Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation
Chen, Jun, Joshi, Shailen K., DiDomenico, Stanley, Perner, Richard J., Mikusa, Joe P., Gauvin, Donna M., Segreti, Jason A., Han, Ping, Zhang, Xu-Feng, Niforatos, Wende, Bianchi, Bruce R., Baker, Scott J., Zhong, Chengmin, Simler, Gricelda H., McDonald, Heath A., Schmidt, Robert G., McGaraughty, Steve P., Chu, Katharine L., Faltynek, Connie R., Kort, Michael E., Reilly, Regina M., Kym, Philip R.
Published in Pain (Amsterdam) (01.05.2011)
Published in Pain (Amsterdam) (01.05.2011)
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Journal Article
TRPA1 Modulation of Spontaneous and Mechanically Evoked Firing of Spinal Neurons in Uninjured, Osteoarthritic, and Inflamed Rats
McGaraughty, Steve, Chu, Katharine L, Perner, Richard J, DiDomenico, Stan, Kort, Michael E, Kym, Philip R
Published in Molecular pain (05.03.2010)
Published in Molecular pain (05.03.2010)
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Journal Article
Pore Dilation Occurs in TRPA1 but Not in TRPM8 Channels
Chen, Jun, Kim, Donghee, Bianchi, Bruce R, Cavanaugh, Eric J, Faltynek, Connie R, Kym, Philip R, Reilly, Regina M
Published in Molecular pain (21.01.2009)
Published in Molecular pain (21.01.2009)
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Journal Article
Validation of Diacyl Glycerolacyltransferase I as a Novel Target for the Treatment of Obesity and Dyslipidemia Using a Potent and Selective Small Molecule Inhibitor
Zhao, Gang, Souers, Andrew J, Voorbach, Martin, Falls, H. Doug, Droz, Brian, Brodjian, Sevan, Lau, Yau Yi, Iyengar, Rajesh R, Gao, Ju, Judd, Andrew S, Wagaw, Seble H, Ravn, Matthew M, Engstrom, Kenneth M, Lynch, John K, Mulhern, Mathew M, Freeman, Jennifer, Dayton, Brian D, Wang, Xiaojun, Grihalde, Nelson, Fry, Dennis, Beno, David W. A, Marsh, Kennan C, Su, Zhi, Diaz, Gilbert J, Collins, Christine A, Sham, Hing, Reilly, Regina M, Brune, Michael E, Kym, Philip R
Published in Journal of medicinal chemistry (14.02.2008)
Published in Journal of medicinal chemistry (14.02.2008)
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Journal Article
Molecular Determinants of Species-Specific Activation or Blockade of TRPA1 Channels
Chen, Jun, Zhang, Xu-Feng, Kort, Michael E, Huth, Jeffrey R, Sun, Chaohong, Miesbauer, Laura J, Cassar, Steven C, Neelands, Torben, Scott, Victoria E, Moreland, Robert B, Reilly, Regina M, Hajduk, Philip J, Kym, Philip R, Hutchins, Charles W, Faltynek, Connie R
Published in The Journal of neuroscience (07.05.2008)
Published in The Journal of neuroscience (07.05.2008)
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Journal Article
Discovery of Potent, Selective, Orally Bioavailable Stearoyl-CoA Desaturase 1 Inhibitors
Liu, Gang, Lynch, John K, Freeman, Jennifer, Liu, Bo, Xin, Zhili, Zhao, Hongyu, Serby, Michael D, Kym, Philip R, Suhar, Tom S, Smith, Harriet T, Cao, Ning, Yang, Ruojing, Janis, Rich S, Krauser, Joel A, Cepa, Steven P, Beno, David W. A, Sham, Hing L, Collins, Christine A, Surowy, Teresa K, Camp, Heidi S
Published in Journal of medicinal chemistry (28.06.2007)
Published in Journal of medicinal chemistry (28.06.2007)
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Journal Article
Diacylglycerol Acyltransferase 1 Inhibition Lowers Serum Triglycerides in the Zucker Fatty Rat and the Hyperlipidemic Hamster
King, Andrew J, Segreti, Jason A, Larson, Kelly J, Souers, Andrew J, Kym, Philip R, Reilly, Regina M, Zhao, Gang, Mittelstadt, Scott W, Cox, Bryan F
Published in The Journal of pharmacology and experimental therapeutics (01.08.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2009)
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Journal Article
Targeting TRP channels for pain relief
Brederson, Jill-Desiree, Kym, Philip R., Szallasi, Arpad
Published in European journal of pharmacology (15.09.2013)
Published in European journal of pharmacology (15.09.2013)
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Journal Article
Synthesis and biological evaluation of 5-substituted and 4,5-disubstituted-2-arylamino oxazole TRPV1 antagonists
Perner, Richard J., Koenig, John R., DiDomenico, Stanley, Gomtsyan, Arthur, Schmidt, Robert G., Lee, Chih-Hung, Hsu, Margaret C., McDonald, Heath A., Gauvin, Donna M., Joshi, Shailen, Turner, Teresa M., Reilly, Regina M., Kym, Philip R., Kort, Michael E.
Published in Bioorganic & medicinal chemistry (01.07.2010)
Published in Bioorganic & medicinal chemistry (01.07.2010)
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Journal Article
TRPV1 antagonist, A-889425, inhibits mechanotransmission in a subclass of rat primary afferent neurons following peripheral inflammation
Brederson, Jill-Desiree, Chu, Katharine L., Reilly, Regina M., Brown, Brian S., Kym, Philip R., Jarvis, Michael F., McGaraughty, Steve
Published in Synapse (New York, N.Y.) (01.03.2012)
Published in Synapse (New York, N.Y.) (01.03.2012)
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Journal Article
Foslevodopa/Foscarbidopa: A New Subcutaneous Treatment for Parkinson's Disease
Rosebraugh, Matthew, Voight, Eric A., Moussa, Ehab M., Jameel, Feroz, Lou, Xiaochun, Zhang, Geoff G. Z., Mayer, Peter T., Stolarik, Deanne, Carr, Robert A., Enright, Brian P., Liu, Wei, Facheris, Maurizio F., Kym, Philip R.
Published in Annals of neurology (01.07.2021)
Published in Annals of neurology (01.07.2021)
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Journal Article
Parkinson’s Disease: Advances in Treatment and the Syntheses of Various Classes of Pharmaceutical Drug Substances
Hill, David R., Huters, Alexander D., Towne, Timothy B., Reddy, Rajarathnam E., Fogle, Jace L., Voight, Eric A., Kym, Philip R.
Published in Chemical reviews (13.12.2023)
Published in Chemical reviews (13.12.2023)
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Journal Article
Nonsteroidal Selective Glucocorticoid Modulators: The Effect of C-10 Substitution on Receptor Selectivity and Functional Potency of 5-Allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines
Kym, Philip R, Kort, Michael E, Coghlan, Michael J, Moore, Jimmie L, Tang, Rui, Ratajczyk, James D, Larson, Daniel P, Elmore, Steven W, Pratt, John K, Stashko, Michael A, Falls, H. Douglass, Lin, Chun W, Nakane, Masake, Miller, Loan, Tyree, Curtis M, Miner, Jeffery N, Jacobson, Peer B, Wilcox, Denise M, Nguyen, Phong, Lane, Benjamin C
Published in Journal of medicinal chemistry (13.03.2003)
Published in Journal of medicinal chemistry (13.03.2003)
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Journal Article
Fueling the Pipeline via Innovations in Organic Synthesis
Voight, Eric A, Greszler, Stephen N, Kym, Philip R
Published in ACS medicinal chemistry letters (09.09.2021)
Published in ACS medicinal chemistry letters (09.09.2021)
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Journal Article
Liver-Selective Glucocorticoid Antagonists: A Novel Treatment for Type 2 Diabetes
von Geldern, Thomas W, Tu, Noah, Kym, Philip R, Link, James T, Jae, Hwan-Soo, Lai, Chunqiu, Apelqvist, Theresa, Rhonnstad, Patrik, Hagberg, Lars, Koehler, Konrad, Grynfarb, Marlena, Goos-Nilsson, Annika, Sandberg, Johnny, Österlund, Marie, Barkhem, Tomas, Höglund, Marie, Wang, Jiahong, Fung, Steven, Wilcox, Denise, Nguyen, Phong, Jakob, Clarissa, Hutchins, Charles, Färnegårdh, Mathias, Kauppi, Björn, Öhman, Lars, Jacobson, Peer B
Published in Journal of medicinal chemistry (12.08.2004)
Published in Journal of medicinal chemistry (12.08.2004)
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Journal Article
Free Energy Perturbation Approach for Accurate Crystalline Aqueous Solubility Predictions
Hong, Richard S., Rojas, Ana V., Bhardwaj, Rajni Miglani, Wang, Lingle, Mattei, Alessandra, Abraham, Nathan S., Cusack, Kevin P., Pierce, M. Olivia, Mondal, Sayan, Mehio, Nada, Bordawekar, Shailendra, Kym, Philip R., Abel, Robert, Sheikh, Ahmad Y.
Published in Journal of medicinal chemistry (14.12.2023)
Published in Journal of medicinal chemistry (14.12.2023)
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Journal Article
Biological Characterization of F508delCFTR Protein Processing by the CFTR Corrector ABBV-2222/GLPG2222
Singh, Ashvani K, Fan, Yihong, Balut, Corina, Alani, Sara, Manelli, Arlene M, Swensen, Andrew M, Jia, Ying, Neelands, Torben R, Vortherms, Timothy A, Liu, Bo, Searle, Xenia B, Wang, Xueqing, Gao, Wenqing, Hwang, Tzyh-Chang, Ren, Hong Y, Cyr, Douglas, Kym, Philip R, Conrath, Katja, Tse, Chris
Published in The Journal of pharmacology and experimental therapeutics (01.01.2020)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2020)
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