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Resistance Mutations in Human Immunodeficiency Virus Type 1 Integrase Selected with Elvitegravir Confer Reduced Susceptibility to a Wide Range of Integrase Inhibitors

Resistance Mutations in Human Immunodeficiency Virus Type 1 Integrase Selected with Elvitegravir Confer Reduced Susceptibility to a Wide Range of Integrase Inhibitors

by GOETHALS, Olivia, CLAYTON, Reginald, MEERSSEMAN, Geert, JOCHMANS, Dirk, VERMEIRE, Kurt, SCHOLS, Dominique, HALLENBERGER, Sabine, HERTOGS, Kurt, VAN GINDEREN, Marcia, VEREYCKEN, Inge, WAGEMANS, Elisabeth, GELUYKENS, Peggy, DOCKX, Koen, STRIJBOS, Rudy, SMITS, Veerle, VOS, Ann
Published in Journal of Virology (01.11.2008)

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Binding Kinetics of Darunavir to Human Immunodeficiency Virus Type 1 Protease Explain the Potent Antiviral Activity and High Genetic Barrier

Binding Kinetics of Darunavir to Human Immunodeficiency Virus Type 1 Protease Explain the Potent Antiviral Activity and High Genetic Barrier

by DIERYNCK, Inge, DE WIT, Mieke, GUSTIN, Emmanuel, KEULEERS, Inge, VANDERSMISSEN, Johan, HALLENBERGER, Sabine, HERTOGS, Kurt
Published in Journal of Virology (01.12.2007)

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A bacterial-two-hybrid selection system for one-step isolation of intracellularly functional Nanobodies

A bacterial-two-hybrid selection system for one-step isolation of intracellularly functional Nanobodies

by Pellis, Mireille, Pardon, Els, Zolghadr, Kourosh, Rothbauer, Ulrich, Vincke, Cécile, Kinne, Joerg, Dierynck, Inge, Hertogs, Kurt, Leonhardt, Heinrich, Messens, Joris, Muyldermans, Serge, Conrath, Katja
Published in Archives of biochemistry and biophysics (15.10.2012)

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Indolopyridones Inhibit Human Immunodeficiency Virus Reverse Transcriptase with a Novel Mechanism of Action

Indolopyridones Inhibit Human Immunodeficiency Virus Reverse Transcriptase with a Novel Mechanism of Action

by JOCHMANS, Dirk, DEVAL, Jérome, EHTESHAMI, Maryam, WIGERINCK, Piet, GÖTTE, Matthias, HERTOGS, Kurt, KESTELEYN, Bart, VAN MARCK, Herwig, BETTENS, Eva, DE BAERE, Inky, DEHERTOGH, Pascale, IVENS, Tania, VAN GINDEREN, Marcia, VAN SCHOUBROECK, Bertrand
Published in Journal of Virology (01.12.2006)

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Genotypic Correlates of Phenotypic Resistance to Efavirenz in Virus Isolates from Patients Failing Nonnucleoside Reverse Transcriptase Inhibitor Therapy

Genotypic Correlates of Phenotypic Resistance to Efavirenz in Virus Isolates from Patients Failing Nonnucleoside Reverse Transcriptase Inhibitor Therapy

by Bacheler, L, Jeffrey, S, Hanna, G, D'Aquila, R, Wallace, L, Logue, K, Cordova, B, Hertogs, K, Larder, B, Buckery, R, Baker, D, Gallagher, K, Scarnati, H, Tritch, R, Rizzo, C
Published in Journal of Virology (01.06.2001)

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A Rapid Method for Simultaneous Detection of Phenotypic Resistance to Inhibitors of Protease and Reverse Transcriptase in Recombinant Human Immunodeficiency Virus Type 1 Isolates from Patients Treated with Antiretroviral Drugs

A Rapid Method for Simultaneous Detection of Phenotypic Resistance to Inhibitors of Protease and Reverse Transcriptase in Recombinant Human Immunodeficiency Virus Type 1 Isolates from Patients Treated with Antiretroviral Drugs

by HERTOGS, K, DE BETHUNE, M.-P, PEETERS, F, STASZEWSKI, S, CONANT, M, BLOOR, S, KEMP, S, LARDER, B, PAUWELS, R, MILLER, V, IVENS, T, SCHEL, P, VAN CAUWENBERGE, A, VAN DEN EYNDE, C, VAN GERWEN, V, AZIJN, H, VAN HOUTTE, M
Published in Antimicrobial Agents and Chemotherapy (01.02.1998)

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Short-Cycle Structured Intermittent Treatment of Chronic HIV Infection with Highly Active Antiretroviral Therapy: Effects on Virologic, Immunologic, and Toxicity Parameters

Short-Cycle Structured Intermittent Treatment of Chronic HIV Infection with Highly Active Antiretroviral Therapy: Effects on Virologic, Immunologic, and Toxicity Parameters

by Dybul, Mark, Chun, Tae-Wook, Yoder, Christian, Hidalgo, Bertha, Belson, Michael, Hertogs, Kurt, Larder, Brendan, Dewar, Robin L., Fox, Cecil H., Hallahan, Claire W., Justement, J. Shawn, Migueles, Stephen A., Metcalf, Julia A., Davey, Richard T., Daucher, Marybeth, Pandya, Punita, Baseler, Michael, Ward, Douglas J., Fauci, Anthony S.
Published in Proceedings of the National Academy of Sciences - PNAS (18.12.2001)

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Tipranavir inhibits broadly protease inhibitor-resistant HIV-1 clinical samples

Tipranavir inhibits broadly protease inhibitor-resistant HIV-1 clinical samples

by LARDER, Brendan A, HERTOGS, Kurt, BLOOR, Stuart, VAN DEN EYNDE, Ch, DECIAN, Wanda, YENYUN WANG, FREIMUTH, William W, TARPLEY, Gary
Published in AIDS (London) (08.09.2000)

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A Family of Insertion Mutations between Codons 67 and 70 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confer Multinucleoside Analog Resistance

A Family of Insertion Mutations between Codons 67 and 70 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confer Multinucleoside Analog Resistance

by LARDER, B. A, BLOOR, S, STUART, D. I, PAUWELS, R, KEMP, S. D, HERTOGS, K, DESMET, R. L, MILLER, V, STURMER, M, STASZEWSKI, S, REN, J, STAMMERS, D. K
Published in Antimicrobial Agents and Chemotherapy (01.08.1999)

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Screening and selecting for optimized antiretroviral drugs: rising to the challenge of drug resistance

Screening and selecting for optimized antiretroviral drugs: rising to the challenge of drug resistance

by Béthune, Marie-Pierre de, Hertogs, Kurt
Published in Current medical research and opinion (01.12.2006)

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A Novel Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutational Pattern Confers Phenotypic Lamivudine Resistance in the Absence of Mutation 184V

A Novel Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutational Pattern Confers Phenotypic Lamivudine Resistance in the Absence of Mutation 184V

by HERTOGS, K, BLOOR, S, MILLER, V, LARDER, B. A, DE VROEY, V, VAN DEN EYNDE, C, DEHERTOGH, P, VAN CAUWENBERGE, A, STÜRMER, M, ALCORN, T, WEGNER, S, VAN HOUTTE, M
Published in Antimicrobial Agents and Chemotherapy (01.03.2000)

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Development of robust antiviral assays for profiling compounds against a panel of positive-strand RNA viruses using ATP/luminescence readout

Development of robust antiviral assays for profiling compounds against a panel of positive-strand RNA viruses using ATP/luminescence readout

by Gong, Edwin, Ivens, Tania, Van den Eynde, Christel, Hallenberger, Sabine, Hertogs, Kurt
Published in Journal of virological methods (01.07.2008)

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Interference between D30N and L90M in Selection and Development of Protease Inhibitor-Resistant Human Immunodeficiency Virus Type 1

Interference between D30N and L90M in Selection and Development of Protease Inhibitor-Resistant Human Immunodeficiency Virus Type 1

by SUGIURA, Wataru, MATSUDA, Zene, ABUMI, Hanae, TAKATA, Noboru, SHIRAHATA, Satoshi, YAMADA, Kaneo, YOSHIKURA, Hiroshi, NAGAI, Yoshiyuki, YOKOMAKU, Yoshiyuki, HERTOGS, Kurt, LARDER, Brendan, OISHI, Tsuyoshi, OKANO, Aiko, SHIINO, Teiichirou, TATSUMI, Masashi, MATSUDA, Masakazu
Published in Antimicrobial Agents and Chemotherapy (01.03.2002)

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Correlation between Viral Resistance to Zidovudine and Resistance at the Reverse Transcriptase Level for a Panel of Human Immunodeficiency Virus Type 1 Mutants

Correlation between Viral Resistance to Zidovudine and Resistance at the Reverse Transcriptase Level for a Panel of Human Immunodeficiency Virus Type 1 Mutants

by Lennerstrand, J, Hertogs, K, Stammers, D K, Larder, B A
Published in Journal of Virology (01.08.2001)

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Correlation of Phenotypic Zidovudine Resistance with Mutational Patterns in the Reverse Transcriptase of Human Immunodeficiency Virus Type 1: Interpretation of Established Mutations and Characterization of New Polymorphisms at Codons 208, 211, and 214

Correlation of Phenotypic Zidovudine Resistance with Mutational Patterns in the Reverse Transcriptase of Human Immunodeficiency Virus Type 1: Interpretation of Established Mutations and Characterization of New Polymorphisms at Codons 208, 211, and 214

by STÜRMER, Martin, STASZEWSKI, Schlomo, DOERR, Hans-Wilhelm, LARDER, Brendan, BLOOR, Stuart, HERTOGS, Kurt
Published in Antimicrobial Agents and Chemotherapy (01.01.2003)

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Prevalence of Protease and Reverse Transcriptase Drug Resistance Mutations over Time in Drug-Naïve Human Immunodeficiency Virus Type 1-Positive Individuals in Rio de Janeiro, Brazil

Prevalence of Protease and Reverse Transcriptase Drug Resistance Mutations over Time in Drug-Naïve Human Immunodeficiency Virus Type 1-Positive Individuals in Rio de Janeiro, Brazil

by DUMANS, Ana T, SOARES, Marcelo A, PIENIAZEK, Danuta, KALISH, Marcia L, DE VROEY, Veronique, HERTOGS, Kurt, TANURI, Amilcar
Published in Antimicrobial Agents and Chemotherapy (01.09.2002)

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Comparative Analysis of Two Commercial Phenotypic Assays for Drug Susceptibility Testing of Human Immunodeficiency Virus Type 1

Comparative Analysis of Two Commercial Phenotypic Assays for Drug Susceptibility Testing of Human Immunodeficiency Virus Type 1

by QARI, Shoukat H, RESPESS, Richard, WEINSTOCK, Hillard, BELTRAMI, Elise M, HERTOGS, Kurt, LARDER, Brendan A, PETROPOULOS, Christos J, HELLMANN, Nicholas, HENEINE, Walid
Published in Journal of Clinical Microbiology (01.01.2002)

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High Degree of Interlaboratory Reproducibility of Human Immunodeficiency Virus Type 1 Protease and Reverse Transcriptase Sequencing of Plasma Samples from Heavily Treated Patients

High Degree of Interlaboratory Reproducibility of Human Immunodeficiency Virus Type 1 Protease and Reverse Transcriptase Sequencing of Plasma Samples from Heavily Treated Patients

by SHAFER, Robert W, HERTOGS, Kurt, ZOLOPA, Andrew R, WARFORD, Ann, BLOOR, Stuart, BETTS, Bradley J, MERIGAN, Thomas C, HARRIGAN, Richard, LARDER, Brendon A
Published in Journal of Clinical Microbiology (01.04.2001)

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Testing Genotypic and Phenotypic Resistance in Human Immunodeficiency Virus Type 1 Isolates of Clade B and Other Clades from Children Failing Antiretroviral Therapy

Testing Genotypic and Phenotypic Resistance in Human Immunodeficiency Virus Type 1 Isolates of Clade B and Other Clades from Children Failing Antiretroviral Therapy

by BRINDEIRO, Patricia A, BRINDEIRO, Rodrigo M, TANURI, Amilcar, MORTENSEN, Claudio, HERTOGS, Kurt, DE VROEY, Veronique, RUBINI, Norma P. M, SION, Fernando S, DE SA, Carlos A. M, MACHADO, Deisy M, SUCCI, Regina C. M
Published in Journal of Clinical Microbiology (01.12.2002)

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ANTIVIRAL ACTIVITY OF TENOFOVIR (PMPA) AGAINST NUCLEOSIDE-RESISTANT CLINICAL HIV SAMPLES

ANTIVIRAL ACTIVITY OF TENOFOVIR (PMPA) AGAINST NUCLEOSIDE-RESISTANT CLINICAL HIV SAMPLES

by Miller, Michael D., Margot, Nicolas A., Hertogs, Kurt, Larder, Brendan, Miller, Veronica
Published in Nucleosides, nucleotides & nucleic acids (31.03.2001)

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