Structure of the human marker of self 5-transmembrane receptor CD47
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Published in Nature communications (01.09.2021)
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Modulation of CD47-SIRPα innate immune checkpoint axis with Fc-function detuned anti-CD47 therapeutic antibody
Narla, Rama Krishna, Modi, Hardik, Bauer, Daniel, Abbasian, Mahan, Leisten, Jim, Piccotti, Joseph R., Kopytek, Stephan, Eckelman, Brendan P., Deveraux, Quinn, Timmer, John, Zhu, Dan, Wong, Lilly, Escoubet, Laure, Raymon, Heather K., Hariharan, Kandasamy
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Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs
Zhang, Mingjun, Haughey, Michael, Wang, Nai-Yu, Blease, Kate, Kapoun, Ann M, Couto, Suzana, Belka, Igor, Hoey, Timothy, Groza, Matthew, Hartke, James, Bennett, Brydon, Cain, Jennifer, Gurney, Austin, Benish, Brent, Castiglioni, Paola, Drew, Clifton, Lachowicz, Jean, Carayannopoulos, Leon, Nathan, Steven D, Distler, Jorg, Brenner, David A, Hariharan, Kandasamy, Cho, Ho, Xie, Weilin
Published in PloS one (11.03.2020)
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CC-96673 (BMS-986358), an affinity-tuned anti-CD47 and CD20 bispecific antibody with fully functional fc, selectively targets and depletes non-Hodgkin's lymphoma
Zhu, Dan, Hadjivassiliou, Haralambos, Jennings, Catherine, Mikolon, David, Ammirante, Massimo, Acharya, Sharmistha, Lloyd, Jon, Abbasian, Mahan, Narla, Rama Krishna, Piccotti, Joseph R, Stamp, Katie, Cho, Ho, Hariharan, Kandasamy
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Rituximab-Mediated Cell Signaling and Chemo/Immuno-sensitization of Drug-Resistant B-NHL Is Independent of Its Fc Functions
Vega, Mario I., Huerta-Yepez, Sara, Martinez-Paniagua, Melisa, Martinez-Miguel, Bernardo, Hernandez-Pando, Rogelio, González-Bonilla, Cesar R., Chinn, Paul, Hanna, Nabil, Hariharan, Kandasamy, Jazirehi, Ali R., Bonavida, Benjamin
Published in Clinical cancer research (01.11.2009)
Published in Clinical cancer research (01.11.2009)
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Combination of two insulin-like growth factor-I receptor inhibitory antibodies targeting distinct epitopes leads to an enhanced antitumor response
Dong, Jianying, Demarest, Stephen J, Sereno, Arlene, Tamraz, Susan, Langley, Emma, Doern, Adam, Snipas, Tracey, Perron, Keli, Joseph, Ingrid, Glaser, Scott M, Ho, Steffan N, Reff, Mitchell E, Hariharan, Kandasamy
Published in Molecular cancer therapeutics (01.09.2010)
Published in Molecular cancer therapeutics (01.09.2010)
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Stable IgG-like Bispecific Antibodies Directed toward the Type I Insulin-like Growth Factor Receptor Demonstrate Enhanced Ligand Blockade and Anti-tumor Activity
Dong, Jianying, Sereno, Arlene, Snyder, William B., Miller, Brian R., Tamraz, Susan, Doern, Adam, Favis, Michael, Wu, Xiufeng, Tran, Hon, Langley, Emma, Joseph, Ingrid, Boccia, Antonio, Kelly, Rebecca, Wortham, Kathleen, Wang, Qin, Berquist, Lisa, Huang, Flora, Gao, Sharon X., Zhang, Ying, Lugovskoy, Alexey, Martin, Shelly, Gouvis, Heather, Berkowitz, Steven, Chiang, Gisela, Reff, Mitchell, Glaser, Scott M., Hariharan, Kandasamy, Demarest, Stephen J.
Published in The Journal of biological chemistry (11.02.2011)
Published in The Journal of biological chemistry (11.02.2011)
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A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity
Dong, Jianying, Sereno, Arlene, Aivazian, Dikran, Langley, Emma, Miller, Brian R., Snyder, William B, Chan, Eric, Cantele, Matt, Morena, Ronald, Joseph, Ingrid B.J.K., Boccia, Antonio, Virata, Cyrus, Gamez, James, Yco, Grace, Favis, Michael, Wu, Xiufeng, Graff, Christilyn P., Wang, Qin, Rohde, Ellen, Rennard, Rachel, Berquist, Lisa, Huang, Flora, Zhang, Ying, Gao, Sharon X., Ho, Steffan N., Demarest, Stephen J., Reff, Mitchell E., Hariharan, Kandasamy, Glaser, Scott M.
Published in mAbs (01.05.2011)
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Characterization of Inhibitory Anti-insulin-like Growth Factor Receptor Antibodies with Different Epitope Specificity and Ligand-blocking Properties
Doern, Adam, Cao, Xianjun, Sereno, Arlene, Reyes, Christopher L., Altshuler, Angelina, Huang, Flora, Hession, Cathy, Flavier, Albert, Favis, Michael, Tran, Hon, Ailor, Eric, Levesque, Melissa, Murphy, Tracey, Berquist, Lisa, Tamraz, Susan, Snipas, Tracey, Garber, Ellen, Shestowsky, William S., Rennard, Rachel, Graff, Christilyn P., Wu, Xiufeng, Snyder, William, Cole, Lindsay, Gregson, David, Shields, Michael, Ho, Steffan N., Reff, Mitchell E., Glaser, Scott M., Dong, Jianying, Demarest, Stephen J., Hariharan, Kandasamy
Published in The Journal of biological chemistry (10.04.2009)
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Investigation on Phase Change Behavior of Paraffin Phase Change Material in a Spherical Capsule for Solar Thermal Storage Units
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Published in Heat transfer engineering (28.05.2018)
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A humanized anti-human CD154 monoclonal antibody blocks CD154–CD40 mediated human B cell activation
Brams, Peter, Black, Amelia, Padlan, Eduardo A, Hariharan, Kandasamy, Leonard, John, Chambers-Slater, Karen, Noelle, Randolph J, Newman, Roland
Published in International immunopharmacology (01.02.2001)
Published in International immunopharmacology (01.02.2001)
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Discovery and Preclinical Characterization of CC-95251, an Anti-SIRPα Antibody That Enhances Macrophage-Mediated Phagocytosis of Non-Hodgkin Lymphoma (NHL) Cells When Combined with Rituximab
Chan, Henry, Trout, Christina, Mikolon, David, Adams, Preston, Guzman, Roberto, Fenalti, Gustavo, Mavrommatis, Konstantinos, Abbasian, Mahan, Dearth, Lawrence, Fox, Brian, Sivakumar, Pallavur, Hariharan, Kandasamy
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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ENGINEERING OF ANTIBODY FOR TUMOR-SELECTIVE BINDING OF CD47
ZHU DAN, SUN JEONGHOON, HARALAMBOS HADJIVASSILIOU, KANDASAMY HARIHARAN, SHARMISTHA ACHARYA, JEFFREY JOHNSON, CHO HO
Year of Publication 31.05.2024
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Year of Publication 31.05.2024
Patent
Abstract 2009: CC-90002 (anti-CD47 antibody) in vivo anti-tumor activity is associated with an increase in M1-polarized macrophages
Zheng, Bing, Wong, Piu, Yang, WenQing, Narla, Rama, Burgess, Michael, Escoubet, Laure, Raymon, Heather, Hariharan, Kandasamy, Boylan, John, Hege, Kristen, Sung, Victoria
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Discovery and Preclinical Activity of BMS-986351, an Antibody to SIRPα That Enhances Macrophage-mediated Tumor Phagocytosis When Combined with Opsonizing Antibodies
Chan, Henry, Trout, Christina V, Mikolon, David, Adams, Preston, Guzman, Roberto, Mavrommatis, Konstantinos, Abbasian, Mahan, Hadjivassiliou, Haralambos, Dearth, Lawrence, Fox, Brian A, Sivakumar, Pallavur, Cho, Ho, Hariharan, Kandasamy
Published in Cancer research communications (22.02.2024)
Published in Cancer research communications (22.02.2024)
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Abstract 4694: The humanized anti-CD47 monclonal antibody, CC-90002, has antitumor activity in vitro and in vivo
Narla, Rama Krishna, Modi, Hardik, Wong, Lilly, Abassian, Mahan, Bauer, Daniel, Desai, Pragnya, Gaffney, Bonny, Jackson, Pilgrim, Leisten, Jim, Liu, Jing, Lopez-Girona, Antonia, Romero, Maria, Yang, WenQing, Eckelman, Brendan P., Deveraux, Quinn, Phillips, Laurie, Raymon, Heather K., Escoubet, Laure, Boylan, John, Hariharan, Kandasamy
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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SIRPα BINDING PROTEIN AND METHODS OF USE THEREOF
CHRISTINA VALERIE TROUT, LAURE ESCOUBET, MONICA WAI LING LEUNG, SUN JEONGHOON, GUSTAVO FENALTI, KANDASAMY HARIHARAN, HENRY H CHAN, KONSTANTINOS MAVROMMATIS, DAVID P MIKOLON, MAHAN ABBASIAN, HEATHER K RAYMON, CARLO STEVEN SANTOS
Year of Publication 06.06.2023
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Year of Publication 06.06.2023
Patent