A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4
Gilson, Paul R., Kumarasingha, Rasika, Thompson, Jennifer, Zhang, Xinxin, Penington, Jocelyn Sietsma, Kalhor, Robabeh, Bullen, Hayley E., Lehane, Adele M., Dans, Madeline G., de Koning-Ward, Tania F., Holien, Jessica K., Soares da Costa, Tatiana P., Hulett, Mark D., Buskes, Melissa J., Crabb, Brendan S., Kirk, Kiaran, Papenfuss, Anthony T., Cowman, Alan F., Abbott, Belinda M.
Published in Scientific reports (16.07.2019)
Published in Scientific reports (16.07.2019)
Get full text
Journal Article
Antimalarial activity of novel 4-cyano-3-methylisoquinoline inhibitors against Plasmodium falciparum: design, synthesis and biological evaluation
Buskes, Melissa J., Harvey, Katherine L., Richards, Benjamin J., Kalhor, Robabeh, Christoff, Rebecca M., Gardhi, Chamodi K., Littler, Dene R., Cope, Elliott D., Prinz, Boris, Weiss, Greta E., O'Brien, Nathan J., Crabb, Brendan S., Deady, Leslie W., Gilson, Paul R., Abbott, Belinda M.
Published in Organic & biomolecular chemistry (01.01.2016)
Published in Organic & biomolecular chemistry (01.01.2016)
Get full text
Journal Article
Antimalarial activity of novel 4-cyano-3-methylisoquinoline inhibitors against Plasmodium falciparum: design, synthesis and biological evaluationElectronic supplementary information (ESI) available: Copies of the 1H and 13C NMR spectra of compounds 9-50. Counter screen of compounds 4, 12, 13, 23 and 25. Video S1. Live cell image sequence of a Plasmodium falciparum schizont-stage parasite treated with 10 μM compound 25 showing egressing merozoites and their attempts to invade nearby erythrocytes.
Buskes, Melissa J, Harvey, Katherine L, Richards, Benjamin J, Kalhor, Robabeh, Christoff, Rebecca M, Gardhi, Chamodi K, Littler, Dene R, Cope, Elliott D, Prinz, Boris, Weiss, Greta E, O'Brien, Nathan J, Crabb, Brendan S, Deady, Leslie W, Gilson, Paul R, Abbott, Belinda M
Year of Publication 18.05.2016
Year of Publication 18.05.2016
Get full text
Journal Article