Targeted Synthesis of Complex Spiro[3H‐indole‐3,2′‐pyrrolidin]‐2(1H)‐ones by Intramolecular Cyclization of Azomethine Ylides: Highly Potent MDM2–p53 Inhibitors
Gollner, Andreas, Weinstabl, Harald, Fuchs, Julian E., Rudolph, Dorothea, Garavel, Geraldine, Hofbauer, Karin S., Karolyi‐Oezguer, Jale, Gmaschitz, Gerhard, Hela, Wolfgang, Kerres, Nina, Grondal, Elisabeth, Werni, Patrick, Ramharter, Juergen, Broeker, Joachim, McConnell, Darryl B.
Published in ChemMedChem (08.01.2019)
Published in ChemMedChem (08.01.2019)
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Drugging an undruggable pocket on KRAS
Kesslera, Dirk, Gmachla, Michael, Mantoulidisa, Andreas, Martin, Laetitia J., Zoephel, Andreas, Mayer, Moriz, Gollner, Andreas, Covini, David, Fischer, Silke, Gerstberger, Thomas, Gmaschitz, Teresa, Goodwin, Craig, Greb, Peter, Häring, Daniela, Hela, Wolfgang, Hoffmann, Johann, Karolyi-Oezguer, Jale, Knesl, Petr, Kornigg, Stefan, Koegl, Manfred, Kousek, Roland, Lamarre, Lyne, Moser, Franziska, Munico-Martinez, Silvia, Peinsipp, Christoph, Phan, Jason, Rinnenthal, Jörg, Sai, Jiqing, Salamon, Christian, Scherbantin, Yvonne, Schipany, Katharina, Schnitzer, Renate, Schrenk, Andreas, Sharps, Bernadette, Siszler, Gabriella, Sun, Qi, Waterson, Alex, Wolkerstorfer, Bernhard, Zeeb, Markus, Pearson, Mark, Fesik, Stephen W., McConnell, Darryl B.
Published in Proceedings of the National Academy of Sciences - PNAS (06.08.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (06.08.2019)
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BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
Farnaby, William, Koegl, Manfred, Roy, Michael J., Whitworth, Claire, Diers, Emelyne, Trainor, Nicole, Zollman, David, Steurer, Steffen, Karolyi-Oezguer, Jale, Riedmueller, Carina, Gmaschitz, Teresa, Wachter, Johannes, Dank, Christian, Galant, Michael, Sharps, Bernadette, Rumpel, Klaus, Traxler, Elisabeth, Gerstberger, Thomas, Schnitzer, Renate, Petermann, Oliver, Greb, Peter, Weinstabl, Harald, Bader, Gerd, Zoephel, Andreas, Weiss-Puxbaum, Alexander, Ehrenhöfer-Wölfer, Katharina, Wöhrle, Simon, Boehmelt, Guido, Rinnenthal, Joerg, Arnhof, Heribert, Wiechens, Nicola, Wu, Meng-Ying, Owen-Hughes, Tom, Ettmayer, Peter, Pearson, Mark, McConnell, Darryl B., Ciulli, Alessio
Published in Nature chemical biology (01.07.2019)
Published in Nature chemical biology (01.07.2019)
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Discovery of Novel Spiro[3H‑indole-3,2′-pyrrolidin]-2(1H)‑one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2–p53 Interaction
Gollner, Andreas, Rudolph, Dorothea, Arnhof, Heribert, Bauer, Markus, Blake, Sophia M, Boehmelt, Guido, Cockroft, Xiao-Ling, Dahmann, Georg, Ettmayer, Peter, Gerstberger, Thomas, Karolyi-Oezguer, Jale, Kessler, Dirk, Kofink, Christiane, Ramharter, Juergen, Rinnenthal, Jörg, Savchenko, Alexander, Schnitzer, Renate, Weinstabl, Harald, Weyer-Czernilofsky, Ulrike, Wunberg, Tobias, McConnell, Darryl B
Published in Journal of medicinal chemistry (23.11.2016)
Published in Journal of medicinal chemistry (23.11.2016)
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암 치료용 고리형 2-아미노-3-시아노 티오펜 및 유도체
GOLLNER ANDREAS, TREU MATTHIAS, LITTLE ANDREW, MANTOULIDIS ANDREAS, CUI JIANWEN, HODGES TIM, PHAN JASON, SMETHURST CHRISTIAN ALAN PAUL, SARKAR DHRUBA, WATERSON ALEX, FESIK STEPHEN W, BROEKER JOACHIM, KAROLYI OEZGUER JALE, ABBOTT JASON, SUN QI
Year of Publication 08.02.2023
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Year of Publication 08.02.2023
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Synthesis of Indazoles via N–N Bond-Forming Oxidative Cyclization from 2‑Aminomethyl-phenylamines
Schoeggl Toledano, Anna, Bitai, Jacqueline, Covini, David, Karolyi-Oezguer, Jale, Dank, Christian, Berger, Helmut, Gollner, Andreas
Published in Organic letters (16.02.2024)
Published in Organic letters (16.02.2024)
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Synthesis of MDM2-p53 Inhibitor BI-0282 via a Dipolar Cycloaddition and Late-Stage Davis–Beirut Reaction
Ramharter, Juergen, Kulhanek, Michael, Dettling, Maike, Gmaschitz, Gerhard, Karolyi-Oezguer, Jale, Weinstabl, Harald, Gollner, Andreas
Published in Organic process research & development (19.08.2022)
Published in Organic process research & development (19.08.2022)
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Targeting cancer with small-molecule pan-KRAS degraders
Popow, Johannes, Farnaby, William, Gollner, Andreas, Kofink, Christiane, Fischer, Gerhard, Wurm, Melanie, Zollman, David, Wijaya, Andre, Mischerikow, Nikolai, Hasenoehrl, Carina, Prokofeva, Polina, Arnhof, Heribert, Arce-Solano, Silvia, Bell, Sammy, Boeck, Georg, Diers, Emelyne, Frost, Aileen B, Goodwin-Tindall, Jake, Karolyi-Oezguer, Jale, Khan, Shakil, Klawatsch, Theresa, Koegl, Manfred, Kousek, Roland, Kratochvil, Barbara, Kropatsch, Katrin, Lauber, Arnel A, McLennan, Ross, Olt, Sabine, Peter, Daniel, Petermann, Oliver, Roessler, Vanessa, Stolt-Bergner, Peggy, Strack, Patrick, Strauss, Eva, Trainor, Nicole, Vetma, Vesna, Whitworth, Claire, Zhong, Siying, Quant, Jens, Weinstabl, Harald, Kuster, Bernhard, Ettmayer, Peter, Ciulli, Alessio
Published in Science (American Association for the Advancement of Science) (20.09.2024)
Published in Science (American Association for the Advancement of Science) (20.09.2024)
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REPLY TO TRAN ET AL: Dimeric KRAS protein–protein interaction stabilizers
Kessler, Dirk, Gollner, Andreas, Gmachl, Michael, Mantoulidis, Andreas, Martin, Laetitia J., Zoephel, Andreas, Mayer, Moriz, Covini, David, Fischer, Silke, Gerstberger, Thomas, Gmaschitz, Teresa, Goodwin, Craig, Greb, Peter, Häring, Daniela, Hela, Wolfgang, Hoffmann, Johann, Karolyi-Oezguer, Jale, Knesl, Petr, Kornigg, Stefan, Koegl, Manfred, Kousek, Roland, Lamarre, Lyne, Moser, Franziska, Munico-Martinez, Silvia, Peinsipp, Christoph, Phan, Jason, Rinnenthal, Jörg, Sai, Jiqing, Salamon, Christian, Scherbantin, Yvonne, Schipany, Katharina, Schnitzer, Renate, Schrenk, Andreas, Sharps, Bernadette, Siszler, Gabriella, Sun, Qi, Waterson, Alex, Wolkerstorfer, Bernhard, Zeeb, Markus, Pearson, Mark, Fesik, Stephen W., McConnell, Darryl B.
Published in Proceedings of the National Academy of Sciences - PNAS (18.02.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (18.02.2020)
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Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
Farnaby, William, Koegl, Manfred, Roy, Michael J., Whitworth, Claire, Diers, Emelyne, Trainor, Nicole, Zollman, David, Steurer, Steffen, Karolyi-Oezguer, Jale, Riedmueller, Carina, Gmaschitz, Teresa, Wachter, Johannes, Dank, Christian, Galant, Michael, Sharps, Bernadette, Rumpel, Klaus, Traxler, Elisabeth, Gerstberger, Thomas, Schnitzer, Renate, Petermann, Oliver, Greb, Peter, Weinstabl, Harald, Bader, Gerd, Zoephel, Andreas, Weiss-Puxbaum, Alexander, Ehrenhöfer-Wölfer, Katharina, Wöhrle, Simon, Boehmelt, Guido, Rinnenthal, Joerg, Arnhof, Heribert, Wiechens, Nicola, Wu, Meng-Ying, Owen-Hughes, Tom, Ettmayer, Peter, Pearson, Mark, McConnell, Darryl B., Ciulli, Alessio
Published in Nature chemical biology (01.08.2019)
Published in Nature chemical biology (01.08.2019)
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Targeted Synthesis of Complex Spiro3H-indole-3,2'-pyrrolidin-2(1H)-ones by Intramolecular Cyclization of Azomethine Ylides: Highly Potent MDM2-p53 Inhibitors
Gollner, Andreas, Weinstabl, Harald, Fuchs, Julian E, Rudolph, Dorothea, Garavel, Geraldine, Hofbauer, Karin S, Karolyi-Oezguer, Jale, Gmaschitz, Gerhard, Hela, Wolfgang, Kerres, Nina, Grondal, Elisabeth, Werni, Patrick, Ramharter, Juergen, Broeker, Joachim, McConnell, Darryl B
Published in ChemMedChem (08.01.2019)
Published in ChemMedChem (08.01.2019)
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Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
Broeker, Joachim, Gollner, Andreas, Hodges, Tim, Waterson, Alex, Smethurst, Christian Alan Paul, Cui, Jianwen, Karolyi-Oezguer, Jale, Little, Andrew, Abbott, Jason, Mantoulidis, Andreas, Sarkar, Dhruba, Fesik, Steve W, Treu, Matthias, Phan, Jason, Sun, Qi
Year of Publication 02.04.2024
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Year of Publication 02.04.2024
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ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER
MANTOULIDIS, Andreas, SARKAR, Dhruba, TREU, Matthias, LITTLE, Andrew, PHAN, Jason, BROEKER, Joachim, SMETHURST, Christian Alan Paul, SUN, Qi, CUI, Jianwen, WATERSON, Alex, FESIK, Stephen W, ABBOTT, Jason, HODGES, Tim, GOLLNER, Andreas, KAROLYI-OEZGUER, Jale
Year of Publication 06.07.2023
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Year of Publication 06.07.2023
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ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER
MANTOULIDIS, Andreas, SARKAR, Dhruba, TREU, Matthias, LITTLE, Andrew, PHAN, Jason, BROEKER, Joachim, SMETHURST, Christian Alan Paul, SUN, Qi, CUI, Jianwen, WATERSON, Alex, FESIK, Stephen W, ABBOTT, Jason, HODGES, Tim, GOLLNER, Andreas, KAROLYI-OEZGUER, Jale
Year of Publication 05.04.2023
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Year of Publication 05.04.2023
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ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER
MANTOULIDIS, Andreas, SARKAR, Dhruba, TREU, Matthias, LITTLE, Andrew, PHAN, Jason, BROEKER, Joachim, SMETHURST, Christian Alan Paul, SUN, Qi, CUI, Jianwen, WATERSON, Alex, FESIK, Stephen W, ABBOTT, Jason, HODGES, Tim, GOLLNER, Andreas, KAROLYI-OEZGUER, Jale
Year of Publication 05.04.2023
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Year of Publication 05.04.2023
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Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
MANTOULIDIS, Andreas, SARKAR, Dhruba, TREU, Matthias, LITTLE, Andrew, PHAN, Jason, BROEKER, Joachim, SMETHURST, Christian Alan Paul, SUN, Qi, CUI, Jianwen, WATERSON, Alex, FESIK, Stephen W, ABBOTT, Jason, HODGES, Tim, GOLLNER, Andreas, KAROLYI-OEZGUER, Jale
Year of Publication 08.12.2022
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Year of Publication 08.12.2022
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ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER
MANTOULIDIS, Andreas, SARKAR, Dhruba, TREU, Matthias, LITTLE, Andrew, PHAN, Jason, BROEKER, Joachim, SMETHURST, Christian Alan Paul, SUN, Qi, CUI, Jianwen, WATERSON, Alex, FESIK, Stephen W, ABBOTT, Jason, HODGES, Tim, GOLLNER, Andreas, KAROLYI-OEZGUER, Jale
Year of Publication 09.12.2021
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Year of Publication 09.12.2021
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ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER
GOLLNER, ANDREAS, BROEKER, JOACHIM, HODGES, TIM, MANTOULIDIS, ANDREAS, SMETHURST, CHRISTIAN ALAN PAUL, FESIK, STEPHEN W, TREU, MATTHIAS, KAROLYI-OEZGUER, JALE, ABBOTT, JASON, CUI, JIANWEN, LITTLE, ANDREW, PHAN, JASON, WATERSON, ALEX, SUN, QI, SARKAR, DHRUBA
Year of Publication 09.12.2021
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Year of Publication 09.12.2021
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ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER
MANTOULIDIS, Andreas, SARKAR, Dhruba, TREU, Matthias, LITTLE, Andrew, PHAN, Jason, BROEKER, Joachim, SMETHURST, Christian Alan Paul, SUN, Qi, CUI, Jianwen, WATERSON, Alex, FESIK, Steve W, ABBOTT, Jason, HODGES, Tim, GOLLNER, Andreas, KAROLYI-OEZGUER, Jale
Year of Publication 09.12.2021
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Year of Publication 09.12.2021
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ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER
MANTOULIDIS, Andreas, SARKAR, Dhruba, TREU, Matthias, LITTLE, Andrew, PHAN, Jason, BROEKER, Joachim, SMETHURST, Christian Alan Paul, SUN, Qi, CUI, Jianwen, WATERSON, Alex, FESIK, Stephen W, ABBOTT, Jason, HODGES, Tim, GOLLNER, Andreas, KAROLYI-OEZGUER, Jale
Year of Publication 09.12.2021
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Year of Publication 09.12.2021
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