Impact of SARS-CoV-2 infection on patients with systemic lupus erythematosus in England prior to vaccination: a retrospective observational cohort study
Rabe, Adrian Paul J, Loke, Wei Jie, Kalyani, Rubana N, Tummala, Raj, Stirnadel-Farrant, Heide A, Were, John, Winthrop, Kevin L
Published in BMJ open (22.11.2023)
Published in BMJ open (22.11.2023)
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Anifrolumab efficacy and safety by type I interferon gene signature and clinical subgroups in patients with SLE: post hoc analysis of pooled data from two phase III trials
Vital, Edward M, Merrill, Joan T, Morand, Eric F, Furie, Richard A, Bruce, Ian N, Tanaka, Yoshiya, Manzi, Susan, Kalunian, Kenneth C, Kalyani, Rubana N, Streicher, Katie, Abreu, Gabriel, Tummala, Raj
Published in Annals of the rheumatic diseases (01.07.2022)
Published in Annals of the rheumatic diseases (01.07.2022)
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Anifrolumab reduces flare rates in patients with moderate to severe systemic lupus erythematosus
Furie, Richard, Morand, Eric F, Askanase, Anca D, Vital, Edward M, Merrill, Joan T, Kalyani, Rubana N, Abreu, Gabriel, Pineda, Lilia, Tummala, Raj
Published in Lupus (01.07.2021)
Published in Lupus (01.07.2021)
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Safety profile of anifrolumab in patients with active SLE: an integrated analysis of phase II and III trials
Tummala, Raj, Abreu, Gabriel, Pineda, Lilia, Michaels, M Alex, Kalyani, Rubana N, Furie, Richard A, Morand, Eric F
Published in Lupus science & medicine (17.02.2021)
Published in Lupus science & medicine (17.02.2021)
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Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands
Bakshi, Raman K., Hong, Qingmei, Tang, Rui, Kalyani, Rubana N., MacNeil, Tanya, Weinberg, David H., Van der Ploeg, Lex H.T., Patchett, Arthur A., Nargund, Ravi P.
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
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1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: Application in the synthesis of potent human melanocortin-4 receptor selective agonists
Bakshi, Raman K., Hong, Qingmei, Olson, J.T., Ye, Zhixiong, Sebhat, Iyassue K., Weinberg, David H., MacNeil, Tanya, Kalyani, Rubana N., Tang, Rui, Martin, William J., Strack, Alison, McGowan, Erin, Tamvakopoulos, Constantin, Miller, Randy R., Stearns, Ralph A., Tang, Wei, Maclntyre, D. Euan, van der Ploeg, Lex H.T., Patchett, Arthur A., Nargund, Ravi P.
Published in Bioorganic & medicinal chemistry letters (15.07.2005)
Published in Bioorganic & medicinal chemistry letters (15.07.2005)
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Design and Pharmacology of N-[(3R)-1,2,3,4-Tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a Potent, Selective, Melanocortin Subtype-4 Receptor Agonist
Sebhat, Iyassu K, Martin, William J, Ye, Zhixiong, Barakat, Khaled, Mosley, Ralph T, Johnston, David B. R, Bakshi, Raman, Palucki, Brenda, Weinberg, David H, MacNeil, Tanya, Kalyani, Rubana N, Tang, Rui, Stearns, Ralph A, Miller, Randy R, Tamvakopoulos, Constantin, Strack, Alison M, McGowan, Erin, Cashen, Doreen E, Drisko, Jennifer E, Hom, Gary J, Howard, Andrew D, MacIntyre, D. Euan, van der Ploeg, Lex H. T, Patchett, Arthur A, Nargund, Ravi P
Published in Journal of medicinal chemistry (10.10.2002)
Published in Journal of medicinal chemistry (10.10.2002)
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Selective, High Affinity Peptide Antagonists of α-Melanotropin Action at Human Melanocortin Receptor 4: Their Synthesis and Biological Evaluation in Vitro
Bednarek, Maria A, MacNeil, Tanya, Kalyani, Rubana N, Tang, Rui, Van der Ploeg, Lex H. T, Weinberg, David H
Published in Journal of medicinal chemistry (25.10.2001)
Published in Journal of medicinal chemistry (25.10.2001)
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Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands
Hong, Qingmei, Bakshi, Raman K., Dellureficio, James, He, Shuwen, Ye, Zhixiong, Dobbelaar, Peter H., Sebhat, Iyassu K., Guo, Liangqin, Liu, Jian, Jian, Tianying, Tang, Rui, Kalyani, Rubana N., MacNeil, Tanya, Vongs, Aurawan, Rosenblum, Charles I., Weinberg, David H., Peng, Qingping, Tamvakopoulos, Constantin, Miller, Randy R., Stearns, Ralph A., Cashen, Doreen, Martin, Willian J., Chen, Airu S., Metzger, Joseph M., Chen, Howard Y., Strack, Allison M., Fong, Tung M., Maclntyre, Euan, Van der Ploeg, Lex H.T., Wyvratt, Matthew J., Nargund, Ravi P.
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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Discovery of (2 S)- N-[(1 R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist
Palucki, Brenda L., Park, Min K., Nargund, Ravi P., Ye, Zhixiong, Sebhat, Iyassu K., Pollard, Patrick G., Kalyani, Rubana N., Tang, Rui, MacNeil, Tanya, Weinberg, David H., Vongs, Aurawan, Rosenblum, Charles I., Doss, George A., Miller, Randall R., Stearns, Ralph A., Peng, Qianping, Tamvakopoulos, Constantin, McGowan, Erin, Martin, William J., Metzger, Joseph M., Shepherd, Cherrie A., Strack, Alison M., MacIntyre, D. Euan, Van der Ploeg, Lex H.T., Patchett, Arthur A.
Published in Bioorganic & medicinal chemistry letters (03.01.2005)
Published in Bioorganic & medicinal chemistry letters (03.01.2005)
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Design and syntheses of melanocortin subtype-4 receptor agonists. Part 2: Discovery of the dihydropyridazinone motif
Ujjainwalla, Feroze, Warner, Daniel, Snedden, Christine, Grisson, Ricky D., Walsh, Thomas F., Wyvratt, Matthew J., Kalyani, Rubana N., MacNeil, Tanya, Tang, Rui, Weinberg, David H., Van der Ploeg, Lex, Goulet, Mark T.
Published in Bioorganic & medicinal chemistry letters (15.09.2005)
Published in Bioorganic & medicinal chemistry letters (15.09.2005)
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Design and syntheses of melanocortin subtype-4 receptor agonists: Evolution of the pyridazinone archetype
UJJAINWALLA, Feroze, WARNER, Daniel, RUI TANG, VONGS, Aurawan, WEINBERG, David H, GOULET, Mark T, WALSH, Thomas F, WYVRATT, Matthew J, CHANGYOU ZHOU, LIHU YANG, KALYANI, Rubana N, MACNEIL, Tanya, VAN DER PLOEG, Lex H. T, ROSENBLUM, Charles I
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
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Melanocortin subtype 4 receptor agonists: Structure–activity relationships about the 4-alkyl piperidine core
Sebhat, Iyassu K., Lai, Yingjie, Barakat, Khaled, Ye, Zhixiong, Tang, Rui, Kalyani, Rubana N., Vongs, Aurawan, MacNeil, Tanya, Weinberg, David H., Cabello, M. Angeles, Maroto, Marta, Teran, Ana, Fong, Tung M., Van der Ploeg, Lex H.T., Patchett, Arthur A., Nargund, Ravi P.
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
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Structure-activity relationship of linear tetrapeptides Tic-DPhe-Arg-Trp-NH2 at the human melanocortin-4 receptor and effects on feeding behaviors in rat
Ye, Zhixiong, MacNeil, Tanya, Weinberg, David H, Kalyani, Rubana N, Tang, Rui, Strack, Alison M, Murphy, Beth A, Mosley, Ralph T, Euan MacIntyre, D, Van der Ploeg, Lex H T, Patchett, Arthur A, Wyvratt, Matthew J, Nargund, Ravi P
Published in Peptides (New York, N.Y. : 1980) (01.10.2005)
Published in Peptides (New York, N.Y. : 1980) (01.10.2005)
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P186 Early and sustained responses with anifrolumab in patients with systemic lupus erythematosus (SLE) in 2 phase 3 trials
Morand, Eric F, Furie, Richard, Bruce, Ian, Kalunian, Kenneth C, Kalyani, Rubana N, Abreu, Gabriel, Pineda, Lilia, Tummala, Raj
Published in Lupus science & medicine (01.03.2020)
Published in Lupus science & medicine (01.03.2020)
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Potent and Selective Peptide Agonists of α-Melanotropin Action at Human Melanocortin Receptor 4: Their Synthesis and Biological Evaluation in Vitro
Bednarek, Maria A., MacNeil, Tanya, Tang, Rui, Kalyani, Rubana N., Van der Ploeg, Lex H.T., Weinberg, David H.
Published in Biochemical and biophysical research communications (24.08.2001)
Published in Biochemical and biophysical research communications (24.08.2001)
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Discovery and activity of (1 R,4 S,6 R)- N-[(1 R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist
Ye, Zhixiong, Guo, Liangqin, Barakat, Khaled J., Pollard, Patrick G., Palucki, Brenda L., Sebhat, Iyassu K., Bakshi, Raman K., Tang, Rui, Kalyani, Rubana N., Vongs, Aurawan, Chen, Airu S., Chen, Howard Y., Rosenblum, Charles I., MacNeil, Tanya, Weinberg, David H., Peng, Qianping, Tamvakopoulos, Constantin, Miller, Randy R., Stearns, Ralph A., Cashen, Doreen E., Martin, William J., Metzger, Joseph M., Strack, Alison M., MacIntyre, D. Euan, Van der Ploeg, Lex H.T., Patchett, Arthur A., Wyvratt, Matthew J., Nargund, Ravi P.
Published in Bioorganic & medicinal chemistry letters (01.08.2005)
Published in Bioorganic & medicinal chemistry letters (01.08.2005)
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Journal Article
Analogs of MTII, Lactam Derivatives of α-Melanotropin, Modified at the N-Terminus, and Their Selectivity at Human Melanocortin Receptors 3, 4, and 5
Bednarek, Maria A., Macneil, Tanya, Kalyani, Rubana N., Tang, Rui, Van der Ploeg, Lex H.T., Weinberg, David H.
Published in Biochemical and biophysical research communications (22.07.1999)
Published in Biochemical and biophysical research communications (22.07.1999)
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Journal Article
Structure-function studies on the cyclic peptide MT-II, lactam derivative of α-melanotropin
Bednarek, Maria A., Silva, Maria V., Arison, Byron, MacNeil, Tanya, Kalyani, Rubana N., Huang, Ruey-Ruey C., Weinberg, David H.
Published in Peptides (New York, N.Y. : 1980) (01.01.1999)
Published in Peptides (New York, N.Y. : 1980) (01.01.1999)
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