NCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for Iron-Sulfur Cluster Proteins
Santana-Codina, Naiara, Del Rey, Maria Quiles, Kapner, Kevin S, Zhang, Huan, Gikandi, Ajami, Malcolm, Callum, Poupault, Clara, Kuljanin, Miljan, John, Kristen M, Biancur, Douglas E, Chen, Brandon, Das, Nupur K, Lowder, Kristen E, Hennessey, Connor J, Huang, Wesley, Yang, Annan, Shah, Yatrik M, Nowak, Jonathan A, Aguirre, Andrew J, Mancias, Joseph D
Published in Cancer discovery (02.09.2022)
Published in Cancer discovery (02.09.2022)
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Journal Article
Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
Waters, Andrew M., Khatib, Tala O., Papke, Bjoern, Goodwin, Craig M., Hobbs, G. Aaron, Diehl, J. Nathaniel, Yang, Runying, Edwards, A. Cole, Walsh, Katherine H., Sulahian, Rita, McFarland, James M., Kapner, Kevin S., Gilbert, Thomas S.K., Stalnecker, Clint A., Javaid, Sehrish, Barkovskaya, Anna, Grover, Kajal R., Hibshman, Priya S., Blake, Devon R., Schaefer, Antje, Nowak, Katherine M., Klomp, Jennifer E., Hayes, Tikvah K., Kassner, Michelle, Tang, Nanyun, Tanaseichuk, Olga, Chen, Kaisheng, Zhou, Yingyao, Kalkat, Manpreet, Herring, Laura E., Graves, Lee M., Penn, Linda Z., Yin, Hongwei H., Aguirre, Andrew J., Hahn, William C., Cox, Adrienne D., Der, Channing J.
Published in Cell reports (Cambridge) (29.06.2021)
Published in Cell reports (Cambridge) (29.06.2021)
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Journal Article
Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer
Raghavan, Srivatsan, Winter, Peter S., Navia, Andrew W., Williams, Hannah L., DenAdel, Alan, Lowder, Kristen E., Galvez-Reyes, Jennyfer, Kalekar, Radha L., Mulugeta, Nolawit, Kapner, Kevin S., Raghavan, Manisha S., Borah, Ashir A., Liu, Nuo, Väyrynen, Sara A., Costa, Andressa Dias, Ng, Raymond W.S., Wang, Junning, Hill, Emma K., Ragon, Dorisanne Y., Brais, Lauren K., Jaeger, Alex M., Spurr, Liam F., Li, Yvonne Y., Cherniack, Andrew D., Booker, Matthew A., Cohen, Elizabeth F., Tolstorukov, Michael Y., Wakiro, Isaac, Rotem, Asaf, Johnson, Bruce E., McFarland, James M., Sicinska, Ewa T., Jacks, Tyler E., Sullivan, Ryan J., Shapiro, Geoffrey I., Clancy, Thomas E., Perez, Kimberly, Rubinson, Douglas A., Ng, Kimmie, Cleary, James M., Crawford, Lorin, Manalis, Scott R., Nowak, Jonathan A., Wolpin, Brian M., Hahn, William C., Aguirre, Andrew J., Shalek, Alex K.
Published in Cell (09.12.2021)
Published in Cell (09.12.2021)
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Journal Article
Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer
Biancur, Douglas E., Kapner, Kevin S., Yamamoto, Keisuke, Banh, Robert S., Neggers, Jasper E., Sohn, Albert S.W., Wu, Warren, Manguso, Robert T., Brown, Adam, Root, David E., Aguirre, Andrew J., Kimmelman, Alec C.
Published in Cell metabolism (05.01.2021)
Published in Cell metabolism (05.01.2021)
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Journal Article
Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer
Tong, Xinyuan, Patel, Ayushi S., Kim, Eejung, Li, Hongjun, Chen, Yueqing, Li, Shuai, Liu, Shengwu, Dilly, Julien, Kapner, Kevin S., Zhang, Ningxia, Xue, Yun, Hover, Laura, Mukhopadhyay, Suman, Sherman, Fiona, Myndzar, Khrystyna, Sahu, Priyanka, Gao, Yijun, Li, Fei, Li, Fuming, Fang, Zhaoyuan, Jin, Yujuan, Gao, Juntao, Shi, Minglei, Sinha, Satrajit, Chen, Luonan, Chen, Yang, Kheoh, Thian, Yang, Wenjing, Yanai, Itai, Moreira, Andre L., Velcheti, Vamsidhar, Neel, Benjamin G., Hu, Liang, Christensen, James G., Olson, Peter, Gao, Dong, Zhang, Michael Q., Aguirre, Andrew J., Wong, Kwok-Kin, Ji, Hongbin
Published in Cancer cell (11.03.2024)
Published in Cancer cell (11.03.2024)
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Journal Article
Oncogenic Drivers and Therapeutic Vulnerabilities in KRAS Wild-Type Pancreatic Cancer
Singh, Harshabad, Keller, Rachel B, Kapner, Kevin S, Dilly, Julien, Raghavan, Srivatsan, Yuan, Chen, Cohen, Elizabeth F, Tolstorukov, Michael, Andrews, Elizabeth, Brais, Lauren K, da Silva, Annacarolina, Perez, Kimberly, Rubinson, Douglas A, Surana, Rishi, Giannakis, Marios, Ng, Kimmie, Clancy, Thomas E, Yurgelun, Matthew B, Schlechter, Benjamin L, Clark, Jeffrey W, Shapiro, Geoffrey I, Rosenthal, Michael H, Hornick, Jason L, Nardi, Valentina, Li, Yvonne Y, Gupta, Hersh, Cherniack, Andrew D, Meyerson, Matthew, Cleary, James M, Nowak, Jonathan A, Wolpin, Brian M, Aguirre, Andrew J
Published in Clinical cancer research (14.11.2023)
Published in Clinical cancer research (14.11.2023)
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Journal Article
Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity
Williams, Hannah L, Dias Costa, Andressa, Zhang, Jinming, Raghavan, Srivatsan, Winter, Peter S, Kapner, Kevin S, Ginebaugh, Scott P, Väyrynen, Sara A, Väyrynen, Juha P, Yuan, Chen, Navia, Andrew W, Wang, Junning, Yang, Annan, Bosse, Timothy L, Kalekar, Radha L, Lowder, Kristen E, Lau, Mai Chan, Elganainy, Dalia, Morales-Oyarvide, Vicente, Rubinson, Douglas A, Singh, Harshabad, Perez, Kimberly, Cleary, James M, Clancy, Thomas E, Wang, Jiping, Mancias, Joseph D, Brais, Lauren K, Hill, Emma R, Kozak, Margaret M, Linehan, David C, Dunne, Richard F, Chang, Daniel T, Koong, Albert C, Hezel, Aram F, Hahn, William C, Shalek, Alex K, Aguirre, Andrew J, Nowak, Jonathan A, Wolpin, Brian M
Published in Cancer research (Chicago, Ill.) (03.02.2023)
Published in Cancer research (Chicago, Ill.) (03.02.2023)
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Journal Article
Clinical and genomic features of classical and basal transcriptional subtypes in pancreatic cancer
Singh, Harshabad, Xiu, Joanne, Kapner, Kevin S, Yuan, Chen, Narayan, Raja R, Oberley, Matthew, Farrell, Alex, Surana, Rishi, Huffman, Brandon M, Perez, Kimberly, Cleary, James M, Jordan, Alexander C, Dias Costa, Andressa, Williams, Hannah L, Raghavan, Srivatsan, Weinberg, Benjamin, Pishvaian, Michael J, Shroff, Rachna, Goel, Sanjay, Dougan, Stephanie K, Nowak, Jonathan A, Spetzler, David, Sledge, George, Wolpin, Brian M, Aguirre, Andrew J
Published in Clinical cancer research (01.11.2024)
Published in Clinical cancer research (01.11.2024)
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Journal Article
Sotorasib Is a Pan-RASG12C Inhibitor Capable of Driving Clinical Response in NRASG12C Cancers
Rubinson, Douglas A, Tanaka, Noritaka, Fece de la Cruz, Ferran, Kapner, Kevin S, Rosenthal, Michael H, Norden, Bryanna L, Barnes, Haley, Ehnstrom, Sara, Morales-Giron, Alvin A, Brais, Lauren K, Lemke, Christopher T, Aguirre, Andrew J, Corcoran, Ryan B
Published in Cancer discovery (01.05.2024)
Published in Cancer discovery (01.05.2024)
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Journal Article
Differential Outcomes in Codon 12/13 and Codon 61 NRAS -Mutated Cancers in the Phase II NCI-MATCH Trial of Binimetinib in Patients with NRAS -Mutated Tumors
Cleary, James M, Wang, Victoria, Heist, Rebecca S, Kopetz, E Scott, Mitchell, Edith P, Zwiebel, James A, Kapner, Kevin S, Chen, Helen X, Li, Shuli, Gray, Robert J, McShane, Lisa M, Rubinstein, Larry V, Patton, David R, Meric-Bernstam, Funda, Dillmon, Melissa S, Williams, P Mickey, Hamilton, Stanley R, Conley, Barbara A, Aguirre, Andrew J, O'Dwyer, Peter J, Harris, Lyndsay N, Arteaga, Carlos L, Chen, Alice P, Flaherty, Keith T
Published in Clinical cancer research (01.06.2021)
Published in Clinical cancer research (01.06.2021)
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Journal Article
A Phase I Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-dose Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma
Huffman, Brandon M, Feng, Hanrong, Parmar, Kalindi, Wang, Junning, Kapner, Kevin S, Kochupurakkal, Bose, Martignetti, David B, Sadatrezaei, Golbahar, Abrams, Thomas A, Biller, Leah H, Giannakis, Marios, Ng, Kimmie, Patel, Anuj K, Perez, Kimberly J, Singh, Harshabad, Rubinson, Douglas A, Schlechter, Benjamin L, Andrews, Elizabeth, Hannigan, Alison M, Dunwell, Stanley, Getchell, Zoe, Raghavan, Srivatsan, Wolpin, Brian M, Fortier, Caroline, D'Andrea, Alan D, Aguirre, Andrew J, Shapiro, Geoffrey I, Cleary, James M
Published in Clinical cancer research (15.12.2023)
Published in Clinical cancer research (15.12.2023)
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Journal Article
1408 Non-canonical peptide sources broaden the landscape of targetable antigens in pancreatic cancer
Ely, Zackery A, Kulstad, Zachary J, Abelin, Jennifer G, Verzani, Eva K, Addepalli, Sudarsana, Clauser, Karl, Kapner, Kevin S, Hennessey, Connor J, Agus, Miles, Klaeger, Susan, Jaeger, Alex M, Su, Jennifer, Greenberg, Philip D, Aguirre, Andrew J, Carr, Steven, Jacks, Tyler, Freed-Pastor, William
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity
Kwon, Jason J, Dilly, Julien, Liu, Shengwu, Kim, Eejung, Bian, Yuemin, Dharmaiah, Srisathiyanarayanan, Tran, Timothy H, Kapner, Kevin S, Ly, Seav Huong, Yang, Xiaoping, Rabara, Dana, Waybright, Timothy J, Giacomelli, Andrew O, Hong, Andrew L, Misek, Sean, Wang, Belinda, Ravi, Arvind, Doench, John G, Beroukhim, Rameen, Lemke, Christopher T, Haigis, Kevin M, Esposito, Dominic, Root, David E, Nissley, Dwight V, Stephen, Andrew G, McCormick, Frank, Simanshu, Dhirendra K, Hahn, William C, Aguirre, Andrew J
Published in bioRxiv (25.10.2024)
Published in bioRxiv (25.10.2024)
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Journal Article
Sotorasib Is a Pan- RAS G12C Inhibitor Capable of Driving Clinical Response in NRAS G12C Cancers
Rubinson, Douglas A., Tanaka, Noritaka, Fece de la Cruz, Ferran, Kapner, Kevin S., Rosenthal, Michael H., Norden, Bryanna L., Barnes, Haley, Ehnstrom, Sara, Morales-Giron, Alvin A., Brais, Lauren K., Lemke, Christopher T., Aguirre, Andrew J., Corcoran, Ryan B.
Published in Cancer discovery (01.05.2024)
Published in Cancer discovery (01.05.2024)
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Journal Article
Clinical genomic implications of transcriptional subtypes in pancreatic cancer
Singh, Harshabad, Kapner, Kevin S, Xiu, Joanne, Oberley, Matthew James, Farrell, Alex Patrick, Guo, Jimmy, Surana, Rishi, Perez, Kimberly, Cleary, James M., Raghavan, Srivatsan, Weinberg, Benjamin Adam, Pishvaian, Michael J., Shroff, Rachna T., Goel, Sanjay, Dougan, Stephanie, Nowak, Jonathan, Spetzler, David, Sledge, George W., Wolpin, Brian M., Aguirre, Andrew
Published in Journal of clinical oncology (01.06.2023)
Published in Journal of clinical oncology (01.06.2023)
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Journal Article
A Phase 1 Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-Dose Gemcitabine in Metastatic Pancreatic Adenocarcinoma Patients
Huffman, Brandon M., Feng, Hanrong, Parmar, Kalindi, Wang, Junning, Kapner, Kevin S., Kochupurakkal, Bose, Martignetti, David B., Sadatrezaei, Golbahar, Abrams, Thomas A., Biller, Leah H., Giannakis, Marios, Ng, Kimmie, Patel, Anuj K., Perez, Kimberly J., Singh, Harshabad, Rubinson, Douglas A., Schlechter, Benjamin L., Andrews, Elizabeth, Hannigan, Alison M., Dunwell, Stanley, Getchell, Zoe, Raghavan, Srivatsan, Wolpin, Brian M., Fortier, Caroline, D’Andrea, Alan D., Aguirre, Andrew J., Shapiro, Geoffrey I., Cleary, James M.
Published in Clinical cancer research (15.12.2023)
Published in Clinical cancer research (15.12.2023)
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Journal Article
Abstract PR-006: Integrative genomic characterization of therapeutic targets for pancreatic cancer
Guo, Jimmy A., Zhao, Daniel, Ginebaugh, Scott P., Wang, Steven, Jambhale, Ananya D., Yu, Patrick Z., Wu, Westley W., Chen, Peter, Zhao, Maryann, Lowder, Kristen E., Kapner, Kevin S., Hoffman, Hannah I., Cheng, Stephanie W., Kim, Daniel Y., Boiarsky, Rebecca, Aguet, Francois, Paolella, Brenton, Krill-Burger, John M., McFarland, James M., Oni, Tobiloba, Jacks, Tyler, Regev, Aviv, Getz, Gad, Hwang, William L., Singh, Harshabad, Aguirre, Andrew J.
Published in Cancer research (Chicago, Ill.) (15.11.2021)
Published in Cancer research (Chicago, Ill.) (15.11.2021)
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Journal Article
Spatially-resolved single-cell assessment of pancreatic cancer expression subtypes reveals co-expressor phenotypes and extensive intra-tumoral heterogeneity
Williams, Hannah L., Dias Costa, Andressa, Zhang, Jinming, Raghavan, Srivatsan, Winter, Peter S., Kapner, Kevin S., Ginebaugh, Scott P., Väyrynen, Sara A., Väyrynen, Juha P., Yuan, Chen, Navia, Andrew W., Wang, Junning, Yang, Annan, Bosse, Timothy L., Kalekar, Radha L., Lowder, Kristen E., Lau, Mai Chan, Elganainy, Dalia, Morales-Oyarvide, Vicente, Rubinson, Douglas A., Singh, Harshabad, Perez, Kimberly, Cleary, James M., Clancy, Thomas E., Wang, Jiping, Mancias, Joseph D., Brais, Lauren K., Hill, Emma R., Kozak, Margaret M., Linehan, David C., Dunne, Richard F., Chang, Daniel T., Koong, Albert C., Hezel, Aram F., Hahn, William C., Shalek, Alex K., Aguirre, Andrew J., Nowak, Jonathan A., Wolpin, Brian M.
Published in Cancer research (Chicago, Ill.) (03.02.2023)
Published in Cancer research (Chicago, Ill.) (03.02.2023)
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Abstract PO-013: MTAP protein expression is lost in nearly one-third of primary pancreatic cancers and is associated with sensitivity to MAT2A inhibition in patient-derived organoid models
Väyrynen, Sara A., Yang, Annan, Wang, Junning, Zhang, Jinming, Lowder, Kristen, Kapner, Kevin S., Bosse, Tim, Raghavan, Sri, Costa, Andressa Dias, Williams, Hannah, Yuan, Chen, Pelton, Ashley, Morales-Oyarvide, Vicente, Rubinson, Douglas A., Brais, Lauren, Reilly, Emma, Kozak, Margaret M., Linehan, David C., Dunne, Richard F., Chang, Daniel T., Koong, Albert C., Hezel, Aram F., Wolpin, Brian M., Nowak, Jonathan A, Aguirre, Andrew J
Published in Cancer research (Chicago, Ill.) (15.11.2020)
Published in Cancer research (Chicago, Ill.) (15.11.2020)
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Journal Article
Mechanisms of resistance to oncogenic KRAS inhibition in pancreatic cancer
Dilly, Julien, Hoffman, Megan T, Abbassi, Laleh, Li, Ziyue, Paradiso, Francesca, Parent, Brendan D, Hennessey, Connor J, Jordan, Alexander C, Morgado, Micaela, Dasgupta, Shatavisha, Uribe, Giselle A, Yang, Annan, Kapner, Kevin S, Hambitzer, Felix P, Qiang, Li, Feng, Hanrong, Geisberg, Jacob, Wang, Junning, Evans, Kyle E, Lyu, Hengyu, Schalck, Aislyn, Feng, Ningping, Lopez, Anastasia M, Bristow, Christopher A, Kim, Michael P, Rajapakshe, Kimal I, Bahrambeigi, Vahid, Roth, Jennifer A, Garg, Kavita, Guerrero, Paola A, Stanger, Ben Z, Cristea, Simona, Lowe, Scott W, Baslan, Timour, Van Allen, Eliezer M, Mancias, Joseph D, Chan, Emily, Anderson, Abraham, Katlinskaya, Yuliya V, Shalek, Alex K, Hong, David S, Pant, Shubham, Hallin, Jill, Anderes, Kenna, Olson, Peter, Heffernan, Timothy P, Chugh, Seema, Christensen, James G, Maitra, Anirban, Wolpin, Brian M, Raghavan, Srivatsan, Nowak, Jonathan A, Winter, Peter S, Dougan, Stephanie K, Aguirre, Andrew J
Published in Cancer discovery (01.11.2024)
Published in Cancer discovery (01.11.2024)
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