Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib
CAREY, Kendall D, GARTON, Andrew J, ROMERO, Maria S, KAHLER, Jennifer, THOMSON, Stuart, ROSS, Sarajane, PARK, Frances, HALEY, John D, GIBSON, Neil, SLIWKOWSKI, Mark X
Published in Cancer research (Chicago, Ill.) (15.08.2006)
Published in Cancer research (Chicago, Ill.) (15.08.2006)
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Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin
Bhagwat, Shripad V, Gokhale, Prafulla C, Crew, Andrew P, Cooke, Andy, Yao, Yan, Mantis, Christine, Kahler, Jennifer, Workman, Jennifer, Bittner, Mark, Dudkin, Lorina, Epstein, David M, Gibson, Neil W, Wild, Robert, Arnold, Lee D, Houghton, Peter J, Pachter, Jonathan A
Published in Molecular cancer therapeutics (01.08.2011)
Published in Molecular cancer therapeutics (01.08.2011)
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Enhanced Antitumor Activity of an Anti-5T4 Antibody-Drug Conjugate in Combination with PI3K/mTOR inhibitors or Taxanes
Shor, Boris, Kahler, Jennifer, Dougher, Maureen, Xu, Jane, Mack, Michelle, Rosfjord, Ed, Wang, Fang, Melamud, Eugene, Sapra, Puja
Published in Clinical cancer research (15.01.2016)
Published in Clinical cancer research (15.01.2016)
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Development of Highly Optimized Antibody-Drug Conjugates against CD33 and CD123 for Acute Myeloid Leukemia
Han, Yoon-Chi, Kahler, Jennifer, Piché-Nicholas, Nicole, Hu, Wenyue, Thibault, Stephane, Jiang, Fan, Leal, Mauricio, Katragadda, Madan, Maderna, Andreas, Dushin, Russell, Prashad, Nadira, Charati, Manoj B, Clark, Tracey, Tumey, L Nathan, Tan, Xingzhi, Giannakou, Andreas, Rosfjord, Edward, Gerber, Hans-Peter, Tchistiakova, Lioudmila, Loganzo, Frank, O'Donnell, Christopher J, Sapra, Puja
Published in Clinical cancer research (15.01.2021)
Published in Clinical cancer research (15.01.2021)
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Novel DNA-Damaging Linker Payloads Are Active in Models of Acquired Resistance to Calicheamicin and Standard of Care
Kahler, Jennifer, Dougher, Maureen, Lu, Jia, Xu, Jane, Kausar, Tasneem, Lemon, Luanna, Zhong, Wenyan, Lucas, Judy, Sung, Matthew, Sapra, Puja
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Abstract 3095: The development of CPI as a novel, next-generation DNA-targeting payload for ADCs
Kahler, Jennifer, Dougher, Maureen, Xu, Jane, Doroski, Matthew, Maderna, Andreas, Dushin, Russell, Thibault, Stephane, Leal, Mauricio, Katragadda, Madan, O'Donnell, Christopher J., Sung, Matthew, Sapra, Puja
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Abstract 2463: Enhanced anti-tumor activity of an Auristatin-based antibody-drug conjugate in combination with PI3K/mTOR inhibitors or taxanes: Translational implications and mechanistic insights
Sapra, Puja, Shor, Boris, Dougher, Maureen, Kahler, Jennifer, Mack, Michelle, Xu, Jane, Lu, Shuyan, Melamud, Eugene, Wang, Fang, Rosfjord, Edward
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: Optimization of kinase selectivity and pharmacokinetics
Hornberger, Keith R., Chen, Xin, Crew, Andrew P., Kleinberg, Andrew, Ma, Lifu, Mulvihill, Mark J., Wang, Jing, Wilde, Victoria L., Albertella, Mark, Bittner, Mark, Cooke, Andrew, Kadhim, Salam, Kahler, Jennifer, Maresca, Paul, May, Earl, Meyn, Peter, Romashko, Darlene, Tokar, Brianna, Turton, Roy
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
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Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases
Steinig, Arno G., Li, An-Hu, Wang, Jing, Chen, Xin, Dong, Hanqing, Ferraro, Caterina, Jin, Meizhong, Kadalbajoo, Mridula, Kleinberg, Andrew, Stolz, Kathryn M., Tavares-Greco, Paula A., Wang, Ti, Albertella, Mark R., Peng, Yue, Crew, Linda, Kahler, Jennifer, Kan, Julie, Schulz, Ryan, Cooke, Andy, Bittner, Mark, Turton, Roy W., Franklin, Maryland, Gokhale, Prafulla, Landfair, Darla, Mantis, Christine, Workman, Jen, Wild, Robert, Pachter, Jonathan, Epstein, David, Mulvihill, Mark J.
Published in Bioorganic & medicinal chemistry letters (01.08.2013)
Published in Bioorganic & medicinal chemistry letters (01.08.2013)
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Imidazo[1,5- a]pyrazines: Orally efficacious inhibitors of mTORC1 and mTORC2
Crew, Andrew P., Bhagwat, Shripad V., Dong, Hanqing, Bittner, Mark A., Chan, Anna, Chen, Xin, Coate, Heather, Cooke, Andrew, Gokhale, Prafulla C., Honda, Ayako, Jin, Meizhong, Kahler, Jennifer, Mantis, Christine, Mulvihill, Mark J., Tavares-Greco, Paula A., Volk, Brian, Wang, Jing, Werner, Douglas S., Arnold, Lee D., Pachter, Jonathan A., Wild, Robert, Gibson, Neil W.
Published in Bioorganic & medicinal chemistry letters (01.04.2011)
Published in Bioorganic & medicinal chemistry letters (01.04.2011)
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Discovery of Novel Insulin-Like Growth Factor‑1 Receptor Inhibitors with Unique Time-Dependent Binding Kinetics
Jin, Meizhong, Petronella, Brenda A, Cooke, Andy, Kadalbajoo, Mridula, Siu, Kam W, Kleinberg, Andrew, May, Earl W, Gokhale, Prafulla C, Schulz, Ryan, Kahler, Jennifer, Bittner, Mark A, Foreman, Kenneth, Pachter, Jonathan A, Wild, Robert, Epstein, David, Mulvihill, Mark J
Published in ACS medicinal chemistry letters (11.07.2013)
Published in ACS medicinal chemistry letters (11.07.2013)
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OSI-930 : A novel selective inhibitor of kit and kinase insert domain receptor tyrosine kinases with antitumor activity in mouse xenograft models
GARTON, Andrew J, CREW, Andrew P. A, BITTNER, Mark A, KEILY, John F, BRINER, Paul, HIDDEN, Chris, SREBERNAK, Mary C, PIRRIT, Carrie, O'CONNOR, Matthew, ANNA CHAN, VULEVIC, Bojana, HENNINGER, Dwight, FRANKLIN, Maryland, HART, Karen, SENNELLO, Regina, LI, An-Hu, TAO ZHANG, RICHARDSON, Frank, EMERSON, David L, CASTELHANO, Arlindo L, ARNOLD, Lee D, GIBSON, Neil W, COOKE, Andrew R, WYNNE, Graham M, CASTALDO, Linda, KAHLER, Jennifer, WINSKI, Shannon L, FRANKS, April, BROWN, Eric N
Published in Cancer research (Chicago, Ill.) (15.01.2006)
Published in Cancer research (Chicago, Ill.) (15.01.2006)
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Journal Article
Abstract 4487: OSI-027, a potent and selective small molecule mTORC1/mTORC2 kinase inhibitor is mechanistically distinct from rapamycin
Bhagwat, Shripad V., Crew, Andrew P., Gokhale, Praful C., Yao, Yan, Kahler, Jennifer, Epstein, David M., Wild, Robert, Pachter, Jonathan A.
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Journal Article
High-throughput screening for mTORC1/mTORC2 kinase inhibitors using a chemiluminescence-based ELISA assay
Bhagwat, Shripad V, Kahler, Jennifer, Yao, Yan, Maresca, Paul, Brooks, Maureen, Crew, Andy, Boisclair, Michael, Pachter, Jonathan A
Published in Assay and drug development technologies (01.10.2009)
Published in Assay and drug development technologies (01.10.2009)
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Therapeutic interventions in the treatment of dissociative disorders
Turkus, Joan A, Kahler, Jennifer Aloe
Published in The Psychiatric clinics of North America (01.03.2006)
Published in The Psychiatric clinics of North America (01.03.2006)
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