Search Results - "Kamimura, Hidetaka" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism

Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism

by Uehara, Shotaro, Iida, Yuichi, Ida-Tanaka, Miyuki, Goto, Motohito, Kawai, Kenji, Yamamoto, Masafumi, Higuchi, Yuichiro, Ito, Satoshi, Takahashi, Riichi, Kamimura, Hidetaka, Ito, Mamoru, Yamazaki, Hiroshi, Oshimura, Mitsuo, Kazuki, Yasuhiro, Suemizu, Hiroshi
Published in Scientific reports (01.09.2022)

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Formation of reactive metabolites of benzbromarone in humanized-liver mice

Formation of reactive metabolites of benzbromarone in humanized-liver mice

by Cho, Naoki, Suemizu, Hiroshi, Kamimura, Hidetaka, Ohe, Tomoyuki, Ito, Fumi, Akita, Hidetaka, Kobayashi, Kaoru
Published in Drug metabolism and pharmacokinetics (01.12.2022)

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Human plasma concentration-time profiles of troglitazone and troglitazone sulfate simulated by in vivo experiments with chimeric mice with humanized livers and semi-physiological pharmacokinetic modeling

Human plasma concentration-time profiles of troglitazone and troglitazone sulfate simulated by in vivo experiments with chimeric mice with humanized livers and semi-physiological pharmacokinetic modeling

by Ito, Satoshi, Kamimura, Hidetaka, Yamamoto, Yousuke, Chijiwa, Hiroyuki, Okuzono, Takeshi, Suemizu, Hiroshi, Yamazaki, Hiroshi
Published in Drug metabolism and pharmacokinetics (01.12.2020)

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Human total clearance values and volumes of distribution of typical human cytochrome P450 2C9/19 substrates predicted by single-species allometric scaling using pharmacokinetic data sets from common marmosets genotyped for P450 2C19

Human total clearance values and volumes of distribution of typical human cytochrome P450 2C9/19 substrates predicted by single-species allometric scaling using pharmacokinetic data sets from common marmosets genotyped for P450 2C19

by Matsumoto, Shogo, Uehara, Shotaro, Kamimura, Hidetaka, Ikeda, Hiroshi, Maeda, Satoshi, Hattori, Machiko, Nishiwaki, Megumi, Kato, Kazuhiko, Yamazaki, Hiroshi
Published in Xenobiotica (03.04.2021)

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Simulation of human plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling

Simulation of human plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling

by Kamimura, Hidetaka, Ito, Satoshi, Chijiwa, Hiroyuki, Okuzono, Takeshi, Ishiguro, Tomohiro, Yamamoto, Yosuke, Nishinoaki, Sho, Ninomiya, Shin-Ichi, Mitsui, Marina, Kalgutkar, Amit S., Yamazaki, Hiroshi, Suemizu, Hiroshi
Published in Xenobiotica (04.05.2017)

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Characterization of Human Organic Cation Transporter 1 (OCT1/SLC22A1)- and OCT2 (SLC22A2)-Mediated Transport of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel Small Molecule Survivin Suppressant

Characterization of Human Organic Cation Transporter 1 (OCT1/SLC22A1)- and OCT2 (SLC22A2)-Mediated Transport of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel Small Molecule Survivin Suppressant

by MINEMATSU, Tsuyoshi, IWAI, Megumi, UMEHARA, Ken-Ichi, USUI, Takashi, KAMIMURA, Hidetaka
Published in Drug metabolism and disposition (01.01.2010)

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Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data

Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data

by Nakayama, Keigo, Kamimura, Hidetaka, Suemizu, Hiroshi, Yoneda, Nao, Nishiwaki, Megumi, Iwamoto, Kazuhiko, Mizunaga, Mari, Negoro, Tamotsu, Ito, Soichiro, Yamazaki, Hiroshi, Nomura, Yukihiro
Published in Drug metabolism and pharmacokinetics (01.08.2020)

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The UDP-Glucuronosyltransferase 2B7 Isozyme Is Responsible for Gemfibrozil Glucuronidation in the Human Liver

The UDP-Glucuronosyltransferase 2B7 Isozyme Is Responsible for Gemfibrozil Glucuronidation in the Human Liver

by MANO, Yuji, USUI, Takashi, KAMIMURA, Hidetaka
Published in Drug metabolism and disposition (01.11.2007)

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Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA

Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA

by Kamiyama, Yoshiteru, Matsubara, Tsutomu, Yoshinari, Kouichi, Nagata, Kiyoshi, Kamimura, Hidetaka, Yamazoe, Yasushi
Published in Drug metabolism and pharmacokinetics (2007)

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Role of Human Hepatocyte Nuclear Factor 4α in the Expression of Drug-Metabolizing Enzymes and Transporters in Human Hepatocytes Assessed by Use of Small Interfering RNA

Role of Human Hepatocyte Nuclear Factor 4α in the Expression of Drug-Metabolizing Enzymes and Transporters in Human Hepatocytes Assessed by Use of Small Interfering RNA

by Kamiyama, Yoshiteru, Matsubara, Tsutomu, Yoshinari, Kouichi, Nagata, Kiyoshi, Kamimura, Hidetaka, Yamazoe, Yasushi
Published in Drug metabolism and pharmacokinetics (01.01.2007)

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Predominant Contribution of UDP-Glucuronosyltransferase 2B7 in the Glucuronidation of Racemic Flurbiprofen in the Human Liver

Predominant Contribution of UDP-Glucuronosyltransferase 2B7 in the Glucuronidation of Racemic Flurbiprofen in the Human Liver

by MANO, Yuji, USUI, Takashi, KAMIMURA, Hidetaka
Published in Drug metabolism and disposition (01.07.2007)

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Inhibitory potential of nonsteroidal anti-inflammatory drugs on UDP-glucuronosyltransferase 2B7 in human liver microsomes

Inhibitory potential of nonsteroidal anti-inflammatory drugs on UDP-glucuronosyltransferase 2B7 in human liver microsomes

by MANO, Yuji, USUI, Takashi, KAMIMURA, Hidetaka
Published in European journal of clinical pharmacology (01.02.2007)

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Assessment of Chimeric Mice with Humanized Liver as a Tool for Predicting Circulating Human Metabolites

Assessment of Chimeric Mice with Humanized Liver as a Tool for Predicting Circulating Human Metabolites

by Kamimura, Hidetaka, Nakada, Naoyuki, Suzuki, Katsuhiro, Mera, Ayako, Souda, Kinya, Murakami, Yuichi, Tanaka, Kohichiro, Iwatsubo, Takafumi, Kawamura, Akio, Usui, Takashi
Published in Drug metabolism and pharmacokinetics (01.01.2010)

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Effects of bosentan, an endothelin receptor antagonist, on bile salt export pump and multidrug resistance-associated protein 2

Effects of bosentan, an endothelin receptor antagonist, on bile salt export pump and multidrug resistance-associated protein 2

by Mano, Yuji, Usui, Takashi, Kamimura, Hidetaka
Published in Biopharmaceutics & drug disposition (01.01.2007)

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Carrier-Mediated Uptake of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel Small-Molecule Survivin Suppressant, into Human Solid Tumor and Lymphoma Cells

Carrier-Mediated Uptake of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel Small-Molecule Survivin Suppressant, into Human Solid Tumor and Lymphoma Cells

by MINEMATSU, Tsuyoshi, IWAI, Megumi, SUGIMOTO, Kenji, SHIRAI, Nobuaki, NAKAHARA, Takahito, USUI, Takashi, KAMIMURA, Hidetaka
Published in Drug metabolism and disposition (01.03.2009)

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Comparison of Inhibition Potentials of Drugs against Zidovudine Glucuronidation in Rat Hepatocytes and Liver Microsomes

Comparison of Inhibition Potentials of Drugs against Zidovudine Glucuronidation in Rat Hepatocytes and Liver Microsomes

by MANO, Yuji, USUI, Takashi, KAMIMURA, Hidetaka
Published in Drug metabolism and disposition (01.04.2007)

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Involvement of Human Organic Cation Transporter 1 in the Hepatic Uptake of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel, Small Molecule Survivin Suppressant

Involvement of Human Organic Cation Transporter 1 in the Hepatic Uptake of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel, Small Molecule Survivin Suppressant

by Iwai, Megumi, Minematsu, Tsuyoshi, Narikawa, Shinichi, Usui, Takashi, Kamimura, Hidetaka
Published in Drug metabolism and disposition (01.09.2009)

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Contribution of UDP-glucuronosyltransferases 1A9 and 2B7 to the glucuronidation of indomethacin in the human liver

Contribution of UDP-glucuronosyltransferases 1A9 and 2B7 to the glucuronidation of indomethacin in the human liver

by MANO, Yuji, USUI, Takashi, KAMIMURA, Hidetaka
Published in European journal of clinical pharmacology (01.03.2007)

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Determination of solifenacin succinate, a novel muscarinic receptor antagonist, and its major metabolite in rat plasma by semi-micro high performance liquid chromatography

Determination of solifenacin succinate, a novel muscarinic receptor antagonist, and its major metabolite in rat plasma by semi-micro high performance liquid chromatography

by Yanagihara, Takamitsu, Aoki, Toshiko, Soeishi, Yoshiaki, Iwatsubo, Takafumi, Kamimura, Hidetaka
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.11.2007)

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Identification of human UDP-glucuronosyltransferase responsible for the glucuronidation of niflumic acid in human liver

Identification of human UDP-glucuronosyltransferase responsible for the glucuronidation of niflumic acid in human liver

by MANO, Yuji, USUI, Takashi, KAMIMURA, Hidetaka
Published in Pharmaceutical research (01.07.2006)

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