Phase I Study of a Novel Oral Janus Kinase 2 Inhibitor, SB1518, in Patients With Relapsed Lymphoma: Evidence of Clinical and Biologic Activity in Multiple Lymphoma Subtypes
Younes, Anas, Romaguera, Jorge, Fanale, Michelle, McLaughlin, Peter, Hagemeister, Frederick, Copeland, Amanda, Neelapu, Sattva, Kwak, Larry, Shah, Jatin, de Castro Faria, Silvana, Hart, Stefan, Wood, Jeanette, Jayaraman, Ramesh, Ethirajulu, Kantharaj, Zhu, Joy
Published in Journal of clinical oncology (20.11.2012)
Published in Journal of clinical oncology (20.11.2012)
Get full text
Journal Article
Discovery of (2E)-3-{2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an Orally Active Histone Deacetylase Inhibitor with a Superior Preclinical Profile
Wang, Haishan, Yu, Niefang, Chen, Dizhong, Lee, Ken Chi Lik, Lye, Pek Ling, Chang, Joyce Wei Wei, Deng, Weiping, Ng, Melvin Chi Yeh, Lu, Ting, Khoo, Mui Ling, Poulsen, Anders, Sangthongpitag, Kanda, Wu, Xiaofeng, Hu, Changyong, Goh, Kee Chuan, Wang, Xukun, Fang, Lijuan, Goh, Kay Lin, Khng, Hwee Hoon, Goh, Siok Kun, Yeo, Pauline, Liu, Xin, Bonday, Zahid, Wood, Jeanette M, Dymock, Brian W, Kantharaj, Ethirajulu, Sun, Eric T
Published in Journal of medicinal chemistry (14.07.2011)
Published in Journal of medicinal chemistry (14.07.2011)
Get full text
Journal Article
VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer
Hart, Stefan, Novotny-Diermayr, Veronica, Goh, Kee Chuan, Williams, Meredith, Tan, Yong Cheng, Ong, Lai Chun, Cheong, Albert, Ng, Bee Kheng, Amalini, Chithra, Madan, Babita, Nagaraj, Harish, Jayaraman, Ramesh, Pasha, Khalid M, Ethirajulu, Kantharaj, Chng, Wee Joo, Mustafa, Nurulhuda, Goh, Boon Cher, Benes, Cyril, McDermott, Ultan, Garnett, Mathew, Dymock, Brian, Wood, Jeanette M
Published in Molecular cancer therapeutics (01.02.2013)
Published in Molecular cancer therapeutics (01.02.2013)
Get full text
Journal Article
First‐in‐Human, Healthy Volunteers Integrated Protocol of ETC‐206, an Oral Mnk 1/2 Kinase Inhibitor Oncology Drug
Teneggi, Vincenzo, Novotny‐Diermayr, Veronica, Lee, Lay Hoon, Yasin, Maryam, Yeo, Pauline, Ethirajulu, Kantharaj, Gan, Sylvia Bong Hwa, Blanchard, Stephanie E., Nellore, Ranjani, Umrani, Dhananjay N., Gomeni, Roberto, Teck, Darren Lim Wan, Li, Greg, Lu, Qing Shu, Cao, Yang, Matter, Alex
Published in Clinical and translational science (01.01.2020)
Published in Clinical and translational science (01.01.2020)
Get full text
Journal Article
In Vitro Phase I Cytochrome P450 Metabolism, Permeability and Pharmacokinetics of SB639, a Novel Histone Deacetylase Inhibitor in Preclinical Species
Venkatesh, Pilla Reddy, Goh, Evelyn, Zeng, Peizi, New, Lee Sun, Xin, Liu, Pasha, Mohammed Khalid, Sangthongpitag, Kanda, Yeo, Pauline, Kantharaj, Ethirajulu
Published in Biological & Pharmaceutical Bulletin (01.05.2007)
Published in Biological & Pharmaceutical Bulletin (01.05.2007)
Get full text
Journal Article
Preclinical Metabolism and Pharmacokinetics of SB1317 (TG02), a Potent CDK/JAK2/FLT3 Inhibitor
Mohammed Khalid Pasha, Ramesh Jayaraman, Venkatesh Pilla Reddy, Pauline Yeo, Evelyn Goh, Anthony Williams, Kee Chuan Goh, Ethirajulu Kantharaj
Published in Drug metabolism letters (01.05.2012)
Published in Drug metabolism letters (01.05.2012)
Get full text
Journal Article
Development and validation of high-performance liquid chromatography-tandem mass spectrometry assay for 6-(3-benzoyl-ureido)-hexanoic acid hydroxyamide, a novel HDAC inhibitor, in mouse plasma for pharmacokinetic studies
Yeo, Pauline, Xin, Liu, Goh, Evelyn, New, Lee Sun, Zeng, Peizi, Wu, Xiaofeng, Venkatesh, P., Kantharaj, Ethirajulu
Published in Biomedical chromatography (01.02.2007)
Published in Biomedical chromatography (01.02.2007)
Get full text
Journal Article
The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody
Chan, Conrad E. Z, Seah, Shirley G. K, Chye, De Hoe, Massey, Shane, Torres, Maricela, Lim, Angeline P. C, Wong, Steven K. K, Neo, Jacklyn J. Y, Wong, Pui San, Lim, Jie Hui, Loh, Gary S. L, Wang, Dongling, Boyd-Kirkup, Jerome D, Guan, Siyu, Thakkar, Dipti, Teo, Guo Hui, Purushotorman, Kiren, Hutchinson, Paul E, Young, Barnaby E, Low, Jenny G, MacAry, Paul A, Hentze, Hannes, Prativadibhayankara, Venkateshan S, Ethirajulu, Kantharaj, Comer, Jason E, Tseng, Chien-Te K, Barrett, Alan D. T, Ingram, Piers J, Brasel, Trevor, Hanson, Brendon John
Published in PloS one (23.06.2021)
Published in PloS one (23.06.2021)
Get full text
Journal Article
Discovery of the Macrocycle 11-(2-Pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a Potent Janus Kinase 2/Fms-Like Tyrosine Kinase-3 (JAK2/FLT3) Inhibitor for the Treatment of Myelofibrosis and Lymphoma
William, Anthony D, Lee, Angeline C.-H, Blanchard, Stéphanie, Poulsen, Anders, Teo, Ee Ling, Nagaraj, Harish, Tan, Evelyn, Chen, Dizhong, Williams, Meredith, Sun, Eric T, Goh, Kee Chuan, Ong, Wai Chung, Goh, Siok Kun, Hart, Stefan, Jayaraman, Ramesh, Pasha, Mohammed Khalid, Ethirajulu, Kantharaj, Wood, Jeanette M, Dymock, Brian W
Published in Journal of medicinal chemistry (14.07.2011)
Published in Journal of medicinal chemistry (14.07.2011)
Get full text
Journal Article
Safety and immunogenicity of a virus-like particle pandemic influenza A (H1N1) 2009 vaccine: Results from a double-blinded, randomized Phase I clinical trial in healthy Asian volunteers
Low, Jenny G.H, Lee, Lawrence S, Ooi, Eng Eong, Ethirajulu, Kantharaj, Yeo, Pauline, Matter, Alex, Connolly, John E, Skibinski, David A.G, Saudan, Philippe, Bachmann, Martin, Hanson, Brendon J, Lu, Qingshu, Maurer-Stroh, Sebastian, Lim, Sam, Novotny-Diermayr, Veronica
Published in Vaccine (03.09.2014)
Published in Vaccine (03.09.2014)
Get full text
Journal Article
Discovery of Kinase Spectrum Selective Macrocycle (16E)-14-Methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a Potent Inhibitor of Cyclin Dependent Kinases (CDKs), Janus Kinase 2 (JAK2), and Fms-like Tyrosine Kinase-3 (FLT3) for the Treatment of Cancer
William, Anthony D, Lee, Angeline C.-H, Goh, Kee Chuan, Blanchard, Stéphanie, Poulsen, Anders, Teo, Ee Ling, Nagaraj, Harish, Lee, Chai Ping, Wang, Haishan, Williams, Meredith, Sun, Eric T, Hu, Changyong, Jayaraman, Ramesh, Pasha, Mohammed Khalid, Ethirajulu, Kantharaj, Wood, Jeanette M, Dymock, Brian W
Published in Journal of medicinal chemistry (12.01.2012)
Published in Journal of medicinal chemistry (12.01.2012)
Get full text
Journal Article
SB939, a novel potent and orally active histone deacetylase inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer
Novotny-Diermayr, Veronica, Sangthongpitag, Kanda, Hu, Chang Yong, Wu, Xiaofeng, Sausgruber, Nina, Yeo, Pauline, Greicius, Gediminas, Pettersson, Sven, Liang, Ai Leng, Loh, Yung Kiang, Bonday, Zahid, Goh, Kee Chuan, Hentze, Hannes, Hart, Stefan, Wang, Haishan, Ethirajulu, Kantharaj, Wood, Jeanette Marjorie
Published in Molecular cancer therapeutics (01.03.2010)
Published in Molecular cancer therapeutics (01.03.2010)
Get full text
Journal Article
SB1578, a novel inhibitor of JAK2, FLT3, and c-Fms for the treatment of rheumatoid arthritis
Madan, Babita, Goh, Kee Chuan, Hart, Stefan, William, Anthony D, Jayaraman, Ramesh, Ethirajulu, Kantharaj, Dymock, Brian W, Wood, Jeanette M
Published in The Journal of immunology (1950) (15.10.2012)
Published in The Journal of immunology (1950) (15.10.2012)
Get full text
Journal Article
First-in-human phase 1 study of ETC-159 an oral PORCN inhbitor in patients with advanced solid tumours
Ng, Matthew, Tan, David SP, Subbiah, Vivek, Weekes, Colin D., Teneggi, Vincenzo, Diermayr, Veronica, Ethirajulu, Kantharaj, Yeo, Pauline, Chen, Deborah, Blanchard, Stephanie, Nellore, Ranjani, Gan, Bong Hwa, Yasin, Maryam, Lee, Lay Hoon, Lee, May Ann, Hill, Jeffrey, Madan, Babita, Virshup, David, Matter, Alex
Published in Journal of clinical oncology (20.05.2017)
Published in Journal of clinical oncology (20.05.2017)
Get full text
Journal Article
Discovery of the Macrocycle (9E)-15-(2-(Pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17,20,22-nonaene (SB1578), a Potent Inhibitor of Janus Kinase 2/Fms-LikeTyrosine Kinase-3 (JAK2/FLT3) for the Treatment of Rheumatoid Arthritis
William, Anthony D, Lee, Angeline C.-H, Poulsen, Anders, Goh, Kee Chuan, Madan, Babita, Hart, Stefan, Tan, Evelyn, Wang, Haishan, Nagaraj, Harish, Chen, Dizhong, Lee, Chai Ping, Sun, Eric T, Jayaraman, Ramesh, Pasha, Mohammad Khalid, Ethirajulu, Kantharaj, Wood, Jeanette M, Dymock, Brian W
Published in Journal of medicinal chemistry (22.03.2012)
Published in Journal of medicinal chemistry (22.03.2012)
Get full text
Journal Article
Pharmacodynamic evaluation of the target efficacy of SB939, an oral HDAC inhibitor with selectivity for tumor tissue
Novotny-Diermayr, Veronica, Sausgruber, Nina, Loh, Yung Kiang, Pasha, Mohammed Khalid, Jayaraman, Ramesh, Hentze, Hannes, Yong, Wei-Peng, Goh, Boon-Cher, Toh, Han-Chong, Ethirajulu, Kantharaj, Zhu, Joy, Wood, Jeanette Marjorie
Published in Molecular cancer therapeutics (01.07.2011)
Published in Molecular cancer therapeutics (01.07.2011)
Get full text
Journal Article
First-in-Human Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Rapidly Developed SARS-CoV-2 Therapeutic Antibody, AOD01, in Healthy Adults
Prativadibhayankaram, Venkateshan S., Lee, Lawrence Soon-U, Lye, David, Xiaoying, Xu, Nellore, Ranjani, Pendharkar, Vishal, Hentze, Hannes, Guan, Siyu, Ayers, Benjamin J., Seah, Shirley G. K., Chye, De Hoe, Talib, Najwa S. N., Kaliaperumal, Nivashini, Ong, Wei Yee, Wong, Zi Xin, Au, Veonice B., Alok, Anshula, Connolly, John E., Boyd-Kirkup, Jerome D., Ingram, Piers J., Hanson, Brendon J., Ethirajulu, Kantharaj, O’Connell, Damian, Chan, Conrad E. Z.
Published in Infectious diseases and therapy (01.10.2022)
Published in Infectious diseases and therapy (01.10.2022)
Get full text
Journal Article
MetaSite: Understanding Metabolism in Human Cytochromes from the Perspective of the Chemist
Cruciani, Gabriele, Carosati, Emanuele, De Boeck, Benoit, Ethirajulu, Kantharaj, Mackie, Claire, Howe, Trevor, Vianello, Riccardo
Published in Journal of medicinal chemistry (03.11.2005)
Published in Journal of medicinal chemistry (03.11.2005)
Get full text
Journal Article
Preclinical Metabolism and Disposition of SB939 (Pracinostat), an Orally Active Histone Deacetylase Inhibitor, and Prediction of Human Pharmacokinetics
JAYARAMAN, Ramesh, PILLA REDDY, Venkatesh, SUN NEW, Lee, ETHIRAJULU, Kantharaj, KHALID PASHA, Mohammed, HAISHAN WANG, SANGTHONGPITAG, Kanda, YEO, Pauline, CHANG YONG HU, XIAOFENG WU, LIU XIN, GOH, Evelyn
Published in Drug metabolism and disposition (01.12.2011)
Published in Drug metabolism and disposition (01.12.2011)
Get full text
Journal Article