Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity
Corrales, Leticia, Glickman, Laura Hix, McWhirter, Sarah M., Kanne, David B., Sivick, Kelsey E., Katibah, George E., Woo, Seng-Ryong, Lemmens, Edward, Banda, Tamara, Leong, Justin J., Metchette, Ken, Dubensky, Thomas W., Gajewski, Thomas F.
Published in Cell reports (Cambridge) (19.05.2015)
Published in Cell reports (Cambridge) (19.05.2015)
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STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade
Fu, Juan, Kanne, David B, Leong, Meredith, Glickman, Laura Hix, McWhirter, Sarah M, Lemmens, Edward, Mechette, Ken, Leong, Justin J, Lauer, Peter, Liu, Weiqun, Sivick, Kelsey E, Zeng, Qi, Soares, Kevin C, Zheng, Lei, Portnoy, Daniel A, Woodward, Joshua J, Pardoll, Drew M, Dubensky, Jr, Thomas W, Kim, Young
Published in Science translational medicine (15.04.2015)
Published in Science translational medicine (15.04.2015)
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Journal Article
Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity
Sivick, Kelsey E., Desbien, Anthony L., Glickman, Laura Hix, Reiner, Gabrielle L., Corrales, Leticia, Surh, Natalie H., Hudson, Thomas E., Vu, Uyen T., Francica, Brian J., Banda, Tamara, Katibah, George E., Kanne, David B., Leong, Justin J., Metchette, Ken, Bruml, Jacob R., Ndubaku, Chudi O., McKenna, Jeffrey M., Feng, Yan, Zheng, Lianxing, Bender, Steven L., Cho, Charles Y., Leong, Meredith L., van Elsas, Andrea, Dubensky, Thomas W., McWhirter, Sarah M.
Published in Cell reports (Cambridge) (11.12.2018)
Published in Cell reports (Cambridge) (11.12.2018)
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Journal Article
STING-Activating Adjuvants Elicit a Th17 Immune Response and Protect against Mycobacterium tuberculosis Infection
Van Dis, Erik, Sogi, Kimberly M., Rae, Chris S., Sivick, Kelsey E., Surh, Natalie H., Leong, Meredith L., Kanne, David B., Metchette, Ken, Leong, Justin J., Bruml, Jacob R., Chen, Vivian, Heydari, Kartoosh, Cadieux, Nathalie, Evans, Tom, McWhirter, Sarah M., Dubensky, Thomas W., Portnoy, Daniel A., Stanley, Sarah A.
Published in Cell reports (Cambridge) (01.05.2018)
Published in Cell reports (Cambridge) (01.05.2018)
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Journal Article
Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors
Baird, Jason R, Friedman, David, Cottam, Benjamin, Dubensky, Jr, Thomas W, Kanne, David B, Bambina, Shelly, Bahjat, Keith, Crittenden, Marka R, Gough, Michael J
Published in Cancer research (Chicago, Ill.) (01.01.2016)
Published in Cancer research (Chicago, Ill.) (01.01.2016)
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Journal Article
Nitroso-Imidacloprid Irreversibly Inhibits Rabbit Aldehyde Oxidase
Dick, Ryan A, Kanne, David B, Casida, John E
Published in Chemical research in toxicology (01.12.2007)
Published in Chemical research in toxicology (01.12.2007)
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Journal Article
A STING Agonist Given with OX40 Receptor and PD-L1 Modulators Primes Immunity and Reduces Tumor Growth in Tolerized Mice
Foote, Jeremy B, Kok, Marleen, Leatherman, James M, Armstrong, Todd D, Marcinkowski, Bridget C, Ojalvo, Laureen S, Kanne, David B, Jaffee, Elizabeth M, Dubensky, Jr, Thomas W, Emens, Leisha A
Published in Cancer immunology research (01.06.2017)
Published in Cancer immunology research (01.06.2017)
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Rationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvants
Dubensky, Thomas W., Kanne, David B., Leong, Meredith L.
Published in Therapeutic Advances in Vaccines (01.11.2013)
Published in Therapeutic Advances in Vaccines (01.11.2013)
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Book Review
Journal Article
Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity
Sivick, Kelsey E., Desbien, Anthony L., Glickman, Laura Hix, Reiner, Gabrielle L., Corrales, Leticia, Surh, Natalie H., Hudson, Thomas E., Vu, Uyen T., Francica, Brian J., Banda, Tamara, Katibah, George E., Kanne, David B., Leong, Justin J., Metchette, Ken, Bruml, Jacob R., Ndubaku, Chudi O., McKenna, Jeffrey M., Feng, Yan, Zheng, Lianxing, Bender, Steven L., Cho, Charles Y., Leong, Meredith L., van Elsas, Andrea, Dubensky, Thomas W., McWhirter, Sarah M.
Published in Cell reports (Cambridge) (15.10.2019)
Published in Cell reports (Cambridge) (15.10.2019)
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Journal Article
Abstract 1445: STING activation in the tumor microenvironment with a synthetic human STING-activating cyclic dinucleotide leads to potent anti-tumor immunity
Glickman, Laura Hix, Kanne, David B., Kasibhatla, Shailaja, Li, Jie, Pferdekamper, AnneMarie Culazzo, Gauthier, Kelsey Sivick, Deng, Weiwen, Desbien, Anthony L., Katibah, George E., Leong, Justin J., Sung, Leonard, Metchette, Ken, Ndubaku, Chudi, Zheng, Lianxing, Cho, Charles, Feng, Yan, McKenna, Jeffrey M., Tallarico, John A., Bender, Steven L., Dubensky, Thomas W., McWhirter, Sarah M.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract SY39-02: Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity
Glickman, Laura Hix, Corrales, Leticia, Kanne, David B., Kasibhatla, Shailaja, Li, Jie, Pferdekamper, Anne Marie Culazzo, Gauthier, Kelsey Sivick, Katibah, George E., Leong, Justin J., Sung, Leonard, Metchette, Ken, Deng, Weiwen, Desbien, Anthony L., Ndubaku, Chudi, Zheng, Lianxing, Cho, Charles, Feng, Yan, McKenna, Jeffery M., Tallarico, John A., Bender, Steven L., McWhirter, Sarah M., Gajewski, Thomas F., Dubensky, Thomas W.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Identification of Aldehyde Oxidase as the Neonicotinoid Nitroreductase
Dick, Ryan A, Kanne, David B, Casida, John E
Published in Chemical research in toxicology (01.02.2005)
Published in Chemical research in toxicology (01.02.2005)
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Journal Article
Neonicotinoid Nitroguanidine Insecticide Metabolites: Synthesis and Nicotinic Receptor Potency of Guanidines, Aminoguanidines, and Their Derivatives
Kanne, David B, Dick, Ryan A, Tomizawa, Motohiro, Casida, John E
Published in Chemical research in toxicology (01.09.2005)
Published in Chemical research in toxicology (01.09.2005)
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Journal Article
6′-Methylpyrido[3,4- b]norhomotropane: synthesis and outstanding potency in relation to the α4β2 nicotinic receptor pharmacophore model
Kanne, David B., Tomizawa, Motohiro, Durkin, Kathleen A., Casida, John E.
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
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Journal Article
Abstract 2993: STING signaling in breast tumor microenvironment modulates immune checkpoint blockade efficacy in the neu-N mouse model of breast cancer
Foote, Jeremy B., Kok, Marlene, Leatherman, James M., Armstrong, Todd D., Marcinkowski, Bridget, Kanne, David B., Jaffee, Elizabeth M., Dubensky, Thomas W., Emens, Leisha A.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Abstract 631: Intratumoral activation of STING with a synthetic cyclic dinucleotide elicits antitumor CD8 T-cell immunity that effectively combines with checkpoint inhibitors
Desbien, Anthony L., Gauthier, Kelsey Sivick, Corrales, Leticia, Reiner, Gabrielle, Glickman, Laura Hix, Katibah, George, Hudson, Thomas E., Vu, Uyen, Surh, Natalie H., Francica, Brian, Deng, Weiwen, Kanne, David B., Leong, Justin J., Ndubaku, Chudi, Metchette, Ken, McKenna, Jeffery M., Bender, Steven L., Leong, Meredith L., Dubensky, Thomas W., Elsas, Andrea van, McWhirter, Sarah M.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Radiation therapy combined with novel STING-targeting oligonucleotides results in regression of established tumors
Baird, Jason R., Friedman, David, Cottam, Benjamin, Dubensky, Thomas W., Kanne, David B., Bambina, Shelly, Bahjat, Keith, Crittenden, Marka R., Gough, Michael J.
Published in Cancer research (Chicago, Ill.) (13.11.2015)
Published in Cancer research (Chicago, Ill.) (13.11.2015)
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