Generation of T-cell-redirecting bispecific antibodies with differentiated profiles of cytokine release and biodistribution by CD3 affinity tuning
Haber, Lauric, Olson, Kara, Kelly, Marcus P., Crawford, Alison, DiLillo, David J., Tavaré, Richard, Ullman, Erica, Mao, Shu, Canova, Lauren, Sineshchekova, Olga, Finney, Jennifer, Pawashe, Arpita, Patel, Supriya, McKay, Ryan, Rizvi, Sahar, Damko, Ermelinda, Chiu, Danica, Vazzana, Kristin, Ram, Priyanka, Mohrs, Katja, D’Orvilliers, Amanda, Xiao, Jenny, Makonnen, Sosina, Hickey, Carlos, Arnold, Cody, Giurleo, Jason, Chen, Ya Ping, Thwaites, Courtney, Dudgeon, Drew, Bray, Kevin, Rafique, Ashique, Huang, Tammy, Delfino, Frank, Hermann, Aynur, Kirshner, Jessica R., Retter, Marc W., Babb, Robert, MacDonald, Douglas, Chen, Gang, Olson, William C., Thurston, Gavin, Davis, Samuel, Lin, John C., Smith, Eric
Published in Scientific reports (13.07.2021)
Published in Scientific reports (13.07.2021)
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Journal Article
Translational findings for odronextamab: From preclinical research to a first‐in‐human study in patients with CD20+ B‐cell malignancies
Zhu, Min, Olson, Kara, Kirshner, Jessica R., Khaksar Toroghi, Masood, Yan, Hong, Haber, Lauric, Meagher, Craig, Flink, Dina M., Ambati, Srikanth R., Davis, John D., DiCioccio, A. Thomas, Smith, Eric J., Retter, Marc W.
Published in Clinical and translational science (01.04.2022)
Published in Clinical and translational science (01.04.2022)
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Journal Article
T Cells from the Tumor Microenvironment of Patients with Progressive Myeloma Can Generate Strong, Tumor-Specific Cytolytic Responses to Autologous, Tumor-Loaded Dendritic Cells
Dhodapkar, Madhav V., Krasovsky, Joseph, Olson, Kara
Published in Proceedings of the National Academy of Sciences - PNAS (01.10.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (01.10.2002)
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Journal Article
Enhancing understanding of discrete event simulation models through analysis
Olson, Kara A., Overstreet, C. Michael
Published in 2015 Winter Simulation Conference (WSC) (01.12.2015)
Published in 2015 Winter Simulation Conference (WSC) (01.12.2015)
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Conference Proceeding
Journal Article
A risk-based approach to forecasting component obsolescence
Mastrangelo, Christina M., Olson, Kara A., Summers, Dennis M.
Published in Microelectronics and reliability (01.12.2021)
Published in Microelectronics and reliability (01.12.2021)
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Journal Article
A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys
Smith, Eric J., Olson, Kara, Haber, Lauric J., Varghese, Bindu, Duramad, Paurene, Tustian, Andrew D., Oyejide, Adelekan, Kirshner, Jessica R., Canova, Lauren, Menon, Jayanthi, Principio, Jennifer, MacDonald, Douglas, Kantrowitz, Joel, Papadopoulos, Nicholas, Stahl, Neil, Yancopoulos, George D., Thurston, Gavin, Davis, Samuel
Published in Scientific reports (11.12.2015)
Published in Scientific reports (11.12.2015)
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Journal Article
CD22-targeted CD28 bispecific antibody enhances antitumor efficacy of odronextamab in refractory diffuse large B cell lymphoma models
Wei, Joyce, Montalvo-Ortiz, Welby, Yu, Lola, Krasco, Amanda, Olson, Kara, Rizvi, Sahar, Fiaschi, Nathalie, Coetzee, Sandra, Wang, Fang, Ullman, Erica, Ahmed, Hassan Shakil, Herlihy, Evan, Lee, Ken, Havel, Lauren, Potocky, Terra, Ebstein, Sarah, Frleta, Davor, Khatri, Aditi, Godin, Stephen, Hamon, Sara, Brouwer-Visser, Jurriaan, Gorenc, Travis, MacDonald, Doug, Hermann, Aynur, Chaudhry, Aafia, Sirulnik, Andres, Olson, William, Lin, John, Thurston, Gavin, Lowy, Israel, Murphy, Andrew J, Smith, Eric, Jankovic, Vladimir, Sleeman, Matthew A, Skokos, Dimitris
Published in Science translational medicine (09.11.2022)
Published in Science translational medicine (09.11.2022)
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Journal Article
Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells
Yamazaki, Sayuri, Iyoda, Tomonori, Tarbell, Kristin, Olson, Kara, Velinzon, Klara, Inaba, Kayo, Steinman, Ralph M
Published in The Journal of experimental medicine (21.07.2003)
Published in The Journal of experimental medicine (21.07.2003)
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Journal Article
BISPECIFIC ANTI-BCMA×ANTI-CD3 ANTIBODIES AND USES THEREOF
FRANK DELFINO, JESSICA KIRSHNER, OLGA SINESHCHEKOVA, ERIC SMITH, KARA OLSON, DAVID DILILLO, ZHANG QIAN
Year of Publication 27.09.2023
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Year of Publication 27.09.2023
Patent
Abstract 4555: Selection of CD3 affinity allows generation of T-cell redirecting bispecific antibodies with unique pharmacokinetic and biodistribution properties
Haber, Lauric, Olson, Kara, Babb, Robert, Kelly, Marcus, Crawford, Alison, Retter, Marc, DiLillo, David, Ullman, Erica, Finney, Jennifer, Canova, Lauren, Pawashe, Arpita, Chiu, Danica, Vazzana, Kristin, Ram, Priyanka, Mohrs, Katja, Dorvilliers, Amanda, Xiao, Jenny, Makonnen, Sosina, Hickey, Carlos, Arnold, Cody, Giurleo, Jason, Patel, Supriya, Tavare, Richard, Chen, Ya Ping, Chen, Gang, Olson, William, Thurston, Gavin, Lin, John Chia-Yang, Hermann, Aynur, Kirshner, Jessica, Smith, Eric J.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
A BCMAxCD3 bispecific T cell–engaging antibody demonstrates robust antitumor efficacy similar to that of anti-BCMA CAR T cells
DiLillo, David J., Olson, Kara, Mohrs, Katja, Meagher, Thomas Craig, Bray, Kevin, Sineshchekova, Olga, Startz, Thomas, Kuhnert, Jessica, Retter, Marc W., Godin, Stephen, Sharma, Prachi, Delfino, Frank, Lin, John, Smith, Eric, Thurston, Gavin, Kirshner, Jessica R.
Published in Blood advances (09.03.2021)
Published in Blood advances (09.03.2021)
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Journal Article
REGN5458, a Bispecific BCMAxCD3 T Cell Engaging Antibody, Demonstrates Robust In Vitro and In Vivo Anti-Tumor Efficacy in Multiple Myeloma Models, Comparable to That of BCMA CAR T Cells
Dilillo, David J, Olson, Kara, Mohrs, Katja, Meagher, T. Craig, Bray, Kevin, Sineshchekova, Olga, Startz, Thomas, Retter, Marc, Godin, Stephen, Delfino, Frank, Lin, John, Smith, Eric, Thurston, Olin Gavin, Kirshner, Jessica R.
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Journal Article
CD20xCD3 Bispecific Fully Human Antibody Induces Potent Anti-Tumor Activity Against CD20-Expressing Tumors in Immune Competent Mice Humanized for CD20 and CD3
Varghese, Bindu, Menon, Jayanthi, Rodriguez, Luis, Olson, Kara, Krueger, Pamela, Huang, Tammy, Smith, Eric, Thurston, Gavin, Kirshner, Jessica R.
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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Journal Article
A Novel CD20xCD3 Bispecific Fully Human Antibody Induces Potent Anti-Tumor Effects Against B Cell Lymphoma in Mice
Varghese, Bindu, Menon, Jayanthi, Rodriguez, Luis, Haber, Lauric, Olson, Kara, Duramad, Paurene, Oyejide, Adelekan, Smith, Eric, Thurston, Gavin, Kirshner, Jessica
Published in Blood (06.12.2014)
Published in Blood (06.12.2014)
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Journal Article
Abstract A193: Fully human bispecific antibodies induce potent anti-tumor effects against prostate tumors in mice
Crawford, Alison, Vazzana, Kristin, VanValkenburgh, Jeffrey, Haber, Lauric, Principio, Jennifer, Gurer, Cagan, Olson, Kara, Smith, Eric, Thurston, Gavin, Kirshner, Jessica R.
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Journal Article
Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses
Kelleher, A D, Long, C, Holmes, E C, Allen, R L, Wilson, J, Conlon, C, Workman, C, Shaunak, S, Olson, K, Goulder, P, Brander, C, Ogg, G, Sullivan, J S, Dyer, W, Jones, I, McMichael, A J, Rowland-Jones, S, Phillips, R E
Published in The Journal of experimental medicine (05.02.2001)
Published in The Journal of experimental medicine (05.02.2001)
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Journal Article
Ongoing Dll4‐Notch signaling is required for T‐cell homeostasis in the adult thymus
Billiard, Fabienne, Kirshner, Jessica R., Tait, Michelle, Danave, Amanda, Taheri, Sean, Zhang, Wen, Waite, Janelle C., Olson, Kara, Chen, Guoying, Coetzee, Sandra, Hylton, Donna, Murphy, Andrew J., Yancopoulos, George D., Thurston, Gavin, Skokos, Dimitris
Published in European journal of immunology (01.08.2011)
Published in European journal of immunology (01.08.2011)
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Journal Article