Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response
Nakamura, Akito, Nambu, Tadahiro, Ebara, Shunsuke, Hasegawa, Yuka, Toyoshima, Kosei, Tsuchiya, Yasuko, Tomita, Daisuke, Fujimoto, Jun, Kurasawa, Osamu, Takahara, Chisato, Ando, Ayumi, Nishigaki, Ryuichi, Satomi, Yoshinori, Hata, Akito, Hara, Takahito
Published in Proceedings of the National Academy of Sciences - PNAS (14.08.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (14.08.2018)
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Journal Article
Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase
Tanaka, Yuta, Kurasawa, Osamu, Yokota, Akihiro, Klein, Michael G, Ono, Koji, Saito, Bunnai, Matsumoto, Shigemitsu, Okaniwa, Masanori, Ambrus-Aikelin, Geza, Morishita, Daisuke, Kitazawa, Satoshi, Uchiyama, Noriko, Ogawa, Kazumasa, Kimura, Hiromichi, Imamura, Shinichi
Published in Journal of medicinal chemistry (26.03.2020)
Published in Journal of medicinal chemistry (26.03.2020)
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Journal Article
Discovery of a Novel Pyrrole Derivative 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine Fumarate (TAK-438) as a Potassium-Competitive Acid Blocker (P-CAB)
Arikawa, Yasuyoshi, Nishida, Haruyuki, Kurasawa, Osamu, Hasuoka, Atsushi, Hirase, Keizo, Inatomi, Nobuhiro, Hori, Yasunobu, Matsukawa, Jun, Imanishi, Akio, Kondo, Mitsuyo, Tarui, Naoki, Hamada, Teruki, Takagi, Terufumi, Takeuchi, Toshiyuki, Kajino, Masahiro
Published in Journal of medicinal chemistry (10.05.2012)
Published in Journal of medicinal chemistry (10.05.2012)
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Journal Article
Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones
Kurasawa, Osamu, Oguro, Yuya, Miyazaki, Tohru, Homma, Misaki, Mori, Kouji, Iwai, Kenichi, Hara, Hideto, Skene, Robert, Hoffman, Isaac, Ohashi, Akihiro, Yoshida, Sei, Ishikawa, Tomoyasu, Cho, Nobuo
Published in Bioorganic & medicinal chemistry (01.04.2017)
Published in Bioorganic & medicinal chemistry (01.04.2017)
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Journal Article
Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor
Iwai, Kenichi, Nambu, Tadahiro, Dairiki, Ryo, Ohori, Momoko, Yu, Jie, Burke, Kristine, Gotou, Masamitsu, Yamamoto, Yukiko, Ebara, Shunsuke, Shibata, Sachio, Hibino, Ryosuke, Nishizawa, Satoru, Miyazaki, Tohru, Homma, Misaki, Oguro, Yuya, Imada, Takashi, Cho, Nobuo, Uchiyama, Noriko, Kogame, Akifumi, Takeuchi, Toshiyuki, Kurasawa, Osamu, Yamanaka, Kazunori, Niu, Huifeng, Ohashi, Akihiro
Published in Science advances (01.05.2019)
Published in Science advances (01.05.2019)
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Journal Article
Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers
Nishida, Haruyuki, Hasuoka, Atsushi, Arikawa, Yasuyoshi, Kurasawa, Osamu, Hirase, Keizo, Inatomi, Nobuhiro, Hori, Yasunobu, Sato, Fumihiko, Tarui, Naoki, Imanishi, Akio, Kondo, Mitsuyo, Takagi, Terufumi, Kajino, Masahiro
Published in Bioorganic & medicinal chemistry (15.06.2012)
Published in Bioorganic & medicinal chemistry (15.06.2012)
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Journal Article
A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery
Iwai, Kenichi, Nambu, Tadahiro, Kashima, Yukie, Yu, Jie, Eng, Kurt, Miyamoto, Kazumasa, Kakoi, Kazuyo, Gotou, Masamitsu, Takeuchi, Toshiyuki, Kogame, Akifumi, Sappal, Jessica, Murai, Saomi, Haeno, Hiroshi, Kageyama, Shun-Ichiro, Kurasawa, Osamu, Niu, Huifeng, Kannan, Karuppiah, Ohashi, Akihiro
Published in Science advances (01.05.2021)
Published in Science advances (01.05.2021)
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Journal Article
CCR5 Antagonists as Anti-HIV-1 Agents. 1. Synthesis and Biological Evaluation of 5-Oxopyrrolidine-3-carboxamide Derivatives
Imamura, Shinichi, Ishihara, Yuji, Hattori, Taeko, Kurasawa, Osamu, Matsushita, Yoshihiro, Sugihara, Yoshihiro, Kanzaki, Naoyuki, Iizawa, Yuji, Baba, Masanori, Hashiguchi, Shohei
Published in Chemical & Pharmaceutical Bulletin (2004)
Published in Chemical & Pharmaceutical Bulletin (2004)
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Journal Article
CCR5 antagonists as anti-HIV-1 agents. Part 2: Synthesis and biological evaluation of N-[3-(4-benzylpiperidin-1-yl)propyl]- N, N′-diphenylureas
Imamura, Shinichi, Kurasawa, Osamu, Nara, Yoshi, Ichikawa, Takashi, Nishikawa, Youichi, Iida, Takehiro, Hashiguchi, Shohei, Kanzaki, Naoyuki, Iizawa, Yuji, Baba, Masanori, Sugihara, Yoshihiro
Published in Bioorganic & medicinal chemistry (01.05.2004)
Published in Bioorganic & medicinal chemistry (01.05.2004)
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Journal Article
Synthesis and Properties of Oligonucleotides Having a Phosphorus Chiral Center by Incorporation of Conformationally Rigid 5‘-Cyclouridylic Acid Derivatives
Sekine, Mitsuo, Kurasawa, Osamu, Shohda, Koh-ichiroh, Seio, Kohji, Wada, Takeshi
Published in Journal of organic chemistry (06.10.2000)
Published in Journal of organic chemistry (06.10.2000)
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Journal Article
Discovery of a Novel, Highly Potent, and Selective Thieno[3,2‑d]pyrimidinone-Based Cdc7 Inhibitor with a Quinuclidine Moiety (TAK-931) as an Orally Active Investigational Antitumor Agent
Kurasawa, Osamu, Miyazaki, Tohru, Homma, Misaki, Oguro, Yuya, Imada, Takashi, Uchiyama, Noriko, Iwai, Kenichi, Yamamoto, Yukiko, Ohori, Momoko, Hara, Hideto, Sugimoto, Hiroshi, Iwata, Kentaro, Skene, Robert, Hoffman, Isaac, Ohashi, Akihiro, Nomura, Toshiyuki, Cho, Nobuo
Published in Journal of medicinal chemistry (13.02.2020)
Published in Journal of medicinal chemistry (13.02.2020)
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Journal Article
Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents
Kojima, Takuto, Asano, Yasutomi, Kurasawa, Osamu, Hirata, Yasuhiro, Iwamura, Naoki, Wong, Tzu-Tshin, Saito, Bunnai, Tanaka, Yuta, Arai, Ryosuke, Yonemori, Kazuko, Miyamoto, Yasufumi, Sagiya, Yoji, Yaguchi, Masahiro, Shibata, Sachio, Mizutani, Akio, Sano, Osamu, Adachi, Ryutaro, Satomi, Yoshinori, Hirayama, Megumi, Aoyama, Kazunobu, Hiura, Yuto, Kiba, Atsushi, Kitamura, Shuji, Imamura, Shinichi
Published in Bioorganic & medicinal chemistry (15.05.2018)
Published in Bioorganic & medicinal chemistry (15.05.2018)
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Journal Article
New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase
Tanaka, Yuta, Kurasawa, Osamu, Yokota, Akihiro, Klein, Michael G, Saito, Bunnai, Matsumoto, Shigemitsu, Okaniwa, Masanori, Ambrus-Aikelin, Geza, Uchiyama, Noriko, Morishita, Daisuke, Kimura, Hiromichi, Imamura, Shinichi
Published in ACS medicinal chemistry letters (13.08.2020)
Published in ACS medicinal chemistry letters (13.08.2020)
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Journal Article
Abstract 3073: Potential predictive biomarkers of clinical responses for a novel CDC7-selective inhibitor TAK-931
Iwai, Kenichi, Nambu, Tadahiro, Kurasawa, Osamu, Uchiyama, Noriko, Dairiki, Ryo, Yamamoto, Yukiko, Nishizawa, Satoru, Zhang, Mengkun, Ishii, Yuko, Niu, Huifeng, Ohashi, Akihiro
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Abstract 3847: Inhibition of GCN2 sensitizes ASNS-downregulated cancer cells to asparaginase by disrupting amino acid response
Nakamura, Akito, Nambu, Tadahiro, Ebara, Shunsuke, Hasegawa, Yuka, Toyoshima, Kosei, Tsuchiya, Yasuko, Tomita, Daisuke, Fujimoto, Jun, Kurasawa, Osamu, Takahara, Chisato, Kawamura, Ayumi, Nishigaki, Ryuichi, Satomi, Yoshinori, Hata, Akito, Hara, Takahito
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode
Fujimoto, Jun, Kurasawa, Osamu, Takagi, Terufumi, Liu, Xin, Banno, Hiroshi, Kojima, Takuto, Asano, Yasutomi, Nakamura, Akito, Nambu, Tadahiro, Hata, Akito, Ishii, Tsuyoshi, Sameshima, Tomoya, Debori, Yasuyuki, Miyamoto, Maki, Klein, Michael G, Tjhen, Richard, Sang, Bi-Ching, Levin, Irena, Lane, Scott Weston, Snell, Gyorgy P, Li, Ke, Kefala, Georgia, Hoffman, Isaac D, Ding, Steve C, Cary, Douglas R, Mizojiri, Ryo
Published in ACS medicinal chemistry letters (10.10.2019)
Published in ACS medicinal chemistry letters (10.10.2019)
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Journal Article
NITROGEN-CONTAINING HETEROCYCLIC COMPOUND
HASUI, Tomoaki, TAKASHIMA, Sachie, YAMASHITA, Tohru, DAINI, Masaki, YONEMORI, Jinichi, KAMATA, Makoto, KAKEI, Hiroyuki, KINA, Asato, ITO, Mitsuhiro, HOASHI, Yasutaka, KURASAWA, Osamu, IKEDA, Shuhei, MORIMOTO, Shinji
Year of Publication 01.10.2020
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Year of Publication 01.10.2020
Patent
2-Aminomethylthieno[3,2-d]pyrimidin-4(3H)-ones bearing 3-methylpyrazole hinge binding moiety: Highly potent, selective, and time-dependent inhibitors of Cdc7 kinase
Kurasawa, Osamu, Homma, Misaki, Oguro, Yuya, Miyazaki, Tohru, Mori, Kouji, Uchiyama, Noriko, Iwai, Kenichi, Ohashi, Akihiro, Hara, Hideto, Yoshida, Sei, Cho, Nobuo
Published in Bioorganic & medicinal chemistry (15.07.2017)
Published in Bioorganic & medicinal chemistry (15.07.2017)
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Journal Article
헤테로고리 화합물
LIU XIN, KOJIMA TAKUTO, TAKAGI TERUFUMI, KURASAWA OSAMU, FUJIMOTO JUN, BANNO HIROSHI, ASANO YASUTOMI, CARY DOUGLAS ROBERT
Year of Publication 08.04.2019
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Year of Publication 08.04.2019
Patent