Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease
Greengard, Paul, He, Gen, Luo, Wenjie, Li, Peng, Remmers, Christine, Netzer, William J, Hendrick, Joseph, Bettayeb, Karima, Flajolet, Marc, Gorelick, Fred, Wennogle, Lawrence P
Published in Nature (London) (02.09.2010)
Published in Nature (London) (02.09.2010)
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Journal Article
Meriolins (3-(Pyrimidin-4-yl)-7-azaindoles): Synthesis, Kinase Inhibitory Activity, Cellular Effects, and Structure of a CDK2/Cyclin A/Meriolin Complex
Echalier, Aude, Bettayeb, Karima, Ferandin, Yoan, Lozach, Olivier, Clément, Monique, Valette, Annie, Liger, François, Marquet, Bernard, Morris, Jonathan C, Endicott, Jane A, Joseph, Benoît, Meijer, Laurent
Published in Journal of medicinal chemistry (28.02.2008)
Published in Journal of medicinal chemistry (28.02.2008)
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Journal Article
N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine
Bettayeb, Karima, Sallam, Hatem, Ferandin, Yoan, Popowycz, Florence, Fournet, Guy, Hassan, Moustapha, Echalier, Aude, Bernard, Philippe, Endicott, Jane, Joseph, Benoît, Meijer, Laurent
Published in Molecular cancer therapeutics (01.09.2008)
Published in Molecular cancer therapeutics (01.09.2008)
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Journal Article
GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease
Xu, Peng, Chang, Jerry C, Zhou, Xiaopu, Wang, Wei, Bamkole, Michael, Wong, Eitan, Bettayeb, Karima, Jiang, Lu-Lin, Huang, Timothy, Luo, Wenjie, Xu, Huaxi, Nairn, Angus C, Flajolet, Marc, Ip, Nancy Y, Li, Yue-Ming, Greengard, Paul
Published in The Journal of experimental medicine (02.08.2021)
Published in The Journal of experimental medicine (02.08.2021)
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Journal Article
δ-COP modulates Aβ peptide formation via retrograde trafficking of APP
Bettayeb, Karima, Chang, Jerry C., Luo, Wenjie, Aryal, Suvekshya, Varotsis, Dante, Randolph, Lisa, Netzer, William J., Greengard, Paul, Flajolet, Marc
Published in Proceedings of the National Academy of Sciences - PNAS (10.05.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (10.05.2016)
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Journal Article
Relevance of the COPI complex for Alzheimer’s disease progression in vivo
Bettayeb, Karima, Hooli, Basaraj V., Parrado, Antonio R., Randolph, Lisa, Varotsis, Dante, Aryal, Suvekshya, Gresack, Jodi, Tanzi, Rudolph E., Greengard, Paul, Flajolet, Marc
Published in Proceedings of the National Academy of Sciences - PNAS (10.05.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (10.05.2016)
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Journal Article
Soluble 3′,6-Substituted Indirubins with Enhanced Selectivity toward Glycogen Synthase Kinase -3 Alter Circadian Period
Vougogiannopoulou, Konstantina, Ferandin, Yoan, Bettayeb, Karima, Myrianthopoulos, Vassilios, Lozach, Olivier, Fan, Yunzhen, Johnson, Carl Hirschie, Magiatis, Prokopios, Skaltsounis, Alexios-Leandros, Mikros, Emmanuel, Meijer, Laurent
Published in Journal of medicinal chemistry (23.10.2008)
Published in Journal of medicinal chemistry (23.10.2008)
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Journal Article
[delta]-COP modulates A[Beta] peptide formation via retrograde trafficking of APP
Bettayeb, Karima, Chang, Jerry C, Luo, Wenjie, Aryal, Suvekshya, Varotsis, Dante, Randolph, Lisa, Netzer, William J, Greengard, Paul, Flajolet, Marc
Published in Proceedings of the National Academy of Sciences - PNAS (10.05.2016)
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Published in Proceedings of the National Academy of Sciences - PNAS (10.05.2016)
Journal Article
Roscovitine-Derived, Dual-Specificity Inhibitors of Cyclin-Dependent Kinases and Casein Kinases 1
Oumata, Nassima, Bettayeb, Karima, Ferandin, Yoan, Demange, Luc, Lopez-Giral, Angela, Goddard, Marie-Lorène, Myrianthopoulos, Vassilios, Mikros, Emmanuel, Flajolet, Marc, Greengard, Paul, Meijer, Laurent, Galons, Hervé
Published in Journal of medicinal chemistry (11.09.2008)
Published in Journal of medicinal chemistry (11.09.2008)
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Journal Article
Small-molecule inducers of Aβ-42 peptide production share a common mechanism of action
Bettayeb, Karima, Oumata, Nassima, Zhang, Yuanyuan, Luo, Wenjie, Bustos, Victor, Galons, Hervé, Greengard, Paul, Meijer, Laurent, Flajolet, Marc
Published in The FASEB journal (01.12.2012)
Published in The FASEB journal (01.12.2012)
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Journal Article
Pyrazolo[1,5-a]-1,3,5-triazine as a Purine Bioisostere: Access to Potent Cyclin-Dependent Kinase Inhibitor (R)-Roscovitine Analogue
Popowycz, Florence, Fournet, Guy, Schneider, Cédric, Bettayeb, Karima, Ferandin, Yoan, Lamigeon, Cyrile, Tirado, Oscar M, Mateo-Lozano, Silvia, Notario, Vicente, Colas, Pierre, Bernard, Philippe, Meijer, Laurent, Joseph, Benoît
Published in Journal of medicinal chemistry (12.02.2009)
Published in Journal of medicinal chemistry (12.02.2009)
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Journal Article
3‘-Substituted 7-Halogenoindirubins, a New Class of Cell Death Inducing Agents
Ferandin, Yoan, Bettayeb, Karima, Kritsanida, Marina, Lozach, Olivier, Polychronopoulos, Panagiotis, Magiatis, Prokopios, Skaltsounis, Alexios-Leandros, Meijer, Laurent
Published in Journal of medicinal chemistry (27.07.2006)
Published in Journal of medicinal chemistry (27.07.2006)
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Journal Article
Meriolins, a new class of cell death -Inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases
BETTAYEB, Karima, TIRADE, Oscar M, LIGER, Francois, MARQUET, Bernard, JOSEPH, Benoit, ECHALIER, Aude, ENDICOTT, Jane A, NOTARIO, Vicente, MEIJER, Laurent, MARIONNEAU-LAMBOT, Séverine, FERANDIN, Yoan, LOZACH, Olivier, MORRIS, Jonathan C, MATEO-LOZANO, Silvia, DRUECKES, Peter, SCHÄCHTELE, Christoph, KUBBUTAT, Michael H. G
Published in Cancer research (Chicago, Ill.) (01.09.2007)
Published in Cancer research (Chicago, Ill.) (01.09.2007)
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Journal Article
Aftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease?
Hochard, Arnaud, Oumata, Nassima, Bettayeb, Karima, Gloulou, Olfa, Fant, Xavier, Durieu, Emilie, Buron, Nelly, Porceddu, Mathieu, Borgne-Sanchez, Annie, Galons, Hervé, Flajolet, Marc, Meijer, Laurent
Published in Journal of Alzheimer's disease (2013)
Published in Journal of Alzheimer's disease (2013)
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Journal Article
CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells
Bettayeb, Karima, Baunbæk, Dianne, Delehouze, Claire, Loaëc, Nadège, Hole, Alison J, Baumli, Sonja, Endicott, Jane A, Douc-Rasy, Setha, Bénard, Jean, Oumata, Nassima, Galons, Hervé, Meijer, Laurent
Published in Genes & cancer (01.04.2010)
Published in Genes & cancer (01.04.2010)
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Journal Article
Schéma posologique par titration de l’aducanumab : analyse à 24 mois de Prime, une étude de phase 1b randomisée, en double insu, contrôlée par placebo chez des patients atteints de la maladie d’Alzheimer au stade léger ou prodromal
O’gorman, John, Von Rosenstiel, Philipp, Gheuens, Sarah, Chiao, Ping, Nitsch, Roger, Sandrock, Alfred, Bettayeb, Karima
Published in Revue neurologique (01.04.2018)
Published in Revue neurologique (01.04.2018)
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