Quantitative flux analysis reveals folate-dependent NADPH production
Fan, Jing, Ye, Jiangbin, Kamphorst, Jurre J., Shlomi, Tomer, Thompson, Craig B., Rabinowitz, Joshua D.
Published in Nature (London) (12.06.2014)
Published in Nature (London) (12.06.2014)
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Cancer metabolism at a glance
Vazquez, Alexei, Kamphorst, Jurre J, Markert, Elke K, Schug, Zachary T, Tardito, Saverio, Gottlieb, Eyal
Published in Journal of cell science (15.09.2016)
Published in Journal of cell science (15.09.2016)
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Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis
Guo, Jessie Yanxiang, Karsli-Uzunbas, Gizem, Mathew, Robin, Aisner, Seena C, Kamphorst, Jurre J, Strohecker, Anne M, Chen, Guanghua, Price, Sandy, Lu, Wenyun, Teng, Xin, Snyder, Eric, Santanam, Urmila, Dipaola, Robert S, Jacks, Tyler, Rabinowitz, Joshua D, White, Eileen
Published in Genes & development (01.07.2013)
Published in Genes & development (01.07.2013)
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Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein
Kamphorst, Jurre J, Nofal, Michel, Commisso, Cosimo, Hackett, Sean R, Lu, Wenyun, Grabocka, Elda, Vander Heiden, Matthew G, Miller, George, Drebin, Jeffrey A, Bar-Sagi, Dafna, Thompson, Craig B, Rabinowitz, Joshua D
Published in Cancer research (Chicago, Ill.) (01.02.2015)
Published in Cancer research (Chicago, Ill.) (01.02.2015)
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Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress
Schug, Zachary T., Peck, Barrie, Jones, Dylan T., Zhang, Qifeng, Grosskurth, Shaun, Alam, Israt S., Goodwin, Louise M., Smethurst, Elizabeth, Mason, Susan, Blyth, Karen, McGarry, Lynn, James, Daniel, Shanks, Emma, Kalna, Gabriela, Saunders, Rebecca E., Jiang, Ming, Howell, Michael, Lassailly, Francois, Thin, May Zaw, Spencer-Dene, Bradley, Stamp, Gordon, van den Broek, Niels J.F., Mackay, Gillian, Bulusu, Vinay, Kamphorst, Jurre J., Tardito, Saverio, Strachan, David, Harris, Adrian L., Aboagye, Eric O., Critchlow, Susan E., Wakelam, Michael J.O., Schulze, Almut, Gottlieb, Eyal
Published in Cancer cell (12.01.2015)
Published in Cancer cell (12.01.2015)
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Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids
Kamphorst, Jurre J., Cross, Justin R., Fan, Jing, de Stanchina, Elisa, Mathew, Robin, White, Eileen P., Thompson, Craig B., Rabinowitz, Joshua D.
Published in Proceedings of the National Academy of Sciences - PNAS (28.05.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (28.05.2013)
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Triglycerides Promote Lipid Homeostasis during Hypoxic Stress by Balancing Fatty Acid Saturation
Ackerman, Daniel, Tumanov, Sergey, Qiu, Bo, Michalopoulou, Evdokia, Spata, Michelle, Azzam, Andrew, Xie, Hong, Simon, M. Celeste, Kamphorst, Jurre J.
Published in Cell reports (Cambridge) (04.09.2018)
Published in Cell reports (Cambridge) (04.09.2018)
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Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
Commisso, Cosimo, Davidson, Shawn M., Soydaner-Azeloglu, Rengin G., Parker, Seth J., Kamphorst, Jurre J., Hackett, Sean, Grabocka, Elda, Nofal, Michel, Drebin, Jeffrey A., Thompson, Craig B., Rabinowitz, Joshua D., Metallo, Christian M., Vander Heiden, Matthew G., Bar-Sagi, Dafna
Published in Nature (London) (30.05.2013)
Published in Nature (London) (30.05.2013)
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Glutamine‐driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia
Fan, Jing, Kamphorst, Jurre J, Mathew, Robin, Chung, Michelle K, White, Eileen, Shlomi, Tomer, Rabinowitz, Joshua D
Published in Molecular systems biology (03.12.2013)
Published in Molecular systems biology (03.12.2013)
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Targeting the Metabolic Response to Statin-Mediated Oxidative Stress Produces a Synergistic Antitumor Response
McGregor, Grace H, Campbell, Andrew D, Fey, Sigrid K, Tumanov, Sergey, Sumpton, David, Blanco, Giovanny Rodriguez, Mackay, Gillian, Nixon, Colin, Vazquez, Alexei, Sansom, Owen J, Kamphorst, Jurre J
Published in Cancer research (Chicago, Ill.) (15.01.2020)
Published in Cancer research (Chicago, Ill.) (15.01.2020)
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Metabolic scavenging by cancer cells: when the going gets tough, the tough keep eating
Michalopoulou, Evdokia, Bulusu, Vinay, Kamphorst, Jurre J
Published in British journal of cancer (06.09.2016)
Published in British journal of cancer (06.09.2016)
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A Stromal Lysolipid-Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression
Auciello, Francesca R, Bulusu, Vinay, Oon, Chet, Tait-Mulder, Jacqueline, Berry, Mark, Bhattacharyya, Sohinee, Tumanov, Sergey, Allen-Petersen, Brittany L, Link, Jason, Kendsersky, Nicholas D, Vringer, Esmee, Schug, Michelle, Novo, David, Hwang, Rosa F, Evans, Ronald M, Nixon, Colin, Dorrell, Craig, Morton, Jennifer P, Norman, Jim C, Sears, Rosalie C, Kamphorst, Jurre J, Sherman, Mara H
Published in Cancer discovery (01.05.2019)
Published in Cancer discovery (01.05.2019)
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2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer
Blomme, Arnaud, Ford, Catriona A., Mui, Ernest, Patel, Rachana, Ntala, Chara, Jamieson, Lauren E., Planque, Mélanie, McGregor, Grace H., Peixoto, Paul, Hervouet, Eric, Nixon, Colin, Salji, Mark, Gaughan, Luke, Markert, Elke, Repiscak, Peter, Sumpton, David, Blanco, Giovanny Rodriguez, Lilla, Sergio, Kamphorst, Jurre J., Graham, Duncan, Faulds, Karen, MacKay, Gillian M., Fendt, Sarah-Maria, Zanivan, Sara, Leung, Hing Y.
Published in Nature communications (19.05.2020)
Published in Nature communications (19.05.2020)
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Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation
Bulusu, Vinay, Tumanov, Sergey, Michalopoulou, Evdokia, van den Broek, Niels J., MacKay, Gillian, Nixon, Colin, Dhayade, Sandeep, Schug, Zachary T., Vande Voorde, Johan, Blyth, Karen, Gottlieb, Eyal, Vazquez, Alexei, Kamphorst, Jurre J.
Published in Cell reports (Cambridge) (17.01.2017)
Published in Cell reports (Cambridge) (17.01.2017)
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Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis
Cardaci, Simone, Zheng, Liang, MacKay, Gillian, van den Broek, Niels J. F., MacKenzie, Elaine D., Nixon, Colin, Stevenson, David, Tumanov, Sergey, Bulusu, Vinay, Kamphorst, Jurre J., Vazquez, Alexei, Fleming, Stewart, Schiavi, Francesca, Kalna, Gabriela, Blyth, Karen, Strathdee, Douglas, Gottlieb, Eyal
Published in Nature cell biology (01.10.2015)
Published in Nature cell biology (01.10.2015)
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Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
Guo, Jessie Yanxiang, Chen, Hsin-Yi, Mathew, Robin, Fan, Jing, Strohecker, Anne M, Karsli-Uzunbas, Gizem, Kamphorst, Jurre J, Chen, Guanghua, Lemons, Johanna M S, Karantza, Vassiliki, Coller, Hilary A, Dipaola, Robert S, Gelinas, Celine, Rabinowitz, Joshua D, White, Eileen
Published in Genes & development (01.03.2011)
Published in Genes & development (01.03.2011)
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Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function
Rajeshkumar, N V, Dutta, Prasanta, Yabuuchi, Shinichi, de Wilde, Roeland F, Martinez, Gary V, Le, Anne, Kamphorst, Jurre J, Rabinowitz, Joshua D, Jain, Sanjay K, Hidalgo, Manuel, Dang, Chi V, Gillies, Robert J, Maitra, Anirban
Published in Cancer research (Chicago, Ill.) (15.08.2015)
Published in Cancer research (Chicago, Ill.) (15.08.2015)
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Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth
Rath, Nicola, Munro, June, Cutiongco, Marie Francene, Jagiełło, Alicja, Gadegaard, Nikolaj, McGarry, Lynn, Unbekandt, Mathieu, Michalopoulou, Evdokia, Kamphorst, Jurre J, Sumpton, David, Mackay, Gillian, Vennin, Claire, Pajic, Marina, Timpson, Paul, Olson, Michael F
Published in Cancer research (Chicago, Ill.) (15.06.2018)
Published in Cancer research (Chicago, Ill.) (15.06.2018)
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Central nervous system involvement in childhood acute lymphoblastic leukemia is linked to upregulation of cholesterol biosynthetic pathways
Cousins, A., Olivares, O., Markert, E., Manoharan, A., Bubnova, X., Bresolin, S., Degn, M., Li, Z., Silvestri, D., McGregor, G., Tumanov, S., Sumpton, D., Kamphorst, J. J., Michie, A. M., Herzyk, P., Valsecchi, M. G., Yeoh, A. E., Schmiegelow, K., te Kronnie, G., Gottlieb, E., Halsey, C.
Published in Leukemia (01.12.2022)
Published in Leukemia (01.12.2022)
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Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition
Michalopoulou, Evdokia, Auciello, Francesca R., Bulusu, Vinay, Strachan, David, Campbell, Andrew D., Tait-Mulder, Jacqueline, Karim, Saadia A., Morton, Jennifer P., Sansom, Owen J., Kamphorst, Jurre J.
Published in Cell reports (Cambridge) (25.02.2020)
Published in Cell reports (Cambridge) (25.02.2020)
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