Identification of the Human Cytochrome P450 Enzymes Involved in the Two Oxidative Steps in the Bioactivation of Clopidogrel to Its Pharmacologically Active Metabolite
KAZUI, Miho, NISHIYA, Yumi, ISHIZUKA, Tomoko, HAGIHARA, Katsunobu, FARID, Nagy A, OKAZAKI, Osamu, IKEDA, Toshihiko, KURIHARA, Atsushi
Published in Drug metabolism and disposition (01.01.2010)
Published in Drug metabolism and disposition (01.01.2010)
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A Zone Classification System for Risk Assessment of Idiosyncratic Drug Toxicity Using Daily Dose and Covalent Binding
NAKAYAMA, Shintaro, ATSUMI, Ryo, TAKAKUSA, Hideo, KOBAYASHI, Yoshimasa, KURIHARA, Atsushi, NAGAI, Yoko, NAKAI, Daisuke, OKAZAKI, Osamu
Published in Drug metabolism and disposition (01.09.2009)
Published in Drug metabolism and disposition (01.09.2009)
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Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism
Kazuki, Yasuhiro, Kobayashi, Kaoru, Hirabayashi, Masumi, Abe, Satoshi, Kajitani, Naoyo, Kazuki, Kanako, Takehara, Shoko, Takiguchi, Masato, Satoh, Daisuke, Kuze, Jiro, Sakuma, Tetsushi, Kaneko, Takehito, Mashimo, Tomoji, Osamura, Minori, Hashimoto, Mari, Wakatsuki, Riko, Hirashima, Rika, Fujiwara, Ryoichi, Deguchi, Tsuneo, Kurihara, Atsushi, Tsukazaki, Yasuko, Senda, Naoto, Yamamoto, Takashi, Scheer, Nico, Oshimura, Mitsuo
Published in Proceedings of the National Academy of Sciences - PNAS (19.02.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (19.02.2019)
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A Possible Mechanism for the Differences in Efficiency and Variability of Active Metabolite Formation from Thienopyridine Antiplatelet Agents, Prasugrel and Clopidogrel
HAGIHARA, Katsunobu, KAZUI, Miho, KURIHARA, Atsushi, YOSHIIKE, Michiharu, HONDA, Kokichi, OKAZAKI, Osamu, FARID, Nagy A, IKEDA, Toshihiko
Published in Drug metabolism and disposition (01.11.2009)
Published in Drug metabolism and disposition (01.11.2009)
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Prediction of Human Pharmacokinetics of Therapeutic Monoclonal Antibodies from Simple Allometry of Monkey Data
Oitate, Masataka, Masubuchi, Noriko, Ito, Takashi, Yabe, Yoshiyuki, Karibe, Tsuyoshi, Aoki, Takanori, Murayama, Nobuyuki, Kurihara, Atsushi, Okudaira, Noriko, Izumi, Takashi
Published in DRUG METABOLISM AND PHARMACOKINETICS (01.01.2011)
Published in DRUG METABOLISM AND PHARMACOKINETICS (01.01.2011)
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Predictability of Idiosyncratic Drug Toxicity Risk for Carboxylic Acid-Containing Drugs Based on the Chemical Stability of Acyl Glucuronide
SAWAMURA, Ryoko, OKUDAIRA, Noriko, OKAZAKI, Osamu, WATANABE, Kengo, MURAI, Takahiro, KOBAYASHI, Yoshimasa, TACHIBANA, Masaya, OHNUKI, Takashi, MASUDA, Kayoko, HONMA, Hidehito, KURIHARA, Atsushi
Published in Drug metabolism and disposition (01.10.2010)
Published in Drug metabolism and disposition (01.10.2010)
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The Disposition of Prasugrel, a Novel Thienopyridine, in Humans
FARID, Nagy A, SMITH, Richard L, GILLESPIE, Todd A, RASH, T. James, BLAIR, Patrick E, KURIHARA, Atsushi, GOLDBERG, Mark J
Published in Drug metabolism and disposition (01.07.2007)
Published in Drug metabolism and disposition (01.07.2007)
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Hepatic microsomal thiol methyltransferase is involved in stereoselective methylation of pharmacologically active metabolite of prasugrel
Kazui, Miho, Hagihara, Katsunobu, Izumi, Takashi, Ikeda, Toshihiko, Kurihara, Atsushi
Published in Drug metabolism and disposition (01.07.2014)
Published in Drug metabolism and disposition (01.07.2014)
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INTERACTIONS OF TWO MAJOR METABOLITES OF PRASUGREL, A THIENOPYRIDINE ANTIPLATELET AGENT, WITH THE CYTOCHROMES P450
FAYER REHMEL, Jessica L, ECKSTEIN, James A, FARID, Nagy A, HEIM, John B, KASPER, Steve C, KURIHARA, Atsushi, WRIGHTON, Steven A, RING, Barbara J
Published in Drug metabolism and disposition (01.04.2006)
Published in Drug metabolism and disposition (01.04.2006)
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Prediction of Human Plasma Concentration-time Profiles of Monoclonal Antibodies from Monkey Data by a Species-invariant Time Method
Oitate, Masataka, Nakayama, Shintaro, Ito, Takashi, Kurihara, Atsushi, Okudaira, Noriko, Izumi, Takashi
Published in DRUG METABOLISM AND PHARMACOKINETICS (2012)
Published in DRUG METABOLISM AND PHARMACOKINETICS (2012)
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Analysis of in vitro and in vivo metabolism of zidovudine and gemfibrozil in trans‐chromosomic mouse line expressing human UGT2 enzymes
Kobayashi, Kaoru, Deguchi, Tsuneo, Abe, Satoshi, Kajitani, Naoyo, Kazuki, Kanako, Takehara, Shoko, Nakamura, Kazuomi, Kurihara, Atsushi, Oshimura, Mitsuo, Kazuki, Yasuhiro
Published in Pharmacology research & perspectives (01.12.2022)
Published in Pharmacology research & perspectives (01.12.2022)
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Comparison of Human Cytochrome P450 Inhibition by the Thienopyridines Prasugrel, Clopidogrel, and Ticlopidine
Hagihara, Katsunobu, Nishiya, Yumi, Kurihara, Atsushi, Kazui, Miho, Farid, Nagy A., Ikeda, Toshihiko
Published in DRUG METABOLISM AND PHARMACOKINETICS (01.01.2008)
Published in DRUG METABOLISM AND PHARMACOKINETICS (01.01.2008)
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Human Carboxymethylenebutenolidase as a Bioactivating Hydrolase of Olmesartan Medoxomil in Liver and Intestine
Ishizuka, Tomoko, Fujimori, Izumi, Kato, Mitsunori, Noji-Sakikawa, Chisa, Saito, Motoko, Yoshigae, Yasushi, Kubota, Kazuishi, Kurihara, Atsushi, Izumi, Takashi, Ikeda, Toshihiko, Okazaki, Osamu
Published in The Journal of biological chemistry (16.04.2010)
Published in The Journal of biological chemistry (16.04.2010)
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Paraoxonase 1 as a major bioactivating hydrolase for olmesartan medoxomil in human blood circulation: molecular identification and contribution to plasma metabolism
Ishizuka, Tomoko, Fujimori, Izumi, Nishida, Atsuko, Sakurai, Hidetaka, Yoshigae, Yasushi, Nakahara, Kaori, Kurihara, Atsushi, Ikeda, Toshihiko, Izumi, Takashi
Published in Drug metabolism and disposition (01.02.2012)
Published in Drug metabolism and disposition (01.02.2012)
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Interindividual variability of carboxymethylenebutenolidase homolog, a novel olmesartan medoxomil hydrolase, in the human liver and intestine
Ishizuka, Tomoko, Rozehnal, Veronika, Fischer, Thomas, Kato, Ayako, Endo, Seiko, Yoshigae, Yasushi, Kurihara, Atsushi, Izumi, Takashi
Published in Drug metabolism and disposition (01.05.2013)
Published in Drug metabolism and disposition (01.05.2013)
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Bioactivation of loxoprofen to a pharmacologically active metabolite and its disposition kinetics in human skin
Sawamura, Ryoko, Sakurai, Hidetaka, Wada, Naoya, Nishiya, Yumi, Honda, Tomoyo, Kazui, Miho, Kurihara, Atsushi, Shinagawa, Akira, Izumi, Takashi
Published in Biopharmaceutics & drug disposition (01.09.2015)
Published in Biopharmaceutics & drug disposition (01.09.2015)
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Mechanism-Based Inhibition of Human Cytochrome P450 2B6 by Ticlopidine, Clopidogrel, and the Thiolactone Metabolite of Prasugrel
NISHIYA, Yumi, HAGIHARA, Katsunobu, ITO, Takashi, TAJIMA, Masami, MIURA, Shin-Ichi, KURIHARA, Atsushi, FARID, Nagy A, IKEDA, Toshihiko
Published in Drug metabolism and disposition (01.03.2009)
Published in Drug metabolism and disposition (01.03.2009)
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