Clinical use of current polygenic risk scores may exacerbate health disparities
Martin, Alicia R, Kanai, Masahiro, Kamatani, Yoichiro, Okada, Yukinori, Neale, Benjamin M, Daly, Mark J
Published in Nature genetics (01.04.2019)
Published in Nature genetics (01.04.2019)
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Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases
Kanai, Masahiro, Akiyama, Masato, Takahashi, Atsushi, Matoba, Nana, Momozawa, Yukihide, Ikeda, Masashi, Iwata, Nakao, Ikegawa, Shiro, Hirata, Makoto, Matsuda, Koichi, Kubo, Michiaki, Okada, Yukinori, Kamatani, Yoichiro
Published in Nature genetics (01.03.2018)
Published in Nature genetics (01.03.2018)
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Empirical estimation of genome-wide significance thresholds based on the 1000 Genomes Project data set
Kanai, Masahiro, Tanaka, Toshihiro, Okada, Yukinori
Published in Journal of human genetics (01.10.2016)
Published in Journal of human genetics (01.10.2016)
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Population-specific causal disease effect sizes in functionally important regions impacted by selection
Shi, Huwenbo, Gazal, Steven, Kanai, Masahiro, Koch, Evan M, Schoech, Armin P, Siewert, Katherine M, Kim, Samuel S, Luo, Yang, Amariuta, Tiffany, Huang, Hailiang, Okada, Yukinori, Raychaudhuri, Soumya, Sunyaev, Shamil R, Price, Alkes L
Published in Nature communications (17.02.2021)
Published in Nature communications (17.02.2021)
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Genome-wide association study identifies 112 new loci for body mass index in the Japanese population
Akiyama, Masato, Okada, Yukinori, Kanai, Masahiro, Takahashi, Atsushi, Momozawa, Yukihide, Ikeda, Masashi, Iwata, Nakao, Ikegawa, Shiro, Hirata, Makoto, Matsuda, Koichi, Iwasaki, Motoki, Yamaji, Taiki, Sawada, Norie, Hachiya, Tsuyoshi, Tanno, Kozo, Shimizu, Atsushi, Hozawa, Atsushi, Minegishi, Naoko, Tsugane, Shoichiro, Yamamoto, Masayuki, Kubo, Michiaki, Kamatani, Yoichiro
Published in Nature genetics (01.10.2017)
Published in Nature genetics (01.10.2017)
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Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan
Sakaue, Saori, Kanai, Masahiro, Karjalainen, Juha, Akiyama, Masato, Kurki, Mitja, Matoba, Nana, Takahashi, Atsushi, Hirata, Makoto, Kubo, Michiaki, Matsuda, Koichi, Murakami, Yoshinori, Daly, Mark J, Kamatani, Yoichiro, Okada, Yukinori
Published in Nature medicine (01.04.2020)
Published in Nature medicine (01.04.2020)
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Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power
Atkinson, Elizabeth G, Maihofer, Adam X, Kanai, Masahiro, Martin, Alicia R, Karczewski, Konrad J, Santoro, Marcos L, Ulirsch, Jacob C, Kamatani, Yoichiro, Okada, Yukinori, Finucane, Hilary K, Koenen, Karestan C, Nievergelt, Caroline M, Daly, Mark J, Neale, Benjamin M
Published in Nature genetics (01.02.2021)
Published in Nature genetics (01.02.2021)
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Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese
Okada, Yukinori, Momozawa, Yukihide, Sakaue, Saori, Kanai, Masahiro, Ishigaki, Kazuyoshi, Akiyama, Masato, Kishikawa, Toshihiro, Arai, Yasumichi, Sasaki, Takashi, Kosaki, Kenjiro, Suematsu, Makoto, Matsuda, Koichi, Yamamoto, Kazuhiko, Kubo, Michiaki, Hirose, Nobuyoshi, Kamatani, Yoichiro
Published in Nature communications (24.04.2018)
Published in Nature communications (24.04.2018)
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Dimensionality reduction reveals fine-scale structure in the Japanese population with consequences for polygenic risk prediction
Sakaue, Saori, Hirata, Jun, Kanai, Masahiro, Suzuki, Ken, Akiyama, Masato, Lai Too, Chun, Arayssi, Thurayya, Hammoudeh, Mohammed, Al Emadi, Samar, Masri, Basel K, Halabi, Hussein, Badsha, Humeira, Uthman, Imad W, Saxena, Richa, Padyukov, Leonid, Hirata, Makoto, Matsuda, Koichi, Murakami, Yoshinori, Kamatani, Yoichiro, Okada, Yukinori
Published in Nature communications (26.03.2020)
Published in Nature communications (26.03.2020)
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Construction of a population-specific HLA imputation reference panel and its application to Graves' disease risk in Japanese
Okada, Yukinori, Momozawa, Yukihide, Ashikawa, Kyota, Kanai, Masahiro, Matsuda, Koichi, Kamatani, Yoichiro, Takahashi, Atsushi, Kubo, Michiaki
Published in Nature genetics (01.07.2015)
Published in Nature genetics (01.07.2015)
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Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores
Weissbrod, Omer, Kanai, Masahiro, Shi, Huwenbo, Gazal, Steven, Peyrot, Wouter J, Khera, Amit V, Okada, Yukinori, Martin, Alicia R, Finucane, Hilary K, Price, Alkes L
Published in Nature genetics (01.04.2022)
Published in Nature genetics (01.04.2022)
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Journal Article
Genome-wide functional screen of 3′UTR variants uncovers causal variants for human disease and evolution
Griesemer, Dustin, Xue, James R., Reilly, Steven K., Ulirsch, Jacob C., Kukreja, Kalki, Davis, Joe R., Kanai, Masahiro, Yang, David K., Butts, John C., Guney, Mehmet H., Luban, Jeremy, Montgomery, Stephen B., Finucane, Hilary K., Novina, Carl D., Tewhey, Ryan, Sabeti, Pardis C.
Published in Cell (30.09.2021)
Published in Cell (30.09.2021)
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Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population
Suzuki, Ken, Akiyama, Masato, Ishigaki, Kazuyoshi, Kanai, Masahiro, Hosoe, Jun, Shojima, Nobuhiro, Hozawa, Atsushi, Kadota, Aya, Kuriki, Kiyonori, Naito, Mariko, Tanno, Kozo, Ishigaki, Yasushi, Hirata, Makoto, Matsuda, Koichi, Iwata, Nakao, Ikeda, Masashi, Sawada, Norie, Yamaji, Taiki, Iwasaki, Motoki, Ikegawa, Shiro, Maeda, Shiro, Murakami, Yoshinori, Wakai, Kenji, Tsugane, Shoichiro, Sasaki, Makoto, Yamamoto, Masayuki, Okada, Yukinori, Kubo, Michiaki, Kamatani, Yoichiro, Horikoshi, Momoko, Yamauchi, Toshimasa, Kadowaki, Takashi
Published in Nature genetics (01.03.2019)
Published in Nature genetics (01.03.2019)
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Genetic and phenotypic landscape of the major histocompatibilty complex region in the Japanese population
Hirata, Jun, Hosomichi, Kazuyoshi, Sakaue, Saori, Kanai, Masahiro, Nakaoka, Hirofumi, Ishigaki, Kazuyoshi, Suzuki, Ken, Akiyama, Masato, Kishikawa, Toshihiro, Ogawa, Kotaro, Masuda, Tatsuo, Yamamoto, Kenichi, Hirata, Makoto, Matsuda, Koichi, Momozawa, Yukihide, Inoue, Ituro, Kubo, Michiaki, Kamatani, Yoichiro, Okada, Yukinori
Published in Nature genetics (01.03.2019)
Published in Nature genetics (01.03.2019)
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Journal Article
Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features
Ray, John P, de Boer, Carl G, Fulco, Charles P, Lareau, Caleb A, Kanai, Masahiro, Ulirsch, Jacob C, Tewhey, Ryan, Ludwig, Leif S, Reilly, Steven K, Bergman, Drew T, Engreitz, Jesse M, Issner, Robbyn, Finucane, Hilary K, Lander, Eric S, Regev, Aviv, Hacohen, Nir
Published in Nature communications (06.03.2020)
Published in Nature communications (06.03.2020)
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