NDI-010976, A Potent, Liver-Directed, Oral Inhibitor of Acetyl Coa Carboxylase for Non-Alcoholic Steatohepatitis: A Phase 1 Single Ascending Dose Study in Healthy Volunteers
Westlin, W.F, Harriman, G, Harwood, H.J, Kapeller, R, Lennon, S, Miao, W, Stiede, K, Schmalbach, T
Published in Journal of hepatology (2016)
Published in Journal of hepatology (2016)
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Journal Article
LP30 : Liver-directed allosteric inhibitors of acetyl-coa carboxylase favorably impact pathophysiology in the progression from nafld to nash and hepatocellular carcinoma, including hepatic steatosis, inflammation, and fibrosis
Westlin, W.F, Harwood, H.J, DePeralta, D.K, Moaven, O, Wei, L, Greenwood, J, Bhat, S, Fuchs, B.C, Kapeller, R, Harriman, G
Published in Journal of hepatology (01.04.2015)
Published in Journal of hepatology (01.04.2015)
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Journal Article
NDI-010976, a Potent, Liver-Directed, Oral Inhibitor of Acetyl Coa Carboxylase for Non-Alcoholic Steatohepatitis: Pharmacodynamic Effects on Hepatic De Novo Lipogenesis in Obese but Otherwise Healthy Adult Male Volunteers
Westlin, W.F, Blanchette, H, Harriman, G, Harwood, H.J, Kapeller, R, Lennon, S, Miao, W, Beysen, C, Dalidd, M, Turner, S, Stiede, K, Schmalbach, T
Published in Journal of hepatology (2016)
Published in Journal of hepatology (2016)
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Journal Article
Activation of Phosphatidylinositol 3-Kinase by Insulin
Ruderman, Neil B., Kapeller, Rosana, White, Morris F., Cantley, Lewis C.
Published in Proceedings of the National Academy of Sciences - PNAS (01.02.1990)
Published in Proceedings of the National Academy of Sciences - PNAS (01.02.1990)
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Journal Article
RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes
Yowe, D, Weich, N, Prabhudas, M, Poisson, L, Errada, P, Kapeller, R, Yu, K, Faron, L, Shen, M, Cleary, J, Wilkie, T M, Gutierrez-Ramos, C, Hodge, M R
Published in Biochemical journal (01.10.2001)
Published in Biochemical journal (01.10.2001)
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Internalization of activated platelet-derived growth factor receptor-phosphatidylinositol-3' kinase complexes: potential interactions with the microtubule cytoskeleton
KAPELLER, R, RANJAN CHAKRABARTI, CANTLEY, L, FAY, F, CORVERA, S
Published in Molecular and Cellular Biology (01.10.1993)
Published in Molecular and Cellular Biology (01.10.1993)
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Journal Article
FRI-355 - NDI-010976, A Potent, Liver-Directed, Oral Inhibitor of Acetyl Coa Carboxylase for Non-Alcoholic Steatohepatitis: A Phase 1 Single Ascending Dose Study in Healthy Volunteers
Westlin, W.F., Harriman, G., Harwood, H.J., Kapeller, R., Lennon, S., Miao, W., Stiede, K., Schmalbach, T.
Published in Journal of hepatology (2016)
Published in Journal of hepatology (2016)
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Journal Article
FRI-087 - ACC inhibitor demonstrates potent anti-fibrotic activity in vitro and in vivo
Bates, J., Ghoshal, S., Wei, L., Hollenback, D., Liu, K., Kusam, S., Sulfab, M., Liu, H., Brockett, R., Newstrom, D., Mikaelian, I., Wang, T., Harriman, G., Westlin, W.F., Rocnik, J., Harwood, H.J., Kapeller, R., Ray, A., Breckenridge, D., Fuchs, B.C.
Published in Journal of hepatology (01.04.2018)
Published in Journal of hepatology (01.04.2018)
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Journal Article
ACC inhibitor demonstrates potent anti-fibrotic activity in vitro and in vivo
Bates, J., Ghoshal, S., Wei, L., Hollenback, D., Liu, K., Kusam, S., Sulfab, M., Liu, H., Brockett, R., Newstrom, D., Mikaelian, I., Wang, T., Harriman, G., Westlin, W.F., Rocnik, J., Harwood, H.J., Kapeller, R., Ray, A., Breckenridge, D., Fuchs, B.C.
Published in Journal of hepatology (01.04.2018)
Published in Journal of hepatology (01.04.2018)
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Journal Article
Interactions of polyomavirus middle T with the SH2 domains of the pp85 subunit of phosphatidylinositol-3-kinase
YOAKIM, M, WEIMIN HOU, YUXI LIU, CARPENTER, C. L, KAPELLER, R, SCHAFFHAUSEN, B. S
Published in Journal of Virology (01.09.1992)
Published in Journal of Virology (01.09.1992)
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Journal Article
PS108 - NDI-010976, a Potent, Liver-Directed, Oral Inhibitor of Acetyl Coa Carboxylase for Non-Alcoholic Steatohepatitis: Pharmacodynamic Effects on Hepatic De Novo Lipogenesis in Obese but Otherwise Healthy Adult Male Volunteers
Westlin, W.F., Blanchette, H., Harriman, G., Harwood, H.J., Kapeller, R., Lennon, S., Miao, W., Beysen, C., Dalidd, M., Turner, S., Stiede, K., Schmalbach, T.
Published in Journal of hepatology (2016)
Published in Journal of hepatology (2016)
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Journal Article
Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase
PRASAD, K. V. S, KAPELLER, R, JANSSEN, O, REPKE, H, DUKE-COHAN, J. S, CANTLEY, L. C, RUDD, C. E
Published in Molecular and Cellular Biology (01.12.1993)
Published in Molecular and Cellular Biology (01.12.1993)
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Journal Article
Oncogenes and signal transduction
Cantley, Lewis C, Auger, Kurt R, Carpenter, Christopher, Duckworth, Brian, Graziani, Andrea, Kapeller, Rosana, Soltoff, Stephen
Published in Cell (25.01.1991)
Published in Cell (25.01.1991)
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Book Review
Journal Article
Dual Specificity MAPK Phosphatase 3 Activates PEPCK Gene Transcription and Increases Gluconeogenesis in Rat Hepatoma Cells
Xu, Haiyan, Yang, Qing, Shen, Minhui, Huang, Xueming, Dembski, Marlene, Gimeno, Ruth, Tartaglia, Louis A., Kapeller, Rosana, Wu, Zhidan
Published in The Journal of biological chemistry (28.10.2005)
Published in The Journal of biological chemistry (28.10.2005)
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