Challenging the CNS Targeting Potential of Systemically Administered Nanoemulsion Delivery Systems: a Case Study with Rapamycin-Containing Fish Oil Nanoemulsions in Mice
Kadakia, Ekta, Harpude, Pratiksha, Parayath, Neha, Bottino, Dean, Amiji, Mansoor
Published in Pharmaceutical research (01.09.2019)
Published in Pharmaceutical research (01.09.2019)
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Journal Article
Dose Optimization for Anticancer Drug Combinations: Maximizing Therapeutic Index via Clinical Exposure-Toxicity/Preclinical Exposure-Efficacy Modeling
Bottino, Dean C, Patel, Mayankbhai, Kadakia, Ekta, Zhou, Jilai, Patel, Chirag, Neuwirth, Rachel, Iartchouk, Natasha, Brake, Rachael, Venkatakrishnan, Karthik, Chakravarty, Arijit
Published in Clinical cancer research (15.11.2019)
Published in Clinical cancer research (15.11.2019)
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Journal Article
Long-term drug delivery using implantable electrospun woven polymeric nanotextiles
Padmakumar, Smrithi, Paul-Prasanth, Bindhu, Pavithran, Keechilat, Vijaykumar, Dehannathparambil Kottarathil, Rajanbabu, Anupama, Sivanarayanan, Thangalazhi Balakrishnan, Kadakia, Ekta, Amiji, Mansoor M, Nair, Shantikumar V, Menon, Deepthy
Published in Nanomedicine (01.01.2019)
Published in Nanomedicine (01.01.2019)
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Journal Article
Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis
Himmelbauer, Martin K., Bajrami, Bekim, Basile, Rebecca, Capacci, Andrew, Chen, TeYu, Choi, Colin K., Gilfillan, Rab, Gonzalez-Lopez de Turiso, Felix, Gu, Chungang, Hoemberger, Marc, Johnson, Douglas S., Jones, J. Howard, Kadakia, Ekta, Kirkland, Melissa, Lin, Edward Y., Liu, Ying, Ma, Bin, Magee, Tom, Mantena, Srinivasa, Marx, Isaac E., Metrick, Claire M., Mingueneau, Michael, Murugan, Paramasivam, Muste, Cathy A., Nadella, Prasad, Nevalainen, Marta, Parker Harp, Chelsea R., Pattaropong, Vatee, Pietrasiewicz, Alicia, Prince, Robin J., Purgett, Thomas J., Santoro, Joseph C., Schulz, Jurgen, Sciabola, Simone, Tang, Hao, Vandeveer, H. George, Wang, Ti, Yousaf, Zain, Helal, Christopher J., Hopkins, Brian T.
Published in Journal of medicinal chemistry (23.05.2024)
Published in Journal of medicinal chemistry (23.05.2024)
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Journal Article
Utility of perecnt growth-rate inhibition (% GRI), a tumor growth-rate based metric to more accurately estimate response rate and magnitude of anti-tumor agents
Bottino, Dean, Kadakia, Ekta, Westin, Eric H., Shyu, Wen Chyi, Wu, Jing-Tao, Chakravarty, Arijit
Published in Journal of clinical oncology (20.05.2015)
Published in Journal of clinical oncology (20.05.2015)
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Journal Article
Abstract 3746: Anticipating the maximum tolerated dose for combinations based on early toxicity signals
Kadakia, Ekta, Zopf, Christopher J., Patel, Mayankbhai, Bottino, Dean, Hather, Greg, Shyu, Wen Chyi, Chakravarty, Arijit
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Abstract 3747: Predicting Maximum Tolerated Dose during Phase I using anticipatory toxicity models
Kadakia, Ekta, Samant, Snehal, Zopf, Christopher J., Bottino, Dean, Hather, Greg, Palani, Santhosh, Shyu, Wen Chyi, Chakravarty, Arijit
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Abstract B154: Application of preclinical combination pharmacokinetic(PK)/efficacy(E) modeling to investigate and translate the preclinical scheduling effect for MLN1117 and Taxotere combination
Kadakia, Ekta, Iartchouk, Natasha, Kannan, Karuppiah, Song, Keli, Mei Zhang, Dong, Zopf, Christopher, Patel, Munjal, Patel, Chirag, Chowdhury, Swapan, Shyu, Wen Chyi, Wu, Jing-Tao, Chakravarty, Arijit
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Journal Article
Using preclinical PD/E correlations to derive an optimal PD threshold for phase-1 decision-making
Kadakia, Ekta, Chen, Andrew, Patel, Munjal, Xia, Cindy, Hyer, Marc, Ishii, Yuko, Bottino, Dean, Wu, Jing-Tao, Ecsedy, Jeffrey, Chakravarty, Arijit
Published in Journal of clinical oncology (20.05.2015)
Published in Journal of clinical oncology (20.05.2015)
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Journal Article
Abstract A216: Combination schedule optimization through preclinical PK-efficacy modeling of an investigational novel-novel combination: A case study of MLN0128 an mTORC1/2 inhibitor with MLN1117 a PI3Kα isoform selective inhibitor
Zopf, Christopher, Patel, Mayank, Kadakia, Ekta, Fabry, Robyn, Chakravarty, Arijit, Chowdhury, Swapan, Wu, Jing-Tao, Shyu, Wen Chyi, Manfredi, Mark, Zohren, Fabian, Patel, Chirag, Kuida, Keisuke, Iartchouk, Natasha, Brake, Rachael, Mettetal, Jerome
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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