Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure
Follmann, Markus, Ackerstaff, Jens, Redlich, Gorden, Wunder, Frank, Lang, Dieter, Kern, Armin, Fey, Peter, Griebenow, Nils, Kroh, Walter, Becker-Pelster, Eva-Maria, Kretschmer, Axel, Geiss, Volker, Li, Volkhart, Straub, Alexander, Mittendorf, Joachim, Jautelat, Rolf, Schirok, Hartmut, Schlemmer, Karl-Heinz, Lustig, Klemens, Gerisch, Michael, Knorr, Andreas, Tinel, Hanna, Mondritzki, Thomas, Trübel, Hubert, Sandner, Peter, Stasch, Johannes-Peter
Published in Journal of medicinal chemistry (22.06.2017)
Published in Journal of medicinal chemistry (22.06.2017)
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Discovery of BAY 94-8862: A Nonsteroidal Antagonist of the Mineralocorticoid Receptor for the Treatment of Cardiorenal Diseases
Bärfacker, Lars, Kuhl, Alexander, Hillisch, Alexander, Grosser, Rolf, Figueroa-Pérez, Santiago, Heckroth, Heike, Nitsche, Adam, Ergüden, Jens-Kerim, Gielen-Haertwig, Heike, Schlemmer, Karl-Heinz, Mittendorf, Joachim, Paulsen, Holger, Platzek, Johannes, Kolkhof, Peter
Published in ChemMedChem (01.08.2012)
Published in ChemMedChem (01.08.2012)
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Discovery of the Novel Antithrombotic Agent 5-Chloro-N-({(5S)-2-oxo-3- [4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene- 2-carboxamide (BAY 59-7939): An Oral, Direct Factor Xa Inhibitor
Roehrig, Susanne, Straub, Alexander, Pohlmann, Jens, Lampe, Thomas, Pernerstorfer, Josef, Schlemmer, Karl-Heinz, Reinemer, Peter, Perzborn, Elisabeth
Published in Journal of medicinal chemistry (22.09.2005)
Published in Journal of medicinal chemistry (22.09.2005)
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Discovery of Riociguat (BAY 63-2521): A Potent, Oral Stimulator of Soluble Guanylate Cyclase for the Treatment of Pulmonary Hypertension
Mittendorf, Joachim, Weigand, Stefan, Alonso-Alija, Cristina, Bischoff, Erwin, Feurer, Achim, Gerisch, Michael, Kern, Armin, Knorr, Andreas, Lang, Dieter, Muenter, Klaus, Radtke, Martin, Schirok, Hartmut, Schlemmer, Karl-Heinz, Stahl, Elke, Straub, Alexander, Wunder, Frank, Stasch, Johannes-Peter
Published in ChemMedChem (11.05.2009)
Published in ChemMedChem (11.05.2009)
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Discovery of the Soluble Guanylate Cyclase Activator Runcaciguat (BAY 1101042)
Hahn, Michael G, Lampe, Thomas, El Sheikh, Sherif, Griebenow, Nils, Woltering, Elisabeth, Schlemmer, Karl-Heinz, Dietz, Lisa, Gerisch, Michael, Wunder, Frank, Becker-Pelster, Eva-Maria, Mondritzki, Thomas, Tinel, Hanna, Knorr, Andreas, Kern, Armin, Lang, Dieter, Hueser, Joerg, Schomber, Tibor, Benardeau, Agnes, Eitner, Frank, Truebel, Hubert, Mittendorf, Joachim, Kumar, Vijay, van den Akker, Focco, Schaefer, Martina, Geiss, Volker, Sandner, Peter, Stasch, Johannes-Peter
Published in Journal of medicinal chemistry (13.05.2021)
Published in Journal of medicinal chemistry (13.05.2021)
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Design and Preclinical Characterization Program toward Asundexian (BAY 2433334), an Oral Factor XIa Inhibitor for the Prevention and Treatment of Thromboembolic Disorders
Roehrig, Susanne, Ackerstaff, Jens, Jiménez Núñez, Eloísa, Teller, Henrik, Ellerbrock, Pascal, Meier, Katharina, Heitmeier, Stefan, Tersteegen, Adrian, Stampfuss, Jan, Lang, Dieter, Schlemmer, Karl-Heinz, Schaefer, Martina, Gericke, Kersten M., Kinzel, Tom, Meibom, Daniel, Schmidt, Martina, Gerdes, Christoph, Follmann, Markus, Hillisch, Alexander
Published in Journal of medicinal chemistry (14.09.2023)
Published in Journal of medicinal chemistry (14.09.2023)
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BAY-7081: A Potent, Selective, and Orally Bioavailable Cyanopyridone-Based PDE9A Inhibitor
Meibom, Daniel, Micus, Sina, Andreevski, Anna Lena, Anlauf, Sonja, Bogner, Pamela, von Buehler, Clemens-Jeremias, Dieskau, André P., Dreher, Jan, Eitner, Frank, Fliegner, Daniela, Follmann, Markus, Gericke, Kersten Matthias, Maassen, Stefanie, Meyer, Jutta, Schlemmer, Karl-Heinz, Steuber, Holger, Tersteegen, Adrian, Wunder, Frank
Published in Journal of medicinal chemistry (22.12.2022)
Published in Journal of medicinal chemistry (22.12.2022)
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Inhibition of Hepatitis B Virus Replication by Drug-Induced Depletion of Nucleocapsids
Deres, Karl, Schröder, Claus H., Paessens, Arnold, Goldmann, Siegfried, Hacker, Hans Jörg, Weber, Olaf, Krämer, Thomas, Niewöhner, Ulrich, Pleiss, Ulrich, Stoltefuss, Jürgen, Graef, Erwin, Koletzki, Diana, Ralf N. A. Masantschek, Reimann, Anja, Jaeger, Rainer, Groβ, Rainer, Beckermann, Bernhard, Schlemmer, Karl-Heinz, Haebich, Dieter, Rübsamen-Waigmann, Helga
Published in Science (American Association for the Advancement of Science) (07.02.2003)
Published in Science (American Association for the Advancement of Science) (07.02.2003)
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Predicting biopharmaceutical performance of oral drug candidates – Extending the volume to dissolve applied dose concept
Muenster, Uwe, Mueck, Wolfgang, van der Mey, Dorina, Schlemmer, Karl-Heinz, Greschat-Schade, Susanne, Haerter, Michael, Pelzetter, Christian, Pruemper, Christian, Verlage, Joerg, Göller, Andreas H., Ohm, Andreas
Published in European journal of pharmaceutics and biopharmaceutics (01.05.2016)
Published in European journal of pharmaceutics and biopharmaceutics (01.05.2016)
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Identification of acidic heterocycle-substituted 1H-pyrazolo[3,4-b]pyridines as soluble guanylate cyclase stimulators
Griebenow, Nils, Schirok, Hartmut, Mittendorf, Joachim, Straub, Alexander, Follmann, Markus, Stasch, Johannes-Peter, Knorr, Andreas, Schlemmer, Karl-Heinz, Redlich, Gorden
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
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Cover Picture: Discovery of BAY 94-8862: A Nonsteroidal Antagonist of the Mineralocorticoid Receptor for the Treatment of Cardiorenal Diseases (ChemMedChem 8/2012)
Bärfacker, Lars, Kuhl, Alexander, Hillisch, Alexander, Grosser, Rolf, Figueroa-Pérez, Santiago, Heckroth, Heike, Nitsche, Adam, Ergüden, Jens-Kerim, Gielen-Haertwig, Heike, Schlemmer, Karl-Heinz, Mittendorf, Joachim, Paulsen, Holger, Platzek, Johannes, Kolkhof, Peter
Published in ChemMedChem (01.08.2012)
Published in ChemMedChem (01.08.2012)
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Cover Picture: Discovery of Riociguat (BAY 63-2521): A Potent, Oral Stimulator of Soluble Guanylate Cyclase for the Treatment of Pulmonary Hypertension (ChemMedChem 5/2009)
Mittendorf, Joachim, Weigand, Stefan, Alonso-Alija, Cristina, Bischoff, Erwin, Feurer, Achim, Gerisch, Michael, Kern, Armin, Knorr, Andreas, Lang, Dieter, Muenter, Klaus, Radtke, Martin, Schirok, Hartmut, Schlemmer, Karl-Heinz, Stahl, Elke, Straub, Alexander, Wunder, Frank, Stasch, Johannes-Peter
Published in ChemMedChem (11.05.2009)
Published in ChemMedChem (11.05.2009)
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SUBSTITUTED OXOPYRIDINE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF CARDIOVASCULAR DISORDERS
CHRISTOPH GERDES, HENRIK TELLER, ADRIAN TERSTEEGEN, ANJA BUCHMUELLER, MARTINA SCHAEFER, ELOISA JIMENEZ NUNEZ, TOM KINZEL, KARL-HEINZ SCHLEMMER, JUERGEN KLAR, MARTINA VICTORIA SCHMIDT, JULIA STRASSBURGER, STEFAN HEITMEIER, SUSANNE ROEHRIG, ALEXANDER HILLISCH, HARTMUT SCHIROK
Year of Publication 26.04.2018
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Year of Publication 26.04.2018
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N-(3-BENZOFURANYL)UREA DERIVATIVE USED AS ACTIVE INGREDIENT OF THERAPEUTICS FOR TREATMENT OF ACUTE OR CHRONIC INFLAMMATORY DISEASES
GRAHAM STURTON, RUEDIGER FISCHER, MAZEN ES SAYED, KARL HEINZ SCHLEMMER, GABRIELE BRAEUNLICH, MICHAEL SPERZEL, ULRICH NIELSCH, MARY F. FITZGERALD, ROLF HENNING, STEPHEN TUDHOPE, TREVOR S. ABRAM
Year of Publication 02.07.2004
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Year of Publication 02.07.2004
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Dihydropyrimidines, process of their preparation, medicaments containing such compounds as well as their use
GOLDMANN SIEGFRIED GOLDMANN SIEGFRIED, NIEWOHNER ULRICH NIEWOHNER ULRICH, KRAMER THOMAS KRAMER THOMAS, GRAEF ERWIN GRAEF ERWIN, SCHLEMMER KARL-HEINZ SCHLEMMER KARL-HEINZ, STOLTEFUSS JURGEN STOLTEFUSS JURGEN, PAESSENS ARNOLD PAESSENS ARNOLD, DERES KARK DERES KARK, STOLTING JORN STOLTING JORN, LOTTMANN STEFAN LOTTMANN STEFAN, WEBER OLAF WEBER OLAF
Year of Publication 12.05.2004
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Year of Publication 12.05.2004
Patent
Substituted Uracil Derivatives as Potent Inhibitors of Poly(ADP-ribose)polymerase-1 (PARP-1)
Steinhagen, Henning, Gerisch, Michael, Mittendorf, Joachim, Schlemmer, Karl-Heinz, Albrecht, Barbara
Published in ChemInform (25.02.2003)
Published in ChemInform (25.02.2003)
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Journal Article
Substituted 5-fluoro-1H-pyrazolopyridines and their use
Wunder, Frank, Redlich, Gorden, Hartmann, Elke, Mittendorf, Joachim, Schlemmer, Karl-Heinz, Becker, Eva-Maria, Bierer, Donald, Griebenow, Nils, Jautelat, Rolf, Follmann, Markus, Kroh, Walter, Li, Volkhart Min-Jian, Stasch, Johannes-Peter, Knorr, Andreas, Ackerstaff, Jens
Year of Publication 20.08.2024
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Year of Publication 20.08.2024
Patent
Discovery of riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension
Mittendorf, Joachim, Weigand, Stefan, Alonso-Alija, Cristina, Bischoff, Erwin, Feurer, Achim, Gerisch, Michael, Kern, Armin, Knorr, Andreas, Lang, Dieter, Muenter, Klaus, Radtke, Martin, Schirok, Hartmut, Schlemmer, Karl-Heinz, Stahl, Elke, Straub, Alexander, Wunder, Frank, Stasch, Johannes-Peter
Published in BMC pharmacology (11.08.2009)
Published in BMC pharmacology (11.08.2009)
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AMIDAS DE 4-ARIL-1,4-DIHIDRO-1,6-NAFTIRIDINA SUSTITUIDAS Y COMPOSICIONES FARMACÉU-TICAS QUE LAS CONTIENEN
GROSSER, Rolf, BÁRFACKER, Lars, MÜNTER, Klaus, SCHLEMMER, Karl-Heinz, KLEIN, Martina, ALBRECHT-KÜPPER, Barbara, NITSCHE, Adam, KOLKHOF, Pete, HARTMANN, Elke
Year of Publication 31.08.2021
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Year of Publication 31.08.2021
Patent