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PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity
Yuan, Jing, Mehta, Pramod P, Yin, Min-Jean, Sun, Shaoxian, Zou, Aihua, Chen, Jeffrey, Rafidi, Kristina, Feng, Zheng, Nickel, Jeffrey, Engebretsen, Jon, Hallin, Jill, Blasina, Alessandra, Zhang, Eric, Nguyen, Leslie, Sun, Minghao, Vogt, Peter K, McHarg, Aileen, Cheng, Hengmiao, Christensen, James G, Kan, Julie L C, Bagrodia, Shubha
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Colon carcinoma cells harboring PIK3CA mutations display resistance to growth factor deprivation induced apoptosis
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An integrated genomic approach to identify predictive biomarkers of response to the aurora kinase inhibitor PF-03814735
Hook, Kenneth E, Garza, Scott J, Lira, Maruja E, Ching, Keith A, Lee, Nathan V, Cao, Joan, Yuan, Jing, Ye, Jingjing, Ozeck, Mark, Shi, Stephanie T, Zheng, Xianxian, Rejto, Paul A, Kan, Julie L C, Christensen, James G, Pavlicek, Adam
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Molecular predictors of sensitivity to the insulin-like growth factor 1 receptor inhibitor Figitumumab (CP-751,871)
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Published in Molecular cancer therapeutics (01.12.2013)
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Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR
Belmont, Peter J, Jiang, Ping, McKee, Trevor D, Xie, Tao, Isaacson, Jason, Baryla, Nicole E, Roper, Jatin, Sinnamon, Mark J, Lee, Nathan V, Kan, Julie L C, Guicherit, Oivin, Wouters, Bradly G, O'Brien, Catherine A, Shields, David, Olson, Peter, VanArsdale, Todd, Weinrich, Scott L, Rejto, Paul, Christensen, James G, Fantin, Valeria R, Hung, Kenneth E, Martin, Eric S
Published in Science signaling (11.11.2014)
Published in Science signaling (11.11.2014)
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Inducible expression of TGFβ, Snail and Zeb1 recapitulates EMT in vitro and in vivo in a NSCLC model
Argast, Gretchen M., Krueger, Joseph S., Thomson, Stuart, Sujka-Kwok, Isabela, Carey, Krista, Silva, Stacia, O’Connor, Matthew, Mercado, Peter, Mulford, Iain J., Young, G. David, Sennello, Regina, Wild, Robert, Pachter, Jonathan A., Kan, Julie L. C., Haley, John, Rosenfeld-Franklin, Maryland, Epstein, David M.
Published in Clinical & experimental metastasis (01.10.2011)
Published in Clinical & experimental metastasis (01.10.2011)
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3-[6-(2-Dimethylamino-1-imidazol-1-yl-butyl)-naphthalen-2-yloxy]-2,2-dimethyl-propionic acid as a highly potent and selective retinoic acid metabolic blocking agent
Mulvihill, Mark J., Kan, Julie L.C., Cooke, Andrew, Bhagwat, Shripad, Beck, Patricia, Bittner, Mark, Cesario, Cara, Keane, David, Lazarescu, Viorica, Nigro, Anthony, Nillson, Christy, Panicker, Bijoy, Smith, Vanessa, Srebernak, Mary, Sun, Feng-Lei, O’Connor, Matthew, Russo, Suzanne, Fischetti, Gia, Vrkljan, Michael, Winski, Shannon, Castelhano, Arlindo L., Emerson, David, Gibson, Neil W.
Published in Bioorganic & medicinal chemistry letters (15.05.2006)
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Cooperative Signaling between Oncostatin M, Hepatocyte Growth Factor and Transforming Growth Factor-β Enhances Epithelial to Mesenchymal Transition in Lung and Pancreatic Tumor Models
Argast, Gretchen M., Mercado, Peter, Mulford, Iain J., O’Connor, Matthew, Keane, David M., Shaaban, Salam, Epstein, David M., Pachter, Jonathan A., Kan, Julie L.C.
Published in Cells, tissues, organs (01.01.2011)
Published in Cells, tissues, organs (01.01.2011)
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Potent and selective [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines as retinoic acid metabolic blocking agents (RAMBAs)
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Published in Bioorganic & medicinal chemistry letters (15.03.2005)
Published in Bioorganic & medicinal chemistry letters (15.03.2005)
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Cooperative Signaling between Oncostatin M, Hepatocyte Growth Factor and Transforming Growth Factor-[beta] Enhances Epithelial to Mesenchymal Transition in Lung and Pancreatic Tumor Models
Argast, Gretchen M, Mercado, Peter, Mulford, Iain J, O'connor, Matthew, Keane, David M, Shaaban, Salam, Epstein, David M, Pachter, Jonathan A, Kan, Julie L C
Published in Cells, tissues, organs (01.12.2010)
Published in Cells, tissues, organs (01.12.2010)
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Inducible expression of TGF[beta], Snail and Zeb1 recapitulates EMT in vitro and in vivo in a NSCLC model
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Published in Clinical & experimental metastasis (01.10.2011)
Published in Clinical & experimental metastasis (01.10.2011)
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