R, Vogel, Z, Ginzburg, I, Treves, T A, Verchovsky, R, Klimowsky, S, Korczyn, A D
Published in Annals of the New York Academy of Sciences (17.01.1996)
Published in Annals of the New York Academy of Sciences (17.01.1996)
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Journal Article
Amyloid Precursor Protein Secretion via Muscarinic Receptors: Reduced Desensitization Using the M1-Selective Agonist AF102B
Haring, R., Gurwitz, D., Barg, J., Pinkaskramarski, R., Heldman, E., Pittel, Z., Wengier, A., Meshulam, H., Marciano, D., Karton, Y., Fisher, A.
Published in Biochemical and biophysical research communications (30.08.1994)
Published in Biochemical and biophysical research communications (30.08.1994)
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Journal Article
NGF Promotes Amyloid Precursor Protein Secretion via Muscarinic Receptor Activation
Haring, R., Gurwitz, D., Barg, J., Pinkaskramarski, R., Heldman, E., Pittel, Z., Danenberg, H.D., Wengier, A., Meshulam, H., Marciano, D., Karton, Y., Fisher, A.
Published in Biochemical and biophysical research communications (04.08.1995)
Published in Biochemical and biophysical research communications (04.08.1995)
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Journal Article
Stereoselectivity toward VX Is Determined by Interactions with Residues of the Acyl Pocket as Well as of the Peripheral Anionic Site of AChE
Ordentlich, Arie, Barak, Dov, Sod-Moriah, Gali, Kaplan, Dana, Mizrahi, Dana, Segall, Yoffi, Kronman, Chanoch, Karton, Yishai, Lazar, Arie, Marcus, Dino, Velan, Baruch, Shafferman, Avigdor
Published in Biochemistry (Easton) (07.09.2004)
Published in Biochemistry (Easton) (07.09.2004)
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Journal Article
Progress in medicinal chemistry of novel selective muscarinic agonists
Fisher, A, Karton, Y, Heldman, E, Gurwitz, D, Haring, R, Meshulam, H, Brandeis, R, Pittel, Z, Segall, Y, Marciano, D
Published in Drug design and discovery (1993)
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Published in Drug design and discovery (1993)
Journal Article
STRUCTURE-ACTIVITY-RELATIONSHIPS OF 8-STYRYLXANTHINES AS A(2)-SELECTIVE ADENOSINE ANTAGONISTS
JACOBSON, KA, GALLORODRIGUEZ, C, MELMAN, N, FISCHER, B, MAILLARD, M, VANBERGEN, A, VANGALEN, PJM, KARTON, Y
Published in Journal of medicinal chemistry (14.05.1993)
Published in Journal of medicinal chemistry (14.05.1993)
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Journal Article
The role of AChE active site gorge in determining stereoselectivity of charged and noncharged VX enantiomers
Ordentlich, Arie, Barak, Dov, Sod-Moriah, Gali, Kaplan, Dana, Mizrahi, Dana, Segall, Yoffi, Kronman, Chanoch, Karton, Yishai, Lazar, Arie, Marcus, Dino, Velan, Baruch, Shafferman, Avigdor
Published in Chemico-biological interactions (15.12.2005)
Published in Chemico-biological interactions (15.12.2005)
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Journal Article
Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonists
Jacobson, Kenneth A, Gallo-Rodriguez, Carola, Melman, Neli, Fischer, Bilha, Maillard, Michel, van Bergen, Andrew, van Galen, Philip J. M, Karton, Yishai
Published in Journal of medicinal chemistry (14.05.1993)
Published in Journal of medicinal chemistry (14.05.1993)
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Journal Article
NGF-dependent neurotrophic-like effects of AF102B, an M1 muscarinic agonist, in PC12M1 cells
Gurwitz, D, Haring, R, Pinkas-Kramarski, R, Stein, R, Heldman, E, Karton, Y, Fisher, A
Published in Neuroreport (15.02.1995)
Published in Neuroreport (15.02.1995)
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Journal Article
Selective signaling via unique M1 muscarinic agonists
Fisher, A, Heldman, E, Gurwitz, D, Haring, R, Barak, D, Meshulam, H, Marciano, D, Brandeis, R, Pittel, Z, Segal, M
Published in Annals of the New York Academy of Sciences (24.09.1993)
Published in Annals of the New York Academy of Sciences (24.09.1993)
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Journal Article
Synthesis and biological activities of flavonoid derivatives as A sub(3) adenosine receptor antagonists
Karton, Y, Jiang, J, Ji, X, Melman, N, Olah, ME, Stiles, G L, Jacobson, KA
Published in Journal of medicinal chemistry (01.01.1996)
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Published in Journal of medicinal chemistry (01.01.1996)
Journal Article
Novel m1 muscarinic agonists in treatment and delaying the progression of Alzheimer's disease: An unifying hypothesis
Fisher, Abraham, Brandeis, Rachel, Haring, Rachel, Eshhar, Naomi, Heldman, Eliahu, Karton, Yishai, Eisenberg, Orli, Meshulam, Haim, Marciano, Daniele, Bar-Ner, Nira, Pittel, Zipora
Published in Journal of physiology, Paris (01.10.1998)
Published in Journal of physiology, Paris (01.10.1998)
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Journal Article
192 Novel m1 muscarinic agonists: From symptomatic treatment to delaying the progression of Alzheimer's disease (AD)
Fisher, A., Haring, R., Ginzburg, I., Sadot, E., Pittel, Z., Barg, Y., Behar, L., Gunwitz, D., Karton, Y., Meshulam, H., Marciano, D., Brandeis, R., Heldman, E.
Published in Neurobiology of aging (1996)
Published in Neurobiology of aging (1996)
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Journal Article
Acyl-hydrazide derivatives of a xanthine carboxylic congener (XCC) as selective antagonists at human A2B adenosine receptors
Kim, Yong-Chul, Karton, Yishai, Ji, Xiao-duo, Melman, Neli, Linden, Joel, Jacobson, Kenneth A.
Published in Drug development research (01.08.1999)
Published in Drug development research (01.08.1999)
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Journal Article
Functionalized congener approach to muscarinic antagonists: analogs of pirenzepine
Karton, Yishai, Bradbury, Barton J, Baumgold, Jesse, Paek, Robert, Jacobson, Kenneth A
Published in Journal of medicinal chemistry (01.07.1991)
Published in Journal of medicinal chemistry (01.07.1991)
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Journal Article
Molecular probes for muscarinic receptors: derivatives of the M1-antagonist telenzepine
Karton, Yishai, Baumgold, Jesse, Handen, Jeffrey S, Jacobson, Kenneth A
Published in Bioconjugate chemistry (01.05.1992)
Published in Bioconjugate chemistry (01.05.1992)
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