Mechanisms underlying the rapid peroxisome proliferator-activated receptor-γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease
Mandrekar-Colucci, Shweta, Karlo, J Colleen, Landreth, Gary E
Published in The Journal of neuroscience (25.07.2012)
Published in The Journal of neuroscience (25.07.2012)
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The 16p11.2 deletion mouse model of autism exhibits altered cortical progenitor proliferation and brain cytoarchitecture linked to the ERK MAPK pathway
Pucilowska, Joanna, Vithayathil, Joseph, Tavares, Emmanuel J, Kelly, Caitlin, Karlo, J Colleen, Landreth, Gary E
Published in The Journal of neuroscience (18.02.2015)
Published in The Journal of neuroscience (18.02.2015)
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TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models
Jay, Taylor R, Miller, Crystal M, Cheng, Paul J, Graham, Leah C, Bemiller, Shane, Broihier, Margaret L, Xu, Guixiang, Margevicius, Daniel, Karlo, J Colleen, Sousa, Gregory L, Cotleur, Anne C, Butovsky, Oleg, Bekris, Lynn, Staugaitis, Susan M, Leverenz, James B, Pimplikar, Sanjay W, Landreth, Gary E, Howell, Gareth R, Ransohoff, Richard M, Lamb, Bruce T
Published in The Journal of experimental medicine (09.03.2015)
Published in The Journal of experimental medicine (09.03.2015)
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ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models
CRAMER, Paige E, CIRRITO, John R, BRUNDEN, Kurt R, WILSON, Donald A, LANDRETH, Gary E, WESSON, Daniel W, DANIEL LEE, C. Y, COLLEEN KARLO, J, ZINN, Adriana E, CASALI, Brad T, RESTIVO, Jessica L, GOEBET, Whitney D, JAMES, Michael J
Published in Science (American Association for the Advancement of Science) (23.03.2012)
Published in Science (American Association for the Advancement of Science) (23.03.2012)
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The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease
Cheng-Hathaway, Paul J, Reed-Geaghan, Erin G, Jay, Taylor R, Casali, Brad T, Bemiller, Shane M, Puntambekar, Shweta S, von Saucken, Victoria E, Williams, Roxanne Y, Karlo, J Colleen, Moutinho, Miguel, Xu, Guixiang, Ransohoff, Richard M, Lamb, Bruce T, Landreth, Gary E
Published in Molecular neurodegeneration (01.06.2018)
Published in Molecular neurodegeneration (01.06.2018)
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Erk1 and Erk2 regulate endothelial cell proliferation and migration during mouse embryonic angiogenesis
Srinivasan, Ruchika, Zabuawala, Tahera, Huang, Hong, Zhang, Jianying, Gulati, Parul, Fernandez, Soledad, Karlo, J Colleen, Landreth, Gary E, Leone, Gustavo, Ostrowski, Michael C
Published in PloS one (14.12.2009)
Published in PloS one (14.12.2009)
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The PPARγ agonist pioglitazone crosses the blood–brain barrier and reduces tumor growth in a human xenograft model
Grommes, Christian, Karlo, J. Colleen, Caprariello, Andrew, Blankenship, D’Arbra, DeChant, Anne, Landreth, Gary E.
Published in Cancer chemotherapy and pharmacology (01.04.2013)
Published in Cancer chemotherapy and pharmacology (01.04.2013)
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Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development
Newbern, Jason, Zhong, Jian, Wickramasinghe, Rasika S, Li, Xiaoyan, Wu, Yaohong, Samuels, Ivy, Cherosky, Natalie, Karlo, J. Colleen, O'Loughlin, Brianne, Wikenheiser, Jamie, Gargesha, Madhusudhana, Doughman, Yong Qiu, Charron, Jean, Ginty, David D, Watanabe, Michiko, Saitta, Sulagna C, Snider, William D, Landreth, Gary E
Published in Proceedings of the National Academy of Sciences - PNAS (04.11.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (04.11.2008)
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Nerve Growth Factor Stimulates the Concentration of TrkA within Lipid Rafts and Extracellular Signal-Regulated Kinase Activation through c-Cbl-Associated Protein
Limpert, Allison S., Karlo, J. Colleen, Landreth, Gary E.
Published in Molecular and Cellular Biology (01.08.2007)
Published in Molecular and Cellular Biology (01.08.2007)
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Pharmacological Inhibition of ERK Signaling Rescues Pathophysiology and Behavioral Phenotype Associated with 16p11.2 Chromosomal Deletion in Mice
Pucilowska, Joanna, Vithayathil, Joseph, Pagani, Marco, Kelly, Caitlin, Karlo, J Colleen, Robol, Camilla, Morella, Ilaria, Gozzi, Alessandro, Brambilla, Riccardo, Landreth, Gary E
Published in The Journal of neuroscience (25.07.2018)
Published in The Journal of neuroscience (25.07.2018)
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Disrupted ERK signaling during cortical development leads to abnormal progenitor proliferation, neuronal and network excitability and behavior, modeling human neuro-cardio-facial-cutaneous and related syndromes
Pucilowska, Joanna, Puzerey, Pavel A, Karlo, J Colleen, Galán, Roberto F, Landreth, Gary E
Published in The Journal of neuroscience (20.06.2012)
Published in The Journal of neuroscience (20.06.2012)
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Deletion of ERK2 Mitogen-Activated Protein Kinase Identifies Its Key Roles in Cortical Neurogenesis and Cognitive Function
Samuels, Ivy S, Karlo, J. Colleen, Faruzzi, Alicia N, Pickering, Kathryn, Herrup, Karl, Sweatt, J. David, Saitta, Sulagna C, Landreth, Gary E
Published in The Journal of neuroscience (02.07.2008)
Published in The Journal of neuroscience (02.07.2008)
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Inflammatory Mechanisms in Alzheimer's Disease: Inhibition of β-Amyloid-Stimulated Proinflammatory Responses and Neurotoxicity by PPARγ Agonists
Combs, Colin K., Johnson, Derrick E., Karlo, J. Colleen, Cannady, Steven B., Landreth, Gary E.
Published in The Journal of neuroscience (15.01.2000)
Published in The Journal of neuroscience (15.01.2000)
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The PPAR[gamma] agonist pioglitazone crosses the bloodâ[euro]"brain barrier and reduces tumor growth in a human xenograft model
Grommes, Christian, Karlo, J Colleen, Caprariello, Andrew, Blankenship, Dâ[euro](tm)arbra, Dechant, Anne, Landreth, Gary E
Published in Cancer chemotherapy and pharmacology (01.04.2013)
Published in Cancer chemotherapy and pharmacology (01.04.2013)
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ApoE-Directed Therapeutics Rapidly Clear [beta]-Amyloid and Reverse Deficits in AD Mouse Models
Cramer, Paige E, Cirrito, John R, Wesson, Daniel W, Lee, C Y Daniel, Karlo, J Colleen, Zinn, Adriana E, Casali, Brad T, Restivo, Jessica L, Goebel, Whitney D, James, Michael J, Brunden, Kurt R, Wilson, Donald A, Landreth, Gary E
Published in Science (American Association for the Advancement of Science) (23.03.2012)
Published in Science (American Association for the Advancement of Science) (23.03.2012)
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ApoE-Directed Therapeutics Rapidly Clear ß-Amyloid and Reverse Deficits in AD Mouse Models
Cramer, Paige E., Cirrito, John R., Wesson, Daniel W., Lee, C. Y. Daniel, Karlo, J. Colleen, Zinn, Adriana E., Casali, Brad T., Restivo, Jessica L., Goebel, Whitney D., James, Michael J., Brunden, Kurt R., Wilson, Donald A., Landreth, Gary E.
Published in Science (American Association for the Advancement of Science) (23.03.2012)
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Published in Science (American Association for the Advancement of Science) (23.03.2012)
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