Development of AO-176, a Next-Generation Humanized Anti-CD47 Antibody with Novel Anticancer Properties and Negligible Red Blood Cell Binding
Puro, Robyn J, Bouchlaka, Myriam N, Hiebsch, Ronald R, Capoccia, Benjamin J, Donio, Michael J, Manning, Pamela T, Frazier, William A, Karr, Robert W, Pereira, Daniel S
Published in Molecular cancer therapeutics (01.03.2020)
Published in Molecular cancer therapeutics (01.03.2020)
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Journal Article
A repetitive sequence of Epstein–Barr virus nuclear antigen 6 comprises overlapping T cell epitopes which induce HLA-DR-restricted CD4+ T lymphocytes
Rajnavölgyi, Éva, Nagy, Noémi, Thuresson, Britt, Dosztányi, Zsuzsa, Simon, Ágnes, Simon, István, Karr, Robert W., Ernberg, Ingemar, Klein, Eva, Falk, Kerstin I.
Published in International immunology (01.03.2000)
Published in International immunology (01.03.2000)
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Journal Article
CTLA-4-Fc treatment of ongoing EAE improves recovery, but has no effect upon relapse rate.: Implications for the mechanisms involved in disease perpetuation
Cross, Anne H, San, Manuel, Keeling, Richard M, Karr, Robert W
Published in Journal of neuroimmunology (03.05.1999)
Published in Journal of neuroimmunology (03.05.1999)
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Journal Article
Therapeutic Potential of AO-176, a Next Generation Humanized CD47 Antibody, for Hematologic Malignancies
Wilson, W. Casey, Bouchlaka, Myriam N, Capoccia, Ben J, Hiebsch, Ronald R, Donio, Michael J, Puro, Robyn J, Carter, Alun J, Chakraborty, Prabir, Manning, Pamela T, Karr, Robert W, Sung, Vicki, Pereira, Daniel S
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Journal Article
Dual-Function Anti-CD47mAbs Induce Tumor Cell Death and Promote Phagocytosis Resulting in Enhanced in Vivo Efficacy
Manning, Pamela T., Capoccia, Benjamin J., Rettig, Michael P., Hiebsch, Ronald R., Karr, Robert W., DiPersio, John F., Frazier, William A.
Published in Blood (06.12.2014)
Published in Blood (06.12.2014)
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Journal Article
Acidic residues in the DRβ chain third hypervariable region are required for stimulation of a DR(α,β1∗0402)-restricted T-cell clone
Olson, Richard R, Reuter, Jeffrey J, McNicholl, Janet, Alber, Carol, Klohe, Ellen, Callahan, Kevin, Siliciano, Robert F, Karr, Robert W
Published in Human immunology (01.11.1994)
Published in Human immunology (01.11.1994)
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Journal Article
Markedly Impaired Humoral Immune Response in Mice Deficient in Complement Receptors 1 and 2
Molina, Hector, Holers, V. Michael, Li, Bin, Fang, Yi-Fu, Mariathasan, Sanjeev, Goellner, Joseph, Strauss-Schoenberger, Jena, Karr, Robert W., Chaplin, David D.
Published in Proceedings of the National Academy of Sciences - PNAS (16.04.1996)
Published in Proceedings of the National Academy of Sciences - PNAS (16.04.1996)
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Journal Article
Peptide binding specificity of HLA-DR4 molecules: correlation with rheumatoid arthritis association
Hammer, J, Gallazzi, F, Bono, E, Karr, R W, Guenot, J, Valsasnini, P, Nagy, Z A, Sinigaglia, F
Published in The Journal of experimental medicine (01.05.1995)
Published in The Journal of experimental medicine (01.05.1995)
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Journal Article
Antigen-dependent clonal expansion of a trace population of antigen- specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4
Kearney, ER, Walunas, TL, Karr, RW, Morton, PA, Loh, DY, Bluestone, JA, Jenkins, MK
Published in The Journal of immunology (1950) (01.08.1995)
Published in The Journal of immunology (1950) (01.08.1995)
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Journal Article
Mice deficient in IL-1 beta manifest impaired contact hypersensitivity to trinitrochlorobenzene
Shornick, L P, De Togni, P, Mariathasan, S, Goellner, J, Strauss-Schoenberger, J, Karr, R W, Ferguson, T A, Chaplin, D D
Published in The Journal of experimental medicine (01.04.1996)
Published in The Journal of experimental medicine (01.04.1996)
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Journal Article
Structural Basis for Major Histocompatibility Complex (MHC)-Linked Susceptibility to Autoimmunity: Charged Residues of a Single MHC Binding Pocket Confer Selective Presentation of Self-Peptides in Pemphigus Vulgaris
Wucherpfennig, Kai W., Yu, Bei, Bhol, Kailash, Monos, Dimitri S., Argyris, Elias, Karr, Robert W., Ahmed, A. Razzaque, Strominger, Jack L.
Published in Proceedings of the National Academy of Sciences - PNAS (05.12.1995)
Published in Proceedings of the National Academy of Sciences - PNAS (05.12.1995)
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Journal Article
Collagen-induced arthritis in the BB rat. Prevention of disease by treatment with CTLA-4-Ig
Knoerzer, D B, Karr, R W, Schwartz, B D, Mengle-Gaw, L J
Published in The Journal of clinical investigation (01.08.1995)
Published in The Journal of clinical investigation (01.08.1995)
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Journal Article
Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA-4-Fc supports a key role for CD28 costimulation
Cross, A H, Girard, T J, Giacoletto, K S, Evans, R J, Keeling, R M, Lin, R F, Trotter, J L, Karr, R W
Published in The Journal of clinical investigation (01.06.1995)
Published in The Journal of clinical investigation (01.06.1995)
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Journal Article
THERAPEUTIC CD47 ANTIBODIES
FRAZIER, William A, KARR, Robert W, MANNING, Pamela T, CHANG, Hwai Wen, FREY, Gerhard
Year of Publication 22.06.2023
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Year of Publication 22.06.2023
Patent
THERAPEUTIC SIRPalpha ANTIBODIES
MANNING, Pamela, T, PURO, Robyn, ANDREJEVA, Gabriela, KARR, Robert, W, CAPOCCIA, Benjamin, J, HIEBSCH, Ronald, R
Year of Publication 23.11.2022
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Year of Publication 23.11.2022
Patent
Analysis of host-virus interactions in AIDS with anti-gp120 T cell clones: Effect of HIV sequence variation and a mechanism for CD4 + cell depletion
Siliciano, Robert F., Lawton, Trebor, Knall, Cindy, Karr, Robert W., Berman, Phillip, Gregory, Timothy, Reinherz, Ellis L.
Published in Cell (12.08.1988)
Published in Cell (12.08.1988)
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Journal Article
Therapeutic CD47 antibodies
Manning, Pamela T, Karr, Robert W, Frey, Gerhard, Frazier, William A, Chang, Hwai Wen
Year of Publication 05.04.2022
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Year of Publication 05.04.2022
Patent