TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1
Dibble, Christian C., Elis, Winfried, Menon, Suchithra, Qin, Wei, Klekota, Justin, Asara, John M., Finan, Peter M., Kwiatkowski, David J., Murphy, Leon O., Manning, Brendan D.
Published in Molecular cell (24.08.2012)
Published in Molecular cell (24.08.2012)
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Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas
Campbell, Joshua D, Alexandrov, Anton, Kim, Jaegil, Wala, Jeremiah, Berger, Alice H, Pedamallu, Chandra Sekhar, Shukla, Sachet A, Guo, Guangwu, Brooks, Angela N, Murray, Bradley A, Imielinski, Marcin, Hu, Xin, Ling, Shiyun, Akbani, Rehan, Rosenberg, Mara, Cibulskis, Carrie, Ramachandran, Aruna, Collisson, Eric A, Kwiatkowski, David J, Lawrence, Michael S, Weinstein, John N, Verhaak, Roel G W, Wu, Catherine J, Hammerman, Peter S, Cherniack, Andrew D, Getz, Gad, Artyomov, Maxim N, Schreiber, Robert, Govindan, Ramaswamy, Meyerson, Matthew
Published in Nature genetics (01.06.2016)
Published in Nature genetics (01.06.2016)
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A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations
Zhang, Yiqun, Kwok-Shing Ng, Patrick, Kucherlapati, Melanie, Chen, Fengju, Liu, Yuexin, Tsang, Yiu Huen, de Velasco, Guillermo, Jeong, Kang Jin, Akbani, Rehan, Hadjipanayis, Angela, Pantazi, Angeliki, Bristow, Christopher A., Lee, Eunjung, Mahadeshwar, Harshad S., Tang, Jiabin, Zhang, Jianhua, Yang, Lixing, Seth, Sahil, Lee, Semin, Ren, Xiaojia, Song, Xingzhi, Sun, Huandong, Seidman, Jonathan, Luquette, Lovelace J., Xi, Ruibin, Chin, Lynda, Protopopov, Alexei, Westbrook, Thomas F., Shelley, Carl Simon, Choueiri, Toni K., Ittmann, Michael, Van Waes, Carter, Weinstein, John N., Liang, Han, Henske, Elizabeth P., Godwin, Andrew K., Park, Peter J., Kucherlapati, Raju, Scott, Kenneth L., Mills, Gordon B., Kwiatkowski, David J., Creighton, Chad J.
Published in Cancer cell (12.06.2017)
Published in Cancer cell (12.06.2017)
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Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways
Yecies, Jessica L., Zhang, Hui H., Menon, Suchithra, Liu, Sihao, Yecies, Derek, Lipovsky, Alex I., Gorgun, Cem, Kwiatkowski, David J., Hotamisligil, Gökhan S., Lee, Chih-Hao, Manning, Brendan D.
Published in Cell metabolism (06.07.2011)
Published in Cell metabolism (06.07.2011)
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Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors: Guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology
Lindeman, Neal I., Cagle, Philip T., Beasley, Mary Beth, Chitale, Dhananjay Arun, Dacic, Sanja, Giaccone, Giuseppe, Jenkins, Robert Brian, Kwiatkowski, David J., Saldivar, Juan-Sebastian, Squire, Jeremy, Thunnissen, Erik, Ladanyi, Marc
Published in Journal of thoracic oncology (01.07.2013)
Published in Journal of thoracic oncology (01.07.2013)
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An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers
Chan, Kin, Roberts, Steven A, Klimczak, Leszek J, Sterling, Joan F, Saini, Natalie, Malc, Ewa P, Kim, Jaegil, Kwiatkowski, David J, Fargo, David C, Mieczkowski, Piotr A, Getz, Gad, Gordenin, Dmitry A
Published in Nature genetics (01.09.2015)
Published in Nature genetics (01.09.2015)
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MET IHC Is a Poor Screen for MET Amplification or MET Exon 14 Mutations in Lung Adenocarcinomas: Data from a Tri-Institutional Cohort of the Lung Cancer Mutation Consortium
Guo, Robin, Berry, Lynne D., Aisner, Dara L., Sheren, Jamie, Boyle, Theresa, Bunn, Paul A., Johnson, Bruce E., Kwiatkowski, David J., Drilon, Alexander, Sholl, Lynette M., Kris, Mark G.
Published in Journal of thoracic oncology (01.09.2019)
Published in Journal of thoracic oncology (01.09.2019)
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Using Multiplexed Assays of Oncogenic Drivers in Lung Cancers to Select Targeted Drugs
Kris, Mark G, Johnson, Bruce E, Berry, Lynne D, Kwiatkowski, David J, Iafrate, A. John, Wistuba, Ignacio I, Varella-Garcia, Marileila, Franklin, Wilbur A, Aronson, Samuel L, Su, Pei-Fang, Shyr, Yu, Camidge, D. Ross, Sequist, Lecia V, Glisson, Bonnie S, Khuri, Fadlo R, Garon, Edward B, Pao, William, Rudin, Charles, Schiller, Joan, Haura, Eric B, Socinski, Mark, Shirai, Keisuke, Chen, Heidi, Giaccone, Giuseppe, Ladanyi, Marc, Kugler, Kelly, Minna, John D, Bunn, Paul A
Published in JAMA : the journal of the American Medical Association (21.05.2014)
Published in JAMA : the journal of the American Medical Association (21.05.2014)
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Mutational Analysis of 472 Urothelial Carcinoma Across Grades and Anatomic Sites
Nassar, Amin H, Umeton, Renato, Kim, Jaegil, Lundgren, Kevin, Harshman, Lauren, Van Allen, Eliezer M, Preston, Mark, Dong, Fei, Bellmunt, Joaquim, Mouw, Kent W, Choueiri, Toni K, Sonpavde, Guru, Kwiatkowski, David J
Published in Clinical cancer research (15.04.2019)
Published in Clinical cancer research (15.04.2019)
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Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology
Lindeman, Neal I, Cagle, Philip T, Beasley, Mary Beth, Chitale, Dhananjay Arun, Dacic, Sanja, Giaccone, Giuseppe, Jenkins, Robert Brian, Kwiatkowski, David J, Saldivar, Juan-Sebastian, Squire, Jeremy, Thunnissen, Erik, Ladanyi, Marc
Published in Archives of pathology & laboratory medicine (1976) (01.06.2013)
Published in Archives of pathology & laboratory medicine (1976) (01.06.2013)
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Coordinated regulation of protein synthesis and degradation by mTORC1
Zhang, Yinan, Nicholatos, Justin, Dreier, John R., Ricoult, Stéphane J. H., Widenmaier, Scott B., Hotamisligil, Gökhan S., Kwiatkowski, David J., Manning, Brendan D.
Published in Nature (London) (18.09.2014)
Published in Nature (London) (18.09.2014)
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Mosaic and Intronic Mutations in TSC1/TSC2 Explain the Majority of TSC Patients with No Mutation Identified by Conventional Testing
Tyburczy, Magdalena E, Dies, Kira A, Glass, Jennifer, Camposano, Susana, Chekaluk, Yvonne, Thorner, Aaron R, Lin, Ling, Krueger, Darcy, Franz, David N, Thiele, Elizabeth A, Sahin, Mustafa, Kwiatkowski, David J
Published in PLoS genetics (01.11.2015)
Published in PLoS genetics (01.11.2015)
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mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion
Liu, Heng-Jia, Du, Heng, Khabibullin, Damir, Zarei, Mahsa, Wei, Kevin, Freeman, Gordon J., Kwiatkowski, David J., Henske, Elizabeth P.
Published in Nature communications (03.03.2023)
Published in Nature communications (03.03.2023)
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Somatic Mutations Activating the mTOR Pathway in Dorsal Telencephalic Progenitors Cause a Continuum of Cortical Dysplasias
D’Gama, Alissa M., Woodworth, Mollie B., Hossain, Amer A., Bizzotto, Sara, Hatem, Nicole E., LaCoursiere, Christopher M., Najm, Imad, Ying, Zhong, Yang, Edward, Barkovich, A. James, Kwiatkowski, David J., Vinters, Harry V., Madsen, Joseph R., Mathern, Gary W., Blümcke, Ingmar, Poduri, Annapurna, Walsh, Christopher A.
Published in Cell reports (Cambridge) (26.12.2017)
Published in Cell reports (Cambridge) (26.12.2017)
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Response of a Neuronal Model of Tuberous Sclerosis to Mammalian Target of Rapamycin (mTOR) Inhibitors: Effects on mTORC1 and Akt Signaling Lead to Improved Survival and Function
Meikle, Lynsey, Pollizzi, Kristen, Egnor, Anna, Kramvis, Ioannis, Lane, Heidi, Sahin, Mustafa, Kwiatkowski, David J
Published in The Journal of neuroscience (21.05.2008)
Published in The Journal of neuroscience (21.05.2008)
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Invasive Bladder Cancer: Genomic Insights and Therapeutic Promise
Kim, Jaegil, Akbani, Rehan, Creighton, Chad J, Lerner, Seth P, Weinstein, John N, Getz, Gad, Kwiatkowski, David J
Published in Clinical cancer research (15.10.2015)
Published in Clinical cancer research (15.10.2015)
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Multi-institutional Oncogenic Driver Mutation Analysis in Lung Adenocarcinoma: The Lung Cancer Mutation Consortium Experience
Sholl, Lynette M., Aisner, Dara L., Varella-Garcia, Marileila, Berry, Lynne D., Dias-Santagata, Dora, Wistuba, Ignacio I., Chen, Heidi, Fujimoto, Junya, Kugler, Kelly, Franklin, Wilbur A., Iafrate, A. John, Ladanyi, Marc, Kris, Mark G., Johnson, Bruce E., Bunn, Paul A., Minna, John D., Kwiatkowski, David J.
Published in Journal of thoracic oncology (01.05.2015)
Published in Journal of thoracic oncology (01.05.2015)
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