Conformational transitions of a neurotensin receptor 1–Gi1 complex
Kato, Hideaki E., Zhang, Yan, Hu, Hongli, Suomivuori, Carl-Mikael, Kadji, Francois Marie Ngako, Aoki, Junken, Krishna Kumar, Kaavya, Fonseca, Rasmus, Hilger, Daniel, Huang, Weijiao, Latorraca, Naomi R., Inoue, Asuka, Dror, Ron O., Kobilka, Brian K., Skiniotis, Georgios
Published in Nature (London) (01.08.2019)
Published in Nature (London) (01.08.2019)
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Journal Article
Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex
Krishna Kumar, Kaavya, Shalev-Benami, Moran, Robertson, Michael J., Hu, Hongli, Banister, Samuel D., Hollingsworth, Scott A., Latorraca, Naomi R., Kato, Hideaki E., Hilger, Daniel, Maeda, Shoji, Weis, William I., Farrens, David L., Dror, Ron O., Malhotra, Sanjay V., Kobilka, Brian K., Skiniotis, Georgios
Published in Cell (24.01.2019)
Published in Cell (24.01.2019)
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Journal Article
Structural basis for activation of CB1 by an endocannabinoid analog
Krishna Kumar, Kaavya, Robertson, Michael J., Thadhani, Elina, Wang, Haoqing, Suomivuori, Carl-Mikael, Powers, Alexander S., Ji, Lipin, Nikas, Spyros P., Dror, Ron O., Inoue, Asuka, Makriyannis, Alexandros, Skiniotis, Georgios, Kobilka, Brian
Published in Nature communications (09.05.2023)
Published in Nature communications (09.05.2023)
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Journal Article
Structural Basis for Hemoglobin Capture by Staphylococcus aureus Cell-surface Protein, IsdH
Krishna Kumar, Kaavya, Jacques, David A., Pishchany, Gleb, Caradoc-Davies, Tom, Spirig, Thomas, Malmirchegini, G. Reza, Langley, David B., Dickson, Claire F., Mackay, Joel P., Clubb, Robert T., Skaar, Eric P., Guss, J. Mitchell, Gell, David A.
Published in The Journal of biological chemistry (04.11.2011)
Published in The Journal of biological chemistry (04.11.2011)
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Journal Article
Negative allosteric modulation of the glucagon receptor by RAMP2
Krishna Kumar, Kaavya, O’Brien, Evan S., Habrian, Chris H., Latorraca, Naomi R., Wang, Haoqing, Tuneew, Inga, Montabana, Elizabeth, Marqusee, Susan, Hilger, Daniel, Isacoff, Ehud Y., Mathiesen, Jesper Mosolff, Kobilka, Brian K.
Published in Cell (30.03.2023)
Published in Cell (30.03.2023)
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Journal Article
Stepwise activation of a metabotropic glutamate receptor
Krishna Kumar, Kaavya, Wang, Haoqing, Habrian, Chris, Latorraca, Naomi R., Xu, Jun, O’Brien, Evan S., Zhang, Chensong, Montabana, Elizabeth, Koehl, Antoine, Marqusee, Susan, Isacoff, Ehud Y., Kobilka, Brian K.
Published in Nature (London) (23.05.2024)
Published in Nature (London) (23.05.2024)
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Journal Article
The ubiquitination status of the glucagon receptor determines signal bias
Kaur, Suneet, Sokrat, Badr, Capozzi, Megan E., El, Kimberley, Bai, Yushi, Jazic, Aeva, Han, Bridgette, Krishna Kumar, Kaavya, D'Alessio, David A., Campbell, Jonathan E., Bouvier, Michel, Shenoy, Sudha K.
Published in The Journal of biological chemistry (01.05.2023)
Published in The Journal of biological chemistry (01.05.2023)
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Journal Article
A µ-opioid receptor modulator that works cooperatively with naloxone
O’Brien, Evan S., Rangari, Vipin Ashok, El Daibani, Amal, Eans, Shainnel O., Hammond, Haylee R., White, Elizabeth, Wang, Haoqing, Shiimura, Yuki, Krishna Kumar, Kaavya, Jiang, Qianru, Appourchaux, Kevin, Huang, Weijiao, Zhang, Chensong, Kennedy, Brandon J., Mathiesen, Jesper M., Che, Tao, McLaughlin, Jay P., Majumdar, Susruta, Kobilka, Brian K.
Published in Nature (London) (18.07.2024)
Published in Nature (London) (18.07.2024)
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Journal Article
Staphylococcus aureus Uses a Novel Multidomain Receptor to Break Apart Human Hemoglobin and Steal Its Heme
Spirig, Thomas, Malmirchegini, G. Reza, Zhang, Jiang, Robson, Scott A., Sjodt, Megan, Liu, Mengyao, Krishna Kumar, Kaavya, Dickson, Claire F., Gell, David A., Lei, Benfang, Loo, Joseph A., Clubb, Robert T.
Published in The Journal of biological chemistry (11.01.2013)
Published in The Journal of biological chemistry (11.01.2013)
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Journal Article
Structure of the Hemoglobin-IsdH Complex Reveals the Molecular Basis of Iron Capture by Staphylococcus aureus
Dickson, Claire F., Kumar, Kaavya Krishna, Jacques, David A., Malmirchegini, G. Reza, Spirig, Thomas, Mackay, Joel P., Clubb, Robert T., Guss, J. Mitchell, Gell, David A.
Published in The Journal of biological chemistry (07.03.2014)
Published in The Journal of biological chemistry (07.03.2014)
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Journal Article
The role of proteases and inflammatory molecules in triggering neovascular age-related macular degeneration: basic science to clinical relevance
Balasubramanian, Sivaraman A, Krishna Kumar, Kaavya, Baird, Paul N
Published in Translational research : the journal of laboratory and clinical medicine (01.09.2014)
Published in Translational research : the journal of laboratory and clinical medicine (01.09.2014)
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Journal Article
The structure of α-haemoglobin in complex with a haemoglobin-binding domain from Staphylococcus aureus reveals the elusive α-haemoglobin dimerization interface
Krishna Kumar, Kaavya, Jacques, David A., Guss, J. Mitchell, Gell, David A.
Published in Acta crystallographica. Section F, Structural biology communications (01.08.2014)
Published in Acta crystallographica. Section F, Structural biology communications (01.08.2014)
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Journal Article
Structural insights into differences in G protein activation by family A and family B GPCRs
Hilger, Daniel, Kumar, Kaavya Krishna, Hu, Hongli, Pedersen, Mie Fabricius, O'Brien, Evan S, Giehm, Lise, Jennings, Christine, Eskici, Gözde, Inoue, Asuka, Lerch, Michael, Mathiesen, Jesper Mosolff, Skiniotis, Georgios, Kobilka, Brian K
Published in Science (American Association for the Advancement of Science) (31.07.2020)
Published in Science (American Association for the Advancement of Science) (31.07.2020)
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Journal Article
Large library docking for cannabinoid-1 receptor agonists with reduced side effects
Tummino, Tia A, Iliopoulos-Tsoutsouvas, Christos, Braz, Joao M, O'Brien, Evan S, Stein, Reed M, Craik, Veronica, Tran, Ngan K, Ganapathy, Suthakar, Liu, Fangyu, Shiimura, Yuki, Tong, Fei, Ho, Thanh C, Radchenko, Dmytro S, Moroz, Yurii S, Rosado, Sian Rodriguez, Bhardwaj, Karnika, Benitez, Jorge, Liu, Yongfeng, Kandasamy, Herthana, Normand, Claire, Semache, Meriem, Sabbagh, Laurent, Glenn, Isabella, Irwin, John J, Kumar, Kaavya Krishna, Makriyannis, Alexandros, Basbaum, Allan I, Shoichet, Brian K
Published in bioRxiv (28.02.2024)
Published in bioRxiv (28.02.2024)
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Journal Article
Paper
Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation
Wei, Tzu-Tang, Chandy, Mark, Nishiga, Masataka, Zhang, Angela, Kumar, Kaavya Krishna, Thomas, Dilip, Manhas, Amit, Rhee, Siyeon, Justesen, Johanne Marie, Chen, Ian Y., Wo, Hung-Ta, Khanamiri, Saereh, Yang, Johnson Y., Seidl, Frederick J., Burns, Noah Z., Liu, Chun, Sayed, Nazish, Shie, Jiun-Jie, Yeh, Chih-Fan, Yang, Kai-Chien, Lau, Edward, Lynch, Kara L., Rivas, Manuel, Kobilka, Brian K., Wu, Joseph C.
Published in Cell (12.05.2022)
Published in Cell (12.05.2022)
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Journal Article
Viewing rare conformations of the β₂ adrenergic receptor with pressure-resolved DEER spectroscopy
Lerch, Michael T., Matt, Rachel A., Masureel, Matthieu, Elgeti, Matthias, Kumar, Kaavya Krishna, Hilger, Daniel, Foys, Bryon, Kobilka, Brian K., Hubbell, Wayne L.
Published in Proceedings of the National Academy of Sciences - PNAS (15.12.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (15.12.2020)
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Journal Article
Author Correction: Stepwise activation of a metabotropic glutamate receptor
Krishna Kumar, Kaavya, Wang, Haoqing, Habrian, Chris, Latorraca, Naomi R., Xu, Jun, O’Brien, Evan S., Zhang, Chensong, Montabana, Elizabeth, Koehl, Antoine, Marqusee, Susan, Isacoff, Ehud Y., Kobilka, Brian K.
Published in Nature (London) (23.05.2024)
Published in Nature (London) (23.05.2024)
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Journal Article
Negative allosteric modulation of the µ-opioid receptor
O'Brien, Evan S., Rangari, Vipin A., El Daibani, Amal, Eans, Shainnel O., White, Betsy, Wang, Haoqing, Shiimura, Yuki, Kumar, Kaavya Krishna, Appourchaux, Kevin, Zhang, Chensong, Mathiesen, Jesper M., Che, Tao, McLaughlin, Jay P., Majumdar, Susruta, Kobilka, Brian K.
Published in Biophysical journal (08.02.2024)
Published in Biophysical journal (08.02.2024)
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Journal Article